Lupo Lab

Janine Lupo, PhD

Associate Professor
Department of Radiology and Biomedical Imaging

Lupo Pubmed Search

 

Our group is focused on developing novel methods for acquisition, reconstruction, post-processing, and quantitative analysis of Magnetic Resonance (MR) brain images. Using a combination of multiparametric structural, physiological, and metabolic MRI techniques, our goal is to quantitatively characterize heterogeneity within malignant brain tumors, monitor response to novel treatment regimens, and investigate the long-term effects of therapy on healthy brain tissue structure and cognitive function. As part of the Surbeck Laboratory for Advanced Imaging, we are based in Byers Hall at the UCSF Mission Bay campus and have access to state-of-the-art 3T and 7T human research scanners.  Many of the methodologies we develop initially to evaluate patients with brain tumors are also being applied to other neurological diseases.


People

Sivakami Avadiappan
Sivakami Avadiappan
Junior specialist
Email:  [email protected]

Sivakami is working on acquisition, processing and interpretation of vascular MR images from brain tumor survivors post radiation therapy. She is interested in devising strategies for advanced quantification of vascular metrics and relating them to cognitive impairment.



Julia Cluceru
PhD candidate
Email: [email protected]

Julia is a PhD student in the Pharmaceutical Sciences and Pharmacogenomics (PSPG) prgram at UCSF. In 2013, she received her undergraduate degrees in Chemistry and Mathematics from the University of North Carolina - Chapel Hill. Currently, her work in the Lupo lab focuses on using multi-parametric approaches to understand differences between glioma recurrence and pseudoprogression & treatment necrosis. Outside of the lab, you will find her galavanting around Golden Gate Park, cooking, attending live music events, skiing and practicing guitar. 


Ozan Genc
Ozan Genc
Assistant Specialist
Email:  [email protected]

Ozan is interested in applying both classical machine learning and deep learning techniques to medical image data. In his previous research, he focused on dimensionality reduction techniques to find possible MRI biomarkers identifying Mild Cognitive Impairment in Parkinson’s disease. Currently in the Lupo lab, he works on synthesizing MR images using deep convolutional neural networks. Ozan has completed his MSc in Biomedical Engineering at Bogazici University, Istanbul after getting his BSc degree in Electrical & Electronics Engineering.  


James Golden, PhD
James Golden
Postdoctoral Scholar
Email:  [email protected]

James is interested in both the application and theory of deep learning. James is building deep networks for the detection of cerebral microbleeds and symptom onset in Huntington's disease. For his PhD, James worked on theoretical approaches to a sparse coding neural network that simulates primate visual cortex, as well as sensory neurophysiology in the jumping spider and dragonfly. James completed a postdoctoral research position focused on computational modeling of the primate retina and simulating visual perception with a retinal prosthesis. See jamesgolden.net for previous work.



Angela Jakary, BA
Staff Research Associate III
Email: [email protected]

Angela enjoys acquiring, processing, and analyzing high-field 3T and 7T MRI data for a variety of brain research studies. She also analyzes multi-modal MRI data to provide neurosurgeons with research tissue targets during surgery to elucidate the relationship between brain tumor pathology and neuroimaging measures and performs neurocognitive testing to relate to imaging metrics. She likes the people she works with and hopes our combined efforts will have a positive impact on the world.


Melanie Morrison, PhD
Postdoctoral Researcher
Email: [email protected]

Melanie's research is focused on the use of ultra-high field MRI (7T) to better understand the long-term effects of radiotherapy on the developing brain. She uses different MRI techniques, image processing and statistical methods to evaluiate the relationship between at radiotherapy-induced vascular changes, brain connectivity, and neurocognitive function. Melanie is originally from Toronto, Canada where she completed her PhD at the University of Toronto. She enjoys living in San Francisco and working at the Lupo Lab. In her spare time, she loves traveling, dancing ballet, and surfing in California.



Devika Nair
Clinical Research Coordinator
Email: [email protected]

Devika oversees the image-guided tissue studies for patients with recurrent and newly diagnosed primary brain tumors (i.e., gliomas). In addition to ensuring proper collection of targets during surgery and maintaining clinical study records, she enjoys retrieving anatomic and physiologic imaging parameters to better understand the molecular characteristics of these tumors.


Vareth, Maryam
Maryam Vareth
Research Data Analyst
Email: [email protected]

Maryam role is to design and development of techniques for acquisition, reconstruction, post-processing and quantitative analysis of multi-channel, phased array detectors for high field Magnetic Resonance Spectroscopy imaging (MRSI) with the goal of improving the sensitivity and specificity of the data obtained for characterizing human disease.


Erin Felton, BA
Clinical Research Coordinator
Email: e[email protected]

Past Group Members/Alumni

Yicheng (Eason) Chen, former PhD candidate. Eason focused on applying quantitative susceptibility mapping (QSM) to dieases related to brain iron deposition. He was also interested in incorporating deep learning techniques into medical imaging.

Guanzhong Su was a graduate student in the Master of Science in Biomedical Imaging (MSBI) program at UCSF.  His research was focused on developing a pipeline for integration of metabolic and physiology imaging into clinical workflow for radiation treatment planning for glioblastoma (GBM) patients. 

Justin P. Yuan was an Assistant Specialist at UCSF Radiology & Biomedical Imaging. His research interests were in the usage of MRI to characterize adolescent brain changes and the reliability of such measures.

Xiaowei Zou, PhD, Former Post doctoral Scholar: Dr. Xiaowei Zou worked with Dr. Lupo from 2014-2016 on image acquisition, reconstruction, and post-processing algorithms for the detection and quantification of cerebral microbleeds.

Prasanna Parvathaneni, MSc, worked on incorporating distortion correction of EPI images into our perfusion image processing pipeline, implementing a faster tool for NODDI modeling of diffusion imaging data and relating derived metrics to histopathology. Her interests lay in integrating software to facilitate the processing and visualization of more advanced MRI imaging modalities for research.

Shauna O’Donnell was the previous Clinical Research Coordinator.

Publications

Essock-Burns E, Lupo JM, Cha S, Polley MY, Butowski NA, Chang SM, Nelson SJ. Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma.  Neuro Oncol. 2011 Jan;13(1):119-31. Epub 2010 Oct 29. (pdf)

Tropp J, Lupo JM, Chen AP, Calderon P, Grafendorfer T, McCune D, Robb F, Yen Y, Larson PE, Bok R, Hu S, Schulte R, Vigneron DB, Hurd R, Nelson SJ. Multi-Channel Metabolic Imaging, with SENSE reconstruction, of  Hyperpolarized [1-13C] Pyruvate in a Live Rat at 3.0 tesla on a Clinical MR Scanner.  J Magn Reson. 2010 Oct 14. [Epub ahead of print] (pdf)

Lupo JM, Chen AP, Cunningham CH, Bok R, Kurhanewicz J, Vigneron DB, and Nelson SJ.   Hyperpolarized dynamic 13C lactate imaging of disease progression in a Transgenic Mouse Model of Prostate Cancer. Magn Reson Imaging. 2010 Feb;28(2):153-62. Epub 2009 Aug 18. (pdf)

Bian W, Khayal IS, Lupo JM, Cloyd C, Vandenberg V, Lamborn KR, Chang SM, Cha S, Nelson SJ. Multiparametric characterization of grade 2 glioma subtypes using magnetic resonance spectroscopic, perfusion, and diffusion imaging. Transl Oncol. 2009 Dec;2(4):271-80. (pdf)

Lupo JM, Banerjee S, Hammond KE, Kelley DAC, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson SJ. GRAPPA-based Susceptibility-Weighted Imaging of Normal Volunteers and Brain Tumor Patients at 7T. Magn Reson Imaging. 2009 May;27(4):480-8. Epub 2008 Sep 26. (pdf)

Cunningham CH, Chen AP, Lustig M, Hargreaves BA, Lupo J, Xu D, Kurhanewicz J, Hurd RE, Pauly JM, Nelson SJ, Vigneron DB. Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products. J Magn Reson. 2008 Jul;193(1):139-46. Epub 2008 Mar 23. (pdf)

Hammond KE, Lupo JM, Xu D, Metcalf M, Kelley DA, Pelletier D, Chang SM, Mukherjee P, Vigneron DB, Nelson SJ. Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases.  Neuroimage. 2008 Feb 15;39(4):1682-92. Epub 2007 Nov 7. (pdf)