Charles Higgins, MD

Professor Emeritus
Professor

Biography

Dr. Higgins, MD, is a Professor of Radiology in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. He retired January 2012 after over 27 years in the Department of Radiology, but continues to contribute his clinical, research, and teaching skills as a Professor Emeritus. Dr. Higgins obtained his medical degree from Jefferson Medical College in Philadelphia. He completed a residency from the University of California, Los Angeles and a residency from the University of California, San Diego, followed by a fellowship in Cardiovascular Radiology from Stanford University Hospital, California.

Dr. Higgins is an expert in cardiovascular magnetic resonance imaging, congenital heart disease, ischemic heart disease, acquired heart disease, thoracic aortic disease, and contrast media. He has laboratory research on interventional MRI, which is developing MR guided techniques for transcatheter delivery of aortic and pulmonary valves and aortic stents in pigs and dogs.

Dr. Higgins has delivered 36 titled lectureships in the Unites States and abroad. He is and has been a member of the editorial boards of 14 scientific journals, and he is currently a member of Circulation, the American Journal of Cardiology, the Journal of American College of Cardiology, the Journal of Magnetic Resonance Imaging, and the Journal of Cardiovascular MR. Dr. Higgins has published 746 articles, and he has written 126 book chapters and 26 books.

Expertise:
Cardiac and Pulmonary Imaging

Specialty:
Heart and thoracic disease

Professional Interests:
Cardiovascular magnetic resonance imaging, congenital heart disease, ischemic heart disease, acquired heart disease, thoracic aortic disease, and contrast media

Education and Training:
• Medical School: Jefferson Medical College, Philadelphia
• Internship: University of California, Los Angeles
• Residency: University of California, Los Angeles
• Residency: University of California, San Diego
• Fellowship: Stanford University Hospital, California - Cardiovascular Radiology

Education

Clinical Fellowship, - School of Medicine - Radiology, University of California, San Francisco

Honors and Awards

Distinguished Scientist, American Heart Association, 2011
Gold Medal, Society of Cardiovascular MR, 2011
Outstanding Researcher Award, Radiology Society of North America, 2000
PA-Pendergrass Lecture, University of Pennsylvania Medical Center, Philadelphia, 1998
Gordon Richards Memorial Lecture, Canadian Association of Radiologists, Vancouver, 1990
Herbert Stauffer Memorial Lecture, Temple University, 1986
New Horizons Lecture Award of Honor, Radiology Society of North America, 1984

Publications

Tahir E, Sinn M, Bohnen S, Avanesov M, Säring D, Stehning C, Schnackenburg B, Eulenburg C, Wien J, Radunski UK, Blankenberg S, Adam G, Higgins CB, Saeed M, Muellerleile K, Lund GK. Acute versus Chronic Myocardial Infarction: Diagnostic Accuracy of Quantitative Native T1 and T2 Mapping versus Assessment of Edema on Standard T2-weighted Cardiovascular MR Images for Differentiation. Radiology. 2017 10; 285(1):83-91.
Kathiria NN, Devcic Z, Chen JS, Naeger DM, Hope MD, Higgins CB, Ordovas KG. Assessment of Left Ventricular Enlargement at Multidetector Computed Tomography. J Comput Assist Tomogr. 2015 Sep-Oct; 39(5):794-6.
Kathiria NN, Higgins CB, Ordovas KG. Advances in MR imaging assessment of adults with congenital heart disease. Magn Reson Imaging Clin N Am. 2015 Feb; 23(1):35-40.
Naeger DM, Higgins C, De Marco T, Muzzarelli S, Ordovas KG. Low-intensity late gadolinium enhancement predominates in hypertrophic cardiomyopathy. Clin Imaging. 2015 May-Jun; 39(3):432-6.
de Roos A, Higgins CB. Cardiac radiology: centenary review. Radiology. 2014 Nov; 273(2 Suppl):S142-59.
Kohi MP, Ordovas KG, Naeger DM, Meadows AK, Foster E, Higgins CB. CMR assessment of right ventricular function in patients with combined pulmonary stenosis and insufficiency after correction of tetralogy of Fallot. Acta Radiol. 2013 Dec; 54(10):1132-7.
Ordovas KG, Muzzarelli S, Hope MD, Naeger DM, Karl T, Reddy GP, Marchiori E, Higgins CB. Cardiovascular MR imaging after surgical correction of tetralogy of Fallot: approach based on understanding of surgical procedures. Radiographics. 2013 Jul-Aug; 33(4):1037-52.
Moraes GL, Higgins CB, Ordovas KG. Delayed enhancement magnetic resonance imaging in nonischemic myocardial disease. J Thorac Imaging. 2013 Mar; 28(2):84-92; quiz 93-5.
Cannavale A, Ordovás KG, Higgins CB. Magnetic resonance imaging of hypertrophic cardiomyopathy. J Thorac Imaging. 2013 Jan; 28(1):W12-8.
Adjemian J, Weber IB, McQuiston J, Griffith KS, Mead PS, Nicholson W, Roche A, Schriefer M, Fischer M, Kosoy O, Laven JJ, Stoddard RA, Hoffmaster AR, Smith T, Bui D, Wilkins PP, Jones JL, Gupton PN, Quinn CP, Messonnier N, Higgins C, Wong D. Zoonotic infections among employees from Great Smoky Mountains and Rocky Mountain National Parks, 2008-2009. Vector Borne Zoonotic Dis. 2012 Nov; 12(11):922-31.
Muzzarelli S, Ordovas KG, Higgins CB, Meadows AK. Collateral flow measurement by phase-contrast magnetic resonance imaging for the assessment of systemic venous baffle patency after atrial switch repair for transposition of the great arteries. J Thorac Imaging. 2012 May; 27(3):175-8.
Chung JH, Mitsumori LM, Ordovas KG, Elicker BM, Higgins CB, Reddy GP. Heart as a source of stroke: imaging evaluation with computed tomography. J Thorac Imaging. 2012 May; 27(3):W52-60.
Muzzarelli S, Ordovas KG, Cannavale G, Naeger D, Michaels AD, Higgins CB. Potential of delayed gadolinium enhancement magnetic resonance imaging for quantification of reverse remodeling of the peri-infarct zone in patients with ischemic cardiomyopathy treated with chronic vasodilator therapy: initial experience. J Thorac Imaging. 2012 Mar; 27(2):121-4.
Muzzarelli S, Meadows AK, Ordovas KG, Higgins CB, Meadows JJ. Usefulness of cardiovascular magnetic resonance imaging to predict the need for intervention in patients with coarctation of the aorta. Am J Cardiol. 2012 Mar 15; 109(6):861-5.
Ordovas KG, Higgins CB. Delayed contrast enhancement on MR images of myocardium: past, present, future. Radiology. 2011 Nov; 261(2):358-74.
Ordovas KG, Carlsson M, Lease KE, Foster E, Meadows AK, Martin AJ, Hope M, Do L, Higgins CB, Saeed M. Impaired regional left ventricular strain after repair of tetralogy of Fallot. J Magn Reson Imaging. 2012 Jan; 35(1):79-85.
Muzzarelli S, Meadows AK, Ordovas KG, Hope MD, Higgins CB, Nielsen JC, Geva T, Meadows JJ. Prediction of hemodynamic severity of coarctation by magnetic resonance imaging. Am J Cardiol. 2011 Nov 01; 108(9):1335-40.
Hope MD, Hope TA, Crook SE, Ordovas KG, Urbania TH, Alley MT, Higgins CB. 4D flow CMR in assessment of valve-related ascending aortic disease. JACC Cardiovasc Imaging. 2011 Jul; 4(7):781-7.
Muzzarelli S, Ordovas KG, Hope MD, Meadows JJ, Higgins CB, Meadows AK. Diagnostic value of the flow profile in the distal descending aorta by phase-contrast magnetic resonance for predicting severe coarctation of the aorta. J Magn Reson Imaging. 2011 Jun; 33(6):1440-6.
Muzzarelli S, Ordovas K, Higgins CB. Cardiovascular MRI for the assessment of heart failure: focus on clinical management and prognosis. J Magn Reson Imaging. 2011 Feb; 33(2):275-86.
Muzzarelli S, Ordovas KG, Cannavale G, Meadows AK, Higgins CB. Tetralogy of Fallot: impact of the excursion of the interventricular septum on left ventricular systolic function and fibrosis after surgical repair. Radiology. 2011 May; 259(2):375-83.
Hope MD, Hope TA, Urbania TH, Higgins CB. Four-dimensional flow magnetic resonance imaging with wall shear stress analysis before and after repair of aortopulmonary fistula. Circ Cardiovasc Imaging. 2010 Nov; 3(6):766-8.
Cannavale A, Ordovás KG, Rame EJ, Higgins CB. Hypertrophic cardiomyopathy with restrictive phenotype and myocardial crypts. J Thorac Imaging. 2010 Nov; 25(4):W121-3.
Cannavale G, Higgins CB, Ordovas KG. Unroofing the diagnosis. Int J Cardiovasc Imaging. 2010 Dec; 26(8):841-2.
Hope MD, Hope TA, Meadows AK, Ordovas KG, Urbania TH, Alley MT, Higgins CB. Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patterns. Radiology. 2010 Apr; 255(1):53-61.
Hope MD, Meadows AK, Hope TA, Ordovas KG, Saloner D, Reddy GP, Alley MT, Higgins CB. Clinical evaluation of aortic coarctation with 4D flow MR imaging. J Magn Reson Imaging. 2010 Mar; 31(3):711-8.
Hundley WG, Bluemke D, Bogaert JG, Friedrich MG, Higgins CB, Lawson MA, McConnell MV, Raman SV, van Rossum AC, Flamm S, Kramer CM, Nagel E, Neubauer S. Society for Cardiovascular Magnetic Resonance guidelines for reporting cardiovascular magnetic resonance examinations. J Cardiovasc Magn Reson. 2009 Mar 03; 11:5.
Higgins CB. Early use of contrast in cardiac magnetic resonance. JACC Cardiovasc Imaging. 2009 Feb; 2(2):241-4.
Carlsson M, Arheden H, Higgins CB, Saeed M. Magnetic resonance imaging as a potential gold standard for infarct quantification. J Electrocardiol. 2008 Nov-Dec; 41(6):614-20.
Saeed M, Martin A, Jacquier A, Bucknor M, Saloner D, Do L, Ursell P, Su H, Kan YW, Higgins CB. Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model. Radiology. 2008 Nov; 249(2):560-71.
Saeed M, Martin A, Ursell P, Do L, Bucknor M, Higgins CB, Saloner D. MR assessment of myocardial perfusion, viability, and function after intramyocardial transfer of VM202, a new plasmid human hepatocyte growth factor in ischemic swine myocardium. Radiology. 2008 Oct; 249(1):107-18.
Knauth Meadows A, Ordovas K, Higgins CB, Reddy GP. Magnetic resonance imaging in the adult with congenital heart disease. Semin Roentgenol. 2008 Jul; 43(3):246-58.
Ordovás KG, Reddy GP, Higgins CB. MRI in nonischemic acquired heart disease. J Magn Reson Imaging. 2008 Jun; 27(6):1195-213.
Hope MD, Meadows AK, Hope TA, Ordovas KG, Reddy GP, Alley MT, Higgins CB. Images in cardiovascular medicine. Evaluation of bicuspid aortic valve and aortic coarctation with 4D flow magnetic resonance imaging. Circulation. 2008 May 27; 117(21):2818-9.
Jacquier A, Wendland M, Do L, Robert P, Corot C, Higgins CB, Saeed M. MR imaging assessment of the kinetics of P846, a new gadolinium-based MR contrast medium, in ischemically injured myocardium. Contrast Media Mol Imaging. 2008 May-Jun; 3(3):112-9.
Reddy GP, Pujadas S, Ordovas KG, Higgins CB. MR imaging of ischemic heart disease. Magn Reson Imaging Clin N Am. 2008 May; 16(2):201-12, viii.
Jacquier A, Bucknor M, Do L, Robert P, Corot C, Higgins CB, Saeed M. P846, a new gadolinium based low diffusion magnetic resonance contrast agent, in characterizing occlusive infarcts, reperfused ischemic myocardium and reperfused infarcts in rats. MAGMA. 2008 May; 21(3):207-18.
Mewton N, Croisille P, Revel D, Weber O, Higgins CB, Saeed M. Left ventricular postmyocardial infarction remodeling studied by combining MR-tagging with delayed MR contrast enhancement. Invest Radiol. 2008 Apr; 43(4):219-28.
Jacquier A, Higgins CB, Martin AJ, Do L, Saloner D, Saeed M. Injection of adeno-associated viral vector encoding vascular endothelial growth factor gene in infarcted swine myocardium: MR measurements of left ventricular function and strain. Radiology. 2007 Oct; 245(1):196-205.
Akhtar M, Ordovas K, Martin A, Higgins CB, Michaels AD. Effect of chronic sustained-release dipyridamole on myocardial blood flow and left ventricular function in patients with ischemic cardiomyopathy. Congest Heart Fail. 2007 May-Jun; 13(3):130-5.
Ordovás KG, Tan C, Reddy GP, Weber OM, Lu Y, Higgins CB. Disparity between ratios of diameters and blood flows in central pulmonary arteries in postoperative congenital heart disease using MRI. J Magn Reson Imaging. 2007 Apr; 25(4):721-6.
Saeed M, Saloner D, Martin A, Do L, Weber O, Ursell PC, Jacquier A, Lee R, Higgins CB. Adeno-associated viral vector-encoding vascular endothelial growth factor gene: effect on cardiovascular MR perfusion and infarct resorption measurements in swine. Radiology. 2007 May; 243(2):451-60.
Jun SL, Chanani NK, Moore P, Higgins CB. Images in cardiovascular medicine. Magnetic resonance imaging of a posttraumatic myocardial infarction and ventricular septal defect with a closure device in place. Circulation. 2007 Jan 16; 115(2):e13-5.
Kim RJ, de Roos A, Fleck E, Higgins CB, Pohost GM, Prince M, Manning WJ. Guidelines for training in Cardiovascular Magnetic Resonance (CMR). J Cardiovasc Magn Reson. 2007; 9(1):3-4.
Jacquier A, Higgins CB, Saeed M. MR imaging in assessing cardiovascular interventions and myocardial injury. Contrast Media Mol Imaging. 2007 Jan-Feb; 2(1):1-15.
Saeed M, Weber O, Lee R, Do L, Martin A, Saloner D, Ursell P, Robert P, Corot C, Higgins CB. Discrimination of myocardial acute and chronic (scar) infarctions on delayed contrast enhanced magnetic resonance imaging with intravascular magnetic resonance contrast media. J Am Coll Cardiol. 2006 Nov 21; 48(10):1961-8.
Woodard PK, Bluemke DA, Cascade PN, Finn JP, Stillman AE, Higgins CB, White RD, Yucel EK. ACR practice guideline for the performance and interpretation of cardiac magnetic resonance imaging (MRI). J Am Coll Radiol. 2006 Sep; 3(9):665-76.
Saeed M, Henk CB, Weber O, Martin A, Wilson M, Shunk K, Saloner D, Higgins CB. Delivery and assessment of endovascular stents to repair aortic coarctation using MR and X-ray imaging. J Magn Reson Imaging. 2006 Aug; 24(2):371-8.
Pujadas S, Reddy GP, Weber O, Tan C, Moore P, Higgins CB. Phase contrast MR imaging to measure changes in collateral blood flow after stenting of recurrent aortic coarctation: initial experience. J Magn Reson Imaging. 2006 Jul; 24(1):72-6.
Saeed M, Martin AJ, Lee RJ, Weber O, Revel D, Saloner D, Higgins CB. MR guidance of targeted injections into border and core of scarred myocardium in pigs. Radiology. 2006 Aug; 240(2):419-26.
Kramer CM, Neubauer S, Kraitchman D, Higgins CB, Fogel MA, Friedrich MG, Manning WJ. Meeting highlights of the 9th annual scientific sessions of the society for cardiovascular magnetic resonance: Miami, Florida, January 20-22, 2006. J Am Coll Cardiol. 2006 Jul 04; 48(1):187-92.
Weber OM, Higgins CB. MR evaluation of cardiovascular physiology in congenital heart disease: flow and function. J Cardiovasc Magn Reson. 2006; 8(4):607-17.
Saeed M, Lee RJ, Weber O, Do L, Martin A, Ursell P, Saloner D, Higgins CB. Scarred myocardium imposes additional burden on remote viable myocardium despite a reduction in the extent of area with late contrast MR enhancement. Eur Radiol. 2006 Apr; 16(4):827-36.
Henk CB, Higgins CB, Saeed M. Endovascular interventional MRI. J Magn Reson Imaging. 2005 Oct; 22(4):451-60.
Kramer CM, Friedrich MG, Neubauer S, Stuber M, Geva T, Higgins CB, Manning WJ. Meeting highlights of the 8th Annual Scientific Sessions of the Society For Cardiovascular Magnetic Resonance, January 21 to 23, 2005. J Am Coll Cardiol. 2005 Aug 02; 46(3):411-6.
Krombach GA, Higgins CB, Chujo M, Saeed M. Gadomer-enhanced MR imaging in the detection of microvascular obstruction: alleviation with nicorandil therapy. Radiology. 2005 Aug; 236(2):510-8.
Kuehne T, Gleason BK, Saeed M, Turner D, Weil J, Teitel DF, Higgins CB, Moore P. Combined pulmonary stenosis and insufficiency preserves myocardial contractility in the developing heart of growing swine at midterm follow-up. J Appl Physiol (1985). 2005 Oct; 99(4):1422-7.
Gotway MB, Araoz PA, Macedo TA, Stanson AW, Higgins CB, Ring EJ, Dawn SK, Webb WR, Leung JW, Reddy GP. Imaging findings in Takayasu's arteritis. AJR Am J Roentgenol. 2005 Jun; 184(6):1945-50.
Schalla S, Higgins CB, Saeed M. Long-term oral treatment with nicorandil prevents the progression of left ventricular hypertrophy and preserves viability. J Cardiovasc Pharmacol. 2005 Apr; 45(4):333-40.
Watzinger N, Lund GK, Saeed M, Reddy GP, Araoz PA, Yang M, Schwartz AB, Bedigian M, Higgins CB. Myocardial blood flow in patients with dilated cardiomyopathy: quantitative assessment with velocity-encoded cine magnetic resonance imaging of the coronary sinus. J Magn Reson Imaging. 2005 Apr; 21(4):347-53.
Schalla S, Saeed M, Higgins CB, Weber O, Martin A, Moore P. Balloon sizing and transcatheter closure of acute atrial septal defects guided by magnetic resonance fluoroscopy: assessment and validation in a large animal model. J Magn Reson Imaging. 2005 Mar; 21(3):204-11.
Kuehne T, Yilmaz S, Meinus C, Moore P, Saeed M, Weber O, Higgins CB, Blank T, Elsaesser E, Schnackenburg B, Ewert P, Lange PE, Nagel E. Magnetic resonance imaging-guided transcatheter implantation of a prosthetic valve in aortic valve position: Feasibility study in swine. J Am Coll Cardiol. 2004 Dec 07; 44(11):2247-9.
Pennell DJ, Sechtem UP, Higgins CB, Manning WJ, Pohost GM, Rademakers FE, van Rossum AC, Shaw LJ, Yucel EK. Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. Eur Heart J. 2004 Nov; 25(21):1940-65.
Kuehne T, Yilmaz S, Steendijk P, Moore P, Groenink M, Saaed M, Weber O, Higgins CB, Ewert P, Fleck E, Nagel E, Schulze-Neick I, Lange P. Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension. Circulation. 2004 Oct 05; 110(14):2010-6.
Schalla S, Higgins CB, Chujo M, Saeed M. Effect of potassium-channel opener therapy on reperfused infarction in hypertrophied hearts: demonstration of preconditioning by using functional and contrast-enhanced magnetic resonance imaging. J Cardiovasc Pharmacol Ther. 2004 Sep; 9(3):193-202.
Weber OM, Pujadas S, Martin AJ, Higgins CB. Free-breathing, three-dimensional coronary artery magnetic resonance angiography: comparison of sequences. J Magn Reson Imaging. 2004 Sep; 20(3):395-402.
Viswamitra S, Higgins CB, Meacham DF, Mehta JL. Magnetic resonance imaging in myocardial ischemia. Curr Opin Cardiol. 2004 Sep; 19(5):510-6.
Pujadas S, Reddy GP, Weber O, Lee JJ, Higgins CB. MR imaging assessment of cardiac function. J Magn Reson Imaging. 2004 Jun; 19(6):789-99.
Saeed M, Lee R, Martin A, Weber O, Krombach GA, Schalla S, Lee M, Saloner D, Higgins CB. Transendocardial delivery of extracellular myocardial markers by using combination X-ray/MR fluoroscopic guidance: feasibility study in dogs. Radiology. 2004 Jun; 231(3):689-96.
Lund GK, Stork A, Saeed M, Bansmann MP, Gerken JH, Müller V, Mester J, Higgins CB, Adam G, Meinertz T. Acute myocardial infarction: evaluation with first-pass enhancement and delayed enhancement MR imaging compared with 201Tl SPECT imaging. Radiology. 2004 Jul; 232(1):49-57.
Schalla S, Wendland MF, Higgins CB, Ebert W, Saeed M. Accentuation of high susceptibility of hypertrophied myocardium to ischemia: complementary assessment of Gadophrin-enhancement and left ventricular function with MRI. Magn Reson Med. 2004 Mar; 51(3):552-8.
Pennell DJ, Sechtem UP, Higgins CB, Manning WJ, Pohost GM, Rademakers FE, van Rossum AC, Shaw LJ, Yucel EK. Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. J Cardiovasc Magn Reson. 2004; 6(4):727-65.
Ansari M, Araoz PA, Gerard SK, Watzinger N, Lund GK, Massie BM, Higgins CB, Saloner DA. Comparison of late enhancement cardiovascular magnetic resonance and thallium SPECT in patients with coronary disease and left ventricular dysfunction. J Cardiovasc Magn Reson. 2004; 6(2):549-56.
Krombach GA, Saeed M, Higgins CB, Novikov V, Wendland MF. Contrast-enhanced MR delineation of stunned myocardium with administration of MnCl(2) in rats. Radiology. 2004 Jan; 230(1):183-90.
Wang ZJ, Reddy GP, Gotway MB, Higgins CB, Jablons DM, Ramaswamy M, Hawkins RA, Webb WR. Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET. Radiographics. 2004 Jan-Feb; 24(1):105-19.
Weber OM, Martin AJ, Higgins CB. Whole-heart steady-state free precession coronary artery magnetic resonance angiography. Magn Reson Med. 2003 Dec; 50(6):1223-8.
Krombach GA, Baireuther R, Higgins CB, Saeed M. Distribution of intramyocardially injected extracellular MR contrast medium: effects of concentration and volume. Eur Radiol. 2004 Feb; 14(2):334-40.
Kuehne T, Saeed M, Gleason K, Turner D, Teitel D, Higgins CB, Moore P. Effects of pulmonary insufficiency on biventricular function in the developing heart of growing swine. Circulation. 2003 Oct 21; 108(16):2007-13.
Wang ZJ, Reddy GP, Gotway MB, Yeh BM, Hetts SW, Higgins CB. CT and MR imaging of pericardial disease. Radiographics. 2003 Oct; 23 Spec No:S167-80.
Wang ZJ, Reddy GP, Gotway MB, Yeh BM, Higgins CB. Cardiovascular shunts: MR imaging evaluation. Radiographics. 2003 Oct; 23 Spec No:S181-94.
Araoz PA, Gotway MB, Trowbridge RL, Bailey RA, Auerbach AD, Reddy GP, Dawn SK, Webb WR, Higgins CB. Helical CT pulmonary angiography predictors of in-hospital morbidity and mortality in patients with acute pulmonary embolism. J Thorac Imaging. 2003 Oct; 18(4):207-16.
Weber OM, Schalla S, Martin AJ, Saeed M, Lee R, Shunk KA, Moore P, Higgins CB. Interventional cardiac magnetic resonance imaging. Semin Roentgenol. 2003 Oct; 38(4):352-7.
Pujadas S, Reddy GP, Lee JJ, Higgins CB. Magnetic resonance imaging in ischemic heart disease. Semin Roentgenol. 2003 Oct; 38(4):320-9.
Reddy GP, Higgins CB. Magnetic resonance imaging of congenital heart disease: evaluation of morphology and function. Semin Roentgenol. 2003 Oct; 38(4):342-51.
Schalla S, Saeed M, Higgins CB, Martin A, Weber O, Moore P. Magnetic resonance--guided cardiac catheterization in a swine model of atrial septal defect. Circulation. 2003 Oct 14; 108(15):1865-70.
Lund GK, Watzinger N, Saeed M, Reddy GP, Yang M, Araoz PA, Curatola D, Bedigian M, Higgins CB. Chronic heart failure: global left ventricular perfusion and coronary flow reserve with velocity-encoded cine MR imaging: initial results. Radiology. 2003 Apr; 227(1):209-15.
Kuehne T, Saeed M, Higgins CB, Gleason K, Krombach GA, Weber OM, Martin AJ, Turner D, Teitel D, Moore P. Endovascular stents in pulmonary valve and artery in swine: feasibility study of MR imaging-guided deployment and postinterventional assessment. Radiology. 2003 Feb; 226(2):475-81.
Araoz PA, Reddy GP, Tarnoff H, Roge CL, Higgins CB. MR findings of collateral circulation are more accurate measures of hemodynamic significance than arm-leg blood pressure gradient after repair of coarctation of the aorta. J Magn Reson Imaging. 2003 Feb; 17(2):177-83.
Keller RL, Aaroz PA, Hawgood S, Higgins CB. MR imaging of hepatic pulmonary fusion in neonates. AJR Am J Roentgenol. 2003 Feb; 180(2):438-40.
Bluemke DA, Krupinski EA, Ovitt T, Gear K, Unger E, Axel L, Boxt LM, Casolo G, Ferrari VA, Funaki B, Globits S, Higgins CB, Julsrud P, Lipton M, Mawson J, Nygren A, Pennell DJ, Stillman A, White RD, Wichter T, Marcus F. MR Imaging of arrhythmogenic right ventricular cardiomyopathy: morphologic findings and interobserver reliability. Cardiology. 2003; 99(3):153-62.
Watzinger N, Lund GK, Higgins CB, Wendland MF, Weinmann HJ, Saeed M. The potential of contrast-enhanced magnetic resonance imaging for predicting left ventricular remodeling. J Magn Reson Imaging. 2002 Dec; 16(6):633-40.
Krombach GA, Wendland MF, Higgins CB, Saeed M. MR imaging of spatial extent of microvascular injury in reperfused ischemically injured rat myocardium: value of blood pool ultrasmall superparamagnetic particles of iron oxide. Radiology. 2002 Nov; 225(2):479-86.
Wilson MW, LaBerge JM, Kerlan RK, Martin AJ, Weber OM, Roberts T, Vitalich C, Higgins CB, Gordon RL. MR portal venography: preliminary results of fast acquisition without contrast material or breath holding. Acad Radiol. 2002 Oct; 9(10):1179-84.
Saeed M, Watzinger N, Krombach GA, Lund GK, Wendland MF, Chujo M, Higgins CB. Left ventricular remodeling after infarction: sequential MR imaging with oral nicorandil therapy in rat model. Radiology. 2002 Sep; 224(3):830-7.
Wendland MF, Krombach GA, Higgins CB, Novikov V, Saeed M. Contrast enhanced MRI of stunned myocardium using Mn-based MRI contrast media. Acad Radiol. 2002 Aug; 9 Suppl 2:S341-2.
Gotway MB, Leung JW, Gooding GA, Litt HI, Reddy GP, Morita ET, Webb WR, Clark OH, Higgins CB. Hyperfunctioning parathyroid tissue: spectrum of appearances on noninvasive imaging. AJR Am J Roentgenol. 2002 Aug; 179(2):495-502.
Varaprasathan GA, Araoz PA, Higgins CB, Reddy GP. Quantification of flow dynamics in congenital heart disease: applications of velocity-encoded cine MR imaging. Radiographics. 2002 Jul-Aug; 22(4):895-905; discussion 905-6.
Saeed M, Wendland MF, Bremerich GL, Weinmann HJ, Higgins CB. Assessment of myocardial viability using standard extracellular and necrosis specific MR contrast media. Acad Radiol. 2002 May; 9 Suppl 1:S84-7.
Krombach GA, Higgins CB, Chujo M, Saeed M. Blood pool contrast-enhanced MRI detects suppression of microvascular permeability in early postinfarction reperfusion after nicorandil therapy. Magn Reson Med. 2002 May; 47(5):896-902.
Kuehne T, Saeed M, Moore P, Gleason K, Reddy G, Teitel D, Higgins CB. Influence of blood-pool contrast media on MR imaging and flow measurements in the presence of pulmonary arterial stents in swine. Radiology. 2002 May; 223(2):439-45.
Wendland MF, Saeed M, Bremerich J, Arheden H, Higgins CB. Thallium-like test for myocardial viability with MnDPDP-enhanced MRI. Acad Radiol. 2002 May; 9 Suppl 1:S82-3.
Olsen SJ, Miller G, Breuer T, Kennedy M, Higgins C, Walford J, McKee G, Fox K, Bibb W, Mead P. A waterborne outbreak of Escherichia coli O157:H7 infections and hemolytic uremic syndrome: implications for rural water systems. Emerg Infect Dis. 2002 Apr; 8(4):370-5.
Watzinger N, Lund GK, Higgins CB, Chujo M, Saeed M. Noninvasive assessment of the effects of nicorandil on left ventricular volumes and function in reperfused myocardial infarction. Cardiovasc Res. 2002 Apr; 54(1):77-84.
Araoz PA, Reddy GP, Thomson PD, Higgins CB. Images in cardiovascular medicine. Magnetic resonance angiography of criss-cross heart. Circulation. 2002 Jan 29; 105(4):537-8.
Schalla S, Higgins CB, Saeed M. Contrast agents for cardiovascular magnetic resonance imaging. Current status and future directions. Drugs R D. 2002; 3(5):285-302.