We use multi-parametric in vivo imaging data to target cancer tissues in prostate cancer patients who undergo biopsy and/or radical prostatectomy for prostate cancer for the purpose of new biomarker development, validation and clinical translation. 1H HR-MAS is a non-destructive ex vivo technique that can enhance spectral resolution in spectroscopic examinations of intact biological tissues prior to the pathologic, immunohistochemical and genetic and proteomic analysis of the same tissue sample. This imaging biomarker discovery research has lead to the establishment of the Biomedical NMR lab, which I direct. The Biomedical NMR lab is a UCSF research resource and is being utilized by a large number of UCSF investigators performing biomarker studies of a variety of diseases.