Contrast Material and CT Translational Research Lab

Mission Statement: To validate new CT techniques and develop novel contrast material to improve clinical CT imaging.

Our translational research group, run by radiologist Benjamin Yeh, MD and chemist Yanjun Fu, PhD, focuses on the exploration and development of novel CT techniques, including dual energy CT and equilibrium phase imaging, for the diagnosis of clinical disease. Our preclinical work involves validating and testing the limits of CT scanning in both phantom and preclinical models, and includes the development and testing of novel CT contrast materials. Our research extends into the clinical realm by retrospective and prospective assessment of the value of dynamic contrast enhanced imaging for clinical use. Also, we test the validity of commonly held assumptions in a series of retrospective evaluation of clinical radiological examinations. The facilities include a 1,080 square foot chemistry lab conveniently located near preclinical labs and clinical scanners.

Our Research

Our research group works closely with the abdominal imaging subspecialty of the UCSF Department of Radiology and Biomedical Imaging, and includes the former Center for Pharmaceutical and Molecular Imaging. Members of our lab have included five Howard Hughes Medical Student Fellows since 2007 as well as international scholars, residents, and fellows.

Honors and Awards

  • 2006 RSNA Trainee Prize for GU Radiology, Resident ZJ Wang, MD
  • 2007 UCSF Medical Student Summer Research Stipend, Simon Baxter, BA
  • 2007 Harvard Medical School Medical Student Research Stipend, Alison Yang, BA
  • 2007 RSNA Trainee Prize for GU Radiology, Fellow ZJ Wang, MD.
  • 2007 RSNA Trainee Prize for GI Radiology, Medical Student Lisa Chu, BA.
  • 2007 RSNA Poster Design Award, Medical Student, Sandeep Arora, MD
  • 2008 Cum laude Award, Society of Computed Body Tomography and Magnetic Resonance, Medical Student Johnathan Gabe Schneider, MD
  • 2008-09 Howard Hughes Research Grant for Medical Student, Lisa Chu, BA

Research Directions

Our translational research group focuses on the exploration and development of novel CT techniques for the diagnosis of clinical disease. Our preclinical work involves validating and testing the limits of CT scanning in both phantom and animal models, and includes the development and testing of novel CT contrast materials. Our research extends into the clinical realm by retrospective and prospective assessment of the value of dynamic contrast enhanced imaging for clinical use. Also, we test the validity of commonly held assumptions in a series of retrospective evaluation of clinical radiological examinations.

Selected Active Grants

  • Application ID: 1R01CA122257-01A1. CT Monitoring of angiogenesis. NIH RO1 grant to the National Cancer Institute. August 1, 2007 – June 30, 2011. $1,700,000.
    Role: Principal Investigator
  • American Roenten Ray Scholar Award. Development of a Abdominal Perfusion Imaging Program. July 1, 2006 – June 1, 2008. $140,000
    Role: Principal Investigator
  • CT Perfusion Imaging of Early Response to Chemotherapy in Colorectal Cancer Metastases to the Liver: Awarded the RSNA Seed Grant from the E-Z-EM/RSNA Research and Education Foundation. July 1, 2003 – present: $30,000
    Role: Principal Investigator
  • MR assessment of renal medullary tip physiology in normal renal transplants: Awarded the Society of Uroradiology Seed Grant. February 20, 2006 – present: $10,000. PI: Zhen Jane Wang (fellow).
    Role: Co-PI

We are accepting applications of persons who are interested in pursuing or learning about radiological research. Please contact us by email.