UCSF Radiology Matthew Bucknor and High Intensity Focused Ultrasound (HIFU)

Dr. Matthew Bucknor of the University of California San Francisco's Radiology Department, talks about his research with High Intensity Focused Ultrasound (HIFU) and it's application in Radiology and Imaging.

UCSF Imaging Center at Montgomery Street

The UCSF Imaging Center at Montgomery Street provides advanced radiological and imaging services as part of an integrated medical center that offers innovations found in a world-renowned university. At a convenient downtown location, we offer comprehensive health services at a single site in San Francisco’s North Waterfront area.  Services offered: Bone Density Scan (DXA), Screening Mammography, and Ultrasound.

Ultrasound-Guided Breast Biopsy

Biopsy is defined as small amount of tissue removed from the breast to be studied under the microscope. An ultrasound biopsy will require you to lie on your back with your arm on the biopsy side above your head. They will use ultrasound to identify the target area. During your biopsy you need to lie very still since you will feel pressure and possibly mild pain, and if you feel severe or sharp pain let your doctor know. They will then use ultrasound to guide the biopsy needle into target area and take approximately five samples.

Operating on Twins in the Womb

Multidisciplinary approach to fetal Invasive Therapy

Common Values

Problems with Twins

Two-thirds or three-fourths of identical twins are monozygotic twins so they share a placenta. When you share placenta you share vascularity so the two twins have to share blood supply. Two problems develop as a result of this that have been the focus of a lot effort a UCSF.

Operating in the Womb

Myelomeningocele: Birth defect in which the backbone and spinal canal do not close before birth.  The damage to spinal cord and peripheral nerves are irreversible.

Fetal Myelomeningocele (Open spina bifida) 3.4/10,000 live births in USA

Disease affects even with current recommendation and folate supplements.

Breakthrough in Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia (CDH): Birth defect in which malformation of the diaphragm allows the abdominal organs to push into the thorax and interfere with proper lung formation

  • Results from the trial (Outcome was poor)
  • Chorio-aminiotic separation
  • Preterm rupture of membrane

Boston Children is looking at other ways to make lungs grow through studying very rare disease Congenital High Airway Obstruction (CHAOS) which has the characteristics of enhanced lung growth.


Success by Collaboration

UCSF Fetal Intervention Center
Multiple UCSF departments have been cross-collaborating for 40 years to improve fetal health. Here are four examples that highlight imaging and fetal therapy. 
  1. Fetal lung mass
  2. Congenital diaphragmatic hernia
  3. Myelomeningocele, a birth defect in which the backbone and spinal canal do not close before birth
  4. Monochorionic twin syndromes (TTTS, TRAP)