Myriam Chaumeil, PhD

Associate Professor
Assoc Professor In Residence

Biography

I am an Assistant Professor in residence in the departments of Physiological Therapy and Rehabilitation Science, and Radiology and Biomedical Imaging at UCSF since 2016. My lab focuses on preclinically developing and biologically validating hyperpolarized 13C methods for in vivo measurement of brain metabolism, in physiological and pathological conditions. We have a particular interest  in expanding the use of MR metabolic imaging to the study of neurodegeneration and neuroinflammation using preclinical models of Multiple Sclerosis (MS), Traumatic Brain Injury and Alzheimer’s disease (AD). While our main field of expertise is preclinical imaging, our ultimate goal is to have a positive impact on healthcare, designing imaging solutions aiming at refining diagnosis, prognosis and therapeutic regimen in a patient-specific way. 

Biography

Myriam M. Chaumeil, PhD, is an Associate Professor in Residence in the departments of Physical Therapy & Rehabilitation Science, and Radiology & Biomedical Imaging at the University of California, San Francisco (UCSF). She is also a research group leader in Metabolic Imaging of Neurological disorders, a core member of the UCSF/UC Berkeley BioEngineering Graduate Program, a core member of the UCSF Biomedical Science Graduate program, a core member of the UCSF PhD in Rehabilitation Science Graduate Program, and a faculty member of the California Institute for Quantitative Biosciences (QBI).

Dr. Chaumeil's research focuses on developing and validating magnetic resonance (MR)-based imaging and spectroscopy methods for in vivo measurement of brain metabolism, in physiological and pathological conditions, in preclinical models and in patients. She has experience in studies of Huntington’s disease, Multiple Sclerosis, Alzheimer’s disease, Traumatic Brain Injury, cerebral small vascular diseases and CNS lymphoma. She has extensive internationally recognized expertise in MR metabolic imaging, particularly in state-of-the-art hyperpolarized 13C MRS method, and has a particular interest in expanding the use of this MR metabolic imaging method to the study of neurodegeneration with an ultimate goal of clinical translation.

Dr. Chaumeil concurrently obtained a Engineer Diploma - Physics Major - from the Ecole Superieure de Physique et Chimie Industrielles de Paris (EPSCI) and a Master in Medical Imaging from the University of Paris XI/Orsay. She then received her PhD in medical imaging for her graduate work on developing innovative MR spectroscopy approaches for the study of brain metabolism. She completed a postdoctoral fellowship at UCSF before joining the faculty in 2016.

Education

2018 - Diversity, Equity, and Inclusion Champion Training, University of California
Postdoctoral Fellowship, 2014 - Radiology and Biomedical Imaging, University of California, San Francisco
Ph.D. in Medical Physics, 2008 - Medicine, NeuroSpin
Engineer Degree, 2005 - Paris Technology, ESPCI
Master of Science, 2005 - Medicine, University of Orsay, Paris XI

Honors and Awards

Marilyn Hilton Award for Innovation in MS Research, Conrad Hilton Foundation, 2017-2019
David Mahoney Neuroimaging Grant, The Dana Foundation, 2017-2019
Cal-BRAIN Pilot Award, California Brain Initiative, 2015-2017
Bruce Hasegawa Award For Excellence in Biomedical Imaging, UCSF, 2013
Margaret H. Surbeck - Young Investigator Award - 2nd place, UCSF, 2013
Junior Fellow of the Society, ISMRM, 2012
Margaret H. Surbeck - Young Investigator Award - 3rd place, UCSF, 2012
Margaret H. Surbeck - Young Investigator Award - 1st place, UCSF, 2011
Post-doctoral Fellowship In Basic Science, American Brain Tumor Association, 2010-2012
William Negendank Award for Excellence in Cancer Imaging, ISMRM, 2010
Ph.D. Fellowship, French Muscular Dystrophy Association, 2005-2008

Publications

Ben Haim L, Schirmer L, Zulji A, Sabeur K, Tiret B, Ribon M, Chang S, Lamers WH, Boillée S, Chaumeil MM, Rowitch DH. Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes. Glia. 2021 Dec; 69(12):2812-2827.
Qiao K, Le Page LM, Chaumeil MM. Non-Invasive Differentiation of M1 and M2 Activation in Macrophages Using Hyperpolarized 13C MRS of Pyruvate and DHA at 1.47 Tesla. Metabolites. 2021 Jun 22; 11(7).
Guglielmetti C, Levi J, Huynh TL, Tiret B, Blecha J, Tang R, Van Brocklin HF, Chaumeil MM. Longitudinal imaging of T-cells and inflammatory demyelination in a preclinical model of multiple sclerosis using 18F-FAraG PET and MRI. J Nucl Med. 2021 Apr 09.
Lydia M Le Page, Soo Hyun Shin, Kai Qiao, Myriam M Chaumeil. Imaging ketone metabolism in the brain in Alzheimer's disease using hyperpolarized 13C spectroscopy. Alzheimer's & Dementia. 2020 Dec 7; 16(S5).
Le Page LM, Guglielmetti C, Taglang C, Chaumeil MM. Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy. Trends Neurosci. 2020 05; 43(5):343-354.
Guglielmetti C, Boucneau T, Cao P, Van der Linden A, Larson PEZ, Chaumeil MM. Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging. Neuroimage. 2020 03; 208:116415.
Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil MM, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB. First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism. J Magn Reson. 2019 12; 309:106617.
Le Page LM, Guglielmetti C, Najac CF, Tiret B, Chaumeil MM. Hyperpolarized 13 C magnetic resonance spectroscopy detects toxin-induced neuroinflammation in mice. NMR Biomed. 2019 11; 32(11):e4164.
Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM. HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI. NMR Biomed. 2019 02; 32(2):e4044.
Huimin Geng, Brice Tiret, Hua-Xin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Ilwoo Park, Gerd Melkus, Adam Elkhaled, John Kurhanewicz, Lisa Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, Rana Anjum, Andrew Bloecher, Myriam Chaumeil, James Rubenstein. Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NFkB Activation in Preclinical Patient-Derived Models of CNS Lymphoma. Blood. 2018 Nov 29; 132(Supplement 1):2840-2840.
Krukowski K, Chou A, Feng X, Tiret B, Paladini MS, Riparip LK, Chaumeil MM, Lemere C, Rosi S. Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits. Int J Mol Sci. 2018 Nov 26; 19(12).
Nolan A, Hennessy E, Krukowski K, Guglielmetti C, Chaumeil MM, Sohal VS, Rosi S. Repeated Mild Head Injury Leads to Wide-Ranging Deficits in Higher-Order Cognitive Functions Associated with the Prefrontal Cortex. J Neurotrauma. 2018 10 15; 35(20):2425-2434.
Guglielmetti C, Chou A, Krukowski K, Najac C, Feng X, Riparip LK, Rosi S, Chaumeil MM. In vivo metabolic imaging of Traumatic Brain Injury. Sci Rep. 2017 12 13; 7(1):17525.
Brice Tiret, Adam Autry, Ilwoo Park, Ming Lu, Rana Anjum, Liza Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, James Rubenstein, Myriam M Chaumeil. EXTH-71. HYPERPOLARIZED [1-13C] PYRUVATE AS A BIOMARKER FOR TREATMENT MONITORING IN LYMPHOMA MURINE MODELS. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi88-vi88.
Chloe Najac, Marina Radoul, Pavithra Viswanath, Myriam M Chaumeil, Sabrina Ronen. METB-14. DOWN-REGULATION OF ACETATE METABOLISM TOWARDS FATTY ACIDS IN IDH1 MUTANT GLIOMA. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi131-vi131.
Marina Radoul, Myriam M Chaumeil, Pia Eriksson, Chloe Najac, Pavithra Viswanath, Anne Marie Gillespie, Joydeep Mukherjee, Russell Pieper, Sabrina Ronen. TMOD-20. EARLY DETECTION OF HDAC INHIBITION IN GLIOBLASTOMA USING ADVANCED HYPERPOLARIZED 13C MRSI. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi258-vi258.
Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):E6982-E6991.
Chloe Najac, Myriam M. Chaumeil, Gary Kohanbash, Caroline Guglielmetti, Jeremy Gordon, Hideho Okada, Sabrina M. Ronen. IMST-04. IMAGING INFLAMMATORY CELL FUNCTION USING 13C MAGNETIC RESONANCE SPECTROSCOPY OF HYPERPOLARIZED 6-13C-LABELED ARGININE. Neuro-Oncology. 2016 Nov 1; 18(suppl_6):vi86-vi86.
Najac C, Chaumeil MM, Kohanbash G, Guglielmetti C, Gordon JW, Okada H, Ronen SM. Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine. Sci Rep. 2016 08 10; 6:31397.
Chaumeil MM, Radoul M, Najac C, Eriksson P, Viswanath P, Blough MD, Chesnelong C, Luchman HA, Cairncross JG, Ronen SM. Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring. Neuroimage Clin. 2016; 12:180-9.
Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135.
Viswanath P, Chaumeil MM, Ronen SM. Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells. Front Oncol. 2016; 6:60.
Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM. MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival. . 2016 05; 15(5):1113-22.
Pavithra Viswanath, Jose L. Izquierdo-Garcia, Pia Eriksson, Larry Cai, Marina Radoul, Myriam M. Chaumeil, Michael Blough, H. Artee Luchmann, Samuel Weiss, J. Gregory Cairncross, Joanna J. Phillips, Russell O. Pieper, Sabrina M. Ronen. CBIO-42DOWN REGULATION OF PYRUVATE DEHYDROGENASE ACTIVITY IS ESSENTIAL FOR CELL PROLIFERATION IN IDH1 MUTANT GLIOMA CELLS. Neuro-Oncology. 2015 Nov 1; 17(suppl_5):v63-v63.
Chaumeil MM, Lupo JM, Ronen SM. Magnetic Resonance (MR) Metabolic Imaging in Glioma. Brain Pathol. 2015 Nov; 25(6):769-80.
Chaumeil MM, Najac C, Ronen SM. Studies of Metabolism Using (13)C MRS of Hyperpolarized Probes. Methods Enzymol. 2015; 561:1-71.
Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer Res. 2015 Aug 01; 75(15):2999-3009.
Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips JJ, Ronen SM. Metabolic reprogramming in mutant IDH1 glioma cells. PLoS One. 2015; 10(2):e0118781.
Myriam Chaumeil, Peder Larson, Sarah Woods, Larry Cai, Pia Eriksson, Aaron Robinson, Janine Lupo, Daniel Vigneron, Sarah Nelson, Russell Pieper, Joanna Phillips, Sabrina Ronen. BI-07HYPERPOLARIZED [1-13C] GLUTAMATE: A METABOLIC IMAGING BIOMARKER OF IDH1 MUTATIONAL STATUS IN GLIOMA. Neuro-Oncology. 2014 Nov 1; 16(suppl_5):v24-v24.
Jose Izquierdo-Garcia, Pia Eriksson, Larry Cai, Myriam Chaumeil, Russell Pieper, Joanna Phillips, Sabrina Ronen. TM-0713C MRS DETECTS METABOLIC FLUX ADAPTATION IN IDH MUTANT GLIOMA CELLS. Neuro-Oncology. 2014 Nov 1; 16(suppl_5):v214-v214.
Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO. Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res. 2014 Dec 01; 74(23):7115-24.
Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM. Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase. PLoS One. 2014; 9(9):e108289.
Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PEZ. Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites. Magn Reson Med. 2015 Sep; 74(3):622-633.
Sabrina M. Ronen, Jose L. Izquierdo-Garcia, Myriam M. Chaumeil, Larry M. Cai, Joanna J. Phillips, Russell O. Pieper. METABOLIC IMAGING BIOMARKERS FOR MUTANT IDH1 GLIOMAS. Neuro-Oncology. 2014 Jul 1; 16(suppl_3):iii12-iii12.
Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res. 2014 Aug 15; 74(16):4247-57.
Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG. Lactate dehydrogenase A silencing in IDH mutant gliomas. Neuro Oncol. 2014 May; 16(5):686-95.
S. Adams, C. Teo, K. McDonald, A. Zinger, S. Bustamante, C. K. Lim, N. Braidy, B. J. Brew, G. J. Guillemin, S. Agnihotri, K. Burrell, S. Singh, A. Vartanian, A. Wolf, F. Lang, R. Verhaak, C. Hawkins, K. Aldape, G. Zadeh, C. Chesnelong, M. Chaumeil, M. D. Blough, M. Al-Najjar, O. D. Stechishin, S. Ronen, S. Weiss, H. A. Luchman, J. G. Cairncross, E. Fonkem, R. Tobin, J. Griffin, A. Zuzek, M. Rogers, M. Giladi, Y. Wasserman, N. Urman, Y. Porat, R. Schneiderman, M. Munster, U. Weinberg, E. Kirson, Y. Palti, J. Godlewski, A. Bronisz, K. Ansari, D. Ogawa, M. O. Nowicki, E. A. Chiocca, A. Kathagen, A. Schulte, G. Balcke, H. Phillips, H. Gunther, M. Westphal, K. Lamszus, K. Makino, H. Nakamura, T.-i. Hide, S. Yano, J.-i. Kuroda, J.-i. Kuratsu, F. Fack, D. Bonnel, G. Hochart, A. C. Navis, P. Wesseling, W. P. J. Leenders, J. Stauber, S. P. Niclou, F. Sahm, I. Oezen, C. Opitz, B. Radlwimmer, A. von Deimling, H. B. Bode, T. Ahrendt, S. Adams, G. Guillemin, W. Wick, M. Platten, D. Schonberg, D. Lubelski, J. Rich, A. Vartanian, S. K. Singh, K. Burrell, S. Agnihotri, N. Sabha, G. Zadeh. METABOLIC PATHWAYS. Neuro-Oncology. 2013 Nov 1; 15(suppl_3):iii85-iii88.
. Adachi, H. Sasaki, S. Nagahisa, K. Yoshida, N. Hattori, Y. Nishiyama, T. Kawase, M. Hasegawa, M. Abe, Y. Hirose, A. Alentorn, Y. Marie, S. Poggioli, H. Alshehhi, B. Boisselier, C. Carpentier, K. Mokhtari, L. Capelle, D. Figarella-Branger, K. Hoang-Xuan, M. Sanson, J.-Y. Delattre, A. Idbaih, S. Yust-Katz, M. Anderson, A. Olar, A. Eterovic, N. Ezzeddine, K. Chen, H. Zhao, G. Fuller, K. Aldape, J. de Groot, N. Andor, J. Harness, S. G. Lopez, T. L. Fung, H. W. Mewes, C. Petritsch, A. Arivazhagan, K. Somasundaram, K. Thennarasu, P. Pandey, B. Anandh, V. Santosh, B. Chandramouli, A. Hegde, P. Kondaiah, M. Rao, R. Bell, R. Kang, C. Hong, J. Song, J. Costello, R. Bell, R. Nagarajan, B. Zhang, A. Diaz, T. Wang, J. Song, J. Costello, L. Bie, Y. Li, Y. Li, H. Liu, W. F. C. Luyo, M. H. Carnero, M. E. P. Iruegas, A. R. Morell, M. C. Figueiras, R. L. Lopez, C. F. Valverde, A. K.-Y. Chan, J. C.-S. Pang, N. Y.-F. Chung, K. K.-W. Li, W. S. Poon, D. T.-M. Chan, Y. Wang, H.-a. K. Ng, M. Chaumeil, P. Larson, H. Yoshihara, D. Vigneron, S. Nelson, R. Pieper, J. Phillips, S. Ronen, V. Clark, Z. E. Omay, A. Serin, J. Gunel, B. Omay, C. Grady, M. Youngblood, K. Bilguvar, J. Baehring, J. Piepmeier, P. Gutin, A. Vortmeyer, C. Brennan, M. N. Pamir, T. Kilic, B. Krischek, M. Simon, K. Yasuno, M. Gunel, A. L. Cohen, M. Sato, K. D. Aldape, C. Mason, K. Diefes, L. Heathcock, L. Abegglen, D. Shrieve, W. Couldwell, J. D. Schiffman, H. Colman, Q. G. D'Alessandris, T. Cenci, M. Martini, L. Ricci-Vitiani, R. De Maria, L. M. Larocca, R. Pallini, J. de Groot, B. Theeler, K. Aldape, F. Lang, G. Rao, M. Gilbert, E. Sulman, R. Luthra, K. Eterovic, K. Chen, M. Routbort, R. Verhaak, G. Mills, J. Mendelsohn, F. Meric-Bernstam, A. Yung, K. MacArthur, S. Hahn, G. Kao, R. Lustig, M. Alonso-Basanta, S. Chandrasekaran, E. P. Wileyto, E. Reyes, J. Dorsey, K. Fujii, K. Kurozumi, T. Ichikawa, M. Onishi, J. Ishida, Y. Shimazu, B. Kaur, E. A. Chiocca, I. Date, C. Geisenberger, A. Mock, R. Warta, C. Schwager, C. Hartmann, A. von Deimling, A. Abdollahi, C. Herold-Mende, O. Gevaert, A. Achrol, S. Gholamin, S. Mitra, E. Westbroek, J. Loya, L. Mitchell, S. Chang, G. Steinberg, S. Plevritis, S. Cheshier, O. Gevaert, L. Mitchell, A. Achrol, J. Xu, G. Steinberg, S. Cheshier, S. Napel, G. Zaharchuk, S. Plevritis, O. Gevaert, A. Achrol, S. Chang, G. Harsh, G. Steinberg, S. Cheshier, S. Plevritis, D. Gutman, C. Holder, R. Colen, W. Dunn, R. Jain, L. Cooper, S. Hwang, A. Flanders, D. Brat, J. Hayes, A. Droop, H. Thygesen, M. Boissinot, D. Westhead, S. Short, S. Lawler, P. Bady, S. Kurscheid, M. Delorenzi, M. E. Hegi, C. Crosby, C. Faulkner, T. Smye-Rumsby, K. Kurian, M. Williams, K. Hopkins, C. Faulkner, A. Palmer, H. Williams, C. Wragg, H. R. Haynes, M. Williams, K. Hopkins, K. M. Kurian, H. R. Haynes, C. Crosby, H. Williams, P. White, K. Hopkins, M. Williams, K. M. Kurian, J. Ishida, K. Kurozumi, T. Ichikawa, M. Onishi, K. Fujii, Y. Shimazu, T. Oka, I. Date, L. Jalbert, A. Elkhaled, J. Phillips, S. Chang, S. Nelson, R. Jensen, K. Salzman, M. Schabel, D. Gillespie, M. Mumert, B. Johnson, T. Mazor, C. Hong, M. Barnes, S. Yamamoto, H. Ueda, K. Tatsuno, K. Aihara, L. Jalbert, S. Nelson, A. Bollen, M. Hirst, M. Marra, A. Mukasa, N. Saito, H. Aburatani, M. Berger, S. Chang, B. Taylor, J. Costello, S. Popov, A. Mackay, W. Ingram, A. Burford, A. Jury, M. Vinci, C. Jones, D. T. W. Jones, V. Hovestadt, S. Picelli, W. Wang, P. A. Northcott, M. Kool, G. Reifenberger, T. Pietsch, M. Sultan, H. Lehrach, M.-L. Yaspo, A. Borkhardt, P. Landgraf, R. Eils, A. Korshunov, M. Zapatka, B. Radlwimmer, S. M. Pfister, P. Lichter, A. Joy, I. Smirnov, M. Reiser, W. Shapiro, G. Mills, S. Kim, B. Feuerstein, C. Jungk, A. Mock, C. Geisenberger, R. Warta, S. Friauf, A. Unterberg, C. Herold-Mende, T. A. Juratli, J. McElroy, W. Meng, A. Huebner, K. D. Geiger, D. Krex, G. Schackert, A. Chakravarti, T. Lautenschlaeger, B. Y. .... OMICS AND PROGNSTIC MARKERS. Neuro-Oncology. 2013 Nov 1; 15(suppl_3):iii136-iii155.
Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, Tom MW, Paquette J, Tokuyasu TA, Tsao S, Marshall R, Perry A, Bjorgan KM, Chaumeil MM, Ronen SM, Bergers G, Aghi MK. Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance. Clin Cancer Res. 2013 Apr 01; 19(7):1773-83.
Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4:2429.
E. Noch, S. Pina-Oviedo, G. Perez-Liz, M. Bookland, L. Del Valle, J. Gordon, K. Khalili, T. A. Juratli, M. Peitzsch, K. Geiger, G. Schackert, G. Eisenhofer, D. Krex, M. M. Chaumeil, S. M. Woods, R. M. Danforth, H. Yoshihara, A. Lodi, A. Robinson, J. M. Lupo, R. O. Pieper, J. J. Phillips, S. M. Ronen, D. L. Schonberg, J. M. Heddleston, A. B. Hjelmeland, J. N. Rich, S. A. A. Rahim, M. Sanzey, R. Bjerkvig, S. P. Niclou, D. A. M. Mustafa, S. M. A. Swagemakers, P. J. van der Spek, J. M. Kros, A. Vartanian, S. K. Singh, G. Zadeh, K. S. Lim, K. J. Lim, B. A. Orr, A. C. Price, C. G. Eberhart, E. E. Bar, W. M. Liu, P. Huang, A. Nowacki, C. Distelhorst, J. Lathia, J. Rich, J. Kappes, C. Gladson, K. Schwartz, H. Chang, L. Karl Olson. LAB-METABOLIC PATHWAYS. Neuro-Oncology. 2012 Oct 1; 14(suppl_6):vi53-vi55.
Chaumeil MM, Gini B, Yang H, Iwanami A, Sukumar S, Ozawa T, Pieper RO, Mischel PS, James CD, Berger MS, Ronen SM. Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla. Neuro Oncol. 2012 Aug; 14(8):1050-61.
Chaumeil MM, Valette J, Baligand C, Brouillet E, Hantraye P, Bloch G, Gaura V, Rialland A, Krystkowiak P, Verny C, Damier P, Remy P, Bachoud-Levi AC, Carlier P, Lebon V. pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study. J Cereb Blood Flow Metab. 2012 May; 32(5):771-9.
Venkatesh HS, Chaumeil MM, Ward CS, Haas-Kogan DA, James CD, Ronen SM. Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma. Neuro Oncol. 2012 Mar; 14(3):315-25.
Y.-L. Hu, M. De Lay, S. D. Rose, W. S. Carbonell, M. K. Aghi, S. D. Rose, W. S. Carbonell, M. De Lay, Y.-L. Hu, J. Paquette, T. Tokuyasu, S. Tsao, M. Chaumeil, S. Ronen, M. K. Aghi, L. A. Matlaf, L. Soroceanu, C. Cobbs, L. Soroceanu, L. Matlaf, L. Harkins, C. Cobbs, T. Garzon-Muvdi, C. a. Rhys, C. Smith, D.-H. Kim, L. Kone, H. Farber, S. An, A. Levchenko, A. Quinones-Hinojosa, D. Lemke, P.-N. Pfenning, F. Sahm, A.-C. Klein, T. Kempf, M. Schnolzer, M. Platten, W. Wick, S. J. Smith, R. Rahman, C. Rahman, J. Barrow, D. Macarthur, F. Rose, R. G. Grundy, T. J. Kaley, J. Huse, S. Karimi, M. Rosenblum, A. Omuro, L. M. DeAngelis, J. F. de Groot, L.-Y. Kong, J. Wei, T. Wang, Y. Piao, J. Liang, G. N. Fuller, W. Qiao, A. B. Heimberger, N. Jhaveri, H. Cho, S. Torres, W. Wang, A. Schonthal, N. Petasis, S. G. Louie, F. Hofman, T. C. Chen, R. Yamada, S. Sumual, V. Buljan, M. R. Bennett, K. L. McDonald, M. Weiler, P.-N. Pfenning, A.-L. Thiepold, L. Jestaedt, J. Gronych, L. M. Dittmann, M. Jugold, M. Kosch, S. E. Combs, A. von Deimling, M. Weller, M. Bendszus, M. Platten, W. Wick, A. Kwiatkowska, V. Paulino, N. L. Tran, M. Symons, A. L. Stockham, E. Borden, D. Peereboom, Y. Hu, A. Chaturbedi, M. Hamamura, E. Mark, Y.-H. Zhou, S. Abbadi, H. Guerrero-Cazares, F. Pistollato, C. L. Smith, W. Ruff, A. D. Puppa, G. Basso, A. Quinones-Hinojosa, M. Monje, M. E. Freret, M. Masek, P. G. Fisher, T. Haddix, H. Vogel, N. Kijima, N. Hosen, N. Kagawa, N. Hashimoto, Y. Fujimoto, M. Kinoshita, H. Sugiyama, T. Yoshimine, N. Anneke, H. Bob, W. Pieter, H. Arend, L. William, M. Eoli, A. Calleri, L. Cuppini, E. Anghileri, S. Pellegatta, E. Prodi, M. G. Bruzzone, F. Bertolini, G. Finocchiaro, D. Zhu, S. B. Hunter, P. M. Vertino, E. G. Van Meir, S. M. Cork, B. Kaur, L. Cooper, J. H. Saltz, E. M. Sandberg, E. G. Van Meir, K. Burrell, R. Hill, G. Zadeh, J. J. Parker, K. Dionne, R. Massarwa, M. Klaassen, L. Niswander, B. K. Kleinschmidt-DeMasters, A. Waziri, S. Jalali, T. Wataya, F. Salehi, S. Croul, F. Gentili, G. Zadeh, S. Jalali, W. Foltz, K. Burrell, J.-I. Lee, S. Agnihorti, C. Menard, C. Chung, G. Zadeh, S. Torres, N. Jhaveri, W. Wang, A. H. Schonthal, S. G. Louie, F. M. Hofman, T. C. Chen, P. Elena, G. Faivre, A. Demopoulos, S. Taillibert, M. Rosenblum, A. Omuro, M. Kirsch, K. D. Martin, A. Bertram, O. uckermann, E. Leipnitz, P. Weigel, A. Temme, G. Schackert, K. Geiger, E. Gerstner, D. Jennings, A. S. Chi, S. Plotkin, S. J. Kwon, M. Pinho, P. Polaskova, T. T. Batchelor, A. G. Sorensen, M. B. Hossain, A. E. Gururaj, N. Cortes-Santiago, K. Gabrusiewicz, W. K. A. Yung, J. Fueyo, C. Gomez-Manzano, O. D. Gil, S. Noticewala, S. Ivkovic, M. Esencay, D. Zagzagg, S. Rosenfeld, J. N. Bruce, P. Canoll, J. H. Chang, H. J. Seol, A. Weeks, C. A. Smith, J. T. Rutka, J. Georges, G. Samuelson, A. Misra, A. Joy, Y. Huang, M. McQuilkin, A. Yoshihiro, D. Carpenter, L. Butler, B. Feuerstein, S. F. Murphy, T. Vaghaiwalla, M. Wotoczek-Obadia, R. Albright, D. Mack, S. Lawn, F. Henderson, M. Jung, S. Dakshanamurthy, M. Brown, P. Forsyth, S. Brem, M. S. Sadr, D. Maret, E. S. Sadr, V. Siu, J. Alshami, G. Trinh, J.-S. Denault, D. Faury, N. Jabado, A. Nantel, R. Del Maestro. ANGIOGENESIS AND INVASION. Neuro-Oncology. 2011 Nov 1; 13(suppl_3):iii1-iii9.
S. Bluml, A. Panigrahy, M. Laskov, G. Dhall, M. D. Nelson, J. L. Finlay, F. H. Gilles, H. Arita, M. Kinoshita, N. Kagawa, Y. Fujimoto, N. Hashimoto, T. Yoshimine, M. Kinoshita, H. Arita, N. Kagawa, Y. Fujimoto, N. Hashimoto, T. Yoshimine, J. D. Hamilton, J. Wang, V. A. Levin, P. Hou, M. E. Loghin, M. R. Gilbert, N. E. Leeds, J. F. deGroot, V. Puduvalli, E. F. Jackson, W. K. A. Yung, A. J. Kumar, B. M. Ellingson, T. F. Cloughesy, W. B. Pope, T. Zaw, H. Phillips, S. Lalezari, P. L. Nghiemphu, H. Ibrahim, K. Motevalibashinaeini, A. Lai, B. M. Ellingson, T. F. Cloughesy, T. Zaw, R. Harris, S. Lalezari, P. L. Nghiemphu, K. Motevalibashinaeini, A. Lai, W. B. Pope, L. Douw, M. E. Van de Nieuwenhuijzen, J. J. Heimans, J. C. Baayen, C. J. Stam, J. C. Reijneveld, C. Juhasz, S. Mittal, D. Altinok, N. L. Robinette, O. Muzik, P. K. Chakraborty, G. R. Barger, B. M. Ellingson, T. F. Cloughesy, T. M. Zaw, S. Lalezari, P. L. Nghiemphu, K. Motevalibashinaeini, A. Lai, J. Goldin, W. B. Pope, B. M. Ellingson, T. F. Cloughesy, R. Harris, W. B. Pope, P. L. Nghiemphu, A. Lai, T. Zaw, W. Chen, M. A. Ahlman, P. Giglio, T. J. Kaufmann, S. K. Anderson, K. A. Jaeckle, J. H. Uhm, D. W. Northfelt, P. J. Flynn, J. C. Buckner, E. Galanis, O. Zalatimo, C. Weston, D. Allison, D. Bota, S. Kesari, M. Glantz, J. Sheehan, R. E. Harbaugh, Y. Chiba, M. Kinoshita, N. Kagawa, Y. Fujimoto, A. Tsuboi, J. Hatazawa, H. Sugiyama, N. Hashimoto, T. Yoshimine, T. Nariai, J. Toyohara, Y. Tanaka, M. Inaji, M. Aoyagi, M. Yamamoto, K. Ishiwara, K. Ohno, L. Jalilian, E. Essock-Burns, S. Cha, S. Chang, M. Prados, N. Butowski, S. Nelson, Y. Kawahara, M. Nakada, Y. Hayashi, Y. Kai, Y. Hayashi, N. Uchiyama, J.-i. Kuratsu, J.-i. Hamada, K. Yeom, J. Rosenberg, J. B. Andre, P. G. Fisher, M. S. Edwards, P. D. Barnes, S. Partap, E. Essock-Burns, L. Jalilian, J. M. Lupo, J. C. Crane, S. Cha, S. M. Chang, S. J. Nelson, C. A. Romanowski, N. Hoggard, D. A. Jellinek, S. Clenton, F. McKevitt, S. Wharton, I. Craven, A. Buller, C. Waddle, J. Bigley, I. D. Wilkinson, P. Metherall, L. J. Eckel, G. F. Keating, N. M. Wetjen, C. Giannini, C. Wetmore, R. Jain, J. Narang, A. S. Arbab, L. Schultz, L. Scarpace, T. Mikkelsen, A. Babajni-Feremi, R. Jain, L. Poisson, J. Narang, L. Scarpace, D. Gutman, C. Jaffe, J. Saltz, A. Flanders, B. Daniel, T. Mikkelsen, L. Zach, D. Guez, D. Last, D. Daniels, C. Hoffman, Y. Mardor, N. Guha-Thakurta, J. M. Debnam, C. Kotsarini, I. D. Wilkinson, D. Jellinek, P. D. Griffiths, N. Khandanpour, N. Hoggard, C. Kotsarini, I. D. Wilkinson, D. Jellinek, P. D. Griffiths, P. Bambrough, N. Hoggard, J. D. Hamilton, V. A. Levin, P. Hou, S. Prabhu, M. E. Loghin, M. R. Gilbert, R. L. Bassett, J. Wang, W. A. Yung, E. F. Jackson, A. J. Kumar, C. J. Campen, S. Soman, P. G. Fisher, M. S. Edwards, K. W. Yeom, M. J. Vos, J. Berkhof, T. J. Postma, E. Sanchez, E. M. Sizoo, J. J. Heimans, F. J. Lagerwaard, J. Buter, D. P. Noske, J. C. Reijneveld, R. R. Colen, B. Mahajan, F. A. Jolesz, P. O. Zinn, J. M. Lupo, A. Molinaro, S. Chang, K. Lawton, S. Cha, S. J. Nelson, D. Alexandru, D. Bota, M. E. Linskey, M. M. Chaumeil, B. Gini, H. Yang, A. Iwanami, S. Subramanian, T. Ozawa, E. J. Read, R. O. Pieper, P. Mischel, C. D. James, S. M. Ronen, P. S. LaViolette, E. Cochran, M. Al-Gizawiy, J. M. Connelly, M. G. Malkin, S. D. Rand, W. M. Mueller, K. M. Schmainda, P. S. LaViolette, A. D. Cohen, E. Cochran, M. Prah, C. J. Hartman, J. M. Connelly, S. D. Rand, M. G. Malkin, W. M. Mueller, K. M. Schmainda, X. J. Qiao, R. He, M. Brown, J. Goldin, T. Cloughesy, W. B. Pope. RADIOLOGY. Neuro-Oncology. 2011 Nov 1; 13(suppl_3):iii136-iii144.
Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM. Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma. Neuroimage. 2012 Jan 02; 59(1):193-201.
Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, Sukumar S, Nelson SJ, Vigneron DB, Kurhanewicz J, James CD, Haas-Kogan DA, Ronen SM. Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer Res. 2010 Feb 15; 70(4):1296-305.
Chaumeil MM, Valette J, Guillermier M, Brouillet E, Boumezbeur F, Herard AS, Bloch G, Hantraye P, Lebon V. Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3988-93.
Valette J, Chaumeil M, Guillermier M, Bloch G, Hantraye P, Lebon V. Diffusion-weighted NMR spectroscopy allows probing of 13C labeling of glutamate inside distinct metabolic compartments in the brain. Magn Reson Med. 2008 Aug; 60(2):306-11.
Nadrigny F, Rivals I, Hirrlinger PG, Koulakoff A, Personnaz L, Vernet M, Allioux M, Chaumeil M, Ropert N, Giaume C, Kirchhoff F, Oheim M. Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing. Eur Biophys J. 2006 Aug; 35(6):533-47.