Jae Ho Sohn, MD, MS

Resident

Biography

I am interested in the intersection of big data and radiology. As a physician with engineering background, I have been broadly involved in projects that use mathematical techniques to tackle research questions in radiology. I am particularly excited about using deep learning to discover novel imaging biomarkers and develop algorithms that can help patients. My work has received media coverage twice on the AuntMinnie Newsletter. I enjoy participating in machine learning competitions, recently scoring top 2% in the Kaggle Data Science Bowl for lung cancer detection. I have won the global oncology award from the Stanford Health++ hackathon.

Current research projects span computer vision, natural language processing, and translation of engineering innovations to clinical practice. Examples projects include lung nodule characterization from chest CT, rib fracture detection from chest x-rays, integration of survival analysis into convolutional neural network, natural language processing of free-text clinical history to automate radiology protocoling, automated detection of urgent findings from radiology text report, and automated breast density determination from mammograms.

Education

Intern, 2016 - Transitional Year, Santa Clara Valley Medical Center
MD, 2015 - , Geisel School of Medicine at Dartmouth
BA, 2010 - Applied Math & Statistics, Johns Hopkins University
MS, 2010 - Applied Math & Statistics, Johns Hopkins University

Publications

Jaewon Yang, Dookun Park, Jae Ho Sohn, Zhen Jane Wang, Grant T. Gullberg, Youngho Seo.
Joint Correction of Attenuation and Scatter Using Deep Convolutional Neural Networks (DCNN) for Time-of-Flight PET. 2018; (11852).
Ding Y, Sohn JH, Kawczynski MG, Trivedi H, Harnish R, Jenkins NW, Lituiev D, Copeland TP, Aboian MS, Mari Aparici C, Behr SC, Flavell RR, Huang SY, Zalocusky KA, Nardo L, Seo Y, Hawkins RA, Hernandez Pampaloni M, Hadley D, Franc BL. A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain. Radiology. 2018 Nov 06; 180958.
Nam JG, Park S, Hwang EJ, Lee JH, Jin KN, Lim KY, Vu TH, Sohn JH, Hwang S, Goo JM, Park CM. Development and Validation of Deep Learning-based Automatic Detection Algorithm for Malignant Pulmonary Nodules on Chest Radiographs. Radiology. 2019 Jan; 290(1):218-228.
Trivedi HM, Panahiazar M, Liang A, Lituiev D, Chang P, Sohn JH, Chen YY, Franc BL, Joe B, Hadley D. Large Scale Semi-Automated Labeling of Routine Free-Text Clinical Records for Deep Learning. J Digit Imaging. 2018 Aug 20.
Mohibbullah M, Won NE, Jeon JH, An JH, Park Y, Kim H, Bashir KMI, Park SM, Kim YS, Yoon SJ, Sohn JH, Kim A, Choi JS. Effect of superheated steam roasting with hot smoking treatment on improving physicochemical properties of the adductor muscle of pen shell (Atrina pectinate). Food Sci Nutr. 2018 Jul; 6(5):1317-1327.
Trivedi H, Mesterhazy J, Laguna B, Vu T, Sohn JH. Automatic Determination of the Need for Intravenous Contrast in Musculoskeletal MRI Examinations Using IBM Watson's Natural Language Processing Algorithm. J Digit Imaging. 2018 Apr; 31(2):245-251.
Schernthaner RE, Haroun RR, Nguyen S, Duran R, Sohn JH, Sahu S, Chapiro J, Zhao Y, Radaelli A, van der Bom IM, Mauti M, Hong K, Geschwind JH, Lin M. Characteristics of a New X-Ray Imaging System for Interventional Procedures: Improved Image Quality and Reduced Radiation Dose. Cardiovasc Intervent Radiol. 2018 Mar; 41(3):502-508.
Woo M, Park SH, Park K, Park MK, Kim JY, Lee HS, Sohn JH, Lee DW, Nam G, Shin KS, Lee SJ. Draft genome sequence of the halophilic Halobacillus mangrovi KTB 131 isolated from Topan salt of the Jeon-nam in Korea. Genom Data. 2017 Dec; 14:18-20.
Haider SJA, diFlorio-Alexander R, Lam DH, Cho JY, Sohn JH, Harris R. Prospective Comparison of Diagnostic Accuracy Between Point-of-Care and Conventional Ultrasound in a General Diagnostic Department: Implications for Resource-Limited Settings. J Ultrasound Med. 2017 Jul; 36(7):1453-1460.
Ngan NT, Quang TH, Kim KW, Kim HJ, Sohn JH, Kang DG, Lee HS, Kim YC, Oh H. Anti-inflammatory effects of secondary metabolites isolated from the marine-derived fungal strain Penicillium sp. SF-5629. Arch Pharm Res. 2017 Mar; 40(3):328-337.
Sohn JH, Duran R, Zhao Y, Fleckenstein F, Chapiro J, Sahu S, Schernthaner RE, Qian T, Lee H, Zhao L, Hamilton J, Frangakis C, Lin M, Salem R, Geschwind JF. Validation of the Hong Kong Liver Cancer Staging System in Determining Prognosis of the North American Patients Following Intra-arterial Therapy. Clin Gastroenterol Hepatol. 2017 May; 15(5):746-755.e4.
Sahu S, Schernthaner R, Ardon R, Chapiro J, Zhao Y, Sohn JH, Fleckenstein F, Lin M, Geschwind JF, Duran R. Imaging Biomarkers of Tumor Response in Neuroendocrine Liver Metastases Treated with Transarterial Chemoembolization: Can Enhancing Tumor Burden of the Whole Liver Help Predict Patient Survival? Radiology. 2017 06; 283(3):883-894.
Zhao Y, Duran R, Chapiro J, Sohn JH, Sahu S, Fleckenstein F, Smolka S, Pawlik TM, Schernthaner R, Zhao L, Lee H, He S, Lin M, Geschwind JF. Transarterial Chemoembolization for the Treatment of Advanced-Stage Hepatocellular Carcinoma. J Gastrointest Surg. 2016 12; 20(12):2002-2009.
Fleckenstein FN, Schernthaner RE, Duran R, Sohn JH, Sahu S, Marshall K, Lin M, Gebauer B, Chapiro J, Salem R, Geschwind JF. Renal Cell Carcinoma Metastatic to the Liver: Early Response Assessment after Intraarterial Therapy Using 3D Quantitative Tumor Enhancement Analysis. Transl Oncol. 2016 Oct; 9(5):377-383.
Gibtan A, Woo M, Oh D, Park K, Lee HS, Sohn JH, Lee DW, Shin JK, Lee SJ. Draft genome sequence of the extremely halophilic Halorubrum sp. SAH-A6 isolated from rock salts of the Danakil depression, Ethiopia. Genom Data. 2016 Dec; 10:30-2.
Schernthaner RE, Haroun RR, Duran R, Lee H, Sahu S, Sohn JH, Chapiro J, Zhao Y, Gorodetski B, Fleckenstein F, Smolka S, Radaelli A, van der Bom IM, Lin M, Geschwind JF. Improved Visibility of Metastatic Disease in the Liver During Intra-Arterial Therapy Using Delayed Arterial Phase Cone-Beam CT. Cardiovasc Intervent Radiol. 2016 Oct; 39(10):1429-37.
Fleckenstein FN, Schernthaner RE, Duran R, Sohn JH, Sahu S, Zhao Y, Hamm B, Gebauer B, Lin M, Geschwind JF, Chapiro J. 3D Quantitative tumour burden analysis in patients with hepatocellular carcinoma before TACE: comparing single-lesion vs. multi-lesion imaging biomarkers as predictors of patient survival. Eur Radiol. 2016 Sep; 26(9):3243-52.
Tacher V, Duran R, Lin M, Sohn JH, Sharma KV, Wang Z, Chapiro J, Gacchina Johnson C, Bhagat N, Dreher MR, Schäfer D, Woods DL, Lewis AL, Tang Y, Grass M, Wood BJ, Geschwind JF. Multimodality Imaging of Ethiodized Oil-loaded Radiopaque Microspheres during Transarterial Embolization of Rabbits with VX2 Liver Tumors. Radiology. 2016 Jun; 279(3):741-53.
Tacher V, Lin M, Duran R, Yarmohammadi H, Lee H, Chapiro J, Chao M, Wang Z, Frangakis C, Sohn JH, Maltenfort MG, Pawlik T, Geschwind JF. Comparison of Existing Response Criteria in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Using a 3D Quantitative Approach. Radiology. 2016 Jan; 278(1):275-84.
Chockalingam A, Duran R, Sohn JH, Schernthaner R, Chapiro J, Lee H, Sahu S, Nguyen S, Geschwind JF, Lin M. Radiologic-pathologic analysis of quantitative 3D tumour enhancement on contrast-enhanced MR imaging: a study of ROI placement. Eur Radiol. 2016 Jan; 26(1):103-13.
Schernthaner RE, Chapiro J, Sahu S, Withagen P, Duran R, Sohn JH, Radaelli A, van der Bom IM, Geschwind JF, Lin M. Feasibility of a Modified Cone-Beam CT Rotation Trajectory to Improve Liver Periphery Visualization during Transarterial Chemoembolization. Radiology. 2015 Dec; 277(3):833-41.
Park MS, Fong JJ, Oh SY, Houbraken J, Sohn JH, Hong SB, Lim YW. Penicillium jejuense sp. nov., isolated from the marine environments of Jeju Island, Korea. Mycologia. 2015 Jan-Feb; 107(1):209-16.
Quang TH, Ngan NTT, Ko W, Kim DC, Yoon CS, Sohn JH, Yim JH, Kim YC, Oh H. Tanzawaic acid derivatives from a marine isolate of Penicillium sp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities. Bioorg Med Chem Lett. 2014 Dec 15; 24(24):5787-5791.
Choi JS, Seo HJ, Lee YR, Kwon SJ, Moon SH, Park SM, Sohn JH. Characteristics and in vitro Anti-diabetic Properties of the Korean Rice Wine, Makgeolli Fermented with Laminaria japonica. Prev Nutr Food Sci. 2014 Jun; 19(2):98-107.
Choi JS, Lee YR, Ha YM, Seo HJ, Kim YH, Park SM, Sohn JH. Antibacterial effect of grapefruit seed extract (GSE) on Makgeolli-brewing microorganisms and its application in the preservation of fresh Makgeolli. J Food Sci. 2014 Jun; 79(6):M1159-67.
Sohn JH, Lee YR, Lee DS, Kim YC, Oh H. PTP1B inhibitory secondary metabolites from marine-derived fungal strains Penicillium spp. and Eurotium sp. J Microbiol Biotechnol. 2013 Sep 28; 23(9):1206-11.
Ng T, Ryu JR, Sohn JH, Tan T, Song H, Ming GL, Goh EL. Class 3 semaphorin mediates dendrite growth in adult newborn neurons through Cdk5/FAK pathway. PLoS One. 2013; 8(6):e65572.
Cheung YY, Jung B, Sohn JH, Ogrinc G. Quality initiatives: statistical control charts: simplifying the analysis of data for quality improvement. Radiographics. 2012 Nov-Dec; 32(7):2113-26.
Seo C, Sohn JH, Oh H, Kim BY, Ahn JS. Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6095-7.
Seo C, Choi YH, Sohn JH, Ahn JS, Yim JH, Lee HK, Oh H. Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):772-5.
Sohn JH, Han MJ, Lee MY, Kang SK, Yang JS. Simultaneous determination of N-hydroxymethyl-N-methylformamide, N-methylformamide and N-acetyl-S-(N-methylcarbamoyl)cystein in urine samples from workers exposed to N,N-dimethylformamide by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2005 Feb 07; 37(1):165-70.