Interventional Radiology Research Lab

The IR Research Lab is a multi-disciplinary research group whose studies focus on basic, translational and clinical aspects of image-guided therapy. In collaboration with a large number of internal and external academic partners and external industry partners, the IR Lab’s accomplishments included novel endovascular devices, imaging techniques, in vitro and animal models of disease, and industry standard support of multi-center, international clinical device trials. The IR Lab has grown rapidly since its inception; over 100 papers have been published and $4.5 million have been awarded in grant funding from various government and industry sponsors.

Research Directions

ChemoFilter

Developing a family of novel ChemoFilter devices to remove drugs from the blood; this work has also led to additional sponsored funding as well as formation of a startup company.

Schematic of the ChemoFilter Device That Incorporates a Block Copolymer Membrane That Captures Target Drugs In Situ
Schematic of the ChemoFilter Device That Incorporates a Block Copolymer Membrane That Captures Target Drugs In Situ.

Interventional MRI

  • developing tools to perform endovascular stroke treatment under 3T MRI guidance so stroke patients can be treated in any 3T MRI scanner or in a combined X-ray/MRI (XMR) suite
  • designing, prototyping, and testing endovascular devices in vitro and in vivo, the latter at our co-located large animal surgical and imaging facility
  • developing remote controlled endovascular catheter systems and testing them in vitro and in vivo in both the x-ray and 1.5T MRI environments
  • improving sensitivity and safety of endovascular MR imaging at 3T   
  • novel endovascular therapies for stroke, aneurysms, vascular malformations, and tumors of the brain, spine, head and neck
  • translational research on interventional MRI and endovascular therapy, including large animal studies and human studies
  • evaluating treatment of image-guided acute ischemic stroke in patients with wake-up stroke or uncertain time of stroke onset
  • multicenter international clinical trials evaluating of endovascular stents and flow diverters for the treatment of brain aneurysms
  • evaluating endovascular embolectomy devices for stroke treatment
  • evaluation of advanced applications in clinical x-ray angiography

Interventional MRI
1D plots of B1 fields calculated along the dashed white line in the image for TLR catheter coil (left) and a conventional lumped circuit catheter coil (right). The proposed TLR catheter coil achieved 6-fold B1 gain over the conventional lumped element catheter coil. TLR, transmission line resonator. 

 

Publications

IR Research Lab publications can be found under the following:

Grants

  • NIH R01: Endovascular Chemofiltration: Optimizing remov of chemotherapeutics and nanoparticles from the blood to reduce toxicity (current)
  • NIH R01: MARC – Magnetic Assisted Remote Control Catheter (in renewal)
  • NIH R21: Improved sensitivity and safety for endovascular MR imaging at 3T (current)
  • UCSF Radiology Seed Grant: PET/MR Quantification of Multifunctional Magnetic Nanoparticles for Targeted Chemotherapy (current)

New / Events

For information please contact, Teri Moore at [email protected].

Research Team

Bridget KilbrideBridget Kilbride
[email protected]

 

Teri MooreTeri Moore
[email protected]

 

Carol Stillson, RVTCarol Stillson, RVT
[email protected]


 

Keerthi ValluruKeerthi Valluru
[email protected]

 

 

Colin YeeColin Yee
[email protected]

 

Summer Students

Ayushi Gautam, IR Research LabAyushi Gautam

 

 

Anika KrishnaAnika Krishna

 

 

Christina Miller, IR Research LabChristina Miller

 

 

Anna Vardapetyan, IR Research LabAnna Vardapetyan

 

 

Alumni

  • Mariam Aboiam, MD, PhD
  • Curtis Clayton
  • Loi Do
  • Maddie Dowd
  • Scott Goodfriend
  • Caroline Jordan, PhD
  • Kanti Kolli, MD
  • Yuo-Chen Kuo, MD
  • Prasheel Lillaney, PhD
  • Aaron Losey, MD
  • Mark Lum
  • Skylar Nahi
  • Jason Ni
  • Kevin O’Reilly
  • Dare Olorunsola, MD
  • Anand Patel, MD
  • Ryan Sincic
  • Alyssa Talbott
  • Bradford Thorne
  • Ricky Tong, MD, PhD
  • Tiffany Tsai
  • Stephanie Tse
  • Maya Vella
  • Claudia Wong
  • Erin Yee
  • Jay Yu


IR Research Lab Faculty 

Mark Wilson, MD
Professor
Vice Chair, ZSFG
Radiologist-in-Chief, San Francisco General Hospital
Professor in Residence
Steven Hetts, MD
Professor
Division Co-Chief, Neuroendovascular Surgery
Department of Radiology
PROF IN RES-HCOMP
Daniel Cooke, MD
Professor In Residence
Department of Radiology
Professor In Residence
Matthew Amans, MD
Professor
Director, Neuro Interventional Fellowship Program
Co-Director, Pulsatile Tinnitus Clinic
Department of Radiology
Professor Clinical Radiology
Kazim Narsinh, MD
Assistant Professor
Asst Professor In Residence