Imaging Synaptic Density in the Human Brain with PET
Date
Advanced Imaging Technologies SRG (AIT-SRG) and I are inviting you to the presentation by Professor Richard Carson on Tuesday, December 4. The presentation will start at 12:30pm in the large classroom at China Basin. You can also join the presentation by Zoom: https://ucsf.zoom.us/j/132501262
We will provide light refreshments at China Basin.
1876 America/Los_Angeles publicType
Time Duration
Location
Advanced Imaging Technologies SRG (AIT-SRG) and I are inviting you to the presentation by Professor Richard Carson on Tuesday, December 4. The presentation will start at 12:30pm in the large classroom at China Basin. You can also join the presentation by Zoom: https://ucsf.zoom.us/j/132501262
We will provide light refreshments at China Basin.
Speakers
Director of Biomedical Engineering
A wide variety of neuropsychiatric diseases involve the loss of neurons and synapses. Recently, we developed a new PET radiopharmaceutical, [C-11]UCB-J, which binds selectively to a synaptic vesicle protein, SV2A. This target is ubiquitously expressed in the brain, and thus provides an imaging paradigm to measure synaptic density in humans. The presentation will include the development of this ligand, the in vivo and ex vivo validation studies in nonhuman primates, healthy human studies including test/retest scans, kinetic modeling, and blocking studies to identify reference regions. Initial patient results are shown in temporal lobe epilepsy, where UCB-J shows much larger ipsilateral/contralateral asymmetries than FDG, and in Alzheimer’s disease, which showed a large (~40%) reduction in hippocampus and entorhinal cortex.