Daniel Cooke, MD

Assistant Professor
Asst. Professor in Residence

Biography

Daniel Cooke, MD, is an Assistant Professor in Residence of Neuro Interventional Radiology in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. His expertise is in ischemic and hemorrhagic stroke, vascular malignancies of the central nervous system, arteriovenous malformations (AVM), arteriovenous fistula (AVF), and aneurysms of the brain and spine. Dr. Cooke earned his medical degree from Emory University, Atlanta in 2004, and completed his residency in Diagnostic Radiology at the University of Washington, Seattle. He completed a fellowship in Neuroradiology at the University of Washington, Seattle in 2010, followed by another fellowship in Neuro Interventional Radiology from the University of California, San Francisco in 2012.

Dr. Cooke’s primary research is in the use of contemporary endovascular surgical methods to assess endothelial cells in the setting of neurovascular pathology. In his work with MR generated computational fluid dynamic data and microsurgical specimens he aims to characterize the local and regional molecular events underlying the evolution of aneurysms, AVMs, and AVFs.

Dr. Cooke’s research interests include: endovascular biopsy, pre-natal brain AVM detection, endovascular brachytherapy, flat panel CT-fluoroscopically guided intervention, and chemoinfusion. Dr. Cooke is also involved in research on catheter-based interventions for hemorrhagic stroke as well as regenerative cell therapies for ischemic stroke.

Expertise:
Neuro Interventional Radiology

Specialty:
Ischemic and hemorrhagic stroke, vascular malignancies of the central nervous system, and arteriovenous malformations (AVM), arteriovenous fistula (AVF), and aneurysms of the brain and spine

Professional Interests:
Stroke, arteriovenous malformation, arteriovenous fistula, aneurysm, cerebral vascular disease, endothelium, intracerebral hemorrhage, spinal vascular anomalies, vascular cerebral, spinal, and head and neck malignancy, retinoblastoma, high and low flow vascular malformations

Education and Training:
• Medical School: Emory University, Atlanta, Georgia
• Internship: University of Hawaii, Honolulu - Surgery
• Residency: University of Washington, Seattle - Radiology
• Fellowship: University of Washington, Seattle - Neuroradiology
• Fellowship: University of California, San Francisco - Neuro Interventional
• Medical licensure, California
• American Board of Radiology with sub-specialty certification in Neuroradiology

Education

Clinical Fellowship, - Radiology, University of California, San Francisco

Honors and Awards

Neuroradiology Research Award, University of Washington, 2009
Goldberg International Grant, ACR Reeder, 2008

Publications

Talbott JF, Cooke DL, Mabray MC, Larson PS, Amans MR, Hetts SW, Wilson MW, Moore T, Salegio EA. Accuracy of image-guided percutaneous injection into a phantom spinal cord utilizing flat panel detector CT with MR fusion and integrated navigational software. J Neurointerv Surg. 2018 Apr 17.
LaHue SC, Kim H, Pawlikowska L, Nelson J, Cooke DL, Hetts SW, Singh V. Frequency and characteristics associated with inherited thrombophilia in patients with intracranial dural arteriovenous fistula. J Neurosurg. 2018 Apr 06; 1-5.
Morrison J, Alexander MD, Dowd CF, Cooke DL. Flanking the fenestration: circumferential limb-to-limb stent-assisted coiling of a basilar artery fenestration aneurysm. J Neurointerv Surg. 2018 Mar 21.
Yen AJ, Conrad MB, Loftus PA, Kumar V, Nanavati SM, Wilson MW, Cooke DL. Internal Jugular Vein Embolization to Control Life-Threatening Hemorrhage after Penetrating Neck Trauma. J Vasc Interv Radiol. 2018 Mar; 29(3):435-437.
Alexander MD, Hippe DS, Cooke DL, Hallam DK, Hetts SW, Kim H, Lawton MT, Sekhar LN, Kim LJ, Ghodke BV. Targeted Embolization of Aneurysms Associated With Brain Arteriovenous Malformations at High Risk for Surgical Resection: A Case-Control Study. Neurosurgery. 2018 Mar 01; 82(3):343-349.
Hirabayashi KE, Kalin-Hajdu E, Bever GJ, Vagefi MR, de Alba Campomanes AG, Cooke DL, Dowd CF, Kersten RC. Normalization of Congenital Venous Stasis Retinopathy Following Sclerotherapy of a Macrocystic Lymphatic Malformation. Ophthal Plast Reconstr Surg. 2018 Jan/Feb; 34(1):e19-e21.
Alexander MD, Rebhun JM, Hetts SW, Amans MR, Settecase F, Darflinger RJ, Dowd CF, Halbach VV, Higashida RT, Cooke DL. Technical factors affecting outcomes following endovascular treatment of posterior circulation atherosclerotic lesions. Surg Neurol Int. 2017; 8:284.
Morrison J, Alexander MD, Dowd CF, Cooke DL. Flanking the fenestration: circumferential limb-to-limb stent-assisted coiling of a basilar artery fenestration aneurysm. BMJ Case Rep. 2017 Oct 13; 2017.
Burkhardt JK, Chen X, Winkler EA, Weiss M, Yue JK, Cooke DL, Kim H, Lawton MT. Early Hemodynamic Changes Based on Initial Color-Coding Angiography as a Predictor for Developing Subsequent Symptomatic Vasospasm After Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2018 Jan; 109:e363-e373.
Yang JK, Cote AM, Jordan CD, Kondapavulur S, Losey AD, McCoy D, Chu A, Yu JF, Moore T, Stillson C, Settecase F, Alexander MD, Nicholson A, Cooke DL, Saeed M, Barry D, Martin AJ, Wilson MW, Hetts SW. Interventional magnetic resonance imaging guided carotid embolectomy using a novel resonant marker catheter: demonstration of preclinical feasibility. Biomed Microdevices. 2017 Sep 25; 19(4):88.
Chen X, Cooke DL, Saloner D, Nelson J, Su H, Lawton MT, Hess C, Tihan T, Zhao Y, Kim H. Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages. Stroke. 2017 10; 48(10):2881-2884.
Mamlouk MD, Nicholson AD, Cooke DL, Hess CP. Diffusion-weighted imaging for cutaneous vascular anomalies. Clin Imaging. 2017 Nov - Dec; 46:121-122.
Derdeyn CP, Zipfel GJ, Albuquerque FC, Cooke DL, Feldmann E, Sheehan JP, Torner JC. Management of Brain Arteriovenous Malformations: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2017 08; 48(8):e200-e224.
Mamlouk MD, Nicholson AD, Cooke DL, Hess CP. Tips and tricks to optimize MRI protocols for cutaneous vascular anomalies. Clin Imaging. 2017 Sep - Oct; 45:71-80.
Hetts SW, Moftakhar P, Maluste N, Fullerton HJ, Cooke DL, Amans MR, Dowd CF, Higashida RT, Halbach VV. Pediatric intracranial dural arteriovenous fistulas: age-related differences in clinical features, angioarchitecture, and treatment outcomes. J Neurosurg Pediatr. 2016 Nov; 18(5):602-610.
Alexander MD, Cooke DL, Hallam DK, Kim H, Hetts SW, Ghodke BV. Less can be more: Targeted embolization of aneurysms associated with arteriovenous malformations unsuitable for surgical resection. Interv Neuroradiol. 2016 Aug; 22(4):445-51.
Lillaney PV, Yang JK, Losey AD, Martin AJ, Cooke DL, Thorne BR, Barry DC, Chu A, Stillson C, Do L, Arenson RL, Saeed M, Wilson MW, Hetts SW. Endovascular MR-guided Renal Embolization by Using a Magnetically Assisted Remote-controlled Catheter System. Radiology. 2016 10; 281(1):219-28.
Settecase F, Nicholson AD, Amans MR, Higashida RT, Halbach VV, Cooke DL, Dowd CF, Hetts SW. Onyx embolization of an intraosseous pseudoaneurysm of the middle meningeal artery in a patient with meningiomatosis, McCune-Albright syndrome, and gray platelet syndrome. J Neurosurg Pediatr. 2016 Mar; 17(3):324-9.
Narvid J, Amans MR, Cooke DL, Hetts SW, Dillon WP, Higashida RT, Dowd CF, Halbach VV. Spontaneous retroclival hematoma: a case series. J Neurosurg. 2016 Mar; 124(3):716-9.
Cooke DL, Levitt MR, Kim LJ, Hallam DK, Sekhar LN, Ghodke BV. Laser-assisted flat-detector CT-guided intracranial access. Int J Comput Assist Radiol Surg. 2016 Mar; 11(3):467-72.
Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels?. Biotechnol Rep (Amst). 2015 Sep; 7:157-165.
Mabray MC, Datta S, Lillaney PV, Moore T, Gehrisch S, Talbott JF, Levitt MR, Ghodke BV, Larson PS, Cooke DL. Accuracy of flat panel detector CT with integrated navigational software with and without MR fusion for single-pass needle placement. J Neurointerv Surg. 2016 Jul; 8(7):731-5.
Moftakhar P, Lillaney P, Losey AD, Cooke DL, Martin AJ, Thorne BR, Arenson RL, Saeed M, Wilson MW, Hetts SW. New-Generation Laser-lithographed Dual-Axis Magnetically Assisted Remote-controlled Endovascular Catheter for Interventional MR Imaging: In Vitro Multiplanar Navigation at 1.5 T and 3 T versus X-ray Fluoroscopy. Radiology. 2015 Dec; 277(3):842-52.
Alexander MD, Rebhun JM, Hetts SW, Kim AS, Nelson J, Kim H, Amans MR, Settecase F, Dowd CF, Halbach VV, Higashida RT, Cooke DL. Lesion location, stability, and pretreatment management: factors affecting outcomes of endovascular treatment for vertebrobasilar atherosclerosis. J Neurointerv Surg. 2016 May; 8(5):466-70.
Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM. Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Interv Neuroradiol. 2015 Feb; 21(1):120-8.
Moftakhar P, Cooke DL, Fullerton HJ, Ko NU, Amans MR, Narvid JA, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Extent of collateralization predicting symptomatic cerebral vasospasm among pediatric patients: correlations among angiography, transcranial Doppler ultrasonography, and clinical findings. J Neurosurg Pediatr. 2015 Mar; 15(3):282-90.
Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL. Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. J Biotechnol. 2014 Dec 20; 192 Pt A:34-9.
Raygor KP, Rowland NC, Cooke DL, Solomon DA, Huang MC. Aneurysm of the posterior meningeal artery embedded within a dorsal exophytic medullary hemangioblastoma: surgical management and review of literature. J Cerebrovasc Endovasc Neurosurg. 2014 Sep; 16(3):293-8.
Cooke DL, Stout CE, Kim WT, Kansagra AP, Yu JP, Gu A, Jewell NP, Hetts SW, Higashida RT, Dowd CF, Halbach VV. Cerebral arterial fenestrations. Interv Neuroradiol. 2014 May-Jun; 20(3):261-74.
Chow ML, Cooke DL, Fullerton HJ, Amans MR, Narvid J, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Radiological and clinical features of vein of Galen malformations. J Neurointerv Surg. 2015 Jun; 7(6):443-8.
Losey AD, Lillaney P, Martin AJ, Cooke DL, Wilson MW, Thorne BR, Sincic RS, Arenson RL, Saeed M, Hetts SW. Magnetically assisted remote-controlled endovascular catheter for interventional MR imaging: in vitro navigation at 1.5 T versus X-ray fluoroscopy. Radiology. 2014 Jun; 271(3):862-9.
Amans MR, Cooke DL, Vella M, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Contrast staining on CT after DSA in ischemic stroke patients progresses to infarction and rarely hemorrhages. Interv Neuroradiol. 2014 Jan-Feb; 20(1):106-15.
Lillaney P, Caton C, Martin AJ, Losey AD, Evans L, Saeed M, Cooke DL, Wilson MW, Hetts SW. Comparing deflection measurements of a magnetically steerable catheter using optical imaging and MRI. Med Phys. 2014 Feb; 41(2):022305.
Sincic RS, Caton CJ, Lillaney P, Goodfriend S, Ni J, Martin AJ, Losey AD, Shah N, Yee EJ, Evans L, Malba V, Bernhardt AF, Settecase F, Cooke DL, Saeed M, Wilson MW, Hetts SW. System architecture for a magnetically guided endovascular microcatheter. Biomed Microdevices. 2014 Feb; 16(1):97-106.
Cooke DL, Stout CE, Kim WT, Hetts SW, Higashida RT, Halbach VV, Dowd CF, Gould RG. Radiation dose reduction in intra-arterial chemotherapy infusion for intraocular retinoblastoma. J Neurointerv Surg. 2014 Dec; 6(10):785-9.
Hetts SW, English JD, Stiver SI, Singh V, Yee EJ, Cooke DL, Halbach VV. Bilateral cervical spinal dural arteriovenous fistulas with intracranial venous drainage mimicking a foramen magnum dural arteriovenous fistula. Interv Neuroradiol. 2013 Dec; 19(4):483-8.
Amans MR, Stout C, Fox C, Narvid J, Hetts SW, Cooke DL, Higashida RT, Dowd CF, McSwain H, Halbach VV. Cerebral arteriopathy associated with Arg179His ACTA2 mutation. J Neurointerv Surg. 2014 Nov; 6(9):e46.
Cooke DL, Su H, Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV. Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils. Interv Neuroradiol. 2013 Dec; 19(4):399-408.
Amans MR, Stout C, Fox C, Narvid J, Hetts SW, Cooke DL, Higashida RT, Dowd CF, McSwain H, Halbach VV. Cerebral arteriopathy associated with Arg179His ACTA2 mutation. BMJ Case Rep. 2013 Nov 29; 2013.
Sheth SA, Potts MB, Sneed PK, Young WL, Cooke DL, Gupta N, Hetts SW. Angiographic features help predict outcome after stereotactic radiosurgery for the treatment of pediatric arteriovenous malformations. Childs Nerv Syst. 2014 Feb; 30(2):241-7.
Losey AD, Lillaney P, Martin AJ, Halbach VV, Cooke DL, Dowd CF, Higashida RT, Saloner DA, Wilson MW, Saeed M, Hetts SW. Safety of retained microcatheters: an evaluation of radiofrequency heating in endovascular microcatheters with nitinol, tungsten, and polyetheretherketone braiding at 1.5 T and 3 T. J Neurointerv Surg. 2014 May; 6(4):314-9.
Hetts SW, Saeed M, Martin A, Lillaney P, Losey A, Yee EJ, Sincic R, Do L, Evans L, Malba V, Bernhardt AF, Wilson MW, Patel A, Arenson RL, Caton C, Cooke DL. Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging. J Vis Exp. 2013 Apr 04; (74).
Kansagra AP, Cooke DL, English JD, Sincic RM, Amans MR, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Current trends in endovascular management of traumatic cerebrovascular injury. J Neurointerv Surg. 2014 Jan; 6(1):47-50.
Moftakhar P, English JD, Cooke DL, Kim WT, Stout C, Smith WS, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Density of thrombus on admission CT predicts revascularization efficacy in large vessel occlusion acute ischemic stroke. Stroke. 2013 Jan; 44(1):243-5.
Cooke DL, Meisel KM, Kim WT, Stout CE, Halbach VV, Dowd CF, Higashida RT. Serial angiographic appearance of segmental arterial mediolysis manifesting as vertebral, internal mammary and intra-abdominal visceral artery aneurysms in a patient presenting with subarachnoid hemorrhage and review of the literature. J Neurointerv Surg. 2013 Sep 01; 5(5):478-82.
Cooke DL, Johnson G, Levitt MR, Lewis DH, Sekhar LN, Ghodke B. Synchronous chronic middle cerebral artery occlusion and ipsilateral dural arteriovenous fistula. Clin Nucl Med. 2011 Jul; 36(7):570-3.
Levitt MR, Cooke DL, Ghodke BV, Kim LJ, Hallam DK, Sekhar LN. "Stent view" flat-detector CT and stent-assisted treatment strategies for complex intracranial aneurysms. World Neurosurg. 2011 Feb; 75(2):275-8.
Cooke DL, Levitt M, Kim LJ, Hallam DK, Ghodke B. Intraorbital access using fluoroscopic flat panel detector CT navigation and three-dimensional MRI overlay. J Neurointerv Surg. 2010 Sep; 2(3):249-51.
Levitt MR, Ghodke BV, Cooke DL, Hallam DK, Kim LJ, Sekhar LN. Endovascular procedures with CTA and MRA roadmapping. J Neuroimaging. 2011 Jul; 21(3):259-62.