Daniel B. Vigneron Lab

Professor Daniel Vigneron's research focuses on the development of advanced functional and metabolic Magnetic Resonance Imaging (MRI) techniques for the study of prostate cancer, brain tumors, and diseases. He is also a core member of UCB/UCSF Graduate Group in Bioengineering.

Dr. Vigneron's group of researchers focus on developing new metabolic Magnetic Resonance Imaging (MRI) techniques for both basic research and clinical assessments of human diseases. This requires the development of new hardware/software and MR protocols to provide biochemical information in addition to the anatomic information provided by clinical MRI. The Vigneron lab group develops novel coil and software techniques for high field MRI, MR spectroscopy and MR diffusion imaging techniques. The group has optimized these 3T & 7T MR methods for studies of brain, prostate cancer and other organs and diseases. The Vigneron lab, located in Byers Hall on the UCSF Mission Bay campus, are now developing improved acquisition techniques and hardware for multinuclear MR spectroscopy including hyperpolarized carbon-13 metabolic imaging in the Surbeck Laboratory for Advanced Imaging. The group has a particular focus on the development of novel 3T and 7T MR methods and Dr. Vigneron is the Operations Director overseeing the technical operations of the Surbeck Laboratory. Dr. Vigneron is the Director of the NIH-funded Hyperpolarized MRI Technology Resource Center (HMTRC) and project leader for the development of novel DNP methology and HP MR acquisition techniques. He also directs the UCSF Advanced Imaging Technologies Specialized Resource Group and the UCSF RRP Human Imaging Services Core.

Group Events

Danny Gebrezgiabhier's Graduation

Awards

2024 UCSF Radiology & Biomedical Imaging Images Magazine

Detecting Disease Using Advanced MRI: Daniel Vigneron, PhD

UCSF MR Imaging Labs Tour Video

Publication #356 Title: Hyperpolarized ¹³C metabolic imaging of the human abdomen with spatiotemporal denoising

Authors: Nickels TM, Kim Y, Lee PM, Chen HY, Ohliger M, Bok RA, Wang ZJ, Larson PEZ, Vigneron DB, Gordon JW.

Purpose: Improving the quality and maintaining the fidelity of large coverage abdominal hyperpolarize (HP) ¹³C MRI studies with a patch based global-local higher-order singular value decomposition (GL-HOVSD) spatiotemporal denoising approach.

Publication #354 Title: Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2-¹³C]pyruvate MRS

Authors: Chen HY, Gordon JW, Dwork N, Chung BT, Riselli A, Sivalokanathan S, Bok RA, Slater JB, Vigneron DB, Abraham MR, Larson PEZ

Conclusions: HP [2-¹³C]pyruvate imaging is safe and permits noninvasive assessment of TCA cycle intermediates and the acetyl buffer, acetylcarnitine, which is not possible using HP [1-¹³C]pyruvate. Cardiac metabolite measurement in the fasting/fed states provides information on cardiac metabolic flexibility and the acetylcarnitine pool.