Osteoid Osteomas HIFU Clinical Trial

Comparative Treatment of Osteoid Osteomas         (CTOO Trial)

What is an osteoid osteoma?

Osteoid osteomas are painful bone tumors and make up about 10 percent of all benign bone tumors. They are most common in patients under the age of 25, particularly adolescents, with males affected three times more often than females.

Osteoid osteomas produce pain which is typically most severe at night and relieved by non-steroidal anti-inflammatory medications such as ibuprofen. When pain begins to significantly interfere with activities of daily living despite medication, or if severe symptoms persist, many patients are referred for a minimally invasive procedure to treat the tumor.

Treating osteoid osteomas in the San Francisco Bay Area.

Dr. Matthew Bucknor, Co-Director of Focused Ultrasound

This MRI image demonstrates an osteoid osteoma within the femur (blue arrow) being treated with HIFU. In this patient, the central nidus appears bright on this imaging sequence. The HIFU machine focuses sound waves on the small tumor in order to generate heat and destroy the tumor.

High intensity focused ultrasound (HIFU) procedure

Treating osteoid osteomas at UCSF Mission Bay Hospital.

Radiofrequency ablation guided by CT imaging (CTgRFA) is the most common procedure used to treat osteoid osteomas.

   

Osteoid osteomas trial overview

• Osteoid osteomas can become painful enough to interfere with regular activity.
• Many patients over the age of 10 can enroll in a clinical trial to treat osteoid osteomas with high-frequency focused ultrasound (HIFU).

Trial advantages

• Global leader in HIFU
• Keeping the needs of patients front and center
• Formulating new strategies for treating disease
• Trailblazers focused on making improvements in health
• Deep culture of working together to advance medical knowledge

Our commitment

• Top-quality, compassionate care
• Easy access and scheduling
• Expedited results

Clinical trial enrollment

This clinical trial is supported by a grant from the Focused Ultrasound Foundation. UCSF is the coordinating site but patients can enroll at both UCSF and Stanford.

Coordinating Site Team Members