Parallel Imaging and High-Field MR Technology Lab (Zhang Lab)

High Field MR

Research in our lab involves technical development of advanced magnetic resonance imaging with an emphasis on high field imaging instrumentation, cutting edge radio-frequency technology for MR signal detection, efficient imaging in MRgFUS or HIFU, catheterized devices for interventional imaging and treatment, parallel imaging and compressed sensing based fast imaging, and computational electromagnetism in medical imaging, and their applications to neuro imaging, neonatal/fetal imaging, extremity imaging, hyperpolarized 13C MRI, liver imaging and metabolic and molecular imaging in humans and experimental animal models. A recently new research direction in our lab is the MR imaging based precision medicine.

Our research is funded by NIH grants (R01s, R21s, K99/R00 and P41), QB3, National Natural Science Foundation of China, and Springer Med Fund.

Grants

  1. NIH R01 EB004453 (PI: Zhang): RF Coils for Parallel MRI/MRS in vivo at High Fields
  2. NIH R01 EB008699 (PI: Zhang): Multichannel Dual-tuned Transceiver Techniques for Human Low-Gamma Nuclei MR
  3. NIH R01 EB007588-03S1 (MPI: Vigneron, Kurhanewicz, Zhang): Technique Development for Hyperpolarized C-13 MR Studies
  4. Springer Med Foundation (PI: Zhang): Highly sensitive RF probes enabling enhanced quantitative metabolic imaging using ultrahigh field 14T MRI
  5. Cohn Fund Award (PI: Zhang): Flexible and subject-conforming multichannel RF arrays for fast fetal MR imaging at 3T
  6. NIH R21 EB20283 (MPI: Hetts, Zhang): Improved sensitivity and safety for endovascular MR imaging at 3T
  7. QB3 R1 Research Award: Parallel Excitation and Multiple Transceiver Channels for Enhanced Parallel Imaging Capability at 7T
  8. NIH/NCRR UCSF-CTSI  UL1 RR024131-01 (PI: Zhang): Dual-frequency transceiver for detection & quantification of brain tumors using hyperpolarized C-13 and H-1 parallel MR spectroscopic imaging at 7T
  9. NIH R01 EB009756 (PI: Xu, Barkovich): Development of Advanced Techniques for MR of the Newborn Brain
  10. NIH P41 EB013598 (PI: Vigneron): Hyperpolarized MRI Technology Resource Center
  11. NIH 1K99/R00EB015487-01 (PI: Y Pang): Technical Development of High Resolution In-Vivo Imaging of Human Liver at 7T
  12. NIH R01 EB017449 Bioengineering Research Partnership (BRP) (PI: Vigneron): Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI Methods

Education

UCSF & UCB Joint Graduate Program in Bioengineering

BioengineeringThrough the UCSF/UCB Joint Graduate Group in Bioengineering, the Department of Radiology faculty participate in graduate student education and offer significant opportunities for PhD candidates in Bioengineering to participate in research activities.

BioE247 Course Description: Taught by Dr. Xiaoliang Zhang.

Magnetic resonance imaging, as a non-invasive diagnostic modality, has become an important and powerful tool for biomedical research and clinical diagnosis. Knowledge of MR systems, basic principles, and design of MR hardware is essential to use this tool and help to develop more efficient MR methods. This course offers an introduction to the fundamental aspects of MRI systems and related hardware, covering magnets, gradient coils, shimming coils and RF coils. Each topic will include lectures and review of relevant literature.

 

BioE 215: Laboratory Rotation

BioE 250: Research


UCSF School of Medicine Biomedical Imaging Masters Program

Biomed Img 215: Supervised Research

Biomed Img 209: Imaging Laboratory - MR, CT, PET, & SPECT

Biomed Img 201: Principles of MR Imaging

 

Opportunities

Internships

Internships typically happen during the summer months and these can provide opportunities for individuals at all levels of training whether they be an undergraduate student, graduate student, or resident.

Rotations

Rotations provide an opportunity to explore research opportunities in the Zhang Lab that can lead to a commitment of several years to develop and complete dissertation research in conjunction with enrollment in a Graduate Program or Professional School, such as the following:

Available Positions

Employment Opportunities for staff positions are posted on the UCSF Web site at:  UCSF Department of Human Resources.

People

PI: Xiaoliang Zhang, PhD

Professor of Radiology and Bioengineering
Director of Parallel Imaging and High Field MR Technology Lab at UCSF

Team

  • Yong Pang, Postdoctoral Scholar
  • Caroline Jordan, Postdoctoral Scholar
  • Jonathan Lu, Graduate Student
  • Yan Guo, Graduate Student
  • Bingyao Sun, Undergraduate Student
  • Omar Rutledge, Graduate Student
  • Andrew Leynes, Graduate Student
  • Jeff Hu, Graduate Student
  • Nathan Daniel Poulin, Graduate Student
  • Jenny Che, Administrative Assistant
  • Cathy Devine, Administrative Assistant
  • Idonnah Hipolito, Pre-award Assistant
  • Thomas McElderry, Post-award Assistant

Alumni

  • Samuel Chu - Duke University, BME
  • Adam Burr - University of Cincinnati, Physician Scientist Training Program (MD/PHD)
  • Zhentian Xie - GE Healthcare, MR, Milwaukee, WI
  • Mihir Pendse  - Stanford University, graduate student
  • Bing Wu – Philips Medical Systems, Scientist
  • Chunsheng Wang – Wan Kang Medical Instrumentation, CTO
  • Jonathan Lu – UC Berkeley, Department of Electrical Engineering
  • Alex Bai – UC Berkeley, Department of Electrical Engineering
  • Eric Li – Associate Professor, Chinese Academy of Sciences
  • Hong Shang – UCSF/UC Berkeley Joint Graduate Group in Bioengineering, PhD Student
  • Hesamoddin Jahanian – Stanford University, Postdoctoral researcher
  • Tiffany Kwak - UCSF graduate student
  • Jay Felix Yu - UCSF graduate student
  • Yizhe Zhang - UIUC graduate student
  • Xinqiang Yan - Vanderbilt University Postdoctoral researcher
  • Mengxia Yu – University of Electronic Science and Technology of China, Associate Professor