Matthew Zapala, MD

Assistant Professor
Asst Prof Clinical Radiology

Biography

Matthew Zapala, MD, PhD, is an assistant professor of clinical radiology in the Pediatric Radiology section in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. In 2007, he received his PhD in biomedical science-bioinformatics from the University of California, San Diego, where he also completed his medical degree in 2009. In 2010, he completed his one-year internship from Scripps Mercy Hospital in San Diego, California. From 2010-2014, Dr. Zapala finished his four-year Diagnostic Radiology residency from the University of California, San Diego, followed by a pediatric radiology fellowship from Boston Children’s Hospital/Harvard Medical School in 2015.

Dr. Zapala is a member of the Radiologic Society of North America, American Roentgen Ray Society and the Society of Pediatric Radiology.

Specialty:
Pediatric Radiology

Expertise:
Pediatric imaging

Professional Interests:
Pediatric radiology, genomics, radiogenomics, bioinformatics, statistical genetics, low dose CT, child abuse, fluoroscopy

Education and Training:
• Medical School: University of California, San Diego
• PhD: University of California, San Diego
• Internship: Scripps Mercy Hospital, San Diego, California
• Residency: University of California, San Diego
• Fellowship: Boston Children's Hospital – Pediatric Radiology

Honors and Awards

Pediatric Radiology Fellow Teaching Award, Boston Children’s Hospital, 2015
Merck Academic Achievement, University of California, San Diego, 2009
Gold Humanism Honor Society, University of California, San Diego, 2009
Departmental Research Honors, Stanford University, 1998

Publications

Zaccagnino E, Devincent C, Leelakanok N, Phelps AS, Zapala M, Worters PW, Courtier J. Assessment of quiet T2 weighted PROPELLER sequence in pediatric abdominal imaging. Clin Imaging. 2018 Sep 26; 53:12-16.
Edwards EA, Pigg N, Courtier J, Zapala MA, MacKenzie JD, Phelps AS. Intussusception: past, present and future. Pediatr Radiol. 2017 Aug; 47(9):1101-1108.
Leelakanok N, Phelps AS, Zapala MA, Kato K, Ohliger M, Li Y, Courtier J. Assessing 3D T2 FSE sequence for identification of the normal appendix: working toward a single-sequence MR appendicitis protocol. Emerg Radiol. 2017 Dec; 24(6):653-660.
Zapala MA, Ho-Fung VM, Lee EY. Thoracic Neoplasms in Children: Contemporary Perspectives and Imaging Assessment. Radiol Clin North Am. 2017 Jul; 55(4):657-676.
Ho-Fung VM, Zapala MA, Lee EY. Musculoskeletal Traumatic Injuries in Children: Characteristic Imaging Findings and Mimickers. Radiol Clin North Am. 2017 Jul; 55(4):785-802.
Leelakanok N, Zapala MA, Edwards EA, Phelps AS, Mackenzie JD, Courtier J. Incidental Findings on Pediatric Abdominal Magnetic Resonance Angiography. Acad Radiol. 2017 09; 24(9):1107-1113.
Zapala MA, Zurakowski D, Lee EY. Comparison of Mechanical Versus Hand Administration of IV Contrast Agents for Pediatric Pulmonary CT Angiography. AJR Am J Roentgenol. 2017 Mar; 208(3):632-636.
Li Y, Phelps A, Zapala MA, MacKenzie JD, MacKenzie TC, Courtier J. Magnetic resonance imaging of Müllerian duct anomalies in children. Pediatr Radiol. 2016 May; 46(6):796-805.
Zapala MA, Tsai A, Kleinman PK. Growth recovery lines are more common in infants at high vs. low risk for abuse. Pediatr Radiol. 2016 Aug; 46(9):1275-81.
Jamshidi N, Jonasch E, Zapala M, Korn RL, Brooks JD, Ljungberg B, Kuo MD. The radiogenomic risk score stratifies outcomes in a renal cell cancer phase 2 clinical trial. Eur Radiol. 2016 Aug; 26(8):2798-807.
Jamshidi N, Jonasch E, Zapala M, Korn RL, Aganovic L, Zhao H, Tumkur Sitaram R, Tibshirani RJ, Banerjee S, Brooks JD, Ljungberg B, Kuo MD. The Radiogenomic Risk Score: Construction of a Prognostic Quantitative, Noninvasive Image-based Molecular Assay for Renal Cell Carcinoma. Radiology. 2015 Oct; 277(1):114-23.
Zapala MA, Schork NJ. Statistical properties of multivariate distance matrix regression for high-dimensional data analysis. Front Genet. 2012; 3:190.
Luo W, Schork NJ, Marschke KB, Ng SC, Hermann TW, Zhang J, Sanders JM, Tooker P, Malo N, Zapala MA, Dziewanowska ZE, Negro-Vilar A, Meglasson MD. Identification of polymorphisms associated with hypertriglyceridemia and prolonged survival induced by bexarotene in treating non-small cell lung cancer. Anticancer Res. 2011 Jun; 31(6):2303-11.
McLachlan S, Lee SM, Steele TM, Hawthorne PL, Zapala MA, Eskin E, Schork NJ, Anderson GJ, Vulpe CD. In silico QTL mapping of basal liver iron levels in inbred mouse strains. Physiol Genomics. 2011 Feb 11; 43(3):136-47.
Winn ME, Zapala MA, Hovatta I, Risbrough VB, Lillie E, Schork NJ. The effects of globin on microarray-based gene expression analysis of mouse blood. Mamm Genome. 2010 Jun; 21(5-6):268-75.
Zhou D, Wang J, Zapala MA, Xue J, Schork NJ, Haddad GG. Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death. Physiol Genomics. 2008 Feb 19; 32(3):370-9.
Greenhall JA, Zapala MA, Cáceres M, Libiger O, Barlow C, Schork NJ, Lockhart DJ. Detecting genetic variation in microarray expression data. Genome Res. 2007 Aug; 17(8):1228-35.
Wessel J, Zapala MA, Schork NJ. Accommodating pathway information in expression quantitative trait locus analysis. Genomics. 2007 Jul; 90(1):132-42.
Hovatta I, Zapala MA, Broide RS, Schadt EE, Libiger O, Schork NJ, Lockhart DJ, Barlow C. DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biol. 2007; 8(2):R25.
Zapala MA, Schork NJ. Multivariate regression analysis of distance matrices for testing associations between gene expression patterns and related variables. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19430-5.
Zapala MA, Hovatta I, Ellison JA, Wodicka L, Del Rio JA, Tennant R, Tynan W, Broide RS, Helton R, Stoveken BS, Winrow C, Lockhart DJ, Reilly JF, Young WG, Bloom FE, Lockhart DJ, Barlow C. Adult mouse brain gene expression patterns bear an embryologic imprint. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10357-62.
Cáceres M, Lachuer J, Zapala MA, Redmond JC, Kudo L, Geschwind DH, Lockhart DJ, Preuss TM, Barlow C. Elevated gene expression levels distinguish human from non-human primate brains. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):13030-5.
Zapala MA, Lockhart DJ, Pankratz DG, Garcia AJ, Barlow C, Lockhart DJ. Software and methods for oligonucleotide and cDNA array data analysis. Genome Biol. 2002; 3(6):SOFTWARE0001.