Luis Savastano, MD, PhD

Assistant Professor in Neurosurgery, Joint Appointment with Radiology
ASST PROF IN RES-HCOMP

Biography

Dr. Luis E. Savastano is a vascular and endovascular neurosurgeon who cares for patients with conditions involving arteries or veins of the brain, neck or spine. He has experience in both minimally invasive microsurgery and endovascular techniques, and the conditions he treats include brain aneurysms, Moyamoya disease (a rare disorder that causes major blood vessels leading to a child's brain to narrow), arteriovenous malformations (abnormal tangles of arteries and veins in the brain that can rupture) and carotid artery disease.

In his research, Savastano develops minimally invasive technologies and techniques to better diagnose and treat cerebrovascular diseases (those affecting blood flow to the brain). He has pioneered several endovascular devices and techniques to improve outcomes for patients with these conditions.

Savastano earned his medical degree at National University of Cuyo in Argentina, where he also earned a master’s degree in anatomy and a doctorate in medicine. He completed a residency in neurosurgery and a fellowship in neurointerventional radiology at the University of Michigan. Before joining the UCSF faculty, he was an assistant professor of neurosurgery and radiology at the Mayo Clinic in Rochester, Minnesota.

Education

PhD, 2019 - , National University of Cuyo
Fellowship, 2019 - Neurointerventional Radiology, University of Michigan
Residency, 2017 - Neurosurgery, University of Michigan
MD, 2009 - , National University of Cuyo

Publications

Isikbay M, Caton MT, Mattay R, Han W, Cooke DL, Raper D, Winkler EA, Savastano L, Narsinh KH, Hetts SW, Amans MR. Arteriovenous shunts of the cervical spine: patient demographics, presentation, patterns of high-risk venous drainage, and updated classification. J Neurointerv Surg. 2024 Apr 11.
Narsinh KH, Perez E, Haddad AF, Young JS, Savastano L, Villanueva-Meyer JE, Winkler E, de Groot J. Strategies to Improve Drug Delivery Across the Blood-Brain Barrier for Glioblastoma. Curr Neurol Neurosci Rep. 2024 May; 24(5):123-139.
Elguindy MM, Haddad AF, Lu A, Savastano LE. Minimally Invasive Endoscopic Evacuation of Cerebellar Intracerebral Hemorrhage: An Illustrative Case Report. Stroke. 2024 Mar 21.
Cohen-Cohen S, Jabal MS, Rinaldo L, Savastano LE, Lanzino G, Cloft H, Brinjikji W. Middle meningeal artery embolization for chronic subdural hematoma: A single-center experience and predictive modeling of outcomes. Neuroradiol J. 2024 Apr; 37(2):192-198.
Ramesh R, Haddad AF, Letchuman V, Lee YM, Rinaldo L, Abla AA, Savastano LE, Raper DMS. Patient-reported outcome measures in cerebrovascular neurosurgery. J Neurosurg. 2023 Nov 24; 1-12.
Lee YM, Mattay RR, Haddad AF, Rinaldo L, Savastano L. Middle meningeal artery embolization with polyvinyl alcohol particles in a patient with ophthalmic artery origin from middle meningeal artery: Case report and technical note. Interv Neuroradiol. 2023 Jul 17; 15910199231188862.
Nicolai EN, Larco JA, Madhani SI, Asirvatham SJ, Chang SY, Ludwig KA, Savastano LE, Worrell GA. Vagus nerve stimulation using an endovascular electrode array. J Neural Eng. 2023 07 14; 20(4).
Oushy S, Borg N, Madhani SI, Brinjikji W, Savastano LE. Endovascular revascularization of chronically occluded common carotid artery for symptomatic cerebral hypoperfusion. Interv Neuroradiol. 2023 Jul 12; 15910199231187293.
Nogueira RG, Pinheiro A, Brinjikji W, Abbasi M, Al-Bayati AR, Mohammaden MH, Souza Viana L, Ferreira F, Abdelhamid H, Bhatt NR, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Arturo Larco JL, Fitzgerald S, Mereuta OM, Doyle K, Savastano LE, Cloft HJ, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Polley EC, Frankel MR, Kallmes DF, Haussen DC. Clot composition and recanalization outcomes in mechanical thrombectomy. J Neurointerv Surg. 2023 Jul 07.
Benson JC, Shahid A, Larson A, Brinjikji W, Nasr D, Saba L, Lanzino G, Savastano LE. Carotid Artery Tortuosity and Internal Carotid Artery Plaque Composition. Clin Neuroradiol. 2023 Dec; 33(4):1017-1021.
Benson JC, Shahid A, Larson AS, Brinjikji W, Nasr D, Saba L, Lanzino G, Savastano LE. Intraplaque hemorrhage on magnetic resonance angiography: How often do signal abnormalities persist on follow-up imaging? Clin Neurol Neurosurg. 2023 06; 229:107744.
Benson JC, Nardi V, Bois MC, Saba L, Brinjikji W, Savastano L, Lanzino G, Lerman A. Associations between medications and carotid artery plaque morphology using semi-automated CTA analyses. Clin Neurol Neurosurg. 2023 04; 227:107676.
Madhani SI, Oushy S, Savastano L. Revascularization of a Complex Case of Vertebrobasilar Insufficiency with Occipital Artery-Anterior Inferior Cerebellar Artery Bypass. World Neurosurg. 2023 May; 173:3.
Osorio RC, Oh JY, Choudhary N, Lad M, Savastano L, Aghi MK. Pituitary adenomas and cerebrovascular disease: A review on pathophysiology, prevalence, and treatment. Front Endocrinol (Lausanne). 2022; 13:1064216.
Madhani SI, Larco JA, Liu Y, Abbasi M, Shahid AH, Yasin O, Sears V, Morris J, Rosenthal M, Baron S, Savastano L. Construction and Validation of a Benchtop Model for Testing of Mechanical Thrombectomy Devices for Pulmonary Embolism. Cardiovasc Intervent Radiol. 2023 Mar; 46(3):385-391.
Larson AS, Klaas JP, Johnson MP, Benson JC, Shlapak D, Lanzino G, Savastano LE, Lehman VT. Vessel wall imaging features of Moyamoya disease in a North American population: patterns of negative remodelling, contrast enhancement, wall thickening, and stenosis. BMC Med Imaging. 2022 11 17; 22(1):198.
Madhani SI, Abbasi M, Liu Y, Larco JA, Nicolai E, Worrell G, Savastano L. Electroencephalogram and heart rate variability features as predictors of responsiveness to vagus nerve stimulation in patients with epilepsy: a systematic review. Childs Nerv Syst. 2022 11; 38(11):2083-2090.
Arturo Larco JL, Madhani SI, Liu Y, Abbasi M, Lylyk PN, Benike A, Shahid A, Tekin B, Quinton R, Savastano LE. Evaluation of an in vivo preclinical model for human middle meningeal artery embolization using the posterior intercostal artery of the swine. J Neurointerv Surg. 2023 Sep; 15(9):924-930.
Savastano LE, Morreale RF, Eliasoph PI, Forcht-Dagi T, Nijensohn DE. The "Michelangelo Code": The Quest for Universal Truth. Neuroscientist. 2024 Apr; 30(2):157-172.
Madhani SI, Alvi MA, Pando A, Alotaibi NM, Lanzino G, Al-Omran M, Savastano L. Thirty-Day Stroke and Mortality After Carotid Revascularization Among Octogenarians with Symptomatic Carotid Stenosis: Real-World Evidence from a National Surgical Quality Registry. World Neurosurg. 2022 Nov; 167:e40-e52.
Larco JA, Madhani SI, Liu Y, Savastano LE. "Near-Clinical" Testing of Neuroendovascular Technology in a "Live" Human Cadaveric Model. World Neurosurg. 2022 Oct; 166:225-227.
Saba L, Antignani PL, Gupta A, Cau R, Paraskevas KI, Poredos P, Wasserman B, Kamel H, Avgerinos ED, Salgado R, Caobelli F, Aluigi L, Savastano L, Brown M, Hatsukami T, Hussein E, Suri JS, Mansilha A, Wintermark M, Staub D, Montequin JF, Rodriguez RTT, Balu N, Pitha J, Kooi ME, Lal BK, Spence JD, Lanzino G, Marcus HS, Mancini M, Chaturvedi S, Blinc A. International Union of Angiology (IUA) consensus paper on imaging strategies in atherosclerotic carotid artery imaging: From basic strategies to advanced approaches. Atherosclerosis. 2022 08; 354:23-40.
Savastano L, Mousavi H, Liu Y, Khalsa SSS, Zheng Y, Davis E, Reddy A, Brinjikji W, Bhambri A, Cockrum J, Pandey AS, Thompson BG, Gordon D, Seibel EJ, Yonas H. Unifying theory of carotid plaque disruption based on structural phenotypes and forces expressed at the lumen/wall interface. Stroke Vasc Neurol. 2022 Jun 01.
Oushy S, Clarke M, Savastano LE, Brinjikji W, Klaas JP. Dynamic Vertebral Artery Compression by Solitary Osteochondroma Presenting With Recurrent Posterior Circulation Strokes. Stroke. 2022 08; 53(8):e379-e380.
Yuen J, Jabal MS, Savastano LE, Kallmes DF. Bibliometric Trends in Open Surgical and Endovascular Cerebrovascular Research. Cureus. 2022 May; 14(5):e25204.
Mereuta OM, Abbasi M, Arturo Larco JL, Dai D, Liu Y, Arul S, Kadirvel R, Hanel RA, Yoo AJ, Almekhlafi MA, Layton KF, Delgado Almandoz JE, Kvamme P, Mendes Pereira V, Jahromi BS, Nogueira RG, Gounis MJ, Patel B, Aghaebrahim A, Sauvageau E, Bhuva P, Soomro J, Demchuk AM, Thacker IC, Kayan Y, Copelan A, Nazari P, Cantrell DR, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Puri AS, Entwistle J, Meves A, Savastano L, Cloft HJ, Nimjee SM, McBane RD, Kallmes DF, Brinjikji W. Correlation of von Willebrand factor and platelets with acute ischemic stroke etiology and revascularization outcome: an immunohistochemical study. J Neurointerv Surg. 2023 May; 15(5):488-494.
Kumar M, Larson A, Jabal MS, Rinaldo L, Savastano L, Lanzino G, Meyer F, Lehman V, Klaas J. Comparison of Stroke Risk Factors between Symptomatic and Asymptomatic Patients in a North American Moyamoya Disease Cohort. Cerebrovasc Dis Extra. 2022; 12(2):72-75.
Larco JA, Abbasi M, Kadirvel R, Kallmes DF, Savastano LE, Brinjikji W. Intra-procedural cerebral sinus thrombosis during endovascular treatment of idiopathic intracranial hypertension. Neuroradiol J. 2022 Oct; 35(5):654-657.
Holmes DR, Alkhouli MA, Klaas JP, Brinjikji W, Savastano LE, Lanzino G, Benson JC. Change of Heart: The Underexplored Role of Plaque Hemorrhage in the Evaluation of Stroke of Undetermined Etiology. J Am Heart Assoc. 2022 05 03; 11(9):e025323.
Oushy S, Flemming KD, Cloft H, Savastano LE. Use of intravascular optical coherence tomography to confirm the diagnosis of a carotid web in a patient with recurrent ipsilateral embolic strokes and evaluate the response to stenting. Interv Neuroradiol. 2023 Apr; 29(2):217-221.
Arturo Larco JL, Madhani SI, Liu Y, Abbasi M, Shahid AH, Mereuta OM, Kadirvel R, Cloft HJ, Kallmes DF, Brinjikji W, Savastano L. Human "live cadaver" neurovascular model for proximal and distal mechanical thrombectomy in stroke. J Neurointerv Surg. 2023 May; 15(5):465-472.
Nardi V, Benson JC, Larson AS, Brinjikji W, Saba L, Meyer FB, Lanzino G, Lerman A, Savastano LE. Carotid artery endarterectomy in patients with symptomatic non-stenotic carotid artery disease. Stroke Vasc Neurol. 2022 06; 7(3):251-257.
Madhani SI, Oushy S, Savastano L. Extra-Intimal Carotid Endarterectomy: Two-Dimensional Microsurgical Approach. World Neurosurg. 2022 05; 161:169.
Benson JC, Nardi V, Madhavan AA, Bois MC, Saba L, Savastano L, Lerman A, Lanzino G. Reassessing the Carotid Artery Plaque "Rim Sign" on CTA: A New Analysis with Histopathologic Confirmation. AJNR Am J Neuroradiol. 2022 03; 43(3):429-434.
Brinjikji W, Abbasi M, Mereuta OM, Fitzgerald S, Larco JA, Dai D, Kadirvel R, Nogueira RG, Kvamme P, Layton KF, Delgado JE, Hanel RA, Pereira VM, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel BM, Savastano LE, Cloft HJ, Haussen DC, Al-Bayati A, Mohammaden M, Pisani L, Rodrigues G, Thacker IC, Kayan Y, Copelan AZ, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Doyle KM, Entwistle J, Kallmes DF. Histological composition of retrieved emboli in acute ischemic stroke is independent of pre-thrombectomy alteplase use. J Stroke Cerebrovasc Dis. 2022 Apr; 31(4):106376.
Borg N, Cutsforth-Gregory J, Oushy S, Huynh T, Savastano LE, Cloft HJ, Lanzino G, Brinjikji W. Anatomy of Spinal Venous Drainage for the Neurointerventionalist: From Puncture Site to Intervertebral Foramen. AJNR Am J Neuroradiol. 2022 04; 43(4):517-525.
Brinjikji W, Garza I, Whealy M, Kissoon N, Atkinson JLD, Savastano L, Madhavan A, Cutsforth-Gregory J. Clinical and imaging outcomes of cerebrospinal fluid-venous fistula embolization. J Neurointerv Surg. 2022 Oct; 14(10):953-956.
Liu Y, Gebrezgiabhier D, Zheng Y, Shih AJ, Chaudhary N, Pandey AS, Larco JLA, Madhani SI, Abbasi M, Shahid AH, Quinton RA, Kadirvel R, Brinjikji W, Kallmes DF, Savastano LE. Arterial Collapse during Thrombectomy for Stroke: Clinical Evidence and Experimental Findings in Human Brains and In Vivo Models. AJNR Am J Neuroradiol. 2022 02; 43(2):251-257.
Madhani SI, Klein DC, Muñoz EM, Savastano LE. Surgical Techniques and Nuances for Superior Cervical Ganglionectomy and Decentralization in Rats. Methods Mol Biol. 2022; 2550:53-62.
Larco JA, Abbasi M, Liu Y, Dai D, Lanzino G, Savastano LE, Cloft H, Kallmes DF, Kadirvel R, Brinjikji W. Postprocedural Thrombosis following Endovascular Treatment of Intracranial Aneurysm with Flow Diverters or Coiling: A Histologic Study. AJNR Am J Neuroradiol. 2022 02; 43(2):258-264.
Liu Y, Brinjikji W, Abbasi M, Dai D, Arturo Larco JL, Madhani SI, Shahid AH, Mereuta OM, Nogueira RG, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Fitzgerald S, Doyle K, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Kadirvel R, Cloft HJ, Kallmes DF, Savastano L. Quantification of clot spatial heterogeneity and its impact on thrombectomy. J Neurointerv Surg. 2022 Dec; 14(12):1248-1252.
Larco JA, Abbasi M, Madhani SI, Mereuta MO, Liu Y, Dai D, Kadirvel R, Savastano L, Kallmes DF, Brinjikji W. Correlation of Neutrophil to Lymphocyte Ratio with Expression of Neutrophil Extracellular Traps Within Stroke Emboli. Interv Neuroradiol. 2022 Dec; 28(6):726-730.
Abbasi M, Arturo Larco J, Mereuta MO, Liu Y, Fitzgerald S, Dai D, Kadirvel R, Savastano L, Kallmes DF, Brinjikji W. Diverse thrombus composition in thrombectomy stroke patients with longer time to recanalization. Thromb Res. 2022 01; 209:99-104.
Bhambri A, Adapa AR, Liu Y, Boeckh-Behrens T, Procházka V, Hernández-Fernández F, Barbella-Aponte RA, Hashimoto T, Savastano LE, Gemmete JJ, Chaudhary N, Shih AJ, Pandey AS. Thrombus Histology as It Relates to Mechanical Thrombectomy: A Meta-Analysis and Systematic Review. Neurosurgery. 2021 11 18; 89(6):1122-1131.
Nardi V, Benson J, Bois MC, Saba L, Larson AS, Özcan I, Ahmad A, Morse DW, Meyer FB, Brinjikji W, Lanzino G, Lerman LO, Savastano LE, Lerman A. Carotid Plaques From Symptomatic Patients With Mild Stenosis Is Associated With Intraplaque Hemorrhage. Hypertension. 2022 01; 79(1):271-282.
Chiang CC, Shahid AH, Harriott AM, Tietjen GE, Savastano LE, Klaas JP, Lanzino G. Evaluation and treatment of headache associated with moyamoya disease - a narrative review. Cephalalgia. 2022 05; 42(6):542-552.
Borg N, Oushy S, Savastano L, Brinjikji W. Transvenous embolization of a cerebrospinal fluid-venous fistula for the treatment of spontaneous intracranial hypotension. J Neurointerv Surg. 2022 Sep; 14(9):948.
Benson JC, Savastano L, Nardi V, Lanzino G, Lerman A, Brinjikji W. Intraplaque CTA characteristics as predictors of symptomatology: a semiautomated volumetric analysis. Emerg Radiol. 2022 Feb; 29(1):75-80.
Toth G, Savastano L, Jagadeesan BD. The social media conundrum. J Neurointerv Surg. 2021 Oct; 13(10):861-862.
Liu Y, Larco JLA, Madhani SI, Shahid AH, Quinton RA, Kadirvel R, Kallmes DF, Brinjikji W, Savastano LE. A Thrombectomy Model Based on Ex Vivo Whole Human Brains. AJNR Am J Neuroradiol. 2021 11; 42(11):1968-1972.
Malik MH, Brinjikji W, Savastano LE. Asystole during Onyx embolization of 64-year-old patient with dural arteriovenous fistula. Neuroradiol J. 2022 Aug; 35(4):512-514.
Benson JC, Nardi V, Bois MC, Saba L, Brinjikji W, Savastano L, Lanzino G, Lerman A. Correlation between computed tomography angiography and histology of carotid artery atherosclerosis: Can semi-automated imaging software predict a plaque's composition? Interv Neuroradiol. 2022 Jun; 28(3):332-337.
Brinjikji W, Madalina Mereuta O, Dai D, Kallmes DF, Savastano L, Liu Y, Nimjee SM, Nogueira RG, Abbasi M, Kadirvel R. Mechanisms of fibrinolysis resistance and potential targets for thrombolysis in acute ischaemic stroke: lessons from retrieved stroke emboli. Stroke Vasc Neurol. 2021 12; 6(4):658-667.
Larson A, Nardi V, Brinjikji W, Benson J, Lanzino G, Savastano L. Endarterectomy for symptomatic non-stenotic carotids: a systematic review and descriptive analysis. Stroke Vasc Neurol. 2022 02; 7(1):6-12.
Arturo Larco J, Abbasi M, Liu Y, Madhani SI, Shahid AH, Kadirvel R, Brinjikji W, Savastano LE. Per-pass analysis of recanalization and good neurological outcome in thrombectomy for stroke: Systematic review and meta-analysis. Interv Neuroradiol. 2022 Jun; 28(3):358-363.
Larson AS, Brinjikji W, Kroll NJ, Savastano L, Huston J, Benson JC. Normalized intraplaque hemorrhage signal on MP-RAGE as a marker for acute ischemic neurological events. Neuroradiol J. 2022 Feb; 35(1):112-118.
Liu Y, Gebrezgiabhier D, Reddy AS, Davis E, Zheng Y, Arturo Larco JL, Shih AJ, Pandey AS, Savastano LE. Failure modes and effects analysis of mechanical thrombectomy for stroke discovered in human brains. J Neurosurg. 2022 01 01; 136(1):197-204.
Larson AS, Lehman VT, Savastano LE, Lanzino G, Campeau NG, Welker KM, Klaas JP. Implementation and Rationale for a Unified Clinical and Imaging Protocol for Evaluation and Treatment of Moyamoya Angiopathy: A Single Institutional Experience. Front Neurol. 2021; 12:662393.
Mereuta OM, Abbasi M, Fitzgerald S, Dai D, Kadirvel R, Hanel RA, Yoo AJ, Almekhlafi MA, Layton KF, Delgado Almandoz JE, Kvamme P, Mendes Pereira V, Jahromi BS, Nogueira RG, Gounis MJ, Patel B, Aghaebrahim A, Sauvageau E, Bhuva P, Soomro J, Demchuk AM, Thacker IC, Kayan Y, Copelan A, Nazari P, Cantrell DR, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Puri AS, Entwistle J, Meves A, Arturo Larco JL, Savastano L, Cloft HJ, Kallmes DF, Doyle KM, Brinjikji W. Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy. J Neurointerv Surg. 2022 Apr; 14(4):356-361.
Naylor RM, Topinka B, Rinaldo L, Jacobi J, Neth B, Flemming KD, Savastano LE. Progressive Myelopathy From a Craniocervical Junction Dural Arteriovenous Fistula. Stroke. 2021 06; 52(6):e278-e281.
Larson AS, Brinjikji W, Savastano L, Rabinstein AA, Saba L, Huston J, Benson JC. Carotid Intraplaque Hemorrhage and Stenosis: At What Stage of Plaque Progression Does Intraplaque Hemorrhage Occur, and When is It Most Likely to Be Associated with Symptoms? AJNR Am J Neuroradiol. 2021 07; 42(7):1285-1290.
Fitzgerald ST, Liu Y, Dai D, Mereuta OM, Abbasi M, Larco JLA, Douglas AS, Kallmes DF, Savastano L, Doyle KM, Brinjikji W. Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing. AJNR Am J Neuroradiol. 2021 07; 42(7):1250-1257.
Abbasi M, Kvamme P, Layton KF, Hanel RA, Almekhlafi MA, Delgado JE, Pereira VM, Patel BM, Jahromi BS, Yoo AJ, Nogueira RG, Gounis MJ, Fitzgerald S, Mereuta OM, Dai D, Kadirvel R, Kallmes DF, Doyle KM, Savastano LE, Cloft HJ, Liu Y, Thacker IC, Aghaebrahim A, Sauvageau E, Demchuk AM, Kayan Y, Copelan AZ, Entwistle J, Nazari P, Cantrell DR, Bhuva P, Soomro J, Haussen DC, Al-Bayati A, Mohammaden M, Pisani L, Rodrigues G, Puri AS, Brinjikji W. Per pass analysis of thrombus composition retrieved by mechanical thrombectomy. Interv Neuroradiol. 2021 Dec; 27(6):815-820.
Abbasi M, Dai D, Liu Y, Fitzgerald S, Kadirvel R, Savastano LE, Cloft H, Kallmes DF, Brinjikji W. Iatrogenic Foreign Materials Associated with Retrieved Clot Tissue via Mechanical Thrombectomy. AJNR Am J Neuroradiol. 2021 07; 42(7):1239-1249.
Brinjikji W, Nogueira RG, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Abbasi M, Fitzgerald S, Mereuta OM, Dai D, Kadirvel R, Doyle K, Savastano L, Cloft HJ, Haussen DC, Al-Bayati AR, Mohammaden MH, Pisani L, Rodrigues GM, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Polley EC, Kallmes DF. Association between clot composition and stroke origin in mechanical thrombectomy patients: analysis of the Stroke Thromboembolism Registry of Imaging and Pathology. J Neurointerv Surg. 2021 Jul; 13(7):594-598.
Liu Y, Abbasi M, Arturo Larco JL, Kadirvel R, Kallmes DF, Brinjikji W, Savastano L. Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models. J Neurointerv Surg. 2021 Sep; 13(9):816-822.
Essibayi MA, Cloft H, Savastano LE, Brinjikji W. Safety and efficacy of Angio-Seal device for transfemoral neuroendovascular procedures: A systematic review and meta-analysis. Interv Neuroradiol. 2021 Oct; 27(5):703-711.
Ding YH, Fitzgerald S, Liu Y, Dai D, Jakaitis D, Doyle K, Brinjikji W, Kallmes DF, Savastano L, Kadirvel R. A novel rabbit thromboembolic occlusion model. J Neurointerv Surg. 2021 Nov; 13(11):1040-1043.
Benson JC, Lanzino G, Nardi V, Savastano L, Lerman A, Brinjikji W. Semiautomated carotid artery plaque composition: are intraplaque CT imaging features associated with cardiovascular risk factors? Neuroradiology. 2021 Oct; 63(10):1617-1626.
Brinjikji W, Savastano LE, Atkinson JLD, Garza I, Farb R, Cutsforth-Gregory JK. A Novel Endovascular Therapy for CSF Hypotension Secondary to CSF-Venous Fistulas. AJNR Am J Neuroradiol. 2021 05; 42(5):882-887.
Gebrezgiabhier D, Liu Y, Reddy AS, Davis E, Zheng Y, Shih AJ, Pandey AS, Savastano LE. A human brain test bed for research in large vessel occlusion stroke. J Neurosurg. 2021 Jan 22; 135(4):1072-1080.
Abbasi M, Liu Y, Fitzgerald S, Mereuta OM, Arturo Larco JL, Rizvi A, Kadirvel R, Savastano L, Brinjikji W, Kallmes DF. Systematic review and meta-analysis of current rates of first pass effect by thrombectomy technique and associations with clinical outcomes. J Neurointerv Surg. 2021 Mar; 13(3):212-216.
Larson AS, Benson JC, Brinjikji W, Savastano L, Lanzino G, Huston J, Nasr D. Variations in the Presence of Carotid Intraplaque Hemorrhage Across Age Categories: What Age Groups Are Most Likely to Benefit From Plaque Imaging? Front Neurol. 2020; 11:603055.
Oushy SH, Essibayi MA, Savastano LE, Lanzino G. Carotid artery revascularization: endarterectomy versus endovascular therapy. J Neurosurg Sci. 2021 Jun; 65(3):322-326.
Larson AS, Brinjikji W, Savastano L, Scharf E, Huston J, Benson JC. Left-sided carotid arteries have a higher prevalence of intraplaque hemorrhage than right-sided: An asymmetric conundrum. Neuroradiol J. 2020 Dec; 33(6):494-500.
Alawieh A, Al Kasab S, Almallouhi E, Levitt MR, Jabbour PM, Sweid A, Starke RM, Saini V, Fargen KM, Wolfe SQ, Arthur AS, Goyal N, Fragata I, Maier I, Matouk C, Howard BM, Grossberg JA, Cawley M, Kan P, Hafeez M, Singer J, Crowley RW, Joshi KC, Brinjikji W, Savastano LE, Ogilvy CS, Gomez-Paz S, Levy E, Waqas M, Mokin M, Veznedaroglu E, Binning M, Mascitelli J, Yoo AJ, Soomro J, Williamson RW, Chalhoub RM, Grande A, Crosa R, Webb S, Psychogios M, Ducruet AF, Albuquerque FC, Majmundar N, Turner R, Casagrande W, Al-Mufti F, De Leacy R, Mocco J, Fessler RD, Osanai T, Chowdhry SA, Park M, Schirmer CM, Ringer A, Spiotta AM, STAR and ENRG collaborators. Letter: An International Investigation Into the COVID-19 Pandemic and Workforce Depletion in Highly Specialized Neurointerventional Units - Insights From Stroke Thrombectomy and Aneurysm Registry and Endovascular Neurosurgery Research Group. Neurosurgery. 2020 11 16; 87(6):E697-E699.
Larson AS, Nasr DM, Rizvi A, Alzuabi M, Seyedsaadat SM, Lanzino G, Huston J, Lehman VT, Savastano LE, Brinjikji W. Embolic Stroke of Undetermined Source: The Association With Carotid Intraplaque Hemorrhage. JACC Cardiovasc Imaging. 2021 02; 14(2):506-508.
Liu Y, Reddy AS, Cockrum J, Ajulufoh MC, Zheng Y, Shih AJ, Pandey AS, Savastano LE. Standardized Fabrication Method of Human-Derived Emboli with Histologic and Mechanical Quantification for Stroke Research. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105205.
Larson AS, Brinjikji W, Savastano LE, Huston Iii J, Benson JC. Carotid Intraplaque Hemorrhage Is Associated with Cardiovascular Risk Factors. Cerebrovasc Dis. 2020; 49(4):355-360.
Larson AS, Savastano L, Klaas J, Lanzino G. Cardiac manifestations in a western moyamoya disease population: a single-center descriptive study and review. Neurosurg Rev. 2021 Jun; 44(3):1429-1436.
Larson AS, Savastano L, Kadirvel R, Kallmes DF, Hassan AE, Brinjikji W. Coronavirus Disease 2019 and the Cerebrovascular-Cardiovascular Systems: What Do We Know So Far? J Am Heart Assoc. 2020 07 07; 9(13):e016793.
Reddy AS, Liu Y, Cockrum J, Gebrezgiabhier D, Davis E, Zheng Y, Pandey AS, Shih AJ, Savastano LE. Construction of a comprehensive endovascular test bed for research and device development in mechanical thrombectomy in stroke. J Neurosurg. 2020 Apr 03; 134(3):1190-1197.
Liu Y, Zheng Y, Reddy AS, Gebrezgiabhier D, Davis E, Cockrum J, Gemmete JJ, Chaudhary N, Griauzde JM, Pandey AS, Shih AJ, Savastano LE. Analysis of human emboli and thrombectomy forces in large-vessel occlusion stroke. J Neurosurg. 2020 Feb 28; 134(3):893-901.
Coon SL, Fu C, Hartley SW, Holtzclaw L, Mays JC, Kelly MC, Kelley MW, Mullikin JC, Rath MF, Savastano LE, Klein DC. Single Cell Sequencing of the Pineal Gland: The Next Chapter. Front Endocrinol (Lausanne). 2019; 10:590.
Franko LR, Pandian B, Gupta A, Savastano LE, Chen KS, Riddell J, Orringer DA. Posterior Fossa Craniotomy for Adherent Fourth Ventricle Neurocysticercosis. Oper Neurosurg (Hagerstown). 2019 05 01; 16(5):E154-E158.
Linzey JR, Burke JF, Nadel JL, Williamson CA, Savastano LE, Wilkinson DA, Pandey AS. Incidence of the initiation of comfort care immediately following emergent neurosurgical and endovascular procedures. J Neurosurg. 2018 Dec 14; 131(6):1725-1733.
Hollon TC, Savastano LE, Altshuler D, Barkan AL, Sullivan SE. Ventriculoscopic Surgery for Cystic Retrochiasmatic Craniopharyngiomas: Indications, Surgical Technique, and Short-Term Patient Outcomes. Oper Neurosurg (Hagerstown). 2018 08 01; 15(2):109-119.
Wilseck Z, Savastano L, Chaudhary N, Pandey AS, Griauzde J, Sankaran S, Wilkinson D, Gemmete JJ. Delayed extrusion of embolic coils into the airway after embolization of an external carotid artery pseudoaneurysm. J Neurointerv Surg. 2018 Jul; 10(7):e18.
Wilkinson DA, Pandey AS, Garton HJ, Savastano L, Griauzde J, Chaudhary N, Gemmete JJ. Late recanalization of basilar artery occlusion in a previously healthy 17-month-old child. J Neurointerv Surg. 2018 Jul; 10(7):e17.
Saadeh YS, Hollon TC, Fisher-Hubbard A, Savastano LE, McKeever PE, Orringer DA. Primary diffuse leptomeningeal melanomatosis: Description and recommendations. J Clin Neurosci. 2018 Apr; 50:139-143.
Saadeh YS, Savastano LE, Gendreau JL, Pandey AS. Infected symptomatic carotid artery atheroma concurrent with bacterial endocarditis. BMJ Case Rep. 2018 Mar 15; 2018.
Hollon TC, Savastano LE, Argersinger DP, Quint DJ, Thompson BG. Microvascular Brainstem Ischemia After Vestibular Schwannoma Surgery: A Clinical and Microanatomic Study. World Neurosurg. 2018 Apr; 112:e415-e424.
Wilkinson DA, Pandey AS, Garton HJ, Savastano L, Griauzde J, Chaudhary N, Gemmete JJ. Late recanalization of basilar artery occlusion in a previously healthy 17-month-old child. BMJ Case Rep. 2017 Oct 13; 2017.
Savastano LE, Seibel EJ. Scanning Fiber Angioscopy: A Multimodal Intravascular Imaging Platform for Carotid Atherosclerosis. Neurosurgery. 2017 09 01; 64(CN_suppl_1):188-198.
Wilseck Z, Savastano L, Chaudhary N, Pandey AS, Griauzde J, Sankaran S, Wilkinson DA, Gemmete JJ. Delayed extrusion of embolic coils into the airway after embolization of an external carotid artery pseudoaneurysm. BMJ Case Rep. 2017 Aug 29; 2017.
Linzey JR, Chen KS, Savastano L, Thompson BG, Pandey AS. Optic neuropathy after anterior communicating artery aneurysm clipping: 3 cases and techniques to address a correctable pitfall. J Neurosurg. 2018 06; 128(6):1808-1812.
Savastano LE, Hollon TC, Barkan AL, Sullivan SE. Korsakoff syndrome from retrochiasmatic suprasellar lesions: rapid reversal after relief of cerebral compression in 4 cases. J Neurosurg. 2018 06; 128(6):1731-1736.
Savastano LE, Zhou Q, Smith A, Vega K, Murga-Zamalloa C, Gordon D, McHugh J, Zhao L, Wang M, Pandey A, Thompson BG, Xu J, Zhang J, Chen YE, Seibel EJ, Wang TD. Multimodal laser-based angioscopy for structural, chemical and biological imaging of atherosclerosis. Nat Biomed Eng. 2017; 1.
Savastano LE, Chaudhary N, Murga-Zamalloa C, Wang M, Wang T, Thompson BG. Diagnostic and Interventional Optical Angioscopy in Ex Vivo Carotid Arteries. Oper Neurosurg (Hagerstown). 2017 02 01; 13(1):36-46.
Rooney DM, Tai BL, Sagher O, Shih AJ, Wilkinson DA, Savastano LE. Simulator and 2 tools: Validation of performance measures from a novel neurosurgery simulation model using the current Standards framework. Surgery. 2016 09; 160(3):571-9.
Hartley SW, Coon SL, Savastano LE, Mullikin JC, NISC Comparative Sequencing Program, Fu C, Klein DC. Neurotranscriptomics: The Effects of Neonatal Stimulus Deprivation on the Rat Pineal Transcriptome. PLoS One. 2015; 10(9):e0137548.
Sosa P, Dujovny M, Onyekachi I, Sockwell N, Cremaschi F, Savastano LE. Microvascular anatomy of the cerebellar parafloccular perforating space. J Neurosurg. 2016 Feb; 124(2):440-9.
Savastano L, Gemmete JJ, Pandey AS, Roark C, Chaudhary N. Acute ischemic stroke in a child due to basilar artery occlusion treated successfully with a stent retriever. J Neurointerv Surg. 2016 Aug; 8(8):e33.
Savastano L, Gemmete JJ, Pandey AS, Roark C, Chaudhary N. Acute ischemic stroke in a child due to basilar artery occlusion treated successfully with a stent retriever. BMJ Case Rep. 2015 Jul 06; 2015.
Tai BL, Rooney D, Stephenson F, Liao PS, Sagher O, Shih AJ, Savastano LE. Development of a 3D-printed external ventricular drain placement simulator: technical note. J Neurosurg. 2015 Oct; 123(4):1070-6.
Castro AE, Benitez SG, Farias Altamirano LE, Savastano LE, Patterson SI, Muñoz EM. Expression and cellular localization of the transcription factor NeuroD1 in the developing and adult rat pineal gland. J Pineal Res. 2015 May; 58(4):439-51.
Savastano LE, Chaudhary N, Gemmete JJ, Garton HJ, Maher CO, Pandey AS. Stent-assisted coil embolization of a symptomatic middle cerebral artery aneurysm in an infant. J Neurosurg Pediatr. 2014 Nov; 14(5):550-4.
Savastano LE, Laurito SR, Fitt MR, Rasmussen JA, Gonzalez Polo V, Patterson SI. Sciatic nerve injury: a simple and subtle model for investigating many aspects of nervous system damage and recovery. J Neurosci Methods. 2014 Apr 30; 227:166-80.
Nijensohn DE, Savastano LE, Kaplan AD, Laws ER. New evidence of prefrontal lobotomy in the last months of the illness of Eva Perón. World Neurosurg. 2012 Mar-Apr; 77(3-4):583-90.
Savastano LE, Castro AE, Fitt MR, Rath MF, Romeo HE, Muñoz EM. A standardized surgical technique for rat superior cervical ganglionectomy. J Neurosci Methods. 2010 Sep 30; 192(1):22-33.