Heidi Kirsch, MD, MS

Professor in Neurology, Joint Appointment with Radiology
Prof of Clinical Neurology

Biography

Dr. Heidi Kirsch is a specialist in epilepsy treatment (epileptology) and is board certified in epilepsy, neurology and clinical neurophysiology. She joined UCSF Medical Center in 2002 and is a Professor of Clinical Neurology and Radiology and Biomedical Imaging. She is the Clinical Director of the UCSF Biomagnetic Imaging Laboratory (UCSF's MEG lab), where she works mapping epileptic activity and functional areas in the brain to plan epilepsy and other types of brain surgery. In her research, she studies new methods of brain mapping and the ways in which seizures spread in the brain. She also directs the Foundational Science in F2 in the UCSF School of Medicine Bridges Curriculum, where students integrate basic science principles into clinical reasoning.

Kirsch earned an undergraduate degree magna cum laude at Harvard and a master's degree in Health and Medical Sciences and a medical degree from the Joint Medical Program offered by the University of California at Berkeley and UCSF. She completed an internship at Georgetown University and a neurology residency at Johns Hopkins Hospital, where she was a fellow in clinical neurophysiology and epilepsy. During her fellowship, she was a volunteer to the Cognitive Neuroscience Section of the National Institutes of Health (NIH). She is a member of the board of directors of the American Clinical Magentoencephalography Society and past president of the board of directors of the Epilepsy Foundation of Northern California, and a member of the American Neurological Association, the American Academy of Neurology and the American Epilepsy Society. She serves as an ad hoc reviewer for several journals, including the Annals of Neurology and Neurology.

Education

2019 - Diversity, Equity, and Inclusion Champion Training, University of California
Fellowship, 2002 - Epilepsy and Clinical Neurophysiology, Johns Hopkins
Residency, Chief residency, 2000 - Neurology, Johns Hopkins
Residency (PGY-1), 1997 - Medicine/Transitional Year, Georgetown
M.D., 1996 - Medicine, University of California, San Francisco
M.S., 1994 - School of Public Health (Joint Medical Program), University of California, Berkeley
A.B., 1991 - Biological Anthropology, Harvard University

Publications

Prabhu P, Morise H, Kudo K, Beagle A, Mizuiri D, Syed F, Kotegar KA, Findlay A, Miller BL, Kramer JH, Rankin KP, Garcia PA, Kirsch HE, Vossel K, Nagarajan SS, Ranasinghe KG. Abnormal gamma phase-amplitude coupling in the parahippocampal cortex is associated with network hyperexcitability in Alzheimer's disease. Brain Commun. 2024; 6(2):fcae121.
Kudo K, Ranasinghe KG, Morise H, Syed F, Sekihara K, Rankin KP, Miller BL, Kramer JH, Rabinovici GD, Vossel K, Kirsch HE, Nagarajan SS. Neurophysiological trajectories in Alzheimer's disease progression. Elife. 2024 Mar 28; 12.
Kiwamu Kudo, Kamalini G Ranasinghe, Hirofumi Morise, Faatimah Syed, Kensuke Sekihara, Katherine P Rankin, Bruce L Miller, Joel H Kramer, Gil D Rabinovici, Keith Vossel, Heidi E Kirsch, Srikantan S Nagarajan. Neurophysiological trajectories in Alzheimer’s disease progression. eLife. 2024 Mar 28; 12.
Kristin K. Sellers, Joline M. Fan, Leighton B.N. Hinkley, Heidi E. Kirsch. Preprocessing Electrophysiological Data: EEG, iEEG, and MEG Data. Statistical Methods in Epilepsy. 2024 Mar 25; 25-50.
Kudo K, Ranasinghe KG, Morise H, Syed F, Sekihara K, Rankin KP, Miller BL, Kramer JH, Rabinovici GD, Vossel K, Kirsch HE, Nagarajan SS. Neurophysiological trajectories in Alzheimer's disease progression. bioRxiv. 2024 Mar 08.
Samudra N, Lerner H, Yack L, Walsh CM, Kirsch HE, Kudo K, Yballa C, La Joie R, Gorno-Tempini ML, Spina S, Seeley WW, Neylan TC, Miller BL, Rabinovici GD, Boxer A, Grinberg LT, Rankin KP, Nagarajan SS, Ranasinghe KG. Spatiotemporal characteristics of neurophysiological changes in patients with four-repeat tauopathies. Ann Clin Transl Neurol. 2024 02; 11(2):525-535.
Fan JM, Kudo K, Verma P, Ranasinghe KG, Morise H, Findlay AM, Vossel K, Kirsch HE, Raj A, Krystal AD, Nagarajan SS. Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep. J Neurosci. 2023 11 29; 43(48):8157-8171.
Pooja Prabhu, Kamalini G Ranasinghe, Hirofumi Morise, Kiwamu Kudo, Leighton B Hinkley, Hannah M Lerner, Danielle Mizuiri, Abigail Licata, Karunakar A Kotegar, Anne Findlay, Bruce L Miller, Marilu Gorno-Tempini, Joel H. Kramer, Katherine P Rankin, Paul Garcia, Heidi Kirsch, John F Houde, Keith Vossel, Srikantan S Nagarajan. Abnormal gamma frequency phase-amplitude coupling associated with network hyperexcitability in Alzheimer’s Disease. Alzheimer's & Dementia. 2023 Jun 16; 19(S3).
Drew Cheng, Michael Zhu Chen, August Yue Huang, Junseok Park, Heidi Kirsch, Christopher Walsh, Diane Shao. Functional Investigation of Somatic Variants in Pediatric Epilepsy Using Single-Cell DNA/RNA Assays from Patient Derived Single Cells (P3-9.009). Neurology. 2023 Apr 25; 100(17_supplement_2).
Samudra N, Ranasinghe K, Kirsch H, Rankin K, Miller B. Etiology and Clinical Significance of Network Hyperexcitability in Alzheimer's Disease: Unanswered Questions and Next Steps. J Alzheimers Dis. 2023; 92(1):13-27.
Charondo LB, Duque JB, Kirsch HE, Brondfield S. Maintaining Medical Student Motivation During Remote Clinical Learning. Acad Med. 2023 01 01; 98(1):105-111.
Li C, Cai HB, Zhao X, Xi XC, Zhou Q, Luo HY, Tang ZP, Kang HC, Kirsch HE. What Is Different about Teratoma-Associated Anti-LGI1 Encephalitis? A Long-Term Clinical and Neuroimaging Case Series. Eur Neurol. 2022; 85(6):437-445.
Sam Brondfield, Katherine Hyland, Patricia A. Cornett, Heidi Kirsch. Applying cognitive integration to oncology: A novel asynchronous foundational science curriculum for medical students during clerkships. Journal of Clinical Oncology. 2022 Jun 1; 40(16_suppl):11028-11028.
Fan JM, Lee AT, Kudo K, Ranasinghe KG, Morise H, Findlay AM, Kirsch HE, Chang EF, Nagarajan SS, Rao VR. Network connectivity predicts effectiveness of responsive neurostimulation in focal epilepsy. Brain Commun. 2022; 4(3):fcac104.
Ranasinghe KG, Kudo K, Hinkley L, Beagle A, Lerner H, Mizuiri D, Findlay A, Miller BL, Kramer JH, Gorno-Tempini ML, Rabinovici GD, Rankin KP, Garcia PA, Kirsch HE, Vossel K, Nagarajan SS. Neuronal synchrony abnormalities associated with subclinical epileptiform activity in early-onset Alzheimer's disease. Brain. 2022 04 18; 145(2):744-753.
Pai JS, Kirsch HE, O'Sullivan PS, Cornett PA. "What is the mechanism?": Cues, barriers, and opportunities to discuss foundational science during internal medicine rounds. Med Teach. 2022 07; 44(7):765-771.
Bear JJ, Sargent JL, O'Neill BR, Chapman KE, Ghosh D, Kirsch HE, Tregellas JR. Spike-Associated Networks Predict Postsurgical Outcomes in Children With Refractory Epilepsy. J Clin Neurophysiol. 2023 Feb 01; 40(2):123-129.
Vossel K, Ranasinghe KG, Beagle AJ, La A, Ah Pook K, Castro M, Mizuiri D, Honma SM, Venkateswaran N, Koestler M, Zhang W, Mucke L, Howell MJ, Possin KL, Kramer JH, Boxer AL, Miller BL, Nagarajan SS, Kirsch HE. Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial. JAMA Neurol. 2021 11 01; 78(11):1345-1354.
Lan L, Zhao X, Jian S, Li C, Wang M, Zhou Q, Huang S, Zhu S, Kang H, Kirsch HE. Investigation of the risk of valproic acid-induced tremor: clinical, neuroimaging, and genetic factors. Psychopharmacology (Berl). 2022 Jan; 239(1):173-184.
Kang H, Lan L, Jia Y, Li C, Fang Y, Zhu S, Kirsch H. Long QT syndrome with potassium voltage-gated channel subfamily H member 2 gene mutation mimicking refractory epilepsy: case report. BMC Neurol. 2021 Sep 04; 21(1):338.
Kudo K, Morise H, Ranasinghe KG, Mizuiri D, Bhutada AS, Chen J, Findlay A, Kirsch HE, Nagarajan SS. Magnetoencephalography Imaging Reveals Abnormal Information Flow in Temporal Lobe Epilepsy. Brain Connect. 2022 05; 12(4):362-373.
Pham DH, Pitman MR, Kumar R, Jolly LA, Schulz R, Gardner AE, de Nys R, Heron SE, Corbett MA, Kothur K, Gill D, Rajagopalan S, Kolc KL, Halliday BJ, Robertson SP, Regan BM, Kirsch HE, Berkovic SF, Scheffer IE, Pitson SM, Petrovski S, Gecz J. Integrated in silico and experimental assessment of disease relevance of PCDH19 missense variants. Hum Mutat. 2021 08; 42(8):1030-1041.
Bhutada AS, Cai C, Mizuiri D, Findlay A, Chen J, Tay A, Kirsch HE, Nagarajan SS. Clinical Validation of the Champagne Algorithm for Evoked Response Source Localization in Magnetoencephalography. Brain Topogr. 2022 01; 35(1):96-107.
Cai C, Chen J, Findlay AM, Mizuiri D, Sekihara K, Kirsch HE, Nagarajan SS. Clinical Validation of the Champagne Algorithm for Epilepsy Spike Localization. Front Hum Neurosci. 2021; 15:642819.
Joline Fan, Kiwamu Kudo, Kamalini Ranasinghe, Hirofumi Morise, Anne Findlay, Heidi Kirsch, Andrew Krystal, Srikantan Nagarajan. 073 Whole-brain network analysis of neural oscillations during light sleep. Sleep. 2021 May 3; 44(Supplement_2):a30-a31.
Bagic AI, Funke ME, Kirsch HE, Tenney JR, Zillgitt AJ, Burgess RC. The 10 Common Evidence-Supported Indications for MEG in Epilepsy Surgery: An Illustrated Compendium. J Clin Neurophysiol. 2020 Nov; 37(6):483-497.
John D. Hixson, Heidi E. Kirsch. The effects of epilepsy and its treatments on affect and emotion. . 2020 Oct 8; 206-216.
Weisenberg JLZ, Fitzgerald RT, Constantino JN, Winawer MR, Thio LL, EPGP Investigators. Familial aggregation of status epilepticus in generalized and focal epilepsies. Neurology. 2020 10 13; 95(15):e2140-e2149.
Galer PD, Ganesan S, Lewis-Smith D, McKeown SE, Pendziwiat M, Helbig KL, Ellis CA, Rademacher A, Smith L, Poduri A, Seiffert S, von Spiczak S, Muhle H, van Baalen A, NCEE Study Group, EPGP Investigators, EuroEPINOMICS-RES Consortium, Genomics Research and Innovation Network, Thomas RH, Krause R, Weber Y, Helbig I. Semantic Similarity Analysis Reveals Robust Gene-Disease Relationships in Developmental and Epileptic Encephalopathies. Am J Hum Genet. 2020 10 01; 107(4):683-697.
Bear JJ, Kirsch HE, Berman BD, Chapman KE, Tregellas JR. Spike-associated networks and intracranial electrographic findings. Epileptic Disord. 2020 Jun 01; 22(3):291-299.
Hinkley LBN, De Witte E, Cahill-Thompson M, Mizuiri D, Garrett C, Honma S, Findlay A, Gorno-Tempini ML, Tarapore P, Kirsch HE, Mariën P, Houde JF, Berger M, Nagarajan SS. Optimizing Magnetoencephalographic Imaging Estimation of Language Lateralization for Simpler Language Tasks. Front Hum Neurosci. 2020; 14:105.
Dürschmid S, Reichert C, Hinrichs H, Heinze HJ, Kirsch HE, Knight RT, Deouell LY. Direct Evidence for Prediction Signals in Frontal Cortex Independent of Prediction Error. Cereb Cortex. 2019 12 17; 29(11):4530-4538.
Cai C, Kang H, Kirsch HE, Mizuiri D, Chen J, Bhutada A, Sekihara K, Nagarajan SS. Comparison of DSSP and tSSS algorithms for removing artifacts from vagus nerve stimulators in magnetoencephalography data. J Neural Eng. 2019 11 12; 16(6):066045.
Shiota MN, Simpson ML, Kirsch HE, Levenson RW. Emotion recognition in objects in patients with neurological disease. Neuropsychology. 2019 Nov; 33(8):1163-1173.
Cai C, Xu J, Velmurugan J, Knowlton R, Sekihara K, Nagarajan SS, Kirsch H. Evaluation of a dual signal subspace projection algorithm in magnetoencephalographic recordings from patients with intractable epilepsy and vagus nerve stimulators. Neuroimage. 2019 03; 188:161-170.
Kam JWY, Szczepanski SM, Canolty RT, Flinker A, Auguste KI, Crone NE, Kirsch HE, Kuperman RA, Lin JJ, Parvizi J, Knight RT. Differential Sources for 2 Neural Signatures of Target Detection: An Electrocorticography Study. Cereb Cortex. 2018 01 01; 28(1):9-20.
Kleen JK, Kirsch HE. The nociferous influence of interictal discharges on memory. Brain. 2017 08 01; 140(8):2072-2074.
von Spiczak S, Helbig KL, Shinde DN, Huether R, Pendziwiat M, Lourenço C, Nunes ME, Sarco DP, Kaplan RA, Dlugos DJ, Kirsch H, Slavotinek A, Cilio MR, Cervenka MC, Cohen JS, McClellan R, Fatemi A, Yuen A, Sagawa Y, Littlejohn R, McLean SD, Hernandez-Hernandez L, Maher B, Møller RS, Palmer E, Lawson JA, Campbell CA, Joshi CN, Kolbe DL, Hollingsworth G, Neubauer BA, Muhle H, Stephani U, Scheffer IE, Pena SDJ, Sisodiya SM, Helbig I, Epi4K Consortium, EuroEPINOMICS-RES NLES Working Group. DNM1 encephalopathy: A new disease of vesicle fission. Neurology. 2017 Jul 25; 89(4):385-394.
Tobochnik S, Fahlstrom R, Shain C, Winawer MR, EPGP Investigators. Familial aggregation of focal seizure semiology in the Epilepsy Phenome/Genome Project. Neurology. 2017 Jul 04; 89(1):22-28.
Bagic AI, Bowyer SM, Kirsch HE, Funke ME, Burgess RC, ACMEGS Position Statement Committee. American Clinical MEG Society (ACMEGS) Position Statement #2: The Value of Magnetoencephalography (MEG)/Magnetic Source Imaging (MSI) in Noninvasive Presurgical Mapping of Eloquent Cortices of Patients Preparing for Surgical Interventions. J Clin Neurophysiol. 2017 May; 34(3):189-195.
Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Van Berlo V, Barnes DE, Mantle M, Karydas AM, Coppola G, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, Nagarajan SS. Incidence and impact of subclinical epileptiform activity in Alzheimer's disease. Ann Neurol. 2016 12; 80(6):858-870.
Bear J, Kirsch H. Concordance between interictal MEG and stereo-EEG predicts seizure freedom after epilepsy surgery. Brain. 2016 11 01; 139(11):2821-2823.
Elke De Witte, Leighton Hinkley, Danielle Mizuiri, Coleman Garrett, Susanne Honma, Heidi Kirsch, John Houde, Mitchel S. Berger, Sri Nagarajan. NIMG-27. LANGUAGE LATERALIZATION ASSESSED BY MAGNETOENCEPHALOGRAPHY IMAGING USING THREE DIFFERENT LANGUAGE TASKS. Neuro-Oncology. 2016 Nov 1; 18(suppl_6):vi130-vi130.
Dario J. Englot, John David Rolston, Doris D. Wang, Heidi E. Kirsch, Srikantan S. Nagarajan, Edward F. Chang. 206 Spikes, Slowing, and Functional Connectivity. Neurosurgery. 2016 Aug 1; 63:181.
Chong DJ, Dugan P, EPGP Investigators. Ictal fear: Associations with age, gender, and other experiential phenomena. Epilepsy Behav. 2016 09; 62:153-8.
Dürschmid S, Edwards E, Reichert C, Dewar C, Hinrichs H, Heinze HJ, Kirsch HE, Dalal SS, Deouell LY, Knight RT. Hierarchy of prediction errors for auditory events in human temporal and frontal cortex. Proc Natl Acad Sci U S A. 2016 06 14; 113(24):6755-60.
Winawer MR, Shih J, Beck ES, Hunter JE, Epstein MP, EPGP Investigators. Genetic effects on sleep/wake variation of seizures. Epilepsia. 2016 Apr; 57(4):557-65.
Englot DJ, Nagarajan SS, Wang DD, Rolston JD, Mizuiri D, Honma SM, Mantle M, Tarapore PE, Knowlton RC, Chang EF, Kirsch HE. The sensitivity and significance of lateralized interictal slow activity on magnetoencephalography in focal epilepsy. Epilepsy Res. 2016 Mar; 121:21-8.
Selvaraj P, Sleigh JW, Kirsch HE, Szeri AJ. Closed-loop feedback control and bifurcation analysis of epileptiform activity via optogenetic stimulation in a mathematical model of human cortex. Phys Rev E. 2016 Jan; 93(1):012416.
Fallil Z, Pardoe H, Bachman R, Cunningham B, Parulkar I, Shain C, Poduri A, Knowlton R, Kuzniecky R, EPGP Investigators. Phenotypic and imaging features of FLNA-negative patients with bilateral periventricular nodular heterotopia and epilepsy. Epilepsy Behav. 2015 Oct; 51:321-7.
Dario J. Englot, Robert C. Knowlton, Edward F. Chang, Heidi E. Kirsch, Srikantan S. Nagarajan. 106 Functional Network Analysis in Surgical Epilepsy Patients Using Magnetoencephalography. Neurosurgery. 2015 Aug 1; 62(CN_suppl_1):198-198.
McGovern K, Karn CF, Fox K, EPGP Investigators. Surpassing the Target: How a Recruitment Campaign Transformed the Participant Accrual Trajectory in the Epilepsy Phenome/Genome Project. Clin Transl Sci. 2015 Oct; 8(5):518-25.
Englot DJ, Hinkley LB, Kort NS, Imber BS, Mizuiri D, Honma SM, Findlay AM, Garrett C, Cheung PL, Mantle M, Tarapore PE, Knowlton RC, Chang EF, Kirsch HE, Nagarajan SS. Global and regional functional connectivity maps of neural oscillations in focal epilepsy. Brain. 2015 Aug; 138(Pt 8):2249-62.
Englot DJ, Nagarajan SS, Imber BS, Raygor KP, Honma SM, Mizuiri D, Mantle M, Knowlton RC, Kirsch HE, Chang EF. Epileptogenic zone localization using magnetoencephalography predicts seizure freedom in epilepsy surgery. Epilepsia. 2015 Jun; 56(6):949-58.
Dadok VM, Kirsch HE, Sleigh JW, Lopour BA, Szeri AJ. A probabilistic method for determining cortical dynamics during seizures. J Comput Neurosci. 2015 Jun; 38(3):559-75.
Selvaraj P, Sleigh JW, Kirsch HE, Szeri AJ. Optogenetic induced epileptiform activity in a model human cortex. Springerplus. 2015; 4:155.
Carlson C, Dugan P, Kirsch HE, Friedman D, EPGP Investigators. Sex differences in seizure types and symptoms. Epilepsy Behav. 2014 Dec; 41:103-8.
Dugan P, Carlson C, Bluvstein J, Chong DJ, Friedman D, Kirsch HE, EPGP Investigators. Auras in generalized epilepsy. Neurology. 2014 Oct 14; 83(16):1444-9.
Dadok VM, Kirsch HE, Sleigh JW, Lopour BA, Szeri AJ. A probabilistic framework for a physiological representation of dynamically evolving sleep state. J Comput Neurosci. 2014 Aug; 37(1):105-24.
Selvaraj P, Sleigh JW, Freeman WJ, Kirsch HE, Szeri AJ. Open loop optogenetic control of simulated cortical epileptiform activity. J Comput Neurosci. 2014 Jun; 36(3):515-25.
Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013 Sep 01; 70(9):1158-66.
Epi4K Consortium, Epilepsy Phenome/Genome Project, Allen AS, Berkovic SF, Cossette P, Delanty N, Dlugos D, Eichler EE, Epstein MP, Glauser T, Goldstein DB, Han Y, Heinzen EL, Hitomi Y, Howell KB, Johnson MR, Kuzniecky R, Lowenstein DH, Lu YF, Madou MR, Marson AG, Mefford HC, Esmaeeli Nieh S, O'Brien TJ, Ottman R, Petrovski S, Poduri A, Ruzzo EK, Scheffer IE, Sherr EH, Yuskaitis CJ, Abou-Khalil B, Alldredge BK, Bautista JF, Berkovic SF, Boro A, Cascino GD, Consalvo D, Crumrine P, Devinsky O, Dlugos D, Epstein MP, Fiol M, Fountain NB, French J, Friedman D, Geller EB, Glauser T, Glynn S, Haut SR, Hayward J, Helmers SL, Joshi S, Kanner A, Kirsch HE, Knowlton RC, Kossoff EH, Kuperman R, Kuzniecky R, Lowenstein DH, McGuire SM, Motika PV, Novotny EJ, Ottman R, Paolicchi JM, Parent JM, Park K, Poduri A, Scheffer IE, Shellhaas RA, Sherr EH, Shih JJ, Singh R, Sirven J, Smith MC, Sullivan J, Lin Thio L, Venkat A, Vining EP, Von Allmen GK, Weisenberg JL, Widdess-Walsh P, Winawer MR. De novo mutations in epileptic encephalopathies. Nature. 2013 Sep 12; 501(7466):217-21.
EPGP Collaborative, Abou-Khalil B, Alldredge B, Bautista J, Berkovic S, Bluvstein J, Boro A, Cascino G, Consalvo D, Cristofaro S, Crumrine P, Devinsky O, Dlugos D, Epstein M, Fahlstrom R, Fiol M, Fountain N, Fox K, French J, Freyer Karn C, Friedman D, Geller E, Glauser T, Glynn S, Haas K, Haut S, Hayward J, Helmers S, Joshi S, Kanner A, Kirsch H, Knowlton R, Kossoff E, Kuperman R, Kuzniecky R, Lowenstein D, McGuire S, Motika P, Nesbitt G, Novotny E, Ottman R, Paolicchi J, Parent J, Park K, Poduri A, Risch N, Sadleir L, Scheffer I, Shellhaas R, Sherr E, Shih JJ, Shinnar S, Singh R, Sirven J, Smith M, Sullivan J, Thio LL, Venkat A, Vining E, von Allmen G, Weisenberg J, Widdess-Walsh P, Winawer M. The epilepsy phenome/genome project. Clin Trials. 2013 Aug; 10(4):568-86.
Winawer MR, Connors R, EPGP Investigators. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia. 2013 Feb; 54(2):288-95.
Tarapore PE, Martino J, Guggisberg AG, Owen J, Honma SM, Findlay A, Berger MS, Kirsch HE, Nagarajan SS. Magnetoencephalographic imaging of resting-state functional connectivity predicts postsurgical neurological outcome in brain gliomas. Neurosurgery. 2012 Nov; 71(5):1012-22.
Vera M Dadok, Andrew J Szeri, Heidi Kirsch, Jamie Sleigh, Beth Lopour. Interpretation of seizure evolution pathways via a mean-field cortical model. BMC Neuroscience. 2012 Jul 1; 13(Suppl 1):p95.
Keith A. Vossel, Alexander Beagle, Manu Hegde, Mary Mantle, Heidi Kirsch, Paul Garcia, Susanne Honma, Anne Findlay, Gil Rabinovici, William Jagust, Srikantan Nagarajan, Bruce Miller, Erik Roberson, Lennart Mucke. Subclinical epileptiform activity in Alzheimer's disease. Alzheimer's & Dementia. 2012 Jul 1; 8(4):p395-p396.
Vera M Dadok, Andrew J Szeri, Heidi Kirsch, Jamie Sleigh, Rochelle Zak, Beth Lopour. What can be learned from high-resolution sleep data using ECoG. BMC Neuroscience. 2012 Jul 1; 13(Suppl 1):p94.
Knutson KM, Krueger F, Dal Monte O, Raymont V, Snyder AD, Kirsch HE, Wassermann EM, Grafman J. Gustatory cortical lesions affect motivation for snack foods. Cogn Neurosci. 2012; 3(2):131-8.
Nesbitt G, McKenna K, Mays V, Carpenter A, Miller K, Williams M, EPGP Investigators. The Epilepsy Phenome/Genome Project (EPGP) informatics platform. Int J Med Inform. 2013 Apr; 82(4):248-59.
Findlay AM, Ambrose JB, Cahn-Weiner DA, Houde JF, Honma S, Hinkley LB, Berger MS, Nagarajan SS, Kirsch HE. Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging. Ann Neurol. 2012 May; 71(5):668-86.
Ventura MI, Baynes K, Sigvardt KA, Unruh AM, Acklin SS, Kirsch HE, Disbrow EA. Hemispheric asymmetries and prosodic emotion recognition deficits in Parkinson's disease. Neuropsychologia. 2012 Jul; 50(8):1936-45.
Poncelet A, Hirsh D, Arky R, Mazotti L, Ogur B, Bor D, Brooks K, Erickson J, Hansen L, Wamsley M, Shore W, Cohen P, Kirsch H, Elvin D, Gaufberg E, Cave M-T, Clandinin J, Cave A, Batalden M, Lai C, Polevoi S, Stein J, Ghosh A, Maa J, Theodore P, Park P, Bokser S, Robertson P, Griswold T, Meyer R, Schauer R, Konkin J, Strasser S, Strasser R, Worley P, Greenhill J, Hauer K, Krupat E, Tong L, Teherani A, Krupat E. The Alliance for Clinical Education Guidebook for Clerkship Directors. Longitudinal Integrated Clerkships. 2012; 173-224.
Burgess RC, Funke ME, Bowyer SM, Lewine JD, Kirsch HE, Bagic AI, ACMEGS Clinical Practice Guideline (CPG) Committee,. American Clinical Magnetoencephalography Society Clinical Practice Guideline 2: presurgical functional brain mapping using magnetic evoked fields. J Clin Neurophysiol. 2011 Aug; 28(4):355-61.
Poncelet A, Bokser S, Calton B, Hauer KE, Kirsch H, Jones T, Lai CJ, Mazotti L, Shore W, Teherani A, Tong L, Wamsley M, Robertson P. Development of a longitudinal integrated clerkship at an academic medical center. Med Educ Online. 2011 Apr 04; 16.
Martino J, Honma SM, Findlay AM, Guggisberg AG, Owen JP, Kirsch HE, Berger MS, Nagarajan SS. Resting functional connectivity in patients with brain tumors in eloquent areas. Ann Neurol. 2011 Mar; 69(3):521-32.
Flinker A, Chang EF, Kirsch HE, Barbaro NM, Crone NE, Knight RT. Single-trial speech suppression of auditory cortex activity in humans. J Neurosci. 2010 Dec 08; 30(49):16643-50.
Lindsay A. Mazotti, Bridget C. O'Brien, Heidi E. Kirsch. Improving integration of clinical clerkship didactic curriculum. Medical Education Development. 2010 Dec 2; 1(1):1.
Lopour BA, Tasoglu S, Kirsch HE, Sleigh JW, Szeri AJ. A continuous mapping of sleep states through association of EEG with a mesoscale cortical model. J Comput Neurosci. 2011 Apr; 30(2):471-87.
Chang EF, Edwards E, Nagarajan SS, Fogelson N, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT. Cortical spatio-temporal dynamics underlying phonological target detection in humans. J Cogn Neurosci. 2011 Jun; 23(6):1437-46.
Wu JY, Salamon N, Kirsch HE, Mantle MM, Nagarajan SS, Kurelowech L, Aung MH, Sankar R, Shields WD, Mathern GW. Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex. Neurology. 2010 Feb 02; 74(5):392-8.
Kaiboriboon K, Nagarajan S, Mantle M, Kirsch HE. Interictal MEG/MSI in intractable mesial temporal lobe epilepsy: spike yield and characterization. Clin Neurophysiol. 2010 Mar; 121(3):325-31.
Edwards E, Nagarajan SS, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT. Spatiotemporal imaging of cortical activation during verb generation and picture naming. Neuroimage. 2010 Mar; 50(1):291-301.
Chang EF, Nagarajan SS, Mantle M, Barbaro NM, Kirsch HE. Magnetic source imaging for the surgical evaluation of electroencephalography-confirmed secondary bilateral synchrony in intractable epilepsy. J Neurosurg. 2009 Dec; 111(6):1248-56.
Beth A Lopour, Heidi E Kirsch, James W Sleigh, Andrew J Szeri. Model and data-driven representations of the sleep cycle using locally linear embedding. BMC Neuroscience. 2009 Sep 1; 10(Suppl 1):p294.
Jamie Sleigh, Logan Voss, John Barnard, Heidi Kirsch. Propofol: Pro- or Anticonvulsant Drug?. Anesthesia & Analgesia. 2009 Jun 1; 108(6):1994.
Hixson JD, Kirsch HE. The effects of epilepsy and its treatments on affect and emotion. Neurocase. 2009 Jun; 15(3):206-16.
Voss LJ, Sleigh JW, Barnard JP, Kirsch HE. The howling cortex: seizures and general anesthetic drugs. Anesth Analg. 2008 Nov; 107(5):1689-703.
Kirsch HE, Grossman M. Tracing the roots and routes of cognitive dysfunction in epilepsy. Neurology. 2008 Dec 02; 71(23):1854-5.
Nagarajan S, Kirsch H, Lin P, Findlay A, Honma S, Berger MS. Preoperative localization of hand motor cortex by adaptive spatial filtering of magnetoencephalography data. J Neurosurg. 2008 Aug; 109(2):228-37.
Dalal SS, Edwards E, Kirsch HE, Barbaro NM, Knight RT, Nagarajan SS. Localization of neurosurgically implanted electrodes via photograph-MRI-radiograph coregistration. J Neurosci Methods. 2008 Sep 15; 174(1):106-15.
Kramer MA, Kolaczyk ED, Kirsch HE. Emergent network topology at seizure onset in humans. Epilepsy Res. 2008 May; 79(2-3):173-86.
Guggisberg AG, Honma SM, Findlay AM, Dalal SS, Kirsch HE, Berger MS, Nagarajan SS. Mapping functional connectivity in patients with brain lesions. Ann Neurol. 2008 Feb; 63(2):193-203.
Dalal SS, Guggisberg AG, Edwards E, Sekihara K, Findlay AM, Canolty RT, Berger MS, Knight RT, Barbaro NM, Kirsch HE, Nagarajan SS. Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity. Neuroimage. 2008 May 01; 40(4):1686-700.
Canolty RT, Soltani M, Dalal SS, Edwards E, Dronkers NF, Nagarajan SS, Kirsch HE, Barbaro NM, Knight RT. Spatiotemporal dynamics of word processing in the human brain. Front Neurosci. 2007 Nov; 1(1):185-96.
Guggisberg AG, Kirsch HE, Mantle MM, Barbaro NM, Nagarajan SS. Fast oscillations associated with interictal spikes localize the epileptogenic zone in patients with partial epilepsy. Neuroimage. 2008 Jan 15; 39(2):661-8.
Kirsch HE, Zhu Z, Honma S, Findlay A, Berger MS, Nagarajan SS. Predicting the location of mouth motor cortex in patients with brain tumors by using somatosensory evoked field measurements. J Neurosurg. 2007 Sep; 107(3):481-7.
Kirsch HE, Mantle M, Nagarajan SS. Concordance between routine interictal magnetoencephalography and simultaneous scalp electroencephalography in a sample of patients with epilepsy. J Clin Neurophysiol. 2007 Jun; 24(3):215-31.
Wang Y, Greenwood JS, Calcagnotto ME, Kirsch HE, Barbaro NM, Baraban SC. Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1. Ann Neurol. 2007 Feb; 61(2):139-52.
Kirsch HE, Crone NE. GL Krauss, RS Fisher (Eds.). The Johns Hopkins Atlas of Digital EEG: An Interactive Training Guide. The '10-20' system and cortical topography. 2007.
Dalal SS, Guggisberg AG, Edwards E, Sekihara K, Findlay AM, Canolty RT, Knight RT, Barbaro NM, Kirsch HE, Nagarajan SS. Spatial localization of cortical time-frequency dynamics. Annu Int Conf IEEE Eng Med Biol Soc. 2007; 2007:4941-4.
Kramer MA, Szeri AJ, Sleigh JW, Kirsch HE. Mechanisms of seizure propagation in a cortical model. J Comput Neurosci. 2007 Feb; 22(1):63-80.
Canolty RT, Edwards E, Dalal SS, Soltani M, Nagarajan SS, Kirsch HE, Berger MS, Barbaro NM, Knight RT. High gamma power is phase-locked to theta oscillations in human neocortex. Science. 2006 Sep 15; 313(5793):1626-8.
Kirsch HE, Robinson SE, Mantle M, Nagarajan S. Automated localization of magnetoencephalographic interictal spikes by adaptive spatial filtering. Clin Neurophysiol. 2006 Oct; 117(10):2264-71.
Kramer MA, Lopour BA, Kirsch HE, Szeri AJ. Bifurcation control of a seizing human cortex. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Apr; 73(4 Pt 1):041928.
Josephson SA, Kirsch HE. Complex visual hallucinations as post-ictal cortical release phenomena. Neurocase. 2006 Apr; 12(2):107-10.
Kirsch HE. Social cognition and epilepsy surgery. Epilepsy Behav. 2006 Feb; 8(1):71-80.
Kirsch HE, Walker JA, Winstanley FS, Hendrickson R, Wong ST, Barbaro NM, Laxer KD, Garcia PA. Limitations of Wada memory asymmetry as a predictor of outcomes after temporal lobectomy. Neurology. 2005 Sep 13; 65(5):676-80.
Gabrio T, Broser S, Erdinger L, Felder-Kennel A, Fichtner G, Häberle E, Herrmann T, Kirsch H, Kouros B, Link B, Maisner V, Mann V, Päpke O, Piechotowski I, Rzonca E, Schick KH, Schrimpf M, Schröder S, Spöker-Maas K, Weidner U, Wuthe J, Zöllner I, Zöltzer D. [Human biomonitoring investigations of organochlorine compounds -- PCB, DDE, HCB, beta- and gamma-HCH, PCDD/PCDF, Dioxin-like PCB's and polybrominated biphenyl ethers]. Gesundheitswesen. 2005 Apr; 67(4):302-11.
Kramer MA, Kirsch HE, Szeri AJ. Pathological pattern formation and cortical propagation of epileptic seizures. J R Soc Interface. 2005 Mar 22; 2(2):113-27.
Robinson SE, Nagarajan SS, Mantle M, Gibbons V, Kirsch H. Localization of interictal spikes using SAM(g2) and dipole fit. Neurol Clin Neurophysiol. 2004 Nov 30; 2004:74.
Kirsch HE, Sepkuty JP, Crone NE. Multimodal functional mapping of sensorimotor cortex prior to resection of an epileptogenic perirolandic lesion. Epilepsy Behav. 2004 Jun; 5(3):407-10.
Kirsch HE. The utility of a federated web-based information management system in an epilepsy center. Neuroinformatics. 2004; 2(1):119-21.