Suresh Udutha, PhD Postdoctoral Scholar UCSF Profile Research Lab Cancer Metabolic Imaging & Therapy Lab | Viswanath Lab Publications Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas. Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma. Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in H3K27M-mutant gliomas. The 1p/19q co-deletion induces targetable and imageable vulnerabilities in glucose metabolism in oligodendrogliomas. GABA production induced by imipridones is a targetable and imageable metabolic alteration in diffuse midline gliomas. Telomerase reverse transcriptase induces targetable alterations in glutathione and nucleotide biosynthesis in glioblastomas. See All Publications
