Daniel Cooke, MD

Assistant Professor
Asst. Professor in Residence

Biography

Daniel Cooke, MD, is an Assistant Professor in Residence of Neuro Interventional Radiology in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. His expertise is in ischemic and hemorrhagic stroke, vascular malignancies of the central nervous system, arteriovenous malformations (AVM), arteriovenous fistula (AVF), and aneurysms of the brain and spine. Dr. Cooke earned his medical degree from Emory University, Atlanta in 2004, and completed his residency in Diagnostic Radiology at the University of Washington, Seattle. He completed a fellowship in Neuroradiology at the University of Washington, Seattle in 2010, followed by another fellowship in Neuro Interventional Radiology from the University of California, San Francisco in 2012.

Dr. Cooke’s primary research is in the use of contemporary endovascular surgical methods to assess endothelial cells in the setting of neurovascular pathology. In his work with MR generated computational fluid dynamic data and microsurgical specimens he aims to characterize the local and regional molecular events underlying the evolution of aneurysms, AVMs, and AVFs.

Dr. Cooke’s research interests include: endovascular biopsy, pre-natal brain AVM detection, endovascular brachytherapy, flat panel CT-fluoroscopically guided intervention, and chemoinfusion. Dr. Cooke is also involved in research on catheter-based interventions for hemorrhagic stroke as well as regenerative cell therapies for ischemic stroke.

Expertise:
Neuro Interventional Radiology

Specialty:
Ischemic and hemorrhagic stroke, vascular malignancies of the central nervous system, and arteriovenous malformations (AVM), arteriovenous fistula (AVF), and aneurysms of the brain and spine

Professional Interests:
Stroke, arteriovenous malformation, arteriovenous fistula, aneurysm, cerebral vascular disease, endothelium, intracerebral hemorrhage, spinal vascular anomalies, vascular cerebral, spinal, and head and neck malignancy, retinoblastoma, high and low flow vascular malformations

Education and Training:
• Medical School: Emory University, Atlanta, Georgia
• Internship: University of Hawaii, Honolulu - Surgery
• Residency: University of Washington, Seattle - Radiology
• Fellowship: University of Washington, Seattle - Neuroradiology
• Fellowship: University of California, San Francisco - Neuro Interventional
• Medical licensure, California
• American Board of Radiology with sub-specialty certification in Neuroradiology

Honors and Awards

Neuroradiology Research Award, University of Washington, 2009
Goldberg International Grant, ACR Reeder, 2008

Publications

Lum MA, Martin AJ, Alexander MD, McCoy DB, Cooke DL, Lillaney P, Moftakhar P, Amans MR, Settecase F, Nicholson A, Dowd CF, Halbach VV, Higashida RT, McDermott MW, Saloner D, Hetts SW. Intra-Arterial MR Perfusion Imaging of Meningiomas: Comparison to Digital Subtraction Angiography and Intravenous MR Perfusion Imaging. PLoS One. 2016; 11(11):e0163554.
Alexander MD, Nicholson AD, Darflinger RJ, Settecase F, Cooke DL, Dowd CF, Amans MR, Higashida RT, Hetts SW, Halbach VV. Effects on vessel measurement accuracy and subsequent occlusion after calcium channel blocker infusion during treatment of cerebral aneurysms with the Pipeline embolization device. Interv Neuroradiol. 2016 Oct 26.
Hetts SW, Moftakhar P, Maluste N, Fullerton HJ, Cooke DL, Amans MR, Dowd CF, Higashida RT, Halbach VV. Pediatric intracranial dural arteriovenous fistulas: age-related differences in clinical features, angioarchitecture, and treatment outcomes. J Neurosurg Pediatr. 2016 Nov; 18(5):602-610.
Alexander MD, Cooke DL, Hallam DK, Kim H, Hetts SW, Ghodke BV. Less can be more: Targeted embolization of aneurysms associated with arteriovenous malformations unsuitable for surgical resection. Interv Neuroradiol. 2016 Aug; 22(4):445-51.
Lillaney PV, Yang JK, Losey AD, Martin AJ, Cooke DL, Thorne BR, Barry DC, Chu A, Stillson C, Do L, Arenson RL, Saeed M, Wilson MW, Hetts SW. Endovascular MR-guided Renal Embolization by Using a Magnetically Assisted Remote-controlled Catheter System. Radiology. 2016 Oct; 281(1):219-28.
Mabray MC, Lillaney P, Sze CH, Losey AD, Yang J, Kondapavulur S, Liu D, Saeed M, Patel A, Cooke D, Jun YW, El-Sayed I, Wilson M, Hetts SW. In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study. J Vasc Interv Radiol. 2016 Mar; 27(3):426-432.e1.
Settecase F, Nicholson AD, Amans MR, Higashida RT, Halbach VV, Cooke DL, Dowd CF, Hetts SW. Onyx embolization of an intraosseous pseudoaneurysm of the middle meningeal artery in a patient with meningiomatosis, McCune-Albright syndrome, and gray platelet syndrome. J Neurosurg Pediatr. 2016 Mar; 17(3):324-9.
Settecase F, Hetts SW, Nicholson AD, Amans MR, Cooke DL, Dowd CF, Higashida RT, Halbach VV. Superselective Intra-Arterial Ethanol Sclerotherapy of Feeding Artery and Nidal Aneurysms in Ruptured Cerebral Arteriovenous Malformations. AJNR Am J Neuroradiol. 2016 Apr; 37(4):692-7.
Narvid J, Amans MR, Cooke DL, Hetts SW, Dillon WP, Higashida RT, Dowd CF, Halbach VV. Spontaneous retroclival hematoma: a case series. J Neurosurg. 2016 Mar; 124(3):716-9.
Cooke DL, Levitt MR, Kim LJ, Hallam DK, Sekhar LN, Ghodke BV. Laser-assisted flat-detector CT-guided intracranial access. Int J Comput Assist Radiol Surg. 2016 Mar; 11(3):467-72.
Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels(?). Biotechnol Rep (Amst). 2015 Sep; 7:157-165.
Hetts SW, Tsai T, Cooke DL, Amans MR, Settecase F, Moftakhar P, Dowd CF, Higashida RT, Lawton MT, Halbach VV. Progressive versus Nonprogressive Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes. AJNR Am J Neuroradiol. 2015 Oct; 36(10):1912-9.
Mabray MC, Datta S, Lillaney PV, Moore T, Gehrisch S, Talbott JF, Levitt MR, Ghodke BV, Larson PS, Cooke DL. Accuracy of flat panel detector CT with integrated navigational software with and without MR fusion for single-pass needle placement. J Neurointerv Surg. 2016 Jul; 8(7):731-5.
Moftakhar P, Lillaney P, Losey AD, Cooke DL, Martin AJ, Thorne BR, Arenson RL, Saeed M, Wilson MW, Hetts SW. New-Generation Laser-lithographed Dual-Axis Magnetically Assisted Remote-controlled Endovascular Catheter for Interventional MR Imaging: In Vitro Multiplanar Navigation at 1.5 T and 3 T versus X-ray Fluoroscopy. Radiology. 2015 Dec; 277(3):842-52.
Alexander MD, Rebhun JM, Hetts SW, Kim AS, Nelson J, Kim H, Amans MR, Settecase F, Dowd CF, Halbach VV, Higashida RT, Cooke DL. Lesion location, stability, and pretreatment management: factors affecting outcomes of endovascular treatment for vertebrobasilar atherosclerosis. J Neurointerv Surg. 2016 May; 8(5):466-70.
Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM. Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Interv Neuroradiol. 2015 Feb; 21(1):120-8.
Alexander MD, Cooke DL, Nelson J, Guo DE, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H, Hetts SW. Association between Venous Angioarchitectural Features of Sporadic Brain Arteriovenous Malformations and Intracranial Hemorrhage. AJNR Am J Neuroradiol. 2015 May; 36(5):949-52.
Moftakhar P, Cooke DL, Fullerton HJ, Ko NU, Amans MR, Narvid JA, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Extent of collateralization predicting symptomatic cerebral vasospasm among pediatric patients: correlations among angiography, transcranial Doppler ultrasonography, and clinical findings. J Neurosurg Pediatr. 2015 Mar; 15(3):282-90.
Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL. Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. J Biotechnol. 2014 Dec 20; 192 Pt A:34-9.
Alexander MD, Cooke DL, Meyers PM, Amans MR, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Lesion stability characteristics outperform degree of stenosis in predicting outcomes following stenting for symptomatic intracranial atherosclerosis. J Neurointerv Surg. 2016 Jan; 8(1):19-23.
Raygor KP, Rowland NC, Cooke DL, Solomon DA, Huang MC. Aneurysm of the posterior meningeal artery embedded within a dorsal exophytic medullary hemangioblastoma: surgical management and review of literature. J Cerebrovasc Endovasc Neurosurg. 2014 Sep; 16(3):293-8.
Cooke DL, Stout CE, Kim WT, Kansagra AP, Yu JP, Gu A, Jewell NP, Hetts SW, Higashida RT, Dowd CF, Halbach VV. Cerebral arterial fenestrations. Interv Neuroradiol. 2014 May-Jun; 20(3):261-74.
Chow ML, Cooke DL, Fullerton HJ, Amans MR, Narvid J, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Radiological and clinical features of vein of Galen malformations. J Neurointerv Surg. 2015 Jun; 7(6):443-8.
Alexander MD, Meyers PM, English JD, Stradford TR, Sung S, Smith WS, Halbach VV, Higashida RT, Dowd CF, Cooke DL, Hetts SW. Symptom differences and pretreatment asymptomatic interval affect outcomes of stenting for intracranial atherosclerotic disease. AJNR Am J Neuroradiol. 2014 Jun; 35(6):1157-62.
Hetts SW, Cooke DL, Nelson J, Gupta N, Fullerton H, Amans MR, Narvid JA, Moftakhar P, McSwain H, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H. Influence of patient age on angioarchitecture of brain arteriovenous malformations. AJNR Am J Neuroradiol. 2014 Jul; 35(7):1376-80.
Losey AD, Lillaney P, Martin AJ, Cooke DL, Wilson MW, Thorne BR, Sincic RS, Arenson RL, Saeed M, Hetts SW. Magnetically assisted remote-controlled endovascular catheter for interventional MR imaging: in vitro navigation at 1.5 T versus X-ray fluoroscopy. Radiology. 2014 Jun; 271(3):862-9.
Amans MR, Cooke DL, Vella M, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Contrast staining on CT after DSA in ischemic stroke patients progresses to infarction and rarely hemorrhages. Interv Neuroradiol. 2014 Jan-Feb; 20(1):106-15.
Lillaney P, Caton C, Martin AJ, Losey AD, Evans L, Saeed M, Cooke DL, Wilson MW, Hetts SW. Comparing deflection measurements of a magnetically steerable catheter using optical imaging and MRI. Med Phys. 2014 Feb; 41(2):022305.
Sincic RS, Caton CJ, Lillaney P, Goodfriend S, Ni J, Martin AJ, Losey AD, Shah N, Yee EJ, Evans L, Malba V, Bernhardt AF, Settecase F, Cooke DL, Saeed M, Wilson MW, Hetts SW. System architecture for a magnetically guided endovascular microcatheter. Biomed Microdevices. 2014 Feb; 16(1):97-106.
Cooke DL, Stout CE, Kim WT, Hetts SW, Higashida RT, Halbach VV, Dowd CF, Gould RG. Radiation dose reduction in intra-arterial chemotherapy infusion for intraocular retinoblastoma. J Neurointerv Surg. 2014 Dec; 6(10):785-9.
Cooke DL, Su H, Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV. Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils. Interv Neuroradiol. 2013 Dec; 19(4):399-408.
Hetts SW, English JD, Stiver SI, Singh V, Yee EJ, Cooke DL, Halbach VV. Bilateral cervical spinal dural arteriovenous fistulas with intracranial venous drainage mimicking a foramen magnum dural arteriovenous fistula. Interv Neuroradiol. 2013 Dec; 19(4):483-8.
Amans MR, Stout C, Fox C, Narvid J, Hetts SW, Cooke DL, Higashida RT, Dowd CF, McSwain H, Halbach VV. Cerebral arteriopathy associated with Arg179His ACTA2 mutation. J Neurointerv Surg. 2014 Nov; 6(9):e46.
Amans MR, Stout C, Fox C, Narvid J, Hetts SW, Cooke DL, Higashida RT, Dowd CF, McSwain H, Halbach VV. Cerebral arteriopathy associated with Arg179His ACTA2 mutation. BMJ Case Rep. 2013; 2013.
Sheth SA, Potts MB, Sneed PK, Young WL, Cooke DL, Gupta N, Hetts SW. Angiographic features help predict outcome after stereotactic radiosurgery for the treatment of pediatric arteriovenous malformations. Childs Nerv Syst. 2014 Feb; 30(2):241-7.
Meisel K, Yee A, Stout C, Kim W, Cooke D, Halbach V. Arteriovenous fistula after ventriculostomy in aneurysmal subarachnoid hemorrhage. Neurology. 2013 Jun 4; 80(23):2168.
Thampi S, Hetts SW, Cooke DL, Stewart PJ, Robbins E, Banerjee A, Dubois SG, Char D, Halbach V, Matthay K. Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution. Clin Ophthalmol. 2013; 7:981-9.
Losey AD, Lillaney P, Martin AJ, Halbach VV, Cooke DL, Dowd CF, Higashida RT, Saloner DA, Wilson MW, Saeed M, Hetts SW. Safety of retained microcatheters: an evaluation of radiofrequency heating in endovascular microcatheters with nitinol, tungsten, and polyetheretherketone braiding at 1.5 T and 3 T. J Neurointerv Surg. 2014 May; 6(4):314-9.
Hetts SW, Saeed M, Martin A, Lillaney P, Losey A, Yee EJ, Sincic R, Do L, Evans L, Malba V, Bernhardt AF, Wilson MW, Patel A, Arenson RL, Caton C, Cooke DL. Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging. J Vis Exp. 2013; (74).
Kansagra AP, Cooke DL, English JD, Sincic RM, Amans MR, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Current trends in endovascular management of traumatic cerebrovascular injury. J Neurointerv Surg. 2014 Jan; 6(1):47-50.
Moftakhar P, English JD, Cooke DL, Kim WT, Stout C, Smith WS, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Density of thrombus on admission CT predicts revascularization efficacy in large vessel occlusion acute ischemic stroke. Stroke. 2013 Jan; 44(1):243-5.
Cooke DL, Meisel KM, Kim WT, Stout CE, Halbach VV, Dowd CF, Higashida RT. Serial angiographic appearance of segmental arterial mediolysis manifesting as vertebral, internal mammary and intra-abdominal visceral artery aneurysms in a patient presenting with subarachnoid hemorrhage and review of the literature. J Neurointerv Surg. 2013 Sep 1; 5(5):478-82.
Tatum J, Farid H, Cooke D, Fullerton H, Smith W, Higashida R, Halbach VV, Dowd C. Mechanical embolectomy for treatment of large vessel acute ischemic stroke in children. J Neurointerv Surg. 2013 Mar; 5(2):128-34.
Cooke D, Farid H, Kim W, Dowd C, Higashida R, Halbach V. Zygomatico-orbital intra-arterial melphalan infusion for intraocular retinoblastoma. J Neurointerv Surg. 2012 Jul; 4(4):e16.
Cooke D, Tatum J, Farid H, Dowd C, Higashida R, Halbach V. Transvenous embolization of a pediatric pial arteriovenous fistula. J Neurointerv Surg. 2012 Jul; 4(4):e14.
Cooke DL, Johnson G, Levitt MR, Lewis DH, Sekhar LN, Ghodke B. Synchronous chronic middle cerebral artery occlusion and ipsilateral dural arteriovenous fistula. Clin Nucl Med. 2011 Jul; 36(7):570-3.
Levitt MR, Cooke DL, Ghodke BV, Kim LJ, Hallam DK, Sekhar LN. "Stent view" flat-detector CT and stent-assisted treatment strategies for complex intracranial aneurysms. World Neurosurg. 2011 Feb; 75(2):275-8.
Cooke DL, Levitt M, Kim LJ, Hallam DK, Ghodke B. Intraorbital access using fluoroscopic flat panel detector CT navigation and three-dimensional MRI overlay. J Neurointerv Surg. 2010 Sep; 2(3):249-51.
Levitt MR, Ghodke BV, Cooke DL, Hallam DK, Kim LJ, Sekhar LN. Endovascular procedures with CTA and MRA roadmapping. J Neuroimaging. 2011 Jul; 21(3):259-62.
Cooke D, Seiler D, Hallam D, Kim L, Jarvik JG, Sekhar L, Ghodke B. Does treatment modality affect vasospasm distribution in aneurysmal subarachnoid hemorrhage: differential use of intra-arterial interventions for cerebral vasospasm in surgical clipping and endovascular coiling populations. J Neurointerv Surg. 2010 Jun; 2(2):139-44.
Cooke DL, Levitt M, Kim LJ, Hallam DK, Ghodke B. Transcranial access using fluoroscopic flat panel detector CT navigation. AJNR Am J Neuroradiol. 2011 Apr; 32(4):E69-70.
Cooke D, Koppula B, Seiler D, Rajendran J, Hallam D, Ghodke B, Lewis D. Semiquantitative software SPECT analysis in aneurysmal subarachnoid hemorrhage-related vasospasm. Nucl Med Commun. 2010 Jan; 31(1):53-8.
Wilson MA, Cooke DL, Ghodke B, Mirza SK. Retrospective analysis of preoperative embolization of spinal tumors. AJNR Am J Neuroradiol. 2010 Apr; 31(4):656-60.
Cooke D, Ghodke B, Natarajan SK, Hallam D. Embolization in the head and neck. Semin Intervent Radiol. 2008 Sep; 25(3):293-309.
Konowal A, Morrison JC, Brown SV, Cooke DL, Maguire LJ, Verdier DV, Fraunfelder FT, Dennis RF, Epstein RJ. Irreversible corneal decompensation in patients treated with topical dorzolamide. Am J Ophthalmol. 1999 Apr; 127(4):403-6.