Duygu Tosun-Turgut, PhD

Associate Professor
Assoc Professor in Residence

Biography

Duygu Tosun-Turgut, PhD, is an Associate Professor and Co-Director of the Center for Imaging of Neurodegenerative Diseases (CIND) at the San Francisco Veterans Affairs Medical Center. Dr. Tosun obtained her BSc in Electrical and Electronic Engineering from Bilkent University, Turkey in 1999, and she received her MSE in Electrical and Computer Engineering from The Johns Hopkins University, Maryland in 2001. In 2003, she completed her MA in Mathematics from The Johns Hopkins University, and she earned her PhD in Electrical and Computer Engineering from The Johns Hopkins University in 2005, followed by a postdoctoral fellowship in Neurology from the University of California, Los Angeles in 2008.

Dr. Tosun’s long-term research goal is to develop new algorithmic approaches for processing and analysis of multi-disciplinary/modality data including neuroimages, genetics, proteomics, as well as cognitive functioning measures in a unified framework by using recent advances in image processing, medical physics, and computation medicine. The primary aim is to identify multi-disciplinary/modality biomarkers for detecting the changes associated with disease specific neuropathology, improving understanding of pathophysiological progression and potentially providing a means of monitoring the efficacy and regional specificity of drug therapy for neurodegenerative diseases. This will have a broad use in early diagnosis, facilitating initiation of prevention strategies in those at risk, and boost the power of drug therapy trials by selecting those at greatest risk of neurodegenerative diseases.

Dr. Tosun is a reviewer for 17 scientific journals. She has 29 published articles and she has written 30 peer-reviewed articles, 50 abstracts, and 5 significant publications.

Expertise:
Neurodegenerative

Specialty:
Neurodegenerative brain diseases; Neuroimaging; Alzheimer’s disease; Front temporal dementia; Late-life depression; Biomarkers; Imaging statistics

Professional Interests:
Medical image processing and analysis, computational medicine, magnetic resonance imaging (MRI), positron emission tomography (PET), multi-modality neuroimaging research, aging, Alzheimer's disease, neurodegenerative diseases, late-life depression, imaging biomarkers, biomarkers, prediction models, neuropathology

Education and Training:
• Bachelor of Science: Bilkent University, Turkey - Electrical and Electronic Engineering
• Masters of Science: Johns Hopkins University, Maryland - Electrical and Computer Engineering
• Masters in Art: Johns Hopkins University, Maryland - Mathematics
• Doctor of Philosophy: Johns Hopkins University, Maryland - Electrical and Computer Engineering
• Postdoctoral Fellowship: University of California, Los Angeles - Neurology

Honors and Awards

BioData World West, Top Young Artificial Intelligence (AI) Talent, 2017
Parkinson's Progression Markers Initiative (PPMI) Data Challenge, The Michael J Fox Foundation for Parkinson's Research, 2016
de Leon Prize in Neuroimaging, Alzheimer's Association, Paris, France, 2011
AFAR-GE Healthcare Junior Investigator Award for Excellence in Imaging and Aging Research, American Federation for Aging Research and GE Healthcare, Santa Barbara, CA, 2011
AFAR-GE Healthcare Junior Investigator Award for Excellence in Imaging and Aging Research, American Federation for Aging Research and GE Healthcare, Santa Barbara, CA, 2010
Francois Erbsmann Prize, Information Processing in Medical Imaging (IPMI) Conference, Glenwood Springs, CO, 2005

Publications

Lutz J, Mackin RS, Otero MC, Morin R, Bickford D, Tosun D, Satre DD, Gould CE, Nelson JC, Beaudreau SA. Improvements in Functional Disability After Psychotherapy for Depression Are Associated With Reduced Suicide Ideation Among Older Adults. Am J Geriatr Psychiatry. 2021 06; 29(6):557-561.
Mackin RS, Insel PS, Landau S, Bickford D, Morin R, Rhodes E, Tosun D, Rosen HJ, Butters M, Aisen P, Raman R, Saykin A, Toga A, Jack C, Koeppe R, Weiner MW, Nelson C, Alzheimer’s Disease Neuroimaging Initiative and the ADNI Depression Project . Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project. Biol Psychiatry. 2021 04 15; 89(8):757-765.
Ellis R, Ellestad E, Elicker B, Hope MD, Tosun D. Impact of hybrid supervision approaches on the performance of artificial intelligence for the classification of chest radiographs. Comput Biol Med. 2020 05; 120:103699.
Simuni T, Brumm MC, Uribe L, Caspell-Garcia C, Coffey CS, Siderowf A, Alcalay RN, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Nudelman K, Tosun-Turgut D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten S, Bressman S, Marek K, Parkinson's Progression Markers Initiative Investigators . Clinical and Dopamine Transporter Imaging Characteristics of Leucine Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study. Mov Disord. 2020 05; 35(5):833-844.
Simuni T, Uribe L, Cho HR, Caspell-Garcia C, Coffey CS, Siderowf A, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Tosun D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten SJ, Bressman S, Marek K, PPMI Investigators . Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study. Lancet Neurol. 2020 01; 19(1):71-80.
Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, Sperling RA, Bennett DA, Hyman BT, Andreassen OA, Dale AM, Desikan RS, Alzheimer’s Disease Neuroimaging Initiative . Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain. 2019 02 01; 142(2):460-470.
Marek K, Chowdhury S, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Simuni T, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, Weintraub D, Foroud T, Tosun-Turgut D, Poston K, Arnedo V, Frasier M, Sherer T, Parkinson's Progression Markers Initiative . The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort. Ann Clin Transl Neurol. 2018 Dec; 5(12):1460-1477.
Gonzales MM, Insel PS, Nelson C, Tosun D, Schöll M, Mattsson N, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative . Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment. Int J Geriatr Psychiatry. 2018 10; 33(10):1305-1311.
Staffaroni AM, Tosun D, Lin J, Elahi FM, Casaletto KB, Wynn MJ, Patel N, Neuhaus J, Walters SM, Epel ES, Blackburn EH, Kramer JH. Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults. Neurobiol Aging. 2018 09; 69:68-75.
Simuni T, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, Weintraub D, Foroud T, Tosun D, Poston K, Arnedo V, Frasier M, Sherer T, Chowdhury S, Marek K, Parkinson's Progression Marker Initiative* . Longitudinal Change of Clinical and Biological Measures in Early Parkinson's Disease: Parkinson's Progression Markers Initiative Cohort. Mov Disord. 2018 05; 33(5):771-782.
Powell F, Tosun D, Sadeghi R, Weiner M, Raj A, Alzheimer’s Disease Neuroimaging Initiative . Preserved Structural Network Organization Mediates Pathology Spread in Alzheimer's Disease Spectrum Despite Loss of White Matter Tract Integrity. J Alzheimers Dis. 2018; 65(3):747-764.
Elahi FM, Marx G, Cobigo Y, Staffaroni AM, Kornak J, Tosun D, Boxer AL, Kramer JH, Miller BL, Rosen HJ. Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Neuroimage Clin. 2017; 16:595-603.
Weiner MW, Harvey D, Hayes J, Landau SM, Aisen PS, Petersen RC, Tosun D, Veitch DP, Jack CR, Decarli C, Saykin AJ, Grafman J, Neylan TC, Department of Defense Alzheimer's Disease Neuroimaging Initiative . Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary Report. Alzheimers Dement (N Y). 2017 06; 3(2):177-188.
Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D, Parkinson’s Progression Markers Initiative (PPMI) . Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease. PLoS One. 2017; 12(5):e0175674.
Tosun D, Landau S, Aisen PS, Petersen RC, Mintun M, Jagust W, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative . Association between tau deposition and antecedent amyloid-ß accumulation rates in normal and early symptomatic individuals. Brain. 2017 May 01; 140(5):1499-1512.
Gonzales MM, Insel PS, Nelson C, Tosun D, Mattsson N, Mueller SG, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative . ?Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression. Am J Geriatr Psychiatry. 2017 Sep; 25(9):980-991.
Scott JA, Tosun D, Braskie MN, Maillard P, Thompson PM, Weiner M, DeCarli C, Carmichael OT, ADNI . Independent value added by diffusion MRI for prediction of cognitive function in older adults. Neuroimage Clin. 2017; 14:166-173.
Zhang Y, Wu IW, Tosun D, Foster E, Schuff N, Parkinson’s Progression Markers Initiative . Progression of Regional Microstructural Degeneration in Parkinson's Disease: A Multicenter Diffusion Tensor Imaging Study. PLoS One. 2016; 11(10):e0165540.
Tosun D, Schuff N, Rabinovici GD, Ayakta N, Miller BL, Jagust W, Kramer J, Weiner MM, Rosen HJ. Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD. Ann Clin Transl Neurol. 2016 10; 3(10):740-751.
Scott JA, Braskie MN, Tosun D, Maillard P, Thompson PM, Weiner M, DeCarli C, Carmichael OT, ADNI . Cerebral amyloid is associated with greater white-matter hyperintensity accrual in cognitively normal older adults. Neurobiol Aging. 2016 12; 48:48-52.
Tosun D, Chen YF, Yu P, Sundell KL, Suhy J, Siemers E, Schwarz AJ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Amyloid status imputed from a multimodal classifier including structural MRI distinguishes progressors from nonprogressors in a mild Alzheimer's disease clinical trial cohort. Alzheimers Dement. 2016 09; 12(9):977-986.
Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Accelerating rates of cognitive decline and imaging markers associated with ß-amyloid pathology. Neurology. 2016 05 17; 86(20):1887-96.
Chao LL, Tosun D, Woodward SH, Kaufer D, Neylan TC. Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder. Front Behav Neurosci. 2015; 9:333.
Scott JA, Braskie MN, Tosun D, Thompson PM, Weiner M, DeCarli C, Carmichael OT, Alzheimer’s Disease Neuroimaging Initiative . Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. Front Aging Neurosci. 2015; 7:221.
Tosun D, Schuff N, Jagust W, Weiner MW, Alzheimer''s Disease Neuroimaging Initiative . Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-ß-Positive Subjects in the Alzheimer's Disease Continuum. Neurodegener Dis. 2016; 16(1-2):87-94.
Tosun D, Siddarth P, Levitt J, Caplan R. Cortical thickness and sulcal depth: insights on development and psychopathology in paediatric epilepsy. BJPsych Open. 2015 Oct; 1(2):129-135.
Sacuiu S, Insel PS, Mueller S, Tosun D, Mattsson N, Jack CR, DeCarli C, Petersen R, Aisen PS, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative . Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia. Am J Geriatr Psychiatry. 2016 Feb; 24(2):126-35.
Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease. Ann Clin Transl Neurol. 2015 May; 2(5):534-47.
Song Z, Insel PS, Buckley S, Yohannes S, Mezher A, Simonson A, Wilkins S, Tosun D, Mueller S, Kramer JH, Miller BL, Weiner MW. Brain amyloid-ß burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly. J Neurosci. 2015 Feb 18; 35(7):3240-7.
Raj A, LoCastro E, Kuceyeski A, Tosun D, Relkin N, Weiner M, Alzheimer’s Disease Neuroimaging Initiative (ADNI) . Network Diffusion Model of Progression Predicts Longitudinal Patterns of Atrophy and Metabolism in Alzheimer's Disease. Cell Rep. 2015 Jan 20; 10(3):359-369.
Mattsson N, Insel PS, Nosheny R, Tosun D, Trojanowski JQ, Shaw LM, Jack CR, Donohue MC, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative . Emerging ß-amyloid pathology and accelerated cortical atrophy. JAMA Neurol. 2014 Jun; 71(6):725-34.
Laforce R, Tosun D, Ghosh P, Lehmann M, Madison CM, Weiner MW, Miller BL, Jagust WJ, Rabinovici GD. Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology. Neuroimage Clin. 2014; 4:508-16.
Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Association of brain amyloid-ß with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain. 2014 May; 137(Pt 5):1550-61.
Tosun D, Joshi S, Weiner MW, the Alzheimer’s Disease Neuroimaging Initiative . Multimodal MRI-based Imputation of the Aß+ in Early Mild Cognitive Impairment. Ann Clin Transl Neurol. 2014 Mar; 1(3):160-170.
Mattsson N, Insel P, Tosun D, Zhang J, Jack CR, Galasko D, Weiner M, Alzheimer’s Disease Neuroimaging Initiative . Effects of baseline CSF a-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease. PLoS One. 2013; 8(12):e85443.
Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack CR, Tosun D, Weiner M, Alzheimer's Disease Neuroimaging Initiative . Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults. Neurobiol Aging. 2014 Mar; 35(3):614-22.
Tosun D, Joshi S, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Neuroimaging predictors of brain amyloidosis in mild cognitive impairment. Ann Neurol. 2013 Aug; 74(2):188-98.
Mattsson N, Insel P, Nosheny R, Zetterberg H, Trojanowski JQ, Shaw LM, Tosun D, Weiner M, Alzheimer's Disease Neuroimaging Initiative . CSF protein biomarkers predicting longitudinal reduction of CSF ß-amyloid42 in cognitively healthy elders. Transl Psychiatry. 2013 Aug 20; 3:e293.
Liu X, Tosun D, Weiner MW, Schuff N, Alzheimer's Disease Neuroimaging Initiative . Locally linear embedding (LLE) for MRI based Alzheimer's disease classification. Neuroimage. 2013 Dec; 83:148-57.
Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N. Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI. J Neuroimaging. 2014 Sep-Oct; 24(5):435-43.
Naylor MG, Cardenas VA, Tosun D, Schuff N, Weiner M, Schwartzman A. Voxelwise multivariate analysis of multimodality magnetic resonance imaging. Hum Brain Mapp. 2014 Mar; 35(3):831-46.
Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response. Am J Geriatr Psychiatry. 2013 Aug; 21(8):794-802.
Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. Am J Geriatr Psychiatry. 2013 Sep; 21(9):906-14.
Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. Patterns of Reduced Cortical Thickness in Late-Life Depression and Relationship to Psychotherapeutic Response. Am J Geriatr Psychiatry. 2012 Aug 17.
Luders E, Sánchez FJ, Tosun D, Shattuck DW, Gaser C, Vilain E, Toga AW. Increased Cortical Thickness in Male-to-Female Transsexualism. J Behav Brain Sci. 2012 Aug; 2(3):357-362.
Tosun D, Rosen H, Miller BL, Weiner MW, Schuff N. MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia. Neuroimage. 2012 Feb 01; 59(3):2098-109.
Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Impact of apolipoprotein E4-cerebrospinal fluid ß-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimers Dement. 2011 Sep; 7(5):514-20.
Scanlon C, Mueller SG, Tosun D, Cheong I, Garcia P, Barakos J, Weiner MW, Laxer KD. Impact of methodologic choice for automatic detection of different aspects of brain atrophy by using temporal lobe epilepsy as a model. AJNR Am J Neuroradiol. 2011 Oct; 32(9):1669-76.
Zhang Y, Schuff N, Ching C, Tosun D, Zhan W, Nezamzadeh M, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW. Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia. Int J Alzheimers Dis. 2011; 2011:546871.
Tosun D, Caplan R, Siddarth P, Seidenberg M, Gurbani S, Toga AW, Hermann B. Intelligence and cortical thickness in children with complex partial seizures. Neuroimage. 2011 Jul 15; 57(2):337-45.
Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes. Radiology. 2011 Jun; 259(3):844-51.
Tosun D, Siddarth P, Toga AW, Hermann B, Caplan R. Effects of childhood absence epilepsy on associations between regional cortical morphometry and aging and cognitive abilities. Hum Brain Mapp. 2011 Apr; 32(4):580-91.
Tosun D, Schuff N, Mathis CA, Jagust W, Weiner MW, Alzheimer's Disease NeuroImaging Initiative . Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment. Brain. 2011 Apr; 134(Pt 4):1077-88.
Durazzo TC, Tosun D, Buckley S, Gazdzinski S, Mon A, Fryer SL, Meyerhoff DJ. Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence. Alcohol Clin Exp Res. 2011 Jun; 35(6):1187-200.
Tosun D, Dabbs K, Caplan R, Siddarth P, Toga A, Seidenberg M, Hermann B. Deformation-based morphometry of prospective neurodevelopmental changes in new onset paediatric epilepsy. Brain. 2011 Apr; 134(Pt 4):1003-14.
Tosun D, Schuff N, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease NeuroImaging Initiative . Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data. J Alzheimers Dis. 2011; 26 Suppl 3:77-90.
Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects. Neurology. 2010 Nov 30; 75(22):1976-81.
Schuff N, Tosun D, Insel PS, Chiang GC, Truran D, Aisen PS, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Nonlinear time course of brain volume loss in cognitively normal and impaired elders. Neurobiol Aging. 2012 May; 33(5):845-55.
Tosun D, Schuff N, Truran-Sacrey D, Shaw LM, Trojanowski JQ, Aisen P, Peterson R, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study. Neurobiol Aging. 2010 Aug; 31(8):1340-54.
Jack CR, Bernstein MA, Borowski BJ, Gunter JL, Fox NC, Thompson PM, Schuff N, Krueger G, Killiany RJ, Decarli CS, Dale AM, Carmichael OW, Tosun D, Weiner MW, Alzheimer's Disease Neuroimaging Initiative . Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative. Alzheimers Dement. 2010 May; 6(3):212-20.
Tosun D, Mojabi P, Weiner MW, Schuff N. Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging. Neuroimage. 2010 Aug 01; 52(1):186-97.
Tosun D, Schuff N, Weiner M. An integrated multimodality MR brain imaging study: gray matter tissue loss mediates the association between cerebral hypoperfusion and Alzheimer's disease. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:6981-4.
Tosun D, Prince JL. A geometry-driven optical flow warping for spatial normalization of cortical surfaces. IEEE Trans Med Imaging. 2008 Dec; 27(12):1739-53.
Tosun D, Duchesne S, Rolland Y, Toga AW, Vérin M, Barillot C. 3-D analysis of cortical morphometry in differential diagnosis of Parkinson's plus syndromes: mapping frontal lobe cortical atrophy in progressive supranuclear palsy patients. Med Image Comput Comput Assist Interv. 2007; 10(Pt 2):891-9.
Tosun D, Rettmann ME, Naiman DQ, Resnick SM, Kraut MA, Prince JL. Cortical reconstruction using implicit surface evolution: accuracy and precision analysis. Neuroimage. 2006 Feb 01; 29(3):838-52.
Rettmann ME, Tosun D, Tao X, Resnick SM, Prince JL. Program for Assisted Labeling of Sulcal Regions (PALS): description and reliability. Neuroimage. 2005 Jan 15; 24(2):398-416.
Tosun D, Prince JL. Cortical surface alignment using geometry driven multispectral optical flow. Inf Process Med Imaging. 2005; 19:480-92.
Han X, Pham DL, Tosun D, Rettmann ME, Xu C, Prince JL. CRUISE: cortical reconstruction using implicit surface evolution. Neuroimage. 2004 Nov; 23(3):997-1012.
Tosun D, Rettmann ME, Prince JL. Mapping techniques for aligning sulci across multiple brains. Med Image Anal. 2004 Sep; 8(3):295-309.
Tosun D, Rettmann ME, Han X, Tao X, Xu C, Resnick SM, Pham DL, Prince JL. Cortical surface segmentation and mapping. Neuroimage. 2004; 23 Suppl 1:S108-18.