Andrew Burghardt

Specialist
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Biography

Andrew Burghardt is an Imaging Scientist in the Department of Radiology and Biomedical Imaging at University of California, San Francisco where he serves as the Technical Director of the Quantitative Micro-Imaging Facility (QMIF). His area of expertise is high-resolution imaging computational analysis of musculoskeletal tissues. Osteoporosis, rheumatoid arthritis, and bone acquisition and development are the principle focus application areas for his research. As a Principal Investigator he has been awarded two R01s from NIH related to the standardization of HR-pQCT and the development of 3D statistical mapping techniques for population-based analyses of bone quality. He is a co-investigator on a number of significant NIH-funded multicenter skeletal health projects, including Osteoporotic Fractures in Men (MrOS), and the Epidemiology of Diabetes Interventions and Complications (EDIC). He was a member of the joint International Osteoporosis Foundation, ASBMR, and ECTS working group that produced guidelines for the use of HR-pQCT in skeletal health studies. Recently his research interests have expanded to include the development of standardized methods for using HR-pQCT in pediatric populations through collaborations with Stanford University. At UCSF he is developing a multidisciplinary program to study skeletal development in transgender youth. Finally, he is a founding member of the SPECTRA group (Study GrouP for XTrEme-CT in RA) that aims to develop standard methods to detect and quantify early signs of progression and treatment response in rheumatoid arthritis using HR-pQCT.

Publications

Beavers KM, Wolle BR, Ard JD, Beavers DP, Biehl O, Brubaker PH, Burghardt AJ, Calderone CT, Carballido-Gamio J, Fanning J, Kohrt WM, Love M, MacLean CM, Nicklas BJ, Stapleton J, Swanson CM, Weaver AA, Worden M, Wherry SJ. The Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) trial design and methods. Contemp Clin Trials. 2024 Sep 17; 146:107692.
Sinha Gregory N, Burghardt AJ, Backlund JC, Rubin MR, Bebu I, Braffett BH, Kenny DJ, Link TM, Kazakia GJ, Barnie A, Lachin JM, Gubitosi-Klug R, de Boer IH, Schwartz AV, DCCT/EDIC Research Group. Diabetes Risk Factors and Bone Microarchitecture as Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Adults With Long-standing Type 1 Diabetes. Diabetes Care. 2024 Sep 01; 47(9):1548-1558.
Sadoughi S, Subramanian A, Ramil G, Zhou M, Burghardt AJ, Kazakia GJ. HR-pQCT cross-calibration using standard vs. Laplace-Hamming binarization approach. JBMR Plus. 2024 Oct; 8(10):ziae116.
Faraj M, Schwartz AV, Burghardt AJ, Black D, Orwoll E, Strotmeyer ES, Vittinghoff E, Banfi G, Lombardi G, Woods G, Lui LY, Bouxsein M, Napoli N. Risk Factors for Bone Microarchitecture Impairments in Older Men with Type 2 Diabetes - The MrOS Study. J Clin Endocrinol Metab. 2024 Jul 12.
Michael T. Kuczynski, Nathan J. Neeteson, Kathryn S. Stok, Andrew J. Burghardt, Michelle A. Espinosa Hernandez, Jared Vicory, Justin J. Tse, Pholpat Durongbhan, Serena Bonaretti, Andy Kin On Wong, Steven K. Boyd, Sarah L. Manske. ORMIR_XCT: A Python package for high resolution peripheral quantitative computed tomography image processing. The Journal of Open Source Software. 2024 May 1; 9(97):6084.
Al-Khoury Y, Finzel S, Figueiredo C, Burghardt AJ, Stok KS, Tam LS, Cheng I, Tse JJ, Manske SL. Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography. J Vis Exp. 2023 10 06; (200).
Lorentzon M, Burghardt AJ. The Added Value of High-Resolution Peripheral Quantitative Computed Tomography in Fracture Risk Prediction. J Bone Miner Res. 2023 09; 38(9):1225-1226.
Kirk B, Harrison SL, Zanker J, Burghardt AJ, Orwoll E, Duque G, Cawthon PM. Interactions Between HR-pQCT Bone Density and D3 Cr Muscle Mass (or HR-pQCT Bone Structure and HR-pQCT Muscle Density) in Predicting Fractures: The Osteoporotic Fractures in Men Study. J Bone Miner Res. 2023 09; 38(9):1245-1257.
Gabel L, Kent K, Hosseinitabatabaei S, Burghardt AJ, Leonard MB, Rauch F, Willie BM. Recommendations for High-resolution Peripheral Quantitative Computed Tomography Assessment of Bone Density, Microarchitecture, and Strength in Pediatric Populations. Curr Osteoporos Rep. 2023 10; 21(5):609-623.
Sadoughi S, Subramanian A, Ramil G, Burghardt AJ, Kazakia GJ. A Laplace-Hamming Binarization Approach for Second-Generation HR-pQCT Rescues Fine Feature Segmentation. J Bone Miner Res. 2023 07; 38(7):1006-1014.
Heilmeier U, Burghardt AJ, Tse JJ, Kapoor P, Stok KS, Manske S, Voll RE, Schett G, Finzel S. Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis. Calcif Tissue Int. 2023 04; 112(4):440-451.
Lee JY, Fan B, Montenegro G, Long RK, Sanda S, Capodanno G, Schafer AL, Burghardt AJ, Rosenthal SM, Fung EB. Interpretation of Bone Mineral Density Z-Scores by Dual-Energy X-Ray Absorptiometry in Transgender and Gender Diverse Youth Prior to Gender-Affirming Medical Therapy. J Clin Densitom. 2022 Oct-Dec; 25(4):559-568.
Rubin MR, de Boer IH, Backlund JC, Arends V, Gubitosi-Klug R, Wallia A, Sinha Gregory N, Barnie A, Burghardt AJ, Lachin JM, Braffett BH, Schwartz AV. Biochemical Markers of Bone Turnover in Older Adults With Type 1 Diabetes. J Clin Endocrinol Metab. 2022 05 17; 107(6):e2405-e2416.
Orwoll ES, Blackwell T, Cummings SR, Cauley JA, Lane NE, Hoffman AR, Burghardt AJ, Evans WJ, Cawthon PM. CT Muscle Density, D3Cr Muscle Mass, and Body Fat Associations With Physical Performance, Mobility Outcomes, and Mortality Risk in Older Men. J Gerontol A Biol Sci Med Sci. 2022 04 01; 77(4):790-799.
Orwoll ES, Blackwell T, Cummings SR, Cauley JA, Lane NE, Hoffman AR, Burghardt AJ, Evans WJ, Cawthon PM. Corrigendum to: CT Muscle Density, D3Cr Muscle Mass, and Body Fat Associations With Physical Performance, Mobility Outcomes, and Mortality Risk in Older Men. J Gerontol A Biol Sci Med Sci. 2022 Apr 01; 77(4):881.
Pedoia V, Caliva F, Kazakia G, Burghardt AJ, Majumdar S. Augmenting Osteoporosis Imaging with Machine Learning. Curr Osteoporos Rep. 2021 12; 19(6):699-709.
Shiraishi K, Burghardt AJ, Osaki M, Khosla S, Carballido-Gamio J. Global and Spatial Compartmental Interrelationships of Bone Density, Microstructure, Geometry and Biomechanics in the Distal Radius in a Colles' Fracture Study Using HR-pQCT. Front Endocrinol (Lausanne). 2021; 12:568454.
Okazaki N, Chiba K, Burghardt AJ, Kondo C, Doi M, Yokota K, Yonekura A, Tomita M, Osaki M. Differences in bone mineral density and morphometry measurements by fixed versus relative offset methods in high-resolution peripheral quantitative computed tomography. Bone. 2021 08; 149:115973.
Ursula Heilmeier, Courtney Pasco, Meliss Yilmaz, Andrew J. Burghardt, Gabby B. Joseph, Thomas M. Link, Galateia J. Kazakia. HR-pQCT-based regional analysis reveals tibial spatial variability in cortical bone tissue quality in type 2 diabetic postmenopausal women with and without history of fragility fractures. Bone Reports. 2021 Apr 1; 14:100801.
Heilmeier U, Joseph GB, Pasco C, Dinh N, Torabi S, Darakananda K, Youm J, Carballido-Gamio J, Burghardt AJ, Link TM, Kazakia GJ. Longitudinal Evolution of Bone Microarchitecture and Bone Strength in Type 2 Diabetic Postmenopausal Women With and Without History of Fragility Fractures-A 5-Year Follow-Up Study Using High Resolution Peripheral Quantitative Computed Tomography. Front Endocrinol (Lausanne). 2021; 12:599316.
Finzel S, Manske SL, Barnabe CCM, Burghardt AJ, Marotte H, Scharmga A, Hauge EM, Chapurlat R, Engelke K, Li X, van Teeffelen BCJ, Conaghan PG, Stok KS. Reliability and Change in Erosion Measurements by High-resolution Peripheral Quantitative Computed Tomography in a Longitudinal Dataset of Rheumatoid Arthritis Patients. J Rheumatol. 2021 03; 48(3):348-351.
Klose-Jensen R, Tse JJ, Keller KK, Barnabe C, Burghardt AJ, Finzel S, Tam LS, Hauge EM, Stok KS, Manske SL. High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease. Front Med (Lausanne). 2020; 7:337.
Whittier DE, Boyd SK, Burghardt AJ, Paccou J, Ghasem-Zadeh A, Chapurlat R, Engelke K, Bouxsein ML. Guidelines for the assessment of bone density and microarchitecture in vivo using high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2020 Sep; 31(9):1607-1627.
Stok KS, Burghardt AJ, Boutroy S, Peters MPH, Manske SL, Stadelmann V, Vilayphiou N, van den Bergh JP, Geusens P, Li X, Marotte H, van Rietbergen B, Boyd SK, Barnabe C, SPECTRA Collaboration. Consensus approach for 3D joint space width of metacarpophalangeal joints of rheumatoid arthritis patients using high-resolution peripheral quantitative computed tomography. Quant Imaging Med Surg. 2020 Feb; 10(2):314-325.
Langsetmo L, Burghardt AJ, Schousboe JT, Cawthon PM, Cauley JA, Lane NE, Orwoll ES, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Group. Objective measures of moderate to vigorous physical activity are associated with higher distal limb bone strength among elderly men. Bone. 2020 03; 132:115198.
Mikolajewicz N, Bishop N, Burghardt AJ, Folkestad L, Hall A, Kozloff KM, Lukey PT, Molloy-Bland M, Morin SN, Offiah AC, Shapiro J, van Rietbergen B, Wager K, Willie BM, Komarova SV, Glorieux FH. HR-pQCT Measures of Bone Microarchitecture Predict Fracture: Systematic Review and Meta-Analysis. J Bone Miner Res. 2020 03; 35(3):446-459.
Carballido-Gamio J, Yu A, Wang L, Su Y, Burghardt AJ, Lang TF, Cheng X. Hip Fracture Discrimination Based on Statistical Multi-parametric Modeling (SMPM). Ann Biomed Eng. 2019 Nov; 47(11):2199-2212.
Shimizu T, Cruz A, Tanaka M, Mamoto K, Pedoia V, Burghardt AJ, Heilmeier U, Link TM, Graf J, Imboden JB, Li X. Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis. J Rheumatol. 2019 07; 46(7):676-684.
Li Y, Sixou B, Burghardt AJ, Peyrin F. Investigation of Semi-Coupled Dictionary Learning in 3-D Super Resolution HR-pQCT Imaging. IEEE Transactions on Radiation and Plasma Medical Sciences. 2018; 2(3):129-136.
L Langsetmo, K Ensrud, J Cauley, P Cawthon, A Burghardt. THE ASSOCIATION BETWEEN OBJECTIVELY MEASURED PHYSICAL ACTIVITY AND BONE STRENGTH AMONG OLDER MEN. Innovation in Aging. 2018 Nov 1; 2(suppl_1):304-305.
Cauley JA, Burghardt AJ, Harrison SL, Cawthon PM, Schwartz AV, Connor EB, Ensrud KE, Langsetmo L, Majumdar S, Orwoll E, Osteoporotic Fractures in Men (MrOS) Research Group. Accelerated Bone Loss in Older Men: Effects on Bone Microarchitecture and Strength. J Bone Miner Res. 2018 10; 33(10):1859-1869.
Langsetmo L, Peters KW, Burghardt AJ, Ensrud KE, Fink HA, Cawthon PM, Cauley JA, Schousboe JT, Barrett-Connor E, Orwoll ES, Osteoporotic Fractures in Men (MrOS) Study Research Group. Volumetric Bone Mineral Density and Failure Load of Distal Limbs Predict Incident Clinical Fracture Independent HR-pQCT BMD and Failure Load Predicts Incident Clinical Fracture of FRAX and Clinical Risk Factors Among Older Men. J Bone Miner Res. 2018 07; 33(7):1302-1311.
Ensrud KE, Vo TN, Burghardt AJ, Schousboe JT, Cauley JA, Taylor BC, Hoffman AR, Orwoll ES, Lane NE, Langsetmo L, Osteoporotic Fractures in Men (MrOS) Research Group. Weight loss in men in late life and bone strength and microarchitecture: a prospective study. Osteoporos Int. 2018 Jul; 29(7):1549-1558.
Andrew J. Burghardt, Roland Krug, Sharmila Majumdar. Chapter 55 High-Resolution Imaging Techniques for Bone Quality Assessment. Vitamin D. 2018 Jan 1; 1007-1041.
Langsetmo L, Shikany JM, Burghardt AJ, Cawthon PM, Orwoll ES, Cauley JA, Taylor BC, Schousboe JT, Bauer DC, Vo TN, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Research Group. High dairy protein intake is associated with greater bone strength parameters at the distal radius and tibia in older men: a cross-sectional study. Osteoporos Int. 2018 01; 29(1):69-77.
Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden JB, Li X. Assessment of 3-month changes in bone microstructure under anti-TNFα therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT). Arthritis Res Ther. 2017 Oct 04; 19(1):222.
Stok KS, Finzel S, Burghardt AJ, Conaghan PG, Barnabe C, SPECTRA Collaboration. The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions. J Rheumatol. 2017 Dec; 44(12):1911-1915.
Ghasem-Zadeh A, Burghardt A, Wang XF, Iuliano S, Bonaretti S, Bui M, Zebaze R, Seeman E. Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions. Bone. 2017 Aug; 101:206-213.
Bonaretti S, Majumdar S, Lang TF, Khosla S, Burghardt AJ. The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions. Osteoporos Int. 2017 07; 28(7):2115-2128.
Carballido-Gamio J, Bonaretti S, Kazakia GJ, Khosla S, Majumdar S, Lang TF, Burghardt AJ. Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features. Ann Biomed Eng. 2017 04; 45(4):949-962.
Okazaki N, Burghardt AJ, Chiba K, Schafer AL, Majumdar S. Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD. Bone Rep. 2016 Dec; 5:312-319.
Tom S, Frayne M, Manske SL, Burghardt AJ, Stok KS, Boyd SK, Barnabe C. Determining Metacarpophalangeal Flexion Angle Tolerance for Reliable Volumetric Joint Space Measurements by High-resolution Peripheral Quantitative Computed Tomography. J Rheumatol. 2016 10; 43(10):1941-1944.
Heilmeier U, Hackl M, Skalicky S, Weilner S, Schroeder F, Vierlinger K, Patsch JM, Baum T, Oberbauer E, Lobach I, Burghardt AJ, Schwartz AV, Grillari J, Link TM. Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro. J Bone Miner Res. 2016 12; 31(12):2173-2192.
Bonaretti S, Vilayphiou N, Chan CM, Yu A, Nishiyama K, Liu D, Boutroy S, Ghasem-Zadeh A, Boyd SK, Chapurlat R, McKay H, Shane E, Bouxsein ML, Black DM, Majumdar S, Orwoll ES, Lang TF, Khosla S, Burghardt AJ. Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training. Osteoporos Int. 2017 01; 28(1):245-257.
Boutroy S, Khosla S, Sornay-Rendu E, Zanchetta MB, McMahon DJ, Zhang CA, Chapurlat RD, Zanchetta J, Stein EM, Bogado C, Majumdar S, Burghardt AJ, Shane E. Microarchitecture and Peripheral BMD are Impaired in Postmenopausal White Women With Fracture Independently of Total Hip T-Score: An International Multicenter Study. J Bone Miner Res. 2016 06; 31(6):1158-66.
H. Choi, U. Heilmeier, M. Tanaka, A.J. Burghardt, N. Chanchek, T.M. Link, J. Graft, J.B. Imboden, X. Li. SAT0545 The Effect of anti-TNF Alpha Treatment on Erosion Progression in Rheumatoid Arthritis by High-Resolution Peripheral Quantitative Computed Tomography: Three-Month Data. Annals of the Rheumatic Diseases. 2016 Jun 1; 75(Suppl 2):866.
Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G. Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics. Osteoporos Int. 2016 09; 27(9):2791-2802.
Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S. Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study. J Orthop Res. 2016 10; 34(10):1780-1789.
Carballido-Gamio J, Bonaretti S, Saeed I, Harnish R, Recker R, Burghardt AJ, Keyak JH, Harris T, Khosla S, Lang TF. Automatic multi-parametric quantification of the proximal femur with quantitative computed tomography. Quant Imaging Med Surg. 2015 Aug; 5(4):552-68.
Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden JB, Li X. Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography. Int J Rheum Dis. 2017 Mar; 20(3):353-362.
Nirody JA, Cheng KP, Parrish RM, Burghardt AJ, Majumdar S, Link TM, Kazakia GJ. Spatial distribution of intracortical porosity varies across age and sex. Bone. 2015 Jun; 75:88-95.
Heilmeier U, Carpenter DR, Patsch JM, Harnish R, Joseph GB, Burghardt AJ, Baum T, Schwartz AV, Lang TF, Link TM. Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures. Osteoporos Int. 2015 Apr; 26(4):1283-93.
Bonaretti S, Carpenter RD, Saeed I, Burghardt AJ, Yu L, Bruesewitz M, Khosla S, Lang T. Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD. Phys Med Biol. 2014 Dec 21; 59(24):7819-34.
Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R. Validation of bone marrow fat quantification in the presence of trabecular bone using MRI. J Magn Reson Imaging. 2015 Aug; 42(2):539-44.
Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM, Li X. Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis. Int J Rheum Dis. 2015 Jul; 18(6):628-39.
Julio Carballido-Gamio, Serena Bonaretti, Galateia J. Kazakia, Sundeep Khosla, Thomas F. Lang, Andrew J. Burghardt. Population-based local multi-parametric comparisons of HR-pQCT studies. Journal of Orthopaedic Translation. 2014 Oct 1; 2(4):234-235.
Lee TC, Burghardt AJ, Yao W, Lane NE, Majumdar S, Gullberg GT, Seo Y. Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats. Calcif Tissue Int. 2014 Sep; 95(3):282-91.
Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X. Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study. J Rheumatol. 2014 Sep; 41(9):1766-73.
Chiba K, Burghardt AJ, Osaki M, Majumdar S. Three-dimensional analysis of subchondral cysts in hip osteoarthritis: an ex vivo HR-pQCT study. Bone. 2014 Sep; 66:140-5.
Ko CHIBA, ?? ??, Andrew BURGHARDT, Sharmila MAJUMDAR, ?? ?. Latest Developments in Computed Tomographic Imaging in Joint Disease. Japanese Journal of Rheumatism and Joint Surgery. 2014 Jun 1; 31(2):85-89.
C. Barnabe, H. Marotte, A. Scharmga, S. Kraus, A. Burghardt, E.-M. Hauge, S. Boutroy, D. Toepfer, K. Engelke, R. Kocijan, J. de Jong, X. Li, K. Stok, S. Finzel. SAT0178 Rheumatoid Arthritis Erosion Detection and Measurement in Longitudinal Datasets Using High-Resolution Peripheral Quantitative Computed Tomography (HR-PQCT): Reliability Exercise-2 (RELEX-2). Annals of the Rheumatic Diseases. 2014 Jun 1; 73(Suppl 2):654.
Kazakia GJ, Tjong W, Nirody JA, Burghardt AJ, Carballido-Gamio J, Patsch JM, Link T, Feeley BT, Ma CB. The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT. Bone. 2014 Jun; 63:132-40.
Tjong W, Nirody J, Burghardt AJ, Carballido-Gamio J, Kazakia GJ. Structural analysis of cortical porosity applied to HR-pQCT data. Med Phys. 2014 Jan; 41(1):013701.
Patsch JM, Zulliger MA, Vilayphou N, Samelson EJ, Cejka D, Diarra D, Berzaczy G, Burghardt AJ, Link TM, Weber M, Loewe C. Quantification of lower leg arterial calcifications by high-resolution peripheral quantitative computed tomography. Bone. 2014 Jan; 58:42-7.
Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden JB, Link TM, Li X. Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis. Ann Biomed Eng. 2013 Dec; 41(12):2553-64.
Chiba K, Burghardt AJ, Osaki M, Majumdar S. Heterogeneity of bone microstructure in the femoral head in patients with osteoporosis: an ex vivo HR-pQCT study. Bone. 2013 Sep; 56(1):139-46.
Cheung AM, Adachi JD, Hanley DA, Kendler DL, Davison KS, Josse R, Brown JP, Ste-Marie LG, Kremer R, Erlandson MC, Dian L, Burghardt AJ, Boyd SK. High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group. Curr Osteoporos Rep. 2013 Jun; 11(2):136-46.
Schafer AL, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM. Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS). Osteoporos Int. 2013 Oct; 24(10):2591-601.
K. Chiba, A. Burghardt, M. Osaki, S. Majumdar. Multiple subchondral cyst formation has strong correlation with bone sclerosis: ex vivo HR-pQCT study. Osteoarthritis and Cartilage. 2013 Apr 1; 21:s193-s194.
Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res. 2013 Mar; 28(3):524-36.
Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X. Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis. J Rheumatol. 2013 Apr; 40(4):408-16.
Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, Link TM. Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures. J Bone Miner Res. 2013 Feb; 28(2):313-24.
Valentinitsch A, Patsch JM, Burghardt AJ, Link TM, Majumdar S, Fischer L, Schueller-Weidekamm C, Resch H, Kainberger F, Langs G. Computational identification and quantification of trabecular microarchitecture classes by 3-D texture analysis-based clustering. Bone. 2013 May; 54(1):133-40.
Kazakia GJ, Nirody JA, Bernstein G, Sode M, Burghardt AJ, Majumdar S. Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis. Bone. 2013 Feb; 52(2):623-31.
K. Chiba, A. Burghardt, S. Majumdar. Microstructure analysis of subchondral trabecular bone in hip osteoarthritis - ex-vivo HR-pQCT study -. Osteoarthritis and Cartilage. 2012 Apr 1; 20:s223.
Tjong W, Kazakia GJ, Burghardt AJ, Majumdar S. The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure. Med Phys. 2012 Apr; 39(4):1893-903.
Dafni H, Burghardt AJ, Majumdar S, Navone NM, Ronen SM. Vascular patterning and permeability in prostate cancer models with differing osteogenic properties. NMR Biomed. 2012 Jun; 25(6):843-51.
Patsch JM, Burghardt AJ, Kazakia G, Majumdar S. Noninvasive imaging of bone microarchitecture. Ann N Y Acad Sci. 2011 Dec; 1240:77-87.
Pinney JR, Taylor C, Doan R, Burghardt AJ, Li X, Kim HT, Benjamin Ma C, Majumdar S. Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis. Magn Reson Imaging. 2012 Feb; 30(2):271-82.
Pialat JB, Burghardt AJ, Sode M, Link TM, Majumdar S. Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture. Bone. 2012 Jan; 50(1):111-8.
Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM. Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? J Magn Reson Imaging. 2012 Jan; 35(1):117-24.
Jobke B, Burghardt AJ, Muche B, Hahn M, Semler J, Amling M, Majumdar S, Busse B. Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment. PLoS One. 2011; 6(8):e23638.
Rodriguez AG, Rodriguez-Soto AE, Burghardt AJ, Berven S, Majumdar S, Lotz JC. Morphology of the human vertebral endplate. J Orthop Res. 2012 Feb; 30(2):280-7.
Burghardt AJ, Link TM, Majumdar S. High-resolution computed tomography for clinical imaging of bone microarchitecture. Clin Orthop Relat Res. 2011 Aug; 469(8):2179-93.
Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5.
Jobke B, Muche B, Burghardt AJ, Semler J, Link TM, Majumdar S. Teriparatide in bisphosphonate-resistant osteoporosis: microarchitectural changes and clinical results after 6 and 18 months. Calcif Tissue Int. 2011 Aug; 89(2):130-9.
Burghardt AJ, Krug R, Majumdar S. Vitamin D, 3rd Edition, Feldman, Pike, and Adams. Chapter 50: High-Resolution Imaging Techniques for Bone Quality Assessment. 2011; I:891-925.
A.J. Burghardt, G.J. Kazakia?, T.M. Link, S. Majumdar. Age-related differences in cortico-trabecular connectivity and load transfer in the distal radius measured in vivo by HR-pQCT. Bone. 2011 May 1; 48:s174.
W. Tjong, M. Sode, A. Burghardt, S. Majumdar, B. Feeley, B. Ma, G. Kazakia. Longitudinal in vivo HR-pQCT assessment of the influence of non-weight bearing on bone quality. Bone. 2011 May 1; 48:s184.
Rodriguez AG, Slichter CK, Acosta FL, Rodriguez-Soto AE, Burghardt AJ, Majumdar S, Lotz JC. Human disc nucleus properties and vertebral endplate permeability. Spine (Phila Pa 1976). 2011 Apr 01; 36(7):512-20.
Sode M, Burghardt AJ, Pialat JB, Link TM, Majumdar S. Quantitative characterization of subject motion in HR-pQCT images of the distal radius and tibia. Bone. 2011 Jun 01; 48(6):1291-7.
Andrew J. Burghardt, Roland Krug, Sharmila Majumdar. Chapter 50 High-Resolution Imaging Techniques for Bone Quality Assessment. Vitamin D. 2011 Jan 1; 891-925.
Kazakia GJ, Burghardt AJ, Link TM, Majumdar S. Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD. J Biomech. 2011 Jan 11; 44(2):257-66.
Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S. Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women. Bone. 2011 Mar 01; 48(3):611-21.
Burghardt AJ, Issever AS, Schwartz AV, Davis KA, Masharani U, Majumdar S, Link TM. High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2010 Nov; 95(11):5045-55.
Burghardt AJ, Kazakia GJ, Sode M, de Papp AE, Link TM, Majumdar S. A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover. J Bone Miner Res. 2010 Dec; 25(12):2558-71.
Burghardt AJ, Buie HR, Laib A, Majumdar S, Boyd SK. Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT. Bone. 2010 Sep; 47(3):519-28.
Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010 May; 25(5):983-93.
Krug R, Burghardt AJ, Majumdar S, Link TM. High-resolution imaging techniques for the assessment of osteoporosis. Radiol Clin North Am. 2010 May; 48(3):601-21.
Sode M, Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia. Bone. 2010 Jun; 46(6):1652-60.
Easley SK, Jekir MG, Burghardt AJ, Li M, Keaveny TM. Contribution of the intra-specimen variations in tissue mineralization to PTH- and raloxifene-induced changes in stiffness of rat vertebrae. Bone. 2010 Apr; 46(4):1162-9.
Shahnazari M, Yao W, Dai W, Wang B, Ionova-Martin SS, Ritchie RO, Heeren D, Burghardt AJ, Nicolella DP, Kimiecik MG, Lane NE. Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats. Bone. 2010 May; 46(5):1267-74.
Issever AS, Link TM, Kentenich M, Rogalla P, Schwieger K, Huber MB, Burghardt AJ, Majumdar S, Diederichs G. Trabecular bone structure analysis in the osteoporotic spine using a clinical in vivo setup for 64-slice MDCT imaging: comparison to microCT imaging and microFE modeling. J Bone Miner Res. 2009 Sep; 24(9):1628-37.
Issever AS, Link TM, Kentenich M, Rogalla P, Burghardt AJ, Kazakia GJ, Majumdar S, Diederichs G. Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard. Eur Radiol. 2010 Feb; 20(2):458-68.
Sekhon K, Kazakia GJ, Burghardt AJ, Hermannsson B, Majumdar S. Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography. Bone. 2009 Sep; 45(3):473-9.
Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2009 Dec; 20(12):2017-24.
Diederichs G, Link TM, Kentenich M, Schwieger K, Huber MB, Burghardt AJ, Majumdar S, Rogalla P, Issever AS. Assessment of trabecular bone structure of the calcaneus using multi-detector CT: correlation with microCT and biomechanical testing. Bone. 2009 May; 44(5):976-83.
Diederichs G, Link T, Marie K, Huber M, Rogalla P, Burghardt A, Majumdar S, Issever A. Feasibility of measuring trabecular bone structure of the proximal femur using 64-slice multidetector computed tomography in a clinical setting. Calcif Tissue Int. 2008 Nov; 83(5):332-41.
Burghardt AJ, Kazakia GJ, Laib A, Majumdar S. Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcif Tissue Int. 2008 Aug; 83(2):129-38.
Kazakia GJ, Burghardt AJ, Cheung S, Majumdar S. Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements. Med Phys. 2008 Jul; 35(7):3170-9.
Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S. In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res. 2008 Apr; 23(4):463-74.
Krug R, Carballido-Gamio J, Banerjee S, Burghardt AJ, Link TM, Majumdar S. In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T. J Magn Reson Imaging. 2008 Apr; 27(4):854-9.
Sode M, Burghardt AJ, Nissenson RA, Majumdar S. Resolution dependence of the non-metric trabecular structure indices. Bone. 2008 Apr; 42(4):728-36.
Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA. Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology. 2008 Mar; 149(3):1329-37.
Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S. Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int. 2008 May; 19(5):653-61.
Davis KA, Burghardt AJ, Link TM, Majumdar S. The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography. Calcif Tissue Int. 2007 Nov; 81(5):364-71.
Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD. IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J Bone Miner Res. 2007 Sep; 22(9):1329-37.
Burghardt AJ, Kazakia GJ, Majumdar S. A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann Biomed Eng. 2007 Oct; 35(10):1678-86.
Bauer JS, Link TM, Burghardt A, Henning TD, Mueller D, Majumdar S, Prevrhal S. Analysis of trabecular bone structure with multidetector spiral computed tomography in a simulated soft-tissue environment. Calcif Tissue Int. 2007 Jun; 80(6):366-73.
Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP. Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading. J Appl Physiol (1985). 2007 Jul; 103(1):125-31.
Krug R, Carballido-Gamio J, Burghardt AJ, Haase S, Sedat JW, Moss WC, Majumdar S. Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements. Magn Reson Imaging. 2007 Apr; 25(3):392-8.
Burghardt AJ, Wang Y, Elalieh H, Thibault X, Bikle D, Peyrin F, Majumdar S. Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy. Bone. 2007 Jan; 40(1):160-8.
Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD. Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I. J Endocrinol. 2006 May; 189(2):279-87.
David-Vaudey E, Burghardt A, Keshari K, Brouchet A, Ries M, Majumdar S. Fourier Transform Infrared Imaging of focal lesions in human osteoarthritic cartilage. Eur Cell Mater. 2005 Nov 22; 10:51-60; discussion 60.
Inceoglu S, Burghardt A, Akbay A, Majumdar S, McLain RF. Trabecular architecture of lumbar vertebral pedicle. Spine (Phila Pa 1976). 2005 Jul 01; 30(13):1485-90.
Sell CA, Masi JN, Burghardt A, Newitt D, Link TM, Majumdar S. Quantification of trabecular bone structure using magnetic resonance imaging at 3 Tesla--calibration studies using microcomputed tomography as a standard of reference. Calcif Tissue Int. 2005 May; 76(5):355-64.
Krug R, Carballido-Gamio J, Burghardt A, Haase S, Sedat J, Moss W, Majumdar S. Wavelet Based Characterization of Vertebral Trabecular Bone Structure from MR Images of Specimen at 3 Tesla Compared to MicroCT Measurements. Conf Proc IEEE Eng Med Biol Soc. 2005; 2005:7040-3.
Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18111-6.
Cao JJ, Singleton PA, Majumdar S, Boudignon B, Burghardt A, Kurimoto P, Wronski TJ, Bourguignon LY, Halloran BP. Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44. J Bone Miner Res. 2005 Jan; 20(1):30-40.
Morgan EF, Bayraktar HH, Yeh OC, Majumdar S, Burghardt A, Keaveny TM. Contribution of inter-site variations in architecture to trabecular bone apparent yield strains. J Biomech. 2004 Sep; 37(9):1413-20.
Majumdar S, Issever AS, Burghardt A, Lotz J, Arfelli F, Rigon L, Heitner G, Menk RH. Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure. Eur Radiol. 2004 Aug; 14(8):1440-8.
Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6158-63.
Issever AS, Walsh A, Lu Y, Burghardt A, Lotz JC, Majumdar S. Micro-computed tomography evaluation of trabecular bone structure on loaded mice tail vertebrae. Spine (Phila Pa 1976). 2003 Jan 15; 28(2):123-8.
Patel V, Issever AS, Burghardt A, Laib A, Ries M, Majumdar S. MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens. J Orthop Res. 2003 Jan; 21(1):6-13.
Halloran BP, Ferguson VL, Simske SJ, Burghardt A, Venton LL, Majumdar S. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res. 2002 Jun; 17(6):1044-50.
Niebur GL, Yuen JC, Burghardt AJ, Keaveny TM. Sensitivity of damage predictions to tissue level yield properties and apparent loading conditions. J Biomech. 2001 May; 34(5):699-706.