Upcoming Presentations

Date Event Format Location
Tuesday, March 10, 2015

12:00-1:00 PM

"Molecular Imaging and the Advancement of Therapeutic Candidates into Early Clinical Trials"

PSPG/BioE Seminar

Graduate Programs in Bioengineering and Pharmaceutical Sciences & Pharmacogenomics Seminar Series PSPG 220
Presents Visiting Speaker:

Simon Williams, D. Phil.
Principal Scientist, Biomedical Imaging, Genentech

"Molecular imaging and the advancement of therapeutic candidates into early clinical trials"
"Irrational exuberance" isn’t just a problem for asset prices; excitement around potential new cancer therapies often builds on slender evidence prior to testing in a significant number of real patients, and there are too many therapeutic candidates and combinations to test them all empirically in large trials.  Molecular imaging can have an important biomarker role in drug development by helping to confirm, particularly in patients, that a novel therapeutic is exhibiting the expected mechanism of action.  This information bolsters confidence that we really do understand the biological rationale before advancing a candidate for further investment.

The utility of zirconium-89 immuno-PET is particularly clear in the development of antibody-drug conjugates (ADCs) because of the similarities between the biological processes driving image intensity and drug delivery, but the application of this technology to related challenges such as measuring target expression or receptor occupancy need further thought, and other techniques may be optimal.  Examples of the use of immuno-PET and its associated logistics will be discussed along with considerations of what is desirable in PET biomarkers of early treatment response in evaluating novel cancer immunotherapies.

Speaker Biography:
Simon Williams studied biochemistry at the University of Oxford, England, in the eighties where he worked in George Radda’s lab learning the basics of phosphorus-31 NMR spectroscopy in living systems.

After graduate studies and a post-doc using fluorine-19 NMR spectroscopy to examine enzyme dynamics in vivo with Kevin Brindle, Simon moved from Cambridge, England, to Genentech in 1995 to help establish the Biomedical Imaging group there.

Over the years and in response to repeated questions from colleagues about “where is my antibody?”, “can we see apoptosis in vivo?”, “is my drug getting to the tumor?" and suchlike, Simon set up first a SPECT lab (with encouragement from Dr. Bruce Hasegawa) and then a full PET lab to enable more translationally relevant molecular imaging to support research and drug development.

Host: Youngho Seo, Ph.D.Youngho.Seo@ucsf.edu

Contact sarahjane.taylor@ucsf.edu for more information.
Seminar Mission Bay RH-102, Rock Hall, UCSF Mission Bay Campus Simulcast to Room N-217, Parnassus Campus UCSF
Thursday, March 12, 2015

5:00 PM refreshments; 5:30 PM LECTURE

How Radiologists Can Add Value to the Management of Patients with Crohn’s Disease

The Earl Miller Memorial Lecture

Dr. John R Leyendecker

John R. Leyendecker, M.D.
Professor of Radiology
Vice-Chair, Clinical Operations
University of Texas, Southwestern
Dallas, TX

Dr. John R. Leyendecker completed his Medical School at the University of Pennsylvania in Philadelphia and diagnostic radiology residency at Emory University in Atlanta. His first fellowship was in vascular and interventional radiology at Wilford Hall Medical Center in San Antonio in 1993-1994, and his second fellowship was in body MRI at the Mallinckrodt Institute of Radiology in St. Louis in 2001-2002. He has held faculty positions in the Abdominal Imaging sections of the University of Texas Health Sciences Center in San Antonio and Wake Forest University School of Medicine in Winston-Salem. In 2015, he joined the Radiology Department at UT Southwestern where he currently serves as Vice-Chair of Clinical Operations and as a member of the Abdominal Imaging Section.

Dr. Leyendecker has served on numerous committees of the RSNA, SAR, ACR, ABR, and ARRS related to MRI and Genitourinary and Gastrointestinal Imaging. He has co-authored two textbooks on the topics of abdominal imaging and MRI and is currently the Igor Laufer Visiting Professor for the Society of Abdominal Radiology.

About the Earl Miller Lecture:  Earl Miller, MD was one of the outstanding radiologists of his generation, and was the second Chairman of the Department of Radiology and Biomedical Imaging at UCSF.

Contact katherine.murphy@ucsf.edu for more information.
Lecture Parnassus HSW-303
Friday, March 13, 2015

10:30-11:30 AM Surbeck Young Investigator Presentations & Awards
11:30 AM Lunch

The Surbeck Young Investigator Awards

Sponsored by INDNJC Foundation and the Margaret Hart Surbeck Laboratory

Join Dr. Sarah Nelson and members of the INDNJC Foundation at the annual Surbeck Young Investigator Awards on Friday, March 13, 2015 at Mission Bay's Genentech Hall.

Winning scholar presentations will highlight cutting-edge research done in the Surbeck Laboratory. Presentations will be held from 10:30-11:30 AM, followed by the Award Ceremony. Members of the UCSF community and Department of Radiology and Biomedical Imaging are invited to this annual event. 

The Margaret Hart Surbeck Laboratory of Advanced Imaging is dedicated to advancing imaging techniques for biological and medical applicaitons.

Contact cathy.devine@ucsf.edu for more information.
Mission Bay N-114 (Genentech Hall)