Research Directions

General theme: Quantitative molecular imaging instrumentation and physics research

  • Hardware development: Energy-resolving/photon-counting detectors, dark-field x-ray imaging system, novel collimators, and compact systems
  • Software development: Model-based image reconstruction, internal radiation dosimetry calculation, acceleration of algorithms, and radiomics and machine learning-based analysis
  • Application focus: Neuroblastoma, neuroendocrine tumors, small volume imaging (brain, heart, thyroid, etc.), dynamic imaging of heart and brain, prostate cancer, liver cancer, PET/MRI radiomics
  • Preclinical research: Animal imaging (quantification, modeling), molecular imaging probes (in collaboration with radiochemistry groups), molecular pathways (in collaboration with molecular biology groups), and regulatory (IACUC, radiation safety, etc.)
  • Clinical research: Image quantification/quantitation (modeling), protocol development/implementation, scanner QC/QA (phantoms), regulatory (IRB, IND, etc.)

Descriptions of Selected Current and Previous Projects: ( 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 1213)

Recent Key References (PRL PubMed search)

2017

C. Mari Aparici, S. C. Behr, Y. Seo, R. K. Kelley, C. Corvera, K. T. Gao, R. Aggarwal, and M. J. Evans, Imaging hepatocellular carcinoma with 68Ga-citrate PET: First clinical experience, Molecular Imaging 16, 1536012117723256, 2017. [Abstract]

J. S. Huber, A. M. Hernandez, M. Janabi, J. P. O’Neil, K. M. Brennan, S. T. Murphy, Y. Seo, and G. T. Gullberg, Longitudinal evaluation of myocardial fatty acid and glucose metabolism in fasted and non-fasted spontaneously hypertensive rats using microPET/CT, Molecular Imaging 16, 1536012117724558, 2017. [Abstract]

X. Lu, N. Peled, J. Greer, W. Wu, P. Choi, A. H. Berger, S. Wong, K. K. Y. Jen, Y. Seo, B. Hann, A. Brooks, M. Meyerson, and E. A. Collisson, MET exon 14 mutation encodes an actionable therapeutic target in lung adenocarcinoma, Cancer Research 77, 4498-4505, 2017. (Epub ahead of print, published online on May 18, 2017)[Abstract]

J. Yang, Y. Jian, N. Jenkins, S. Behr, T. Hope, P. Larson, D. Vigneron, and Y. Seo, Quantitative evaluation of atlas-based attenuation correction for brain PET imaging using an integrated time-of-flight PET/MRI system, Radiology 284, 169-179, 2017. (Epub ahead of print, published online on February 23, 2017) [Abstract]

M. Hernandez Pampaloni, U. M. Shrestha, M. Sciammarella, Y. Seo, G. T. Gullberg, and E. H. Botvinick, Noninvasive PET quantitative myocardial blood flow with regadenoson for assessing cardiac allograft vasculopathy in orthotopic heart transplantation patients, Journal of Nuclear Cardiology 24, 1134-1144, 2017. (Epub ahead of print, published online on January 30, 2017) [Abstract]

A. P. Leynes, J. Yang, D. D. Shanbhag, S. S. Kaushik, Y. Seo, T. A. Hope, F. Wiesinger, and P. E. Z. Larson, Hybrid ZTE/Dixon MR-based attenuation correction for quantitative uptake estimation of pelvic lesions in PET/MRI, Medical Physics 44, 902-913, 2017. (Epub ahead of print, published online on January 23, 2017) [Abstract]

J. Yang, M. Khalighi, T. A. Hope, K. Ordovas, and Y. Seo, Fast respiratory motion estimation using sorted singles without unlist processing: A feasibility study, Medical Physics 44, 1632-1637, 2017. (Epub ahead of print, published online on January 18, 2017) [Abstract]

E. F. Jones, K. M. Ray, W. Li, Y. Seo, B. L. Franc, A. J. Chien, L. J. Esserman, M. H. Pampaloni, B. N. Joe, N. M. Hylton, Dedicated breast positron emission tomography for the evaluation of early response to neoadjuvant chemotherapy in breast cancer, Clinical Breast Cancer 17, e155-e159, 2017. (Epub ahead of print, published online on December 29, 2016) [Abstract]

E. J. Arentson-Lantz, I. Saeed, L. Frassetto, U. Masharani, R. Harnish, Y. Seo, H. VanBrocklin, R. Hawkins, C. Mari Aparici, M. Hernandez Pampaloni, J. Slater, D. Paddon-Jones, and T. F. Lang, 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: Response to protein supplementation compared to  L-[ring 13C6] phenylalanine infusion with serial muscle biopsy, Annals of Nuclear Medicine 31, 295-303, 2017. (Epub ahead of print, published online on March 4, 2017) [Abstract]

J. Y. Choi, J. Yang, S. Noworolski, S. Behr, J. Kurhanewicz, A. J. Chang, J. P. Simko, H. Nguyen, P. R. Carroll, and Y. Seo, 18F-fluorocholine dynamic time-of-flight PET/MRI in unfavorable intermediate to high risk prostate cancer: Clinicopatholigical comparisons, Radiology 282, 429-436, 2017. (Epub ahead of print, published online on August 11, 2016) [Abstract]

U. Shrestha, M. Sciammarella, F. Alhassen, Y. Yeghiazarians, J. Ellin, E. Verdin, A. Boyle, Y. Seo, E. H. Botvinick, and G. T. Gullberg, Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin, Journal of Nuclear Cardiology 24, 268-277, 2017. (Epub ahead of print, published on December 29, 2015) [Abstract]

U. Shrestha, and Y. Seo, Myocardial blood flow as a biomarker, in V. B. Patel and V. R. Preedy (eds): “Biomarkers in Cardiovascular Disease”, Springer Science+Business Media, 1057-1076, 2016.

2016

N. Tran, A. Giannakidis, G. T. Gullberg, and Y. Seo, Quantitative analysis of hypertrophic myocardium using diffusion tensor magnetic resonance imaging, Journal of Medical Imaging 3, 046001, 2016. [Abstract]

S. Behr, R. Aggarwal, Y. Seo, C. M. Aparici, E. Chang, E. J. Small, and M. J. Evans, A feasibility study showing 68Ga-citrate PET detects prostate cancer, Molecular Imaging and Biology 18, 946-951, 2016. (Epub ahead of print, published on May 16, 2016) [Abstract]

I. L. Aanei, A. M. ElSohly, M. E. Farkas, C. Netirojjanakul, M. Regan, S. T. Murphy, J. P. O’Neil, Y. Seo, and M. B. Francis, Biodistribution of antibody-MS2 viral capsid conjugates in breast cancer models, Molecular Pharmaceutics 13, 3764-3772, 2016. (Epub ahead of print, published on September 9, 2016) [Abstract]

U. Shrestha, and Y. Seo, Myocardial blood flow as a biomarker, in V. B. Patel and V. R. Preedy (eds): “Biomarkers in Cardiovascular Disease”, Springer Science+Business Media, 1-21, 2016.

Aanei IL, ElSohly AM, Farkas ME, Netirojjanakul C, Regan M, Murphy ST, O’Neil JP, Y. Seo, and M. B. Francis, Biodistribution of antibody-MS2 viral capsid conjugates in breast cancer models, Molecular Pharmaceutics 13, 3764-3772, 2016. (Epub ahead of print, published on September 9, 2016) [Abstract]

Li L, et al. Mol Imaging Biol. 2016

L. Li, L. Che, C. Wang, J. E. Blecha, X. Li, H. F. VanBrocklin, D. F. Calvisi, M. Puchowicz, X. Chen, and Y. Seo, [11C]acetate PET imaging is not always associated with increased lipogenesis in hepatocellular carcinoma in mice, Molecular Imaging and Biology 18, 360-367, 2016. (Epub ahead of print, published online on November 13, 2015) [Abstract]

C. J. Schankin, F. H. Maniyar, Y. Seo, S. Kori, M. Eller, D. E. Chou, J. Blecha, S. T. Murphy, J. Slater, R. A. Hawkins, T. Sprenger, H. F. VanBrocklin, and P. J. Goadsby, Ictal lack of binding to brain paranchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine, Brain 139, 1994-2001, 2016. (Epub ahead of print, published online on May 27, 2016) [Abstract]

Y. Chen, Y. Cui, P. O’Connor, Y. Seo, G. S. Camarda, A. Hossain, U. Roy, G. Yang, and R. B. James, Stability of the baseline holder in readout circuits for radiation detectors, IEEE Transactions on Nuclear Science 63, 316-324, 2016. [Abstract]

C. P. Chen, J. Johnson, Y. Seo, V. K. Weinberg, K. Shinohara, I. C. Hsu, M. Roach III, Sentinel lymph node imaging guided IMRT for prostate cancer: Individualized pelvic radiotherapy vs RTOG guidelines, Advances in Radiation Oncology 1, 51-58, 2016. (Epub ahead of print, published on December 16, 2015) [Abstract]

2015

F. Weng, S. Bagchi, Y. Zan, Q. Huang, and Y. Seo, An energy-optimized collimator design for a CZT-based SPECT camera, Nuclear Instruments and Methods A 806, 330-337, 2015.[Abstract]

Shrestha U, et al. Phys Med Biol. 2015

U. Shrestha, Y. Seo, E. H. Botvinick, and G. T. Gullberg, Image reconstruction in higher dimension: Myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration, Physics in Medicine and Biology 60, 8275-8301, 2015.[Abstract]

C. Mari Aparici, R. A. Hawkins, and Y. Seo, Sentinel node SPECT/CT imaging for tumor staging: Protocols, normal findings, artifacts, pitfalls and clinical applications, in G. von Schulthess (ed): “Clinical Molecular Anatomic Imaging: PET/CT, SPECT/CT and PET/MR”, Lippincott Williams & Wilkins, 333-340, 2015. [Abstract]

M. L. Truitt, C. S. Conn, Z. Shi, X. Pang, T. Tokuyasu, A. Coady, Y. Seo, M. Barna, and D. Ruggero, Differential requirements for eIF4E dose in normal development and cancer, Cell 162, 59-71, 2015. [Abstract]

Huang SY, et al. Mol Imaging Biol. 2015

S. Y. Huang, W. E. Bolch, C. Lee, M. Pampaloni, R. A. Hawkins, H. F. VanBrocklin, A. Sznewajs, S. G. DuBois, K. K. Matthay, and Y. Seo, Patient-specific dosimetry using pretherapy [124I]m-iodobenzylguanidine ([124I]mIBG) dynamic PET/CT before [131I]mIBG targeted radionuclide therapy for neuroblastoma, Molecular Imaging and Biology 17, 284-294, 2015. (Epub ahead of print, published online on August 22, 2014) [Abstract]

R. F. Barajas, M. H. Pampaloni, J. L. Clarke, Y. Seo, D. Savic, R. A. Hawkins, S. C. Behr, S. M. Chang, M. Berger, W. P. Dillon, and S. Cha, Assessing biological response to bevacizumab using 18F-fluoromisonidazole PET/MR imaging in a patient with recurrent anaplastic astrocytoma, Case Reports in Radiology 2015, 731361, 2015. [Abstract]

2014

M. D. Bucknor, A. E. Horvai, V. Rieke, Y. Seo, R. A. Hawkins, S. Majumdar, T. M. Link, and M. Saeed, Bone remodeling after MR imaging-guided high intensity focused ultrasound ablation: Evaluation with MR imaging, CT, Na18F, and histopathologic evaluation in a swine model, Radiology, 387-394, 2015. (Epub ahead of print, published online on October 8, 2014) [Abstract]

T. C. Lee, J. D. Bowen, J. R. Ellin, Q. Huang, U. Shrestha, G. T. Gullberg, Y. Seo, Multipinhole collimator with 20 apertures for a brain SPECT application, Medical Physics 41, 112501, 2014. [Abstract]

T. C. Lee, A. J. Burghardt, W. Yao, N. E. Lane, S. Majumdar, G. T. Gullberg, and Y. Seo, Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats, Calcified Tissue International 95, 282-291, 2014. (Epub ahead of print, published online on August 9, 2014) [Abstract]

A. T. Jang, J. D. Lin, Y. Seo, S. Etchin, A. Merkle, K. Fahey, and S. P. Ho, In situ compressive loading and correlative imaging of the bone-periodontal ligament-tooth fibrous joint, Journal of Visualized Experiments 85, e51147, 2014. [Abstract]

Y. Seo and C. Mari Aparici, Dual-modality preclinical SPECT/CT instrumentation, In H Zaidi (ed): “Molecular Imaging of Small-Animals: Instrumentation and Applications”, Springer, 351-365, 2014.

F. Alhassen, N. Nguyen, S. Bains, R. G. Gould,Y. Seo, S. L. Bacharach, X. Song, L. Shao, G. T. Gullberg, and C. Mari Aparici, Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions – A clinical feasibility study, American Journal of Nuclear Medicine and Molecular Imaging 4, 53-59, 2014. [Abstract]

2013

Hernandez AM, et al. J Nucl Med. 2013

A. M. Hernandez, S. T. Murphy, G. L. Zeng, M. Janabi, K. M. Brennan, Y. Seo, and G. T. Gullberg, Longitudinal evaluation of left ventricular substrate metabolism, perfusion, and dysfunction in the SHR model of hypertrophy using microPET imaging, Journal of Nuclear Medicine 54, 1938-1945, 2013. (Epub ahead of print, published online on October 3, 2013) [Abstract]

Bowen JD, et al. Phys Med Biol. 2013

J. D. Bowen, Q. Huang, J. R. Ellin, T. –C. Lee, U. Shrestha, G. T. Gullberg, and Y. Seo, Design and performance evaluation of a 20-aperture multipinhole collimator for myocardial perfusion imaging applications, Physics in Medicine and Biology 58, 7209-7226, 2013. [Abstract]

A. J. Chang, Y. Seo, S. Behr, and M. Roach III, The utility of C-11 choline PET/CT for prostate cancer: Improving detection of locoregional and metastatic disease, Expert Editorial for 2014 Genitourinary Cancers Symposium: A Transformative Multidisciplinary Approach. 2013.

Thuering T, et al. Appl Phys Lett. 2013

T. Thuering, W. C. Barber, Y. Seo, F. Alhassen, and M. Stampanoni, Energy resolved x-ray grating interferometry, Applied Physics Letters 102,191113, 2013. [Abstract]

 

Y. Seo, J. He, and B. L. Franc, PreClinical SPECT and SPECT-CT in Oncology, In Schober O, Riemann B (eds): “Recent Results in Cancer Research, Vol. 187 – Molecular Imaging in Oncology”, Springer Science+Business Media, 193-220, 2013. [Abstract]

2012

J. C. Durack, T. A. Hope, Y. Seo, M. Saeed, J. He, M. W. Wilson, R. K Kerlan, Jr., and E. J. Ring, Intravenous vasopressin for the prevention of nontarget gastrointestinal embolization during liver-directed cancer treatment: Experimental study in a porcine model, Journal of Vascular and Interventional Radiology 23, 1505-1512, 2012. [Abstract]

C. Mari Aparici and Y. Seo, Functional imaging for prostate cancer: Therapeutic implications, Seminars in Nuclear Medicine 42, 328-342, 2012. [Abstract]

L. Carbone, E. T. Carbone, E. M. Yi, D. B. Bauer, K. A. Lindstrom, J. M. Parker, J. A. Austin, Y. Seo, A. D. Gandhi, and J. D. Wilkerson, Assessing cervical dislocation as a humane euthanasia method in mice, Journal of the American Association of Laboratory Animal Science 51, 352-356, 2012. [Abstract]

Seo Y. Mol Imaging Biol. 2012

Y. Seo, W. C. Gustafson, S. Dannoon, C. L. Lee, S. Taylor, H. F. VanBrocklin, M. Hernandez-Pampaloni, D. A. Haas-Kogan, W. A. Weiss, and K. K. Matthay, Tumor dosimetry of 131I-MIBG using 124I-MIBG microPET/CT in animal xenograft model of neuroblastoma, Molecular Imaging and Biology 14, 734-742, 2012. (Epub ahead of print, published online on March 2, 2012). [Abstract]

R. Harnish, T. Streeper, I. Saeed, C. Schreck, S. Dannoon, J. Blecha, H. VanBrocklin, M. Hernandez-Pampaloni, R. Hawkins,Y. Seo, G. Sayre, J. Slater, and T. Lang, Quantification of changes in skeletal muscle amino acid kinetics in adult humans in response to exercise via positron-emission tomography with L-[methyl-11C] methionine, Journal of Molecular Imaging and Dynamics 2, 1000103, 2012. [Abstract]

Yuneva MO, et al. Cell Metab. 2012

M. O. Yuneva, T. W. M. Fan, T. D. Allen, R. M. Higashi, D. V. Ferraris, T. Tsukamoto, J. M. Mates, F. J. Alonso, C. Wang, Y. Seo, X. Chen, and J. M. Bishop, The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metabolism 15, 157-170, 2012. [Abstract]

 


J. Yang, T. Yamamoto, B. C. Cho, Y. Seo, and P. J. Keall, Audiovisual biofeedback reduces motion blurring artifacts in 4D PET images, Medical Physics 39, 1046-1057, 2012. [Abstract]

C. Mari Aparici, D. Carlson, N. Nguyen, R. A. Hawkins, and Y. Seo, Potential of SPECT combined with multidetector CT for prostate cancer evaluations, American Journal of Nuclear Medicine and Molecular Imaging 2, 48-54, 2012. [Abstract]

G. Sayre, S. L. Bacharach, M. W. Dae, and Y. Seo, Combining dynamic and ECG-gated 82Rb-PET for practical implementation in the clinic, Nuclear Medicine Communications 33, 4-13, 2012. [Abstract]

2011

S. Kim, M. McClish, F. Alhassen,Y. Seo, K. S. Shah, and R. G. Gould, Temperature dependent operation of PSAPD-based compact gamma camera for SPECT imaging, IEEE Transactions on Nuclear Science 58, 2169-2174, 2011. [Abstract]

Y. Seo, C. Mari Aparici, and R. A. Hawkins, ProstaScint SPECT/CT Atlas, In Fanti S, Farsad M, Mansi L (eds): “Atlas of SPECT-CT: A quick guide to optimal use”, Springer-Verlag, 80-85, 2011. 

G. A. Sayre, B. L. Franc BL, and Y. Seo, Patient-specific method of generating parametric maps of Patlak Ki without blood sampling or metabolite correction: A feasibility study, International Journal of Molecular Imaging 2011, 185083. (doi:10.1155/2011/185083) [Abstract]

F. Alhassen, H. Kudrolli, B. Singh, S. Kim,Y. Seo, R. G. Gould, and V. V. Nagarkar, Depth-of-interaction compensation using a focused-cut scintillator for a pinhole gamma camera, IEEE Transactions on Nuclear Science 58, 634-638, 2011. [Abstract]

Y. Seo, C. Mari Aparici, P. Chen, C. Hsu, N. Kased, C. Schreck, N. Costouros, R. Hawkins, K. Shinohara, and M. Roach, Mapping of lymphatic drainage from the prostate using filtered 99mTc-sulfur nanocolloid and SPECT/CT, Journal of Nuclear Medicine 52, 1068-1072, 2011. [Abstract]

S. S. More, M. Itsara, X. Yang, E. G. Geier, M. K. Tadano,Y. Seo, H. F. VanBrocklin, W. A. Weiss, S. Mueller, D. A. Haas-Kogan, S. G. DuBois, K. K. Matthay, and K. M. Giacomini, Vorinostat increases expression of functional norepinephrine transporter in neuroblastomain vitroandin vivomodel systems, Clinical Cancer Research 17, 2339-2349, 2011. [Abstract]

A. K. Iyer, X. Lan, X. Zhu, Y. Su, J. Feng, X. Zhang, D. Gao,Y. Seo, H. F. VanBrocklin, V. C. Broaddus, B. Liu, and J. He, Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas, Cancer Research 71, 2428-2432, 2011. [Abstract]

Alhassen F, et al. Proc SPIE. 2011

F. Alhassen, H. Kudrolli, B. Singh, S. Kim,Y. Seo, R. G. Gould, and V. V. Nagarkar, A preclinical SPECT camera with depth-of-interaction compensation using a focused-cut scintillator, Proceedings of SPIE 7961, 796121, 2011. [Abstract]

A. K. Iyer, Y. Su, J. Feng, X. Lan, X. Zhu, Y. Liu, D. Gao,Y. Seo, H. F. VanBrocklin, V. C. Broaddus, B. Liu, and J. He, The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma, Biomaterials 32, 2605-2613, 2011. [Abstract]

2010

S. Kim, M. McClish, F. Alhassen,Y. Seo, K. S. Shah, and R. G. Gould, Phantom experiments on a PSPAD-based compact gamma camera with submillimeter spatial resolution for small animal SPECT, IEEE Transactions on Nuclear Science 57, 2518-2523, 2010. [Abstract]

Junttila MR, et al. Nature. 2010

M. R. Junttila, A. Karnezis, D. Garcia, F. Madriles, R. M. Kortlever, F. Rostker, L. Brown-Swigart, D. M. Pham,Y. Seo, G. I. Evan, and C. P. Martins, Selective activation of p53-mediated tumor suppression in high grade tumours, Nature 468, 567-571, 2010. [Abstract]

 

 

C. L. Lee, H. Wahnishe, G. A. Sayre, H.-M. Cho, H.-J. Kim, M. Hernandez-Pampaloni, R. A. Hawkins, S. F. Dannoon, H. F. VanBrocklin, M. Itsara, W. A. Weiss, X. Yang, D. A. Haas-Kogan, K. K. Matthay, and Y. Seo, Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET, Medical Physics 37,4861-4867, 2010. [Abstract]

C. D. Winant, S. Kim, and Y. Seo, Functional imaging combined with multi-detector CT: A Radionuclide imaging perspective, Current Medical Imaging Reviews 6,100-111, 2010. [Abstract]

J. He, Y. Wang, J. Feng, X. Zhu, X. Lan, A. Iyer,Y. Seo, H. F. VanBrocklin, and B. Liu, Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment, Journal of Nuclear Medicine 51, 427-432 2010. [Abstract]

Seo Y, et al. J Nucl. Med. 2010

Y. Seo, C. Mari Aparici, M. R. Cooperberg, B. R. Konety, and R. A. Hawkins, In vivo tumor grading of prostate cancer using quantitative 111In-capromab pendetide SPECT/CT, Journal of Nuclear Medicine 51, 31-36, 2010. [Abstract]

2009

M. -H. Pan, D. -W. Gao, J. Feng, J. He, Y. Seo, J. Tedesco, J. G. Wolodzko, B. H. Hasegawa, and B. L. Franc, Biodistributions of 177Lu- and 111In- labeled 7E11 antibodies to prostate-specific membrane antigen in xenograft model of prostate cancer and potential use of 111In-7E11 as a pretherapeutic agent for 177Lu-7E11 radioimmunotherapy, Molecular Imaging and Biology 11, 159-166, 2009. [Abstract]

2008

Y. Seo, B. K. Teo, M. Hadi, C. Schreck, S. L. Bacharach, and B. H. Hasegawa, Quantitative accuracy of PET/CT for image-based kinetic analysis, Medical Physics 35, 3086-3089, 2008. [Abstract]

Y. Seo, C. M. Aparici, and B. H. Hasegawa, Technological development and advances in SPECT/CT, Seminars in Nuclear Medicine 38, 177-198, 2008. [Abstract]

Seo Y, et al. Phys Med Biol. 2008

Y. Seo, T. Hashimoto, Y. Nuki, and B. H. Hasegawa, In vivo microCT imaging of rodent cerebral vasculature, Physics in Medicine and Biology 53, N99-N107, 2008. [Abstract]

J. He, H. F. VanBrocklin, B. L. Franc,Y. Seo, and E. F. Jones, Nanoprobes for medical diagnosis: Current status of nanotechnology in molecular imaging, Current Nanoscience 4, 17-29, 2008. [Abstract]

B. K. Teo, S. Badiee, M. Hadi, T. Lam, L. Johnson, Y. Seo, S. L. Bacharach, B. H. Hasegawa, and B. L. Franc, Correcting tumor SUV for enhanced bone marrow uptake: Retrospective 18F-FDG PET-CT studies, Nuclear Medicine Communications 29, 359-366, 2008. [Abstract]

Y. Seo, Quantification of SPECT and PET for drug development, Current Radiopharmaceuticals 1, 17-21, 2008. [Abstract]

2007

Teo BK, et al. J Nucl. Med. 2007

B. K. Teo,Y. Seo, S. L. Bacharach, J. A. Carrasquillo, S. K. Libutti, H. Shukla, B. H. Hasegawa, R. A. Hawkins, and B. L. Franc, Partial volume correction in PET: Validation of an iterative post-reconstruction method with phantom and patient data, Journal of Nuclear Medicine 48, 802-810, 2007. [Abstract]

Y. Seo, D. W. Gao, B. H. Hasegawa, M. W. Dae, and B. L. Franc BL, Rodent brain imaging with SPECT/CT, Medical Physics 34, 1217-1220, 2007. [Abstract]

2006

Y. Seo, B. L. Franc, R. A. Hawkins, K. H. Wong, and B. H. Hasegawa, Progress in SPECT/CT imaging of prostate cancer, Technology in Cancer Research and Treatment 5, 329-336, 2006. [Abstract]

2005

Y. Seo, K. H. Wong, and B. H. Hasegawa, Calculation and validation of the use of effective attenuation coefficient for attenuation correction in In-111 SPECT, Medical Physics 32, 3628-3635, 2005. [Abstract]

Y. Seo, J. Kurhanewicz, B. L. Franc, R. A. Hawkins, and B. H. Hasegawa, Improved prostate cancer imaging with SPECT/CT and MRI/MRSI, IEEE Transactions on Nuclear Science 52, 1316-1320, 2005. [Abstract]

Seo Y, et al. J Nucl Med. 2005

Y. Seo, K. H. Wong, M. Sun, B. L. Franc, R. A. Hawkins, and B. H. Hasegawa, Correction of photon attenuation and collimator response for a body-contouring SPECT/CT imaging system, Journal of Nuclear Medicine 46, 868-877, 2005. [Abstract]

2004

Y. Seo, K. H. Wong, B. L. Franc, R. A. Hawkins, and B. H. Hasegawa, Dual-modality imaging of prostate cancer with a commercial SPECT/CT system, in Proceedings of the XIVth international conference on the use of computers in radiation therapy held at Seoul, Korea, May 10 - May 13, 2004, edited by B. Y. Yi, S. D. Ahn, E. K. Choi, and S. W. Ha (Jeong Publishing Co., Ltd, Seoul, 2004), 559-561, 2004. 

Hasegawa BH, et al. Nucl Instrum Meth A. 2004

B. H. Hasegawa, W. C. Barber, T. Funk, A. B. Hwang, A. E. Sakdinawat, C. Taylor, M. Sun, and Y. Seo, Implementation and applications of dual-modality imaging, Nuclear Instruments and Methods A 525, 236-241, 2004. [Abstract]