Suresh Udutha, PhD Postdoctoral Scholar UCSF Profile Research Lab Cancer Metabolic Imaging & Therapy Lab | Viswanath Lab Publications Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas. The 1p/19q co-deletion induces targetable and imageable vulnerabilities in glucose metabolism in oligodendrogliomas. Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma. Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in H3K27M-mutant gliomas. The 1p/19q co-deletion induces targetable and imageable vulnerabilities in glucose metabolism in oligodendrogliomas. GABA production induced by imipridones is a targetable and imageable metabolic alteration in diffuse midline gliomas. See All Publications
