Valentina Pedoia, PhD

Asst. Professor in Residence

Biography

Valentina Pedoia, PhD, is an Assistant Professor in the Musculoskeletal and Imaging Research Group.

She is a data scientist with a primary interest in developing algorithms for advanced computer vision and machine learning for improving the usage of non-invasive imaging as diagnostic and prognostic tools.

Dr. Pedoia obtained her doctoral degree in computer science working on features extraction from functional and structural brain MRI in subjects with glial tumors. After graduation, in 2013, she joined the Musculoskeletal and Imaging Research Group at UCSF as post-doctoral fellow. Her role was in providing support and expertise in medical computer vision, with a focus to reduce human effort and to extract semantic features from MRI to study degenerative joint disease.

Her current main research focus is on exploring the role of machine learning in the extraction of contributors to osteoarthritis (OA). She is studying analytics to model the complex interactions between morphological, biochemical and biomechanical aspects of the knee joint as a whole; deep learning convolutional neural network for musculoskeletal tissue segmentation and for the extraction of silent features from quantitative relaxation maps for a comprehensive study of the biochemical articular cartilage composition; with ultimate goal of developing a completely data-driven model that is able to extract imaging features and use them to identify risk factors and predict outcomes.

Dr. Pedoia’s recent work on machine learning applied to OA was awarded as annual scientific highlights of the 25th conference of the International Society of Magnetic Resonance In Medicine (ISMRM 2017) and selected as best paper presented at the MRI drug discovery study group.

Education

Ph.D, 2013 - Medical Computer Science, Insubria University, Italy
M.Sc, 2008 - Telecommunication Engineering, Signal Processing Division, Politecnico of Milano, Italy
B.S, 2005 - Telecommunication Engineering, Signal Processing Division, Politecnico of Milano, Italy

Honors and Awards

Magna Cum Lode Abstract; ISMRM 23th Annual Meeting and Exhibition, International Society of Magn. Reson. in Medicine, 2015
Best Poster at the Musculoskeletal MR study group, ISMRM 23th Annual Meeting and Exhibition, International Society of Magn. Reson. in Medicine, 2015
Highly ranked abstract at the ISMRM 8th International Workshop on imaging based measures of OA, International Society of Magn. Reson. in Medicine, 2015
Travel Stipend Award at the ISMRM 8th International Workshop on imaging based measures of OA, International Society of Magn. Reson. in Medicine, 2015
9th Annual Surbeck Young Investigator's Award, Margaret Hart Surbeck Laboratory of Advanced Imaging, 2015
Bruce Hasegawa Award, UCSF, 2015
Research Grants in Women’s Health, SCOR (Principal Investigator), UCSF and UC Davis, 2015

Publications

Pedoia V, Lee J, Norman B, Link TM, Majumdar S. Diagnosing osteoarthritis from T2 maps using deep learning: an analysis of the entire Osteoarthritis Initiative baseline cohort. Osteoarthritis Cartilage. 2019 Mar 21.
Zhong Q, Pedoia V, Tanaka M, Neumann J, Link TM, Ma B, Lin J, Li X. 3D bone-shape changes and their correlations with cartilage T1? and T2 relaxation times and patient-reported outcomes over 3-years after ACL reconstruction. Osteoarthritis Cartilage. 2019 Feb 23.
Shimizu T, Cruz A, Tanaka M, Mamoto K, Pedoia V, Burghardt AJ, Heilmeier U, Link TM, Graf J, Imboden JB, Li X. Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis. J Rheumatol. 2019 Feb 15.
Markes AR, Knox J, Zhong Q, Pedoia V, Li X, Ma CB. An Abnormal Tibial Position Is Associated With Alterations in the Meniscal Matrix: A 3-Year Longitudinal Study After Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med. 2019 Jan; 7(1):2325967118820057.
Samaan MA, Zhang AL, Popovic T, Pedoia V, Majumdar S, Souza RB. Hip joint muscle forces during gait in patients with femoroacetabular impingement syndrome are associated with patient reported outcomes and cartilage composition. J Biomech. 2019 Feb 14; 84:138-146.
Shimizu T, Samaan MA, Tanaka MS, Pedoia V, Souza RB, Li X, Ma CB. Abnormal Biomechanics at 6 Months Are Associated With Cartilage Degeneration at 3 Years After Anterior Cruciate Ligament Reconstruction. Arthroscopy. 2019 Feb; 35(2):511-520.
Pedoia V, Majumdar S. Translation of morphological and functional musculoskeletal imaging. J Orthop Res. 2019 Jan; 37(1):23-34.
Inamdar G, Pedoia V, Rossi-Devries J, Samaan MA, Link TM, Souza RB, Majumdar S. MR study of longitudinal variations in proximal femur 3D morphological shape and associations with cartilage health in hip osteoarthritis. J Orthop Res. 2019 Jan; 37(1):161-170.
Pedoia V, Norman B, Mehany SN, Bucknor MD, Link TM, Majumdar S. 3D convolutional neural networks for detection and severity staging of meniscus and PFJ cartilage morphological degenerative changes in osteoarthritis and anterior cruciate ligament subjects. J Magn Reson Imaging. 2019 Feb; 49(2):400-410.
Norman B, Pedoia V, Noworolski A, Link TM, Majumdar S. Applying Densely Connected Convolutional Neural Networks for Staging Osteoarthritis Severity from Plain Radiographs. J Digit Imaging. 2018 Oct 10.
Chen E, Amano K, Pedoia V, Souza RB, Ma CB, Li X. Longitudinal analysis of tibiofemoral cartilage contact area and position in ACL reconstructed patients. J Orthop Res. 2018 Oct; 36(10):2718-2727.
Rossi-deVries J, Pedoia V, Samaan MA, Ferguson AR, Souza RB, Majumdar S. Using multidimensional topological data analysis to identify traits of hip osteoarthritis. J Magn Reson Imaging. 2018 Oct; 48(4):1046-1058.
Teng HL, Pedoia V, Link TM, Majumdar S, Souza RB. Local associations between knee cartilage T1? and T2 relaxation times and patellofemoral joint stress during walking: A voxel-based relaxometry analysis. Knee. 2018 Jun; 25(3):406-416.
Norman B, Pedoia V, Majumdar S. Use of 2D U-Net Convolutional Neural Networks for Automated Cartilage and Meniscus Segmentation of Knee MR Imaging Data to Determine Relaxometry and Morphometry. Radiology. 2018 07; 288(1):177-185.
Knox J, Pedoia V, Wang A, Tanaka M, Joseph GB, Neumann J, Link TM, Li X, Ma CB. Longitudinal changes in MR T1?/T2 signal of meniscus and its association with cartilage T1p/T2 in ACL-injured patients. Osteoarthritis Cartilage. 2018 May; 26(5):689-696.
Kumar D, Su F, Wu D, Pedoia V, Heitkamp L, Ma CB, Souza RB, Li X. Frontal Plane Knee Mechanics and Early Cartilage Degeneration in People With Anterior Cruciate Ligament Reconstruction: A Longitudinal Study. Am J Sports Med. 2018 Feb; 46(2):378-387.
Lansdown DA, Pedoia V, Zaid M, Amano K, Souza RB, Li X, Ma CB. Variations in Knee Kinematics After ACL Injury and After Reconstruction Are Correlated With Bone Shape Differences. Clin Orthop Relat Res. 2017 Oct; 475(10):2427-2435.
Teng HL, Wu D, Su F, Pedoia V, Souza RB, Ma CB, Li X. Gait Characteristics Associated With a Greater Increase in Medial Knee Cartilage T1? and T2 Relaxation Times in Patients Undergoing Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2017 Dec; 45(14):3262-3271.
Samaan MA, Pedoia V, Zhang AL, Gallo MC, Link TM, Souza RB, Majumdar S. A novel mr-based method for detection of cartilage delamination in femoroacetabular impingement patients. J Orthop Res. 2018 03; 36(3):971-978.
Pedoia V, Samaan MA, Inamdar G, Gallo MC, Souza RB, Majumdar S. Study of the interactions between proximal femur 3d bone shape, cartilage health, and biomechanics in patients with hip Osteoarthritis. J Orthop Res. 2018 01; 36(1):330-341.
Pedoia V, Haefeli J, Morioka K, Teng HL, Nardo L, Souza RB, Ferguson AR, Majumdar S. MRI and biomechanics multidimensional data analysis reveals R2 -R1? as an early predictor of cartilage lesion progression in knee osteoarthritis. J Magn Reson Imaging. 2018 01; 47(1):78-90.
Samaan MA, Facchetti L, Pedoia V, Tanaka MS, Link TM, Souza RB, Ma CB, Li X. Cyclops lesions are associated with altered gait patterns and medial knee joint cartilage degeneration at 1 year after ACL-reconstruction. J Orthop Res. 2017 10; 35(10):2275-2281.
Amano K, Li AK, Pedoia V, Koff MF, Krych AJ, Link TM, Potter H, Rodeo S, Li X, Ma CB, Majumdar S. Effects of Surgical Factors on Cartilage Can Be Detected Using Quantitative Magnetic Resonance Imaging After Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2017 Apr; 45(5):1075-1084.
Gong J, Pedoia V, Facchetti L, Link TM, Ma CB, Li X. Bone marrow edema-like lesions (BMELs) are associated with higher T1? and T2 values of cartilage in anterior cruciate ligament (ACL)-reconstructed knees: a longitudinal study. Quant Imaging Med Surg. 2016 Dec; 6(6):661-670.
Pedoia V, Russell C, Randolph A, Li X, Majumdar S. Principal component analysis-T1? voxel based relaxometry of the articular cartilage: a comparison of biochemical patterns in osteoarthritis and anterior cruciate ligament subjects. Quant Imaging Med Surg. 2016 Dec; 6(6):623-633.
Russell C, Pedoia V, Souza RB, Majumdar S. Cross-sectional and longitudinal study of the impact of posterior meniscus horn lesions on adjacent cartilage composition, patient-reported outcomes and gait biomechanics in subjects without radiographic osteoarthritis. Osteoarthritis Cartilage. 2017 05; 25(5):708-717.
Ku E, Pedoia V, Tanaka M, Heilmeier U, Imboden J, Graf J, Link T, Li X. Evaluating radiocarpal cartilage matrix changes 3-months after anti-TNF treatment for rheumatoid arthritis using MR T1? imaging. J Magn Reson Imaging. 2017 05; 45(5):1514-1522.
Pedoia V, Su F, Amano K, Li Q, McCulloch CE, Souza RB, Link TM, Ma BC, Li X. Analysis of the articular cartilage T1? and T2 relaxation times changes after ACL reconstruction in injured and contralateral knees and relationships with bone shape. J Orthop Res. 2017 03; 35(3):707-717.
Russell C, Pedoia V, Majumdar S. Composite metric R2 ?-?R1? (1/T2 ?-?1/T1? ) as a potential MR imaging biomarker associated with changes in pain after ACL reconstruction: A six-month follow-up. J Orthop Res. 2017 03; 35(3):718-729.
Pedoia V, Gallo MC, Souza RB, Majumdar S. Longitudinal study using voxel-based relaxometry: Association between cartilage T1? and T2 and patient reported outcome changes in hip osteoarthritis. J Magn Reson Imaging. 2017 05; 45(5):1523-1533.
Pandit P, Talbott JF, Pedoia V, Dillon W, Majumdar S. T1? and T2 -based characterization of regional variations in intervertebral discs to detect early degenerative changes. J Orthop Res. 2016 08; 34(8):1373-81.
Russell C, Pedoia V, Amano K, Potter H, Majumdar S. Baseline cartilage quality is associated with voxel-based T1? and T2 following ACL reconstruction: A multicenter pilot study. J Orthop Res. 2017 03; 35(3):688-698.
Amano K, Pedoia V, Su F, Souza RB, Li X, Ma CB. Persistent Biomechanical Alterations After ACL Reconstruction Are Associated With Early Cartilage Matrix Changes Detected by Quantitative MR. Orthop J Sports Med. 2016 Apr; 4(4):2325967116644421.
Gallo MC, Wyatt C, Pedoia V, Kumar D, Lee S, Nardo L, Link TM, Souza RB, Majumdar S. T1? and T2 relaxation times are associated with progression of hip osteoarthritis. Osteoarthritis Cartilage. 2016 08; 24(8):1399-407.
Pedoia V, Majumdar S, Link TM. Segmentation of joint and musculoskeletal tissue in the study of arthritis. MAGMA. 2016 Apr; 29(2):207-21.
Su F, Pedoia V, Teng HL, Kretzschmar M, Lau BC, McCulloch CE, Link TM, Ma CB, Li X. The association between MR T1? and T2 of cartilage and patient-reported outcomes after ACL injury and reconstruction. Osteoarthritis Cartilage. 2016 07; 24(7):1180-9.
Savic D, Pedoia V, Seo Y, Yang J, Bucknor M, Franc BL, Majumdar S. Imaging Bone-Cartilage Interactions in Osteoarthritis Using [18F]-NaF PET-MRI. Mol Imaging. 2016 01 01; 15:1-12.
Lau BC, Thuillier DU, Pedoia V, Chen EY, Zhang Z, Feeley BT, Souza RB. Inter- and intra-rater reliability of patellofemoral kinematic and contact area quantification by fast spin echo MRI and correlation with cartilage health by quantitative T1? MRI. Knee. 2016 Jan; 23(1):13-9.
Wang A, Pedoia V, Su F, Abramson E, Kretzschmar M, Nardo L, Link TM, McCulloch CE, Jin C, Ma CB, Li X. MR T1? and T2 of meniscus after acute anterior cruciate ligament injuries. Osteoarthritis Cartilage. 2016 Apr; 24(4):631-9.
Liu J, Pedoia V, Heilmeier U, Ku E, Su F, Khanna S, Imboden J, Graf J, Link T, Li X. High-temporospatial-resolution dynamic contrast-enhanced (DCE) wrist MRI with variable-density pseudo-random circular Cartesian undersampling (CIRCUS) acquisition: evaluation of perfusion in rheumatoid arthritis patients. NMR Biomed. 2016 Jan; 29(1):15-23.
Pedoia V, Li X, Su F, Calixto N, Majumdar S. Fully automatic analysis of the knee articular cartilage T1? relaxation time using voxel-based relaxometry. J Magn Reson Imaging. 2016 Apr; 43(4):970-80.
Li X, Pedoia V, Kumar D, Rivoire J, Wyatt C, Lansdown D, Amano K, Okazaki N, Savic D, Koff MF, Felmlee J, Williams SL, Majumdar S. Cartilage T1? and T2 relaxation times: longitudinal reproducibility and variations using different coils, MR systems and sites. Osteoarthritis Cartilage. 2015 Dec; 23(12):2214-2223.
Pedoia V, Lansdown DA, Zaid M, McCulloch CE, Souza R, Ma CB, Li X. Three-dimensional MRI-based statistical shape model and application to a cohort of knees with acute ACL injury. Osteoarthritis Cartilage. 2015 Oct; 23(10):1695-703.
Zhou Y, Pandit P, Pedoia V, Rivoire J, Wang Y, Liang D, Li X, Ying L. Accelerating T1? cartilage imaging using compressed sensing with iterative locally adapted support detection and JSENSE. Magn Reson Med. 2016 Apr; 75(4):1617-29.
Zaid M, Lansdown D, Su F, Pedoia V, Tufts L, Rizzo S, Souza RB, Li X, Ma CB. Abnormal tibial position is correlated to early degenerative changes one year following ACL reconstruction. J Orthop Res. 2015 Jul; 33(7):1079-86.
Lansdown DA, Zaid M, Pedoia V, Subburaj K, Souza R, Benjamin C, Li X. Reproducibility measurements of three methods for calculating in vivo MR-based knee kinematics. J Magn Reson Imaging. 2015 Aug; 42(2):533-8.
Binaghi E., Pedoia V., Balbi S.. Collection and fuzzy estimation of truth labels in glial tumor segmentation studies. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. 2014.
Binaghi E., Pedoia V., Guglielmin M.. Snow cover thickness estimation using radial basis function networks. The Cryosphere. 2013; 3(7):841-845.
Pedoia V, Strocchi S, Colli V, Binaghi E, Conte L. Functional magnetic resonance imaging: comparison between activation maps and computation pipelines in a clinical context. Magn Reson Imaging. 2013 May; 31(4):555-66.
Pedoia V, Binaghi E. Automatic MRI 2D brain segmentation using graph searching technique. Int J Numer Method Biomed Eng. 2013 Sep; 29(9):887-904.
Lecture Notes in Computer Science - Image Analysis and Processing. Fully Automatic Brain Tumor Segmentation by using Competitive EM and Graph Cut. 2979:568-578.