Misung Han, PhD

Assistant Researcher

Biography

Misung Han, Ph.D, is a Professional Assistant Researcher in the Department of Radiology and Biomedical Imaging at UCSF. She has developed various MRI techniques ranging over MRI acquisition, reconstruction, and quantification for breast, musculoskeletal, and brain applications both at Stanford (as a graduate student) and at UCSF. At UCSF, she primarily belongs to the Musculoskeletal and Quantitative Imaging Research Group. She has focused on developing new MRI methods for depicting high-resolution structure and quantifying tissue parameters in musculoskeletal tissues including semi-solid/solid tissues. In addition, she has worked with other research groups, applying her technical expertise for diverse clinical applications. By working with the Neuro Imaging group, she developed accelerated DSC perfusion imaging techniques for brain tumor quantification and multiband TOF/SWI techniques to assess vasculature and vascular injury. By working with the Focused Ultrasound Lab, she developed UTE temperature mapping methods that have potentials to assess heat deposition in cortical bone.

She is a recipient of an NIAMS K01 grant to develop MRI techniques to comprehensively assess rotator cuff pathology. She has great interests in developing novel, efficient MRI techniques to improve diagnostic capability and to quantify image biomarkers associated with degeneration.

Education

Postdoctoral Training, 09/2014 - Radiology and Biomedical Imaging, University of California, San Francisco
Ph.D., 08/2010 - Electrical Engineering, Stanford University
M.S., 08/2004 - Electrical Engineering, Stanford University
B.S., 08/2002 - Electrical Engineering, Korea Advanced Institute of Science and Technology

Publications

Fields AJ, Ballatori A, Han M, Bailey JF, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Lotz JC. Measurement of vertebral endplate bone marrow lesion (Modic change) composition with water-fat MRI and relationship to patient-reported outcome measures. Eur Spine J. 2021 Feb 06.
Han M, Yang B, Fernandez B, Lafontaine M, Alcaide-Leon P, Jakary A, Burns BL, Morrison MA, Villanueva-Meyer JE, Chang SM, Banerjee S, Lupo JM. Simultaneous multi-slice spin- and gradient-echo dynamic susceptibility-contrast perfusion-weighted MRI of gliomas. NMR Biomed. 2021 01; 34(1):e4399.
Ashmeik W, Baal JD, Foreman SC, Joseph GB, Bahroos E, Han M, Krug R, Link TM. Investigating the Association of Metabolic Biomarkers With Knee Cartilage Composition and Structural Abnormalities Using MRI: A Pilot Study. Cartilage. 2020 Aug 06; 1947603520946376.
Wang L, Han M, Wong J, Zheng P, Lazar AA, Krug R, Fields AJ. Evaluation of human cartilage endplate composition using MRI: Spatial variation, association with adjacent disc degeneration, and in vivo repeatability. J Orthop Res. 2021 Jul; 39(7):1470-1478.
Chandramohan D, Cao P, Han M, An H, Sunderland JJ, Kinahan PE, Laforest R, Hope TA, Larson PEZ. Bone material analogues for PET/MRI phantoms. Med Phys. 2020 Jun; 47(5):2161-2170.
Roland Krug, Gabrielle B. Joseph, Misung Han, Aaron Fields, Justin Cheung, Maya Mundada, Jeannie Bailey, Alice Rochette, Alexander Ballatori, Charles E. McCulloch, Zachary McCormick, Conor O'Neill, Thomas M. Link, Jeffrey Lotz. Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI. Journal of Magnetic Resonance Imaging. 2019 Oct 1; 50(4):spcone-spcone.
Foreman SC, Ashmeik W, Baal JD, Han M, Bahroos E, von Schacky CE, Carl M, Krug R, Joseph GB, Link TM. Patients with Type 2 Diabetes Exhibit a More Mineralized Deep Cartilage Layer Compared with Nondiabetic Controls: A Pilot Study. Cartilage. 2019 Aug 27; 1947603519870853.
Bailey JF, Fields AJ, Ballatori A, Cohen D, Jain D, Coughlin D, O'Neill C, McCormick Z, Han M, Krug R, Demir-Deviren S, Lotz JC. The Relationship Between Endplate Pathology and Patient-reported Symptoms for Chronic Low Back Pain Depends on Lumbar Paraspinal Muscle Quality. Spine (Phila Pa 1976). 2019 Jul 15; 44(14):1010-1017.
Wu PH, Gibbons M, Foreman SC, Carballido-Gamio J, Han M, Krug R, Liu J, Link TM, Kazakia GJ. Cortical bone vessel identification and quantification on contrast-enhanced MR images. Quant Imaging Med Surg. 2019 Jun; 9(6):928-941.
S.C. Foreman, W. Ashmeik, J.D. Baal, E. Bahroos, R. Krug, M. Han, G.B. Joseph, T.M. Link. Patients with type 2 diabetes exhibit a more calcified deep cartilage layer compared to nondiabetic controls: a pilot study. Osteoarthritis and Cartilage. 2019 Apr 1; 27:s148.
Krug R, Joseph GB, Han M, Fields A, Cheung J, Mundada M, Bailey J, Rochette A, Ballatori A, McCulloch CE, McCormick Z, O'Neill C, Link TM, Lotz J. Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI. J Magn Reson Imaging. 2019 10; 50(4):1219-1226.
Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration. Spine (Phila Pa 1976). 2018 05 15; 43(10):E592-E600.
Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW. Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences. J Magn Reson Imaging. 2018 12; 48(6):1717-1720.
Kazakia GJ, Carballido-Gamio J, Lai A, Nardo L, Facchetti L, Pasco C, Zhang CA, Han M, Parrott AH, Tien P, Krug R. Trabecular bone microstructure is impaired in the proximal femur of human immunodeficiency virus-infected men with normal bone mineral density. Quant Imaging Med Surg. 2018 Feb; 8(1):5-13.
Boucneau T, Cao P, Tang S, Han M, Xu D, Henry RG, Larson PEZ. In vivo characterization of brain ultrashort-T2 components. Magn Reson Med. 2018 08; 80(2):726-735.
Ozhinsky E, Han M, Bucknor M, Krug R, Rieke V. T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound. J Ther Ultrasound. 2016; 4:26.
Larson PE, Han M, Krug R, Jakary A, Nelson SJ, Vigneron DB, Henry RG, McKinnon G, Kelley DA. Ultrashort echo time and zero echo time MRI at 7T. MAGMA. 2016 Jun; 29(3):359-70.
Misung Han, Serena Scott, Eugene Ozhinsky, Vasant Salgaonkar, Peter Jones, Peder Larson, Chris Diederich, Roland Krug, Viola Rieke. Assessing temperature dependence of T1 in cortical bone using ultrashort echo-time MRI. Journal of Therapeutic Ultrasound. 2015 Dec 1; 3(Suppl 1):p5.
Eugene Ozhinsky, Misung Han, Serena Scott, Chris Diederich, Viola Rieke. Relationship between temperature and T2 in subcutaneous fat and bone marrow at 3T. Journal of Therapeutic Ultrasound. 2015 Dec 1; 3(Suppl 1):p89.
Han M, Rieke V, Scott SJ, Ozhinsky E, Salgaonkar VA, Jones PD, Larson PE, Diederich CJ, Krug R. Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI. Magn Reson Med. 2015 Dec; 74(6):1548-55.
Nardo L, Han M, Kretzschmar M, Kretschmar M, Guindani M, Koch K, Vail T, Krug R, Link TM. Metal artifact suppression at the hip: diagnostic performance at 3.0 T versus 1.5 Tesla. Skeletal Radiol. 2015 Nov; 44(11):1609-16.
Misung Han, Ko Chiba, Suchandrima Banerjee, Julio Carballido-Gamio, Roland Krug. Variable flip angle three-dimensional fast spin-echo sequence combined with outer volume suppression for imaging trabecular bone structure of the proximal femur. Journal of Magnetic Resonance Imaging. 2015 May 1; 41(5):spcone-spcone.
Kretzschmar M, Nardo L, Han MM, Heilmeier U, Sam C, Joseph GB, Koch KM, Krug R, Link TM. Metal artefact suppression at 3 T MRI: comparison of MAVRIC-SL with conventional fast spin echo sequences in patients with Hip joint arthroplasty. Eur Radiol. 2015 Aug; 25(8):2403-11.
Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R. Validation of bone marrow fat quantification in the presence of trabecular bone using MRI. J Magn Reson Imaging. 2015 Aug; 42(2):539-44.
Fields AJ, Han M, Krug R, Lotz JC. Cartilaginous end plates: Quantitative MR imaging with very short echo times-orientation dependence and correlation with biochemical composition. Radiology. 2015 Feb; 274(2):482-9.
Han M, Chiba K, Banerjee S, Carballido-Gamio J, Krug R. Variable flip angle three-dimensional fast spin-echo sequence combined with outer volume suppression for imaging trabecular bone structure of the proximal femur. J Magn Reson Imaging. 2015 May; 41(5):1300-10.
Liebl H, Heilmeier U, Lee S, Nardo L, Patsch J, Schuppert C, Han M, Rondak IC, Banerjee S, Koch K, Link TM, Krug R. In vitro assessment of knee MRI in the presence of metal implants comparing MAVRIC-SL and conventional fast spin echo sequences at 1.5 and 3 T field strength. J Magn Reson Imaging. 2015 May; 41(5):1291-9.
Han M, Larson PE, Liu J, Krug R. Depiction of achilles tendon microstructure in vivo using high-resolution 3-dimensional ultrashort echo-time magnetic resonance imaging at 7 T. Invest Radiol. 2014 May; 49(5):339-45.
Scott SJ, Prakash P, Salgaonkar V, Jones PD, Cam RN, Han M, Rieke V, Burdette EC, Diederich CJ. Approaches for modelling interstitial ultrasound ablation of tumours within or adjacent to bone: theoretical and experimental evaluations. Int J Hyperthermia. 2013 Nov; 29(7):629-42.
Han M, Cunningham CH, Pauly JM, Daniel BL, Hargreaves BA. Homogenous fat suppression for bilateral breast imaging using independent shims. Magn Reson Med. 2014 Apr; 71(4):1511-7.
Han M, Hargreaves BA. Reduction of flow artifacts by using partial saturation in RF-spoiled gradient-echo imaging. Magn Reson Med. 2011 May; 65(5):1326-34.
Han M, Beatty PJ, Daniel BL, Hargreaves BA. Independent slab-phase modulation combined with parallel imaging in bilateral breast MRI. Magn Reson Med. 2009 Nov; 62(5):1221-31.
Han M, Daniel BL, Hargreaves BA. Accelerated bilateral dynamic contrast-enhanced 3D spiral breast MRI using TSENSE. J Magn Reson Imaging. 2008 Dec; 28(6):1425-34.