Orit Glenn, MD

Professor
Director of Fetal MRI, Mission Bay Hospital
Professor in Residence

Biography

Orit Glenn, MD, is a Professor in the Neuroradiology Section in the Department of Radiology, with additional expertise in pediatric and fetal neuroimaging. Dr. Glenn is a radiologist, specializing in pediatric and adult neuroradiology, at UCSF Medical Center and UCSF Benioff Children's Hospital. She leads the clinical fetal MR neuroimaging program at UCSF where she is responsible for overseeing and interpreting all fetal MR imaging studies of the brain, spine, and head and neck. Dr. Glenn received her medical degree from the University of California, San Francisco in 1994, and completed her residency in Radiology at the University of California, San Francisco in 1999, followed by a fellowship in Neuroradiology and advanced training in Clinical Research from UCSF as well.

Dr. Glenn’s primary research goal is to improve our understanding of normal and abnormal brain development in utero. Her work using advanced imaging techniques has helped us to better understand how the brain normally develops in utero. Her work on the prenatal diagnosis of agenesis of the corpus callosum has led to better understanding of brain abnormalities associated with agenesis of the corpus callosum. Her work on the etiology and pathogenesis of isolated mild ventriculomegaly is to identify imaging parameters that can be used to better predict neurodevelopmental outcomes and to translate this knowledge into improved prenatal counseling and early treatment intervention during infancy. She works closely with obstetricians, perinatologists, the Fetal Treatment Center, child neurologists, and pediatric neurosurgeons at UCSF.

Dr. Glenn served as Principal Investigator and Co-Principal Investigator in several NIH grants. She has published 58 articles and has written and contributed to 82 abstracts. She has had many significant publications published in the American Journal of Neuroradiology and in these publications she was responsible for supervising, study ideas, study designs, recruitment of study patients, data analyses, collection of data, and writing of the manuscripts.

Expertise:
Neuroradiology

Specialty:
Pediatric neuroradiology, fetal neuroimaging

Professional Interests:
Normal and abnormal fetal brain development, prenatal/fetal magnetic resonance imaging, magnetic resonance technique development and application, neurodevelopmental outcome, normal and abnormal pediatric brain development

Education and Training:
• Medical School: University of California, San Francisco
• Internship: Stanford University Medical Center, California - Internal Medicine
• Residency: University of California, San Francisco - Radiology
• Fellowship: University of California, San Francisco - Neuroradiology and advanced training in Clinical Research Fellowship Program
• Medical Licensure, California
• Board Certification: American Board of Radiology, Diagnostic Radiology
• Certificate of Added Qualification in Neuroradiology: American Board of Radiology

Education

Residency,
School of Medicine - Radiology, University of California, San Francisco

Honors and Awards

Outstanding Teacher Award, International Society of Magnetic Resonance in Medicine, 2011
Philips Academic Faculty Development Program Award, Association of University Radiologists, 2005
Research Academic Fellowship Award, General Electric-Association of University Radiologists, 2004
Clinical Hypothesis in Imaging Award, Dana Foundation, 2001
Research Fellowship Award, Radiological Society of North America, 2001
Research Fellowship Award, Radiology Society of North America, 2000
Alpha Omega Alpha Honor Medical Society, University of California, San Francisco, 1994
Medical School Class of 1962 Scholarship, University of California, San Francisco, 1993
Student Research Committee Fellowship, University of California, San Francisco, 1991
Undergraduate Research Opportunities Scholarship, Massachusetts Institute of Technology, 1988

Publications

Barajas RF, Phelps A, Foster HC, Courtier J, Buelow BD, Gupta N, Nicolaides T, Glenn OA, Banerjee A. Metastatic Diffuse Intrinsic Pontine Glioma to the Peritoneal Cavity Via Ventriculoperitoneal Shunt: Case Report and Literature Review. J Neurol Surg Rep. 2015 Jul; 76(1):e91-6.
Liu J, Glenn OA, Xu D. Fast, free-breathing, in vivo fetal imaging using time-resolved 3D MRI technique: preliminary results. Quant Imaging Med Surg. 2014 Apr; 4(2):123-8.
Young-Lin N, Shalev S, Glenn OA, Gardner M, Lee C, Wynshaw-Boris A, Gelfand AA. Teaching neuroimages: infant with glutaric aciduria type 1 presenting with infantile spasms and hypsarrhythmia. Neurology. 2013 Dec 10; 81(24):e182-3.
Courtier J, Schauer GM, Parer JT, Regenstein AC, Callen PW, Glenn OA. Polymicrogyria in a fetus with human parvovirus B19 infection: a case with radiologic-pathologic correlation. Ultrasound Obstet Gynecol. 2012 Nov; 40(5):604-6.
Scott JA, Hamzelou KS, Rajagopalan V, Habas PA, Kim K, Barkovich AJ, Glenn OA, Studholme C. 3D morphometric analysis of human fetal cerebellar development. Cerebellum. 2012 Sep; 11(3):761-70.
Scott JA, Habas PA, Rajagopalan V, Kim K, Barkovich AJ, Glenn OA, Studholme C. Volumetric and surface-based 3D MRI analyses of fetal isolated mild ventriculomegaly: brain morphometry in ventriculomegaly. Brain Struct Funct. 2013 May; 218(3):645-55.
Glenn OA, Cuneo AA, Barkovich AJ, Hashemi Z, Bartha AI, Xu D. Malformations of cortical development: diagnostic accuracy of fetal MR imaging. Radiology. 2012 Jun; 263(3):843-55.
Rajagopalan V, Scott J, Habas PA, Kim K, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. Mapping directionality specific volume changes using tensor based morphometry: an application to the study of gyrogenesis and lateralization of the human fetal brain. Neuroimage. 2012 Nov 1; 63(2):947-58.
Habas PA, Scott JA, Roosta A, Rajagopalan V, Kim K, Rousseau F, Barkovich AJ, Glenn OA, Studholme C. Early folding patterns and asymmetries of the normal human brain detected from in utero MRI. Cereb Cortex. 2012 Jan; 22(1):13-25.
Jacob FD, Habas PA, Kim K, Corbett-Detig J, Xu D, Studholme C, Glenn OA. Fetal hippocampal development: analysis by magnetic resonance imaging volumetry. Pediatr Res. 2011 May; 69(5 Pt 1):425-9.
Kim K, Habas PA, Rajagopalan V, Scott JA, Corbett-Detig JM, Rousseau F, Barkovich AJ, Glenn OA, Studholme C. Bias field inconsistency correction of motion-scattered multislice MRI for improved 3D image reconstruction. IEEE Trans Med Imaging. 2011 Sep; 30(9):1704-12.
Scott JA, Habas PA, Kim K, Rajagopalan V, Hamzelou KS, Corbett-Detig JM, Barkovich AJ, Glenn OA, Studholme C. Growth trajectories of the human fetal brain tissues estimated from 3D reconstructed in utero MRI. Int J Dev Neurosci. 2011 Aug; 29(5):529-36.
Rajagopalan V, Scott J, Habas PA, Kim K, Corbett-Detig J, Rousseau F, Barkovich AJ, Glenn OA, Studholme C. Local tissue growth patterns underlying normal fetal human brain gyrification quantified in utero. J Neurosci. 2011 Feb 23; 31(8):2878-87.
Glenn O. Contributions of diffusion-weighted imaging to fetal and neonatal imaging. Top Magn Reson Imaging. 2011 Feb; 22(1):3-9.
Li Y, Pang Y, Vigneron D, Glenn O, Xu D, Zhang X. Investigation of multichannel phased array performance for fetal MR imaging on 1.5T clinical MR system. Quant Imaging Med Surg. 2011 Jan 1; 1(1):24-30.
Rajagopalan V, Scott J, Habas PA, Kim K, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. Spatiotemporal morphometry of adjacent tissue layers with application to the study of sulcal formation. Med Image Comput Comput Assist Interv. 2011; 14(Pt 2):476-83.
Corbett-Detig J, Habas PA, Scott JA, Kim K, Rajagopalan V, McQuillen PS, Barkovich AJ, Glenn OA, Studholme C. 3D global and regional patterns of human fetal subplate growth determined in utero. Brain Struct Funct. 2011 Jan; 215(3-4):255-63.
Habas PA, Kim K, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. Atlas-based segmentation of developing tissues in the human brain with quantitative validation in young fetuses. Hum Brain Mapp. 2010 Sep; 31(9):1348-58.
Habas PA, Kim K, Corbett-Detig JM, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. A spatiotemporal atlas of MR intensity, tissue probability and shape of the fetal brain with application to segmentation. Neuroimage. 2010 Nov 1; 53(2):460-70.
Berman JI, Hamrick SE, McQuillen PS, Studholme C, Xu D, Henry RG, Hornberger LK, Glenn OA. Diffusion-weighted imaging in fetuses with severe congenital heart defects. AJNR Am J Neuroradiol. 2011 Feb; 32(2):E21-2.
Rajagopalan V, Scott J, Habas PA, Kim K, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. Measures for characterizing directionality specific volume changes in TBM of brain growth. Med Image Comput Comput Assist Interv. 2010; 13(Pt 2):339-46.
Kim K, Habas P, Rajagopalan V, Scott J, Corbett-Detig J, Rousseau F, Glenn O, Barkovich J, Studholme C. Non-iterative relative bias correction for 3D reconstruction of in utero fetal brain MR imaging. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:879-82.
Glenn OA, Quiroz EM, Berman JI, Studholme C, Xu D. Diffusion-weighted imaging in fetuses with unilateral cortical malformations and callosal agenesis. AJNR Am J Neuroradiol. 2010 Jun; 31(6):1100-2.
Glenn OA. MR imaging of the fetal brain. Pediatr Radiol. 2010 Jan; 40(1):68-81.
Jelin AC, Glenn OA, Strachowski L, Vargas JE. Membranous aplasia cutis congenita: a recognizable lesion on prenatal sonography. J Ultrasound Med. 2009 Oct; 28(10):1393-6.
Kim K, Habas PA, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. Intersection based motion correction of multislice MRI for 3-D in utero fetal brain image formation. IEEE Trans Med Imaging. 2010 Jan; 29(1):146-58.
Waubant E, Chabas D, Okuda DT, Glenn O, Mowry E, Henry RG, Strober JB, Soares B, Wintermark M, Pelletier D. Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adults. Arch Neurol. 2009 Aug; 66(8):967-71.
Glenn OA. Normal development of the fetal brain by MRI. Semin Perinatol. 2009 Aug; 33(4):208-19.
Schneider MM, Berman JI, Baumer FM, Glass HC, Jeng S, Jeremy RJ, Esch M, Biran V, Barkovich AJ, Studholme C, Xu D, Glenn OA. Normative apparent diffusion coefficient values in the developing fetal brain. AJNR Am J Neuroradiol. 2009 Oct; 30(9):1799-803.
Glenn OA, Coakley FV. MRI of the fetal central nervous system and body. Clin Perinatol. 2009 Jun; 36(2):273-300, viii.
Habas PA, Kim K, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. A spatio-temporal atlas of the human fetal brain with application to tissue segmentation. Med Image Comput Comput Assist Interv. 2009; 12(Pt 1):289-96.
Kim DH, Gu M, Cunningham C, Chen A, Baumer F, Glenn OA, Vigneron DB, Spielman DM, Barkovich AJ. Fast 3D (1)H MRSI of the corticospinal tract in pediatric brain. J Magn Reson Imaging. 2009 Jan; 29(1):1-6.
Tang PH, Bartha AI, Norton ME, Barkovich AJ, Sherr EH, Glenn OA. Agenesis of the corpus callosum: an MR imaging analysis of associated abnormalities in the fetus. AJNR Am J Neuroradiol. 2009 Feb; 30(2):257-63.
Jelin AC, Norton ME, Bartha AI, Fick AL, Glenn OA. Intracranial magnetic resonance imaging findings in the surviving fetus after spontaneous monochorionic cotwin demise. Am J Obstet Gynecol. 2008 Oct; 199(4):398.e1-5.
Chabas D, Castillo-Trivino T, Mowry EM, Strober JB, Glenn OA, Waubant E. Vanishing MS T2-bright lesions before puberty: a distinct MRI phenotype? Neurology. 2008 Sep 30; 71(14):1090-3.
Ludeman NA, Berman JI, Wu YW, Jeremy RJ, Kornak J, Bartha AI, Barkovich AJ, Ferriero DM, Henry RG, Glenn OA. Diffusion tensor imaging of the pyramidal tracts in infants with motor dysfunction. Neurology. 2008 Nov 18; 71(21):1676-82.
Callen PW, Callen AL, Glenn OA, Toi A. Columns of the fornix, not to be mistaken for the cavum septi pellucidi on prenatal sonography. J Ultrasound Med. 2008 Jan; 27(1):25-31.
Habas PA, Kim K, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. Atlas-based segmentation of the germinal matrix from in utero clinical MRI of the fetal brain. Med Image Comput Comput Assist Interv. 2008; 11(Pt 1):351-8.
Kim DH, Chung S, Vigneron DB, Barkovich AJ, Glenn OA. Diffusion-weighted imaging of the fetal brain in vivo. Magn Reson Med. 2008 Jan; 59(1):216-20.
Glenn OA, Bianco K, Barkovich AJ, Callen PW, Parer JT. Fetal cerebellar hemorrhage in parvovirus-associated non-immune hydrops fetalis. J Matern Fetal Neonatal Med. 2007 Oct; 20(10):769-72.
Glenn OA, Ludeman NA, Berman JI, Wu YW, Lu Y, Bartha AI, Vigneron DB, Chung SW, Ferriero DM, Barkovich AJ, Henry RG. Diffusion tensor MR imaging tractography of the pyramidal tracts correlates with clinical motor function in children with congenital hemiparesis. AJNR Am J Neuroradiol. 2007 Oct; 28(9):1796-802.
Smith AB, Gupta N, Otto C, Glenn OA. Diagnosis of Chiari III malformation by second trimester fetal MRI with postnatal MRI and CT correlation. Pediatr Radiol. 2007 Oct; 37(10):1035-8.
Vahidi K, Joe BN, Glenn OA, Barkovich AJ, Filly R, Ball R, Coakley FV. Prenatal imaging of congenital maxillomandibular fusion: case report and review of the literature. J Ultrasound Med. 2007 Mar; 26(3):381-9.
Hecht JH, Glenn OA, Wara DW, Wu YW. JC virus granule cell neuronopathy in a child with CD40 ligand deficiency. Pediatr Neurol. 2007 Mar; 36(3):186-9.
Glenn OA, Barkovich J. Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis: part 2. AJNR Am J Neuroradiol. 2006 Oct; 27(9):1807-14.
Rousseau F, Glenn OA, Iordanova B, Rodriguez-Carranza C, Vigneron DB, Barkovich JA, Studholme C. Registration-based approach for reconstruction of high-resolution in utero fetal MR brain images. Acad Radiol. 2006 Sep; 13(9):1072-81.
Glenn OA, Barkovich AJ. Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis, part 1. AJNR Am J Neuroradiol. 2006 Sep; 27(8):1604-11.
Zaharchuk G, Busse RF, Rosenthal G, Manley GT, Glenn OA, Dillon WP. Noninvasive oxygen partial pressure measurement of human body fluids in vivo using magnetic resonance imaging. Acad Radiol. 2006 Aug; 13(8):1016-24.
Barkovich AJ, Miller SP, Bartha A, Newton N, Hamrick SE, Mukherjee P, Glenn OA, Xu D, Partridge JC, Ferriero DM, Vigneron DB. MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. AJNR Am J Neuroradiol. 2006 Mar; 27(3):533-47.
Glenn OA. Fetal central nervous system MR imaging. Neuroimaging Clin N Am. 2006 Feb; 16(1):1-17, vii.
Partridge SC, Mukherjee P, Berman JI, Henry RG, Miller SP, Lu Y, Glenn OA, Ferriero DM, Barkovich AJ, Vigneron DB. Tractography-based quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns. J Magn Reson Imaging. 2005 Oct; 22(4):467-74.
von Koch CS, Glenn OA, Goldstein RB, Barkovich AJ. Fetal magnetic resonance imaging enhances detection of spinal cord anomalies in patients with sonographically detected bony anomalies of the spine. J Ultrasound Med. 2005 Jun; 24(6):781-9.
Glenn OA, Goldstein RB, Li KC, Young SJ, Norton ME, Busse RF, Goldberg JD, Barkovich AJ. Fetal magnetic resonance imaging in the evaluation of fetuses referred for sonographically suspected abnormalities of the corpus callosum. J Ultrasound Med. 2005 Jun; 24(6):791-804.
Glenn OA, Norton ME, Goldstein RB, Barkovich AJ. Prenatal diagnosis of polymicrogyria by fetal magnetic resonance imaging in monochorionic cotwin death. J Ultrasound Med. 2005 May; 24(5):711-6.
Rousseau F, Glenn O, Iordanova B, Rodriguez-Carranza C, Vigneron D, Barkovich J, Studholme C. A novel approach to high resolution fetal brain MR imaging. Med Image Comput Comput Assist Interv. 2005; 8(Pt 1):548-55.
Partridge SC, Mukherjee P, Henry RG, Miller SP, Berman JI, Jin H, Lu Y, Glenn OA, Ferriero DM, Barkovich AJ, Vigneron DB. Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns. Neuroimage. 2004 Jul; 22(3):1302-14.
Williams G, Coakley FV, Qayyum S, Glenn OA, Breiman RS, Callen PW. Evaluation of femur length during the second and third trimesters in fetuses with myelomeningocele. Ultrasound Obstet Gynecol. 2004 Feb; 23(2):148-51.
Coakley FV, Glenn OA, Qayyum A, Barkovich AJ, Goldstein R, Filly RA. Fetal MRI: a developing technique for the developing patient. AJR Am J Roentgenol. 2004 Jan; 182(1):243-52.
Glenn OA, Henry RG, Berman JI, Chang PC, Miller SP, Vigneron DB, Barkovich AJ. DTI-based three-dimensional tractography detects differences in the pyramidal tracts of infants and children with congenital hemiparesis. J Magn Reson Imaging. 2003 Dec; 18(6):641-8.
Sheen VL, Wheless JW, Bodell A, Braverman E, Cotter PD, Rauen KA, Glenn O, Weisiger K, Packman S, Walsh CA, Sherr EH. Periventricular heterotopia associated with chromosome 5p anomalies. Neurology. 2003 Mar 25; 60(6):1033-6.
Barkovich AJ, Simon EM, Glenn OA, Clegg NJ, Kinsman SL, Delgado M, Hahn JS. MRI shows abnormal white matter maturation in classical holoprosencephaly. Neurology. 2002 Dec 24; 59(12):1968-71.
Tsao JW, Gean AD, Glenn OA, Bonovich DC. Hyperdense MCA resolved after tPA. Neurology. 2002 May 28; 58(10):1512.
Glenn OA, Barkovich AJ. Intracranial germ cell tumors: a comprehensive review of proposed embryologic derivation. Pediatr Neurosurg. 1996; 24(5):242-51.