Research Directions

General theme: Quantitative molecular imaging instrumentation and physics research

  • Hardware development: Energy-resolving/photon-counting detectors, dark-field x-ray imaging system, novel collimators, and compact systems
  • Software development: Model-based image reconstruction, internal radiation dosimetry calculation, acceleration of algorithms, and radiomics and machine learning-based analysis
  • Application focus: Neuroblastoma, neuroendocrine tumors, small volume imaging (brain, heart, thyroid, etc.), dynamic imaging of heart and brain, prostate cancer, liver cancer, PET/MRI radiomics
  • Preclinical research: Animal imaging (quantification, modeling), molecular imaging probes (in collaboration with radiochemistry groups), molecular pathways (in collaboration with molecular biology groups), and regulatory (IACUC, radiation safety, etc.)
  • Clinical research: Image quantification/quantitation (modeling), protocol development/implementation, scanner QC/QA (phantoms), regulatory (IRB, IND, etc.)

Descriptions of selected current and past projects supported by major funding agencies: ( 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 1213 | 14 | 15 )

Recent Key References (PRL PubMed search)

2019

S. C. Behr, R. Aggarwal, H. F. VanBrocklin, R. R. Flavell, K. Gao, E. J. Small, J. Blecha, S. Jivan, T. A. Hope, J. P. Simko, J. Kurhanewicz, S. M. Noworolski, N. J. Korn, R. De Los Santos, M. R. Cooperberg, P. R. Carroll, H. G. Nguyen, K. L. Greene, B. Langton-Webster, C. E. Berkman, and Y. Seo, Phase I study of CTT1057, an 18F-labeled imaging agent with phosphoramidate core targeting prostate-specific membrane antigen in prostate cancer, Journal of Nuclear Medicine 60, 910-916, 2019. (Epub ahead of print, published online on November 21, 2018) [Abstract]

Y. Seo, Quantitative imaging of alpha-emitting therapeutic radiopharmaceuticals, Nuclear Medicine and Molecular Imaging 53, 182-188, 2019. (Epub ahead of print, published online on February 18, 2019) [Abstract]

M. Sciammarella, U. M. Shrestha, Y. Seo, G. T. Gullberg, and E. H. Botvinick, A combined static-dynamic single-dose imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT, Journal of Nuclear Cardiology 26, 763-771, 2019. (Epub ahead of print, published online on August 3, 2017) [Abstract]

Y. Seo, Y. Huh, S. Y. Huang, M. Hernandez-Pampaloni, R. A. Hawkins, W. C. Gustafson, K. Vo, and K. K. Matthay, Simplified and practical pretherapy tumor dosimetry – A feasibility study for 131I-MIBG therapy of neuroblastoma using 124I-MIBG PET/CT, Medical Physics 46, 2477-2486, 2019. (Epub ahead of print, published online on February 13, 2019) [Abstract]

E. F. Jones, K. M. Ray, W. Li, A. j. Chien, R. A. Mukhtar, L. J. Esserman, B. L. Franc, Y. Seo, M. Hernandez-Pampaloni, B. N. Joe, and N. M. Hylton, Initial experience of dedicated breast PET imaging of ER+ breast cancers using [F-18]fluoroestradiol, Nature Partner Journal Breast Cancer 5, 12, 2019. [Abstract]

J. Yang, D. Park, G. T. Gullberg, and Y. Seo, Joint correction of attenuation and scatter in image space using deep convolutional neural networks for dedicated brain 18F-FDG PET, Physics in Medicine and Biology 64, 075019, 2019. (Epub ahead of print, published online on February 11, 2019) [Abstract]

D. S. Lituiev, H. Trivedi, M. Panahiazar, B. Norgeot, Y. Seo, B. Franc, R. Harnish, M. Kawczynski,and D. Hadley, Automatic labeling for special diagnostic mammography views based on DICOM headers and images, Journal of Digital Imaging 32, 228-233, 2019. (Epub ahead of print, published online on November 21, 2018) [Abstract]

K. Gong, J. Guan, K. Kim, X. Zhang, J. Yang, Y. Seo, G. El Fakhri, J. Qi, and Q. Li, Iterative PET image reconstruction using convolutional neural network representation, IEEE Transactions on Medical Imaging 38, 675-685, 2019. (Epub ahead of print, published online on September 12, 2018) [Abstract]

K. Kim, D. Kim, J. Yang, G. El Fakhri, Y. Seo, J. A. Fessler, and Q. Li, Time of flight PET reconstruction using non-uniform update for regional recovery uniformity, Medical Physics 46, 649-664, 2019. (Epub ahead of print, published online on December 3, 2018) [Abstract]

Ding Y, et al. Radiology. 2018

Y. Ding, J. H. Sohn, M. G. Kawczynski, H. Trivedi, R. Harnish, N. Jenkins, D. Lituieve, T. Copeland, M. Aboian, C. Mari Aparici, S. Behr, R. Flavell, S. Y. Huang, K. Zalocusky, L. Nardo, Y. Seo, R. A. Hawkins, M. Pampaloni, D. Hadley, and B. L. Franc, A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain, Radiology 290, 456-464, 2019. (Epub ahead of print, published online on November 6, 2018) [Abstract]

S. K. Woo, S. J. Jang, M. J. Seo, J. H. Park, B. S. Kim, E. J. King, Y. J. Lee, T. S. Lee, G. I. An, I. H. Song, Y. Seo, K. I. Kim, and J. H. Kang, Development of 64Cu-NOTA-trastuzumab for HER2 targeting: Radiopharmaceutical with improved pharmacokinetics for human study, Journal of Nuclear Medicine 60, 26-33, 2019. (Epub ahead of print, published online on May 18, 2018) [Abstract]

2018

C. D. Jordan, M. Han, S. Kondapavulur, D. Beckford Vera, K. D. Neumann, C. Stillson, T. Moore, R. Krug, S. Behr, Y. Seo, H. F. VanBrocklin, P. E. Z. Larson, M. Wilson, A. J. Martin, and S. W. Hetts, Quantification of 89Zr-iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE, Journal of Magnetic Resonance Imaging 48, 1717-1720, 2018. (Epub ahead of print, published online on May 14, 2018) [Abstract]

S. C. Behr, J. E. Villanueva-Meyer, Y. Li, Y. H. Wang, J. Wei, A. Moroz, J. Lee, J. C. Hsiao, K. T. Gao, W. Ma, S. Cha, D. M. Wilson, Y. Seo, S. J. Nelson, S. M. Chang, and M. J. Evans, Targeting iron metabolism in high-grade glioma with 68Ga-citrate PET/MR, JCI Insight 3, e93999, 2018. [Abstract]

D. Mitra, M. Abdalah, R. Boutchko, U. Shrestha, E. Botvinick, Y. Seo, G. Gullberg, Comparison of sparse domain approaches for 4D SPECT dynamic image reconstruction, Medical Physics 45, 4493-4509, 2018. (Epub ahead of print, published online on July 20, 2018) [Abstract]

J. Yang, J. Liu, F. Wiesinger, A. Menini, X. Zhu, T. A. Hope, Y. Seo, and P. E. Z. Larson, Developing an efficient phase-matched attenuation correction method for quiescent period PET in abdominal PET/MRI, Physics in Medicine and Biology 29, 2526-2530. 2018. (Epub ahead of print, published online on August 14, 2018) [Abstract]

Y. Su, Y. Liu, C. R. Behrens, S. Bidlingmaier, N. Lee, R. Aggarwal, D. W. Sherbenou, A. L. Burlingame, B. C. Hann, J. P. Simko, G. Premasekharan, P. L. Paris, M. A. Shuman, Y. Seo, E. J. Small, B. Liu, CD46 is a novel antibody target for both adenocarcinoma and neuroendocrine types of metastatic castration resistant prostate cancer, JCI Insight 3, e121497, 2018. [Abstract]

Huang SY, et al. npj Breast Cancer. 2018

S. Y. Huang, B. L. Franc, R. Harnish, G. Liu, D. Mitra, T. P. Copeland, V. A. Arasu, J. Kornak, E. F. Jones, S. C. Behr, N. M. Hylton, and Y. Seo, Exploration of multi-modal PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis, npj Breast Cancer 4, 24, 2018. [Abstract]

L. Aanei, T. Huynh, Y. Seo, and M. B. Francis, Vascular cell adhesion molecule-targeted MS2 viral capsids for the detection of early-stage atherosclerotic plaques, Bioconjugate Chemistry 29, 2526-2530, 2018. (Epub ahead of print, published online on August 2, 2018) [Abstract]

K. Gong, J. Yang, K. Kim, G. El Fakhri, Y. Seo, and Q. Li, Attenuation correction for brain PET imaging using deep neural network based on Dixon and ZTE MR images, Physics in Medicine and Biology 63, 125011, 2018. (Epub ahead of print, published online on May 23, 2018) [Abstract]

S. K. Woo, B. S. Moon, B. S. Kim, M. H. Kim, Y. J. Lee, J. H. Jung, K. C. Lee, Y. Seo, W. Kim, S. M. Lim, B. C. Lee, and S. E Lim, Feasibility of myocardial PET imaging using a benzylguanidine analog: meta-(3-[18F]fluoropropyl)benzylguanidine ([18F]mFPBG), Nuclear Medicine and Biology 61, 63-70, 2018. (Epub ahead of print, published online on May 3, 2018) [Abstract]

S. C. Behr, E. Bahroos, R. A. Hawkins, L. Nardo, V. Ravanfar, E. V. Capbarat, and Y. Seo, Quantitative and visual assessments toward potential sub-mSv or ultrafast FDG-PET using high-sensitivity TOF PET in PET/MRI, Molecular Imaging and Biology 20. 492-500, 2018. (Epub ahead of print, published online on November 30, 2017) [Abstract]

A. P. Leynes, J. Yang, F. Wiesinger, S. S. Kaushik, D. D. Shanbhag, Y. Seo, T. A. Hope, and P. E. Z. Larson, Zero echo-time and Dixon deep pseudoCT (ZeDD-CT): Direct generation of pseudoCT images for pelvic PET/MRI attenuation correction using deep convolutional neural networks with multiparametric MRI, Journal of Nuclear Medicine 59, 852-858, 2018. (Epub ahead of print, published online on October 30, 2017) [Abstract]

2017

H. Pan, H. Chang, D. Mitra, G. T. Gullberg, and Y. Seo, Sparse-domain approaches in dynamic SPECT imaging with high-performance computing, American Journal of Nuclear Medicine and Molecular Imaging 7, 283-294, 2017. [Abstract]

Yang J, et al. J Nucl Med. 2017

J. Yang, F. Wiesinger, S. Kaushik, D. Shanbhag, T. A. Hope, P. E. Z. Larson, and Y. Seo, Evaluation of sinus/edge corrected ZTE-based attenuation correction in brain PET/MRI, Journal of Nuclear Medicine 58, 1873-1879, 2017. (Epub ahead of print, published online on May 4, 2017) [Abstract]

S. C. Behr, B. J. Mollard, J. Yang, R. R. Flavell, R. A. Hawkins, and Y. Seo, Effect of time-of-flight and regularized reconstructions and dual-time point imaging on quantitative measurements and qualitative assessments in newly diagnosed prostate cancer with 18F-fluorocholine PET/MRI, Molecular Imaging 16, 1536012117736703, 2017. [Abstract]

N. W. Jenkins, J. F. Talbott, V. Shah, P. Pandit, Y. Seo, W. P. Dillon, and S. Majumdar, [18F]-Sodium fluoride PET MR -based localization and quantification of bone turnover as a biomarker for facet-joint induced disability, American Journal of Neuroradiology 38, 2028-2031, 2017. (Epub ahead of print, published online on August 31, 2017) [Abstract]

C. Mari Aparici, S. C. Behr, Y. Seo, R. K. Kelley, C. Corvera, K. T. Gao, R. Aggarwal, and M. J. Evans, Imaging hepatocellular carcinoma with 68Ga-citrate PET: First clinical experience, Molecular Imaging 16, 1536012117723256, 2017. [Abstract]

J. S. Huber, A. M. Hernandez, M. Janabi, J. P. O’Neil, K. M. Brennan, S. T. Murphy, Y. Seo, and G. T. Gullberg, Longitudinal evaluation of myocardial fatty acid and glucose metabolism in fasted and non-fasted spontaneously hypertensive rats using microPET/CT, Molecular Imaging 16, 1536012117724558, 2017. [Abstract]

X. Lu, N. Peled, J. Greer, W. Wu, P. Choi, A. H. Berger, S. Wong, K. K. Y. Jen, Y. Seo, B. Hann, A. Brooks, M. Meyerson, and E. A. Collisson, MET exon 14 mutation encodes an actionable therapeutic target in lung adenocarcinoma, Cancer Research 77, 4498-4505, 2017. (Epub ahead of print, published online on May 18, 2017)[Abstract]

J. Yang, Y. Jian, N. Jenkins, S. Behr, T. Hope, P. Larson, D. Vigneron, and Y. Seo, Quantitative evaluation of atlas-based attenuation correction for brain PET imaging using an integrated time-of-flight PET/MRI system, Radiology 284, 169-179, 2017. (Epub ahead of print, published online on February 23, 2017) [Abstract]

M. Hernandez Pampaloni, U. M. Shrestha, M. Sciammarella, Y. Seo, G. T. Gullberg, and E. H. Botvinick, Noninvasive PET quantitative myocardial blood flow with regadenoson for assessing cardiac allograft vasculopathy in orthotopic heart transplantation patients, Journal of Nuclear Cardiology 24, 1134-1144, 2017. (Epub ahead of print, published online on January 30, 2017) [Abstract]

A. P. Leynes, J. Yang, D. D. Shanbhag, S. S. Kaushik, Y. Seo, T. A. Hope, F. Wiesinger, and P. E. Z. Larson, Hybrid ZTE/Dixon MR-based attenuation correction for quantitative uptake estimation of pelvic lesions in PET/MRI, Medical Physics 44, 902-913, 2017. (Epub ahead of print, published online on January 23, 2017) [Abstract]

J. Yang, M. Khalighi, T. A. Hope, K. Ordovas, and Y. Seo, Fast respiratory motion estimation using sorted singles without unlist processing: A feasibility study, Medical Physics 44,1632-1637, 2017. (Epub ahead of print, published online on January 18, 2017) [Abstract]

E. F. Jones, K. M. Ray, W. Li, Y. Seo, B. L. Franc, A. J. Chien, L. J. Esserman, M. H. Pampaloni, B. N. Joe, N. M. Hylton, Dedicated breast positron emission tomography for the evaluation of early response to neoadjuvant chemotherapy in breast cancer, Clinical Breast Cancer 17, e155-e159, 2017. (Epub ahead of print, published online on December 29, 2016) [Abstract]

E. J. Arentson-Lantz, I. Saeed, L. Frassetto, U. Masharani, R. Harnish, Y. Seo, H. VanBrocklin, R. Hawkins, C. Mari Aparici, M. Hernandez Pampaloni, J. Slater, D. Paddon-Jones, and T. F. Lang, 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: Response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy, Annals of Nuclear Medicine 31, 295-303, 2017. (Epub ahead of print, published online on March 4, 2017) [Abstract]

J. Y. Choi, J. Yang, S. Noworolski, S. Behr, J. Kurhanewicz, A. J. Chang, J. P. Simko, H. Nguyen, P. R. Carroll, and Y. Seo, 18F-fluorocholine dynamic time-of-flight PET/MRI in unfavorable intermediate to high risk prostate cancer: Clinicopatholigical comparisons, Radiology 282, 429-436, 2017. (Epub ahead of print, published online on August 11, 2016) [Abstract]

Shrestha U, et al. J Nucl Cardiol. 2017

U. Shrestha, M. Sciammarella, F. Alhassen, Y. Yeghiazarians, J. Ellin, E. Verdin, A. Boyle, Y. Seo, E. H. Botvinick, and G. T. Gullberg, Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin, Journal of Nuclear Cardiology 24, 268-277, 2017. (Epub ahead of print, published on December 29, 2015) [Abstract]

2016

U. Shrestha, and Y. Seo, Myocardial blood flow as a biomarker, in V. B. Patel and V. R. Preedy (eds): “Biomarkers in Cardiovascular Disease”, Springer Science+Business Media, 1057-1076, 2016.

N. Tran, A. Giannakidis, G. T. Gullberg, and Y. Seo, Quantitative analysis of hypertrophic myocardium using diffusion tensor magnetic resonance imaging, Journal of Medical Imaging 3, 046001, 2016. [Abstract]

S. Behr, R. Aggarwal, Y. Seo, C. M. Aparici, E. Chang, E. J. Small, and M. J. Evans, A feasibility study showing 68Ga-citrate PET detects prostate cancer, Molecular Imaging and Biology 18, 946-951, 2016. (Epub ahead of print, published on May 16, 2016) [Abstract]

I. L. Aanei, A. M. ElSohly, M. E. Farkas, C. Netirojjanakul, M. Regan, S. T. Murphy, J. P. O’Neil, Y. Seo, and M. B. Francis, Biodistribution of antibody-MS2 viral capsid conjugates in breast cancer models, Molecular Pharmaceutics 13, 3764-3772, 2016. (Epub ahead of print, published on September 9, 2016) [Abstract]

U. Shrestha, and Y. Seo, Myocardial blood flow as a biomarker, in V. B. Patel and V. R. Preedy (eds): “Biomarkers in Cardiovascular Disease”, Springer Science+Business Media, 1-21, 2016.

Aanei IL, ElSohly AM, Farkas ME, Netirojjanakul C, Regan M, Murphy ST, O’Neil JP, Y. Seo, and M. B. Francis, Biodistribution of antibody-MS2 viral capsid conjugates in breast cancer models, Molecular Pharmaceutics 13, 3764-3772, 2016. (Epub ahead of print, published on September 9, 2016) [Abstract]

Li L, et al. Mol Imaging Biol. 2016

L. Li, L. Che, C. Wang, J. E. Blecha, X. Li, H. F. VanBrocklin, D. F. Calvisi, M. Puchowicz, X. Chen, and Y. Seo, [11C]acetate PET imaging is not always associated with increased lipogenesis in hepatocellular carcinoma in mice, Molecular Imaging and Biology 18, 360-367, 2016. (Epub ahead of print, published online on November 13, 2015) [Abstract]

C. J. Schankin, F. H. Maniyar, Y. Seo, S. Kori, M. Eller, D. E. Chou, J. Blecha, S. T. Murphy, J. Slater, R. A. Hawkins, T. Sprenger, H. F. VanBrocklin, and P. J. Goadsby, Ictal lack of binding to brain paranchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine, Brain 139, 1994-2001, 2016. (Epub ahead of print, published online on May 27, 2016) [Abstract]

Y. Chen, Y. Cui, P. O’Connor, Y. Seo, G. S. Camarda, A. Hossain, U. Roy, G. Yang, and R. B. James, Stability of the baseline holder in readout circuits for radiation detectors, IEEE Transactions on Nuclear Science 63, 316-324, 2016. [Abstract]

C. P. Chen, J. Johnson, Y. Seo, V. K. Weinberg, K. Shinohara, I. C. Hsu, M. Roach III, Sentinel lymph node imaging guided IMRT for prostate cancer: Individualized pelvic radiotherapy vs RTOG guidelines, Advances in Radiation Oncology 1, 51-58, 2016. (Epub ahead of print, published on December 16, 2015) [Abstract]

2015

F. Weng, S. Bagchi, Y. Zan, Q. Huang, and Y. Seo, An energy-optimized collimator design for a CZT-based SPECT camera, Nuclear Instruments and Methods A 806, 330-337, 2015.[Abstract]

Shrestha U, et al. Phys Med Biol. 2015

U. Shrestha, Y. Seo, E. H. Botvinick, and G. T. Gullberg, Image reconstruction in higher dimension: Myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration, Physics in Medicine and Biology 60, 8275-8301, 2015.[Abstract]

C. Mari Aparici, R. A. Hawkins, and Y. Seo, Sentinel node SPECT/CT imaging for tumor staging: Protocols, normal findings, artifacts, pitfalls and clinical applications, in G. von Schulthess (ed): “Clinical Molecular Anatomic Imaging: PET/CT, SPECT/CT and PET/MR”, Lippincott Williams & Wilkins, 333-340, 2015. [Abstract]

M. L. Truitt, C. S. Conn, Z. Shi, X. Pang, T. Tokuyasu, A. Coady, Y. Seo, M. Barna, and D. Ruggero, Differential requirements for eIF4E dose in normal development and cancer, Cell 162, 59-71, 2015. [Abstract]

Huang SY, et al. Mol Imaging Biol. 2015

S. Y. Huang, W. E. Bolch, C. Lee, M. Pampaloni, R. A. Hawkins, H. F. VanBrocklin, A. Sznewajs, S. G. DuBois, K. K. Matthay, and Y. Seo, Patient-specific dosimetry using pretherapy [124I]m-iodobenzylguanidine ([124I]mIBG) dynamic PET/CT before [131I]mIBG targeted radionuclide therapy for neuroblastoma, Molecular Imaging and Biology 17, 284-294, 2015. (Epub ahead of print, published online on August 22, 2014) [Abstract]

R. F. Barajas, M. H. Pampaloni, J. L. Clarke, Y. Seo, D. Savic, R. A. Hawkins, S. C. Behr, S. M. Chang, M. Berger, W. P. Dillon, and S. Cha, Assessing biological response to bevacizumab using 18F-fluoromisonidazole PET/MR imaging in a patient with recurrent anaplastic astrocytoma, Case Reports in Radiology 2015, 731361, 2015. [Abstract]

2014

M. D. Bucknor, A. E. Horvai, V. Rieke, Y. Seo, R. A. Hawkins, S. Majumdar, T. M. Link, and M. Saeed, Bone remodeling after MR imaging-guided high intensity focused ultrasound ablation: Evaluation with MR imaging, CT, Na18F, and histopathologic evaluation in a swine model, Radiology, 387-394, 2015. (Epub ahead of print, published online on October 8, 2014) [Abstract]

T. C. Lee, J. D. Bowen, J. R. Ellin, Q. Huang, U. Shrestha, G. T. Gullberg, Y. Seo, Multipinhole collimator with 20 apertures for a brain SPECT application, Medical Physics 41, 112501, 2014. [Abstract]

T. C. Lee, A. J. Burghardt, W. Yao, N. E. Lane, S. Majumdar, G. T. Gullberg, and Y. Seo, Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats, Calcified Tissue International 95, 282-291, 2014. (Epub ahead of print, published online on August 9, 2014) [Abstract]

A. T. Jang, J. D. Lin, Y. Seo, S. Etchin, A. Merkle, K. Fahey, and S. P. Ho, In situ compressive loading and correlative imaging of the bone-periodontal ligament-tooth fibrous joint, Journal of Visualized Experiments 85, e51147, 2014. [Abstract]

Y. Seo and C. Mari Aparici, Dual-modality preclinical SPECT/CT instrumentation, In H Zaidi (ed): “Molecular Imaging of Small-Animals: Instrumentation and Applications”, Springer, 351-365, 2014.

F. Alhassen, N. Nguyen, S. Bains, R. G. Gould,Y. Seo, S. L. Bacharach, X. Song, L. Shao, G. T. Gullberg, and C. Mari Aparici, Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions – A clinical feasibility study, American Journal of Nuclear Medicine and Molecular Imaging 4, 53-59, 2014. [Abstract]

2013

Hernandez AM, et al. J Nucl Med. 2013

A. M. Hernandez, S. T. Murphy, G. L. Zeng, M. Janabi, K. M. Brennan, Y. Seo, and G. T. Gullberg, Longitudinal evaluation of left ventricular substrate metabolism, perfusion, and dysfunction in the SHR model of hypertrophy using microPET imaging, Journal of Nuclear Medicine 54, 1938-1945, 2013. (Epub ahead of print, published online on October 3, 2013) [Abstract]

Bowen JD, et al. Phys Med Biol. 2013

J. D. Bowen, Q. Huang, J. R. Ellin, T. –C. Lee, U. Shrestha, G. T. Gullberg, and Y. Seo, Design and performance evaluation of a 20-aperture multipinhole collimator for myocardial perfusion imaging applications, Physics in Medicine and Biology 58, 7209-7226, 2013. [Abstract]

A. J. Chang, Y. Seo, S. Behr, and M. Roach III, The utility of C-11 choline PET/CT for prostate cancer: Improving detection of locoregional and metastatic disease, Expert Editorial for 2014 Genitourinary Cancers Symposium: A Transformative Multidisciplinary Approach. 2013.

Thuering T, et al. Appl Phys Lett. 2013

T. Thuering, W. C. Barber, Y. Seo, F. Alhassen, and M. Stampanoni, Energy resolved x-ray grating interferometry, Applied Physics Letters 102,191113, 2013. [Abstract]

Y. Seo, J. He, and B. L. Franc, PreClinical SPECT and SPECT-CT in Oncology, In Schober O, Riemann B (eds): “Recent Results in Cancer Research, Vol. 187 – Molecular Imaging in Oncology”, Springer Science+Business Media, 193-220, 2013. [Abstract]

2012

J. C. Durack, T. A. Hope, Y. Seo, M. Saeed, J. He, M. W. Wilson, R. K Kerlan, Jr., and E. J. Ring, Intravenous vasopressin for the prevention of nontarget gastrointestinal embolization during liver-directed cancer treatment: Experimental study in a porcine model, Journal of Vascular and Interventional Radiology 23, 1505-1512, 2012. [Abstract]

C. Mari Aparici and Y. Seo, Functional imaging for prostate cancer: Therapeutic implications, Seminars in Nuclear Medicine 42, 328-342, 2012. [Abstract]

L. Carbone, E. T. Carbone, E. M. Yi, D. B. Bauer, K. A. Lindstrom, J. M. Parker, J. A. Austin, Y. Seo, A. D. Gandhi, and J. D. Wilkerson, Assessing cervical dislocation as a humane euthanasia method in mice, Journal of the American Association of Laboratory Animal Science 51, 352-356, 2012. [Abstract]

Seo Y, et al. Mol Imaging Biol. 2012

Y. Seo, W. C. Gustafson, S. Dannoon, C. L. Lee, S. Taylor, H. F. VanBrocklin, M. Hernandez-Pampaloni, D. A. Haas-Kogan, W. A. Weiss, and K. K. Matthay, Tumor dosimetry of 131I-MIBG using 124I-MIBG microPET/CT in animal xenograft model of neuroblastoma, Molecular Imaging and Biology 14, 734-742, 2012. (Epub ahead of print, published online on March 2, 2012). [Abstract]

R. Harnish, T. Streeper, I. Saeed, C. Schreck, S. Dannoon, J. Blecha, H. VanBrocklin, M. Hernandez-Pampaloni, R. Hawkins,Y. Seo, G. Sayre, J. Slater, and T. Lang, Quantification of changes in skeletal muscle amino acid kinetics in adult humans in response to exercise via positron-emission tomography with L-[methyl-11C] methionine, Journal of Molecular Imaging and Dynamics 2, 1000103, 2012. [Abstract]

Yuneva MO, et al. Cell Metab. 2012

M. O. Yuneva, T. W. M. Fan, T. D. Allen, R. M. Higashi, D. V. Ferraris, T. Tsukamoto, J. M. Mates, F. J. Alonso, C. Wang, Y. Seo, X. Chen, and J. M. Bishop, The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metabolism 15, 157-170, 2012. [Abstract]

J. Yang, T. Yamamoto, B. C. Cho, Y. Seo, and P. J. Keall, Audiovisual biofeedback reduces motion blurring artifacts in 4D PET images, Medical Physics 39, 1046-1057, 2012. [Abstract]

C. Mari Aparici, D. Carlson, N. Nguyen, R. A. Hawkins, and Y. Seo, Potential of SPECT combined with multidetector CT for prostate cancer evaluations, American Journal of Nuclear Medicine and Molecular Imaging 2, 48-54, 2012. [Abstract]

G. Sayre, S. L. Bacharach, M. W. Dae, and Y. Seo, Combining dynamic and ECG-gated 82Rb-PET for practical implementation in the clinic, Nuclear Medicine Communications 33, 4-13, 2012. [Abstract]

2011

S. Kim, M. McClish, F. Alhassen,Y. Seo, K. S. Shah, and R. G. Gould, Temperature dependent operation of PSAPD-based compact gamma camera for SPECT imaging, IEEE Transactions on Nuclear Science 58, 2169-2174, 2011. [Abstract]

Y. Seo, C. Mari Aparici, and R. A. Hawkins, ProstaScint SPECT/CT Atlas, In Fanti S, Farsad M, Mansi L (eds): “Atlas of SPECT-CT: A quick guide to optimal use”, Springer-Verlag, 80-85, 2011. 

G. A. Sayre, B. L. Franc BL, and Y. Seo, Patient-specific method of generating parametric maps of Patlak Ki without blood sampling or metabolite correction: A feasibility study, International Journal of Molecular Imaging 2011, 185083. (doi:10.1155/2011/185083) [Abstract]

F. Alhassen, H. Kudrolli, B. Singh, S. Kim,Y. Seo, R. G. Gould, and V. V. Nagarkar, Depth-of-interaction compensation using a focused-cut scintillator for a pinhole gamma camera, IEEE Transactions on Nuclear Science 58, 634-638, 2011. [Abstract]

Y. Seo, C. Mari Aparici, P. Chen, C. Hsu, N. Kased, C. Schreck, N. Costouros, R. Hawkins, K. Shinohara, and M. Roach, Mapping of lymphatic drainage from the prostate using filtered 99mTc-sulfur nanocolloid and SPECT/CT, Journal of Nuclear Medicine 52, 1068-1072, 2011. [Abstract]

S. S. More, M. Itsara, X. Yang, E. G. Geier, M. K. Tadano,Y. Seo, H. F. VanBrocklin, W. A. Weiss, S. Mueller, D. A. Haas-Kogan, S. G. DuBois, K. K. Matthay, and K. M. Giacomini, Vorinostat increases expression of functional norepinephrine transporter in neuroblastomain vitroandin vivomodel systems, Clinical Cancer Research 17, 2339-2349, 2011. [Abstract]

A. K. Iyer, X. Lan, X. Zhu, Y. Su, J. Feng, X. Zhang, D. Gao,Y. Seo, H. F. VanBrocklin, V. C. Broaddus, B. Liu, and J. He, Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas, Cancer Research 71, 2428-2432, 2011. [Abstract]

Alhassen F, et al. Proc SPIE. 2011

F. Alhassen, H. Kudrolli, B. Singh, S. Kim,Y. Seo, R. G. Gould, and V. V. Nagarkar, A preclinical SPECT camera with depth-of-interaction compensation using a focused-cut scintillator, Proceedings of SPIE 7961, 796121, 2011. [Abstract]

A. K. Iyer, Y. Su, J. Feng, X. Lan, X. Zhu, Y. Liu, D. Gao,Y. Seo, H. F. VanBrocklin, V. C. Broaddus, B. Liu, and J. He, The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma, Biomaterials 32, 2605-2613, 2011. [Abstract]

2010

S. Kim, M. McClish, F. Alhassen,Y. Seo, K. S. Shah, and R. G. Gould, Phantom experiments on a PSPAD-based compact gamma camera with submillimeter spatial resolution for small animal SPECT, IEEE Transactions on Nuclear Science 57, 2518-2523, 2010. [Abstract]

Junttila MR, et al. Nature. 2010

M. R. Junttila, A. Karnezis, D. Garcia, F. Madriles, R. M. Kortlever, F. Rostker, L. Brown-Swigart, D. M. Pham,Y. Seo, G. I. Evan, and C. P. Martins, Selective activation of p53-mediated tumor suppression in high grade tumours, Nature 468, 567-571, 2010. [Abstract]

C. L. Lee, H. Wahnishe, G. A. Sayre, H.-M. Cho, H.-J. Kim, M. Hernandez-Pampaloni, R. A. Hawkins, S. F. Dannoon, H. F. VanBrocklin, M. Itsara, W. A. Weiss, X. Yang, D. A. Haas-Kogan, K. K. Matthay, and Y. Seo, Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET, Medical Physics 37,4861-4867, 2010. [Abstract]

C. D. Winant, S. Kim, and Y. Seo, Functional imaging combined with multi-detector CT: A Radionuclide imaging perspective, Current Medical Imaging Reviews 6,100-111, 2010. [Abstract]

J. He, Y. Wang, J. Feng, X. Zhu, X. Lan, A. Iyer,Y. Seo, H. F. VanBrocklin, and B. Liu, Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment, Journal of Nuclear Medicine 51, 427-432 2010. [Abstract]

Seo Y, et al. J Nucl. Med. 2010

Y. Seo, C. Mari Aparici, M. R. Cooperberg, B. R. Konety, and R. A. Hawkins, In vivo tumor grading of prostate cancer using quantitative 111In-capromab pendetide SPECT/CT, Journal of Nuclear Medicine 51, 31-36, 2010. [Abstract]

2009

M. -H. Pan, D. -W. Gao, J. Feng, J. He, Y. Seo, J. Tedesco, J. G. Wolodzko, B. H. Hasegawa, and B. L. Franc, Biodistributions of 177Lu- and 111In- labeled 7E11 antibodies to prostate-specific membrane antigen in xenograft model of prostate cancer and potential use of 111In-7E11 as a pretherapeutic agent for 177Lu-7E11 radioimmunotherapy, Molecular Imaging and Biology 11, 159-166, 2009. [Abstract]

2008

Y. Seo, B. K. Teo, M. Hadi, C. Schreck, S. L. Bacharach, and B. H. Hasegawa, Quantitative accuracy of PET/CT for image-based kinetic analysis, Medical Physics 35, 3086-3089, 2008. [Abstract]

Y. Seo, C. M. Aparici, and B. H. Hasegawa, Technological development and advances in SPECT/CT, Seminars in Nuclear Medicine 38, 177-198, 2008. [Abstract]

Seo Y, et al. Phys Med Biol. 2008

Y. Seo, T. Hashimoto, Y. Nuki, and B. H. Hasegawa, In vivo microCT imaging of rodent cerebral vasculature, Physics in Medicine and Biology 53, N99-N107, 2008. [Abstract]

J. He, H. F. VanBrocklin, B. L. Franc,Y. Seo, and E. F. Jones, Nanoprobes for medical diagnosis: Current status of nanotechnology in molecular imaging, Current Nanoscience 4, 17-29, 2008. [Abstract]

B. K. Teo, S. Badiee, M. Hadi, T. Lam, L. Johnson, Y. Seo, S. L. Bacharach, B. H. Hasegawa, and B. L. Franc, Correcting tumor SUV for enhanced bone marrow uptake: Retrospective 18F-FDG PET-CT studies, Nuclear Medicine Communications 29, 359-366, 2008. [Abstract]

Y. Seo, Quantification of SPECT and PET for drug development, Current Radiopharmaceuticals 1, 17-21, 2008. [Abstract]

2007

Teo BK, et al. J Nucl. Med. 2007

B. K. Teo,Y. Seo, S. L. Bacharach, J. A. Carrasquillo, S. K. Libutti, H. Shukla, B. H. Hasegawa, R. A. Hawkins, and B. L. Franc, Partial volume correction in PET: Validation of an iterative post-reconstruction method with phantom and patient data, Journal of Nuclear Medicine 48, 802-810, 2007. [Abstract]

Y. Seo, D. W. Gao, B. H. Hasegawa, M. W. Dae, and B. L. Franc BL, Rodent brain imaging with SPECT/CT, Medical Physics 34, 1217-1220, 2007. [Abstract]

2006

Y. Seo, B. L. Franc, R. A. Hawkins, K. H. Wong, and B. H. Hasegawa, Progress in SPECT/CT imaging of prostate cancer, Technology in Cancer Research and Treatment 5, 329-336, 2006. [Abstract]

2005

Y. Seo, K. H. Wong, and B. H. Hasegawa, Calculation and validation of the use of effective attenuation coefficient for attenuation correction in In-111 SPECT, Medical Physics 32, 3628-3635, 2005. [Abstract]

Y. Seo, J. Kurhanewicz, B. L. Franc, R. A. Hawkins, and B. H. Hasegawa, Improved prostate cancer imaging with SPECT/CT and MRI/MRSI, IEEE Transactions on Nuclear Science 52, 1316-1320, 2005. [Abstract]

Seo Y, et al. J Nucl Med. 2005

Y. Seo, K. H. Wong, M. Sun, B. L. Franc, R. A. Hawkins, and B. H. Hasegawa, Correction of photon attenuation and collimator response for a body-contouring SPECT/CT imaging system, Journal of Nuclear Medicine 46, 868-877, 2005. [Abstract]

2004

Y. Seo, K. H. Wong, B. L. Franc, R. A. Hawkins, and B. H. Hasegawa, Dual-modality imaging of prostate cancer with a commercial SPECT/CT system, in Proceedings of the XIVth international conference on the use of computers in radiation therapy held at Seoul, Korea, May 10 - May 13, 2004, edited by B. Y. Yi, S. D. Ahn, E. K. Choi, and S. W. Ha (Jeong Publishing Co., Ltd, Seoul, 2004), 559-561, 2004. 

Hasegawa BH, et al. Nucl Instrum Meth A. 2004

B. H. Hasegawa, W. C. Barber, T. Funk, A. B. Hwang, A. E. Sakdinawat, C. Taylor, M. Sun, and Y. Seo, Implementation and applications of dual-modality imaging, Nuclear Instruments and Methods A 525, 236-241, 2004. [Abstract]