Marina Lopez Alvarez, PhD
Specialist
Education
Ph.D, 08/2021 - Medical Microbiology, University Medical Center Groningen
Publications
Schoenmakers JWA, López-Álvarez M, IJpma FFA, Wouthuyzen-Bakker M, McNamara JO, van Oosten M, Jutte PC, van Dijl JM. Correction to: A fluorogenic micrococcal nuclease‑based probe for fast detection and optical imaging of Staphylococcus aureus in prosthetic joint and fracture‑related infections. Eur J Nucl Med Mol Imaging. 2024 Aug; 51(10):3149.
Pandey A, Chopra S, Cleary SJ, López-Álvarez M, Quimby FM, Alanizi AAA, Sakhamuri S, Zhang N, Looney MR, Craik CS, Wilson DM, Evans MJ. Imaging the Granzyme Mediated Host Immune Response to Viral and Bacterial Pathogens In Vivo Using Positron Emission Tomography. ACS Infect Dis. 2024 Jun 14; 10(6):2108-2117.
Alanizi AA, Sorlin AM, Parker MFL, López-Álvarez M, Qin H, Lee SH, Blecha J, Rosenberg OS, Engel J, Ohliger MA, Flavell RR, Wilson DM. Bioorthogonal Radiolabeling of Azide-Modified Bacteria Using [18F]FB-sulfo-DBCO. Bioconjug Chem. 2024 04 17; 35(4):517-527.
Sorlin AM, López-Álvarez M, Biboy J, Gray J, Rabbitt SJ, Rahim JU, Lee SH, Bobba KN, Blecha J, Parker MFL, Flavell RR, Engel J, Ohliger M, Vollmer W, Wilson DM. Peptidoglycan-Targeted [18F]3,3,3-Trifluoro-d-alanine Tracer for Imaging Bacterial Infection. JACS Au. 2024 Mar 25; 4(3):1039-1047.
Lee SH, Kim JM, López-Álvarez M, Wang C, Sorlin AM, Bobba KN, Pichardo-González PA, Blecha J, Seo Y, Flavell RR, Engel J, Ohliger MA, Wilson DM. Imaging the Bacterial Cell Wall Using N-Acetyl Muramic Acid-Derived Positron Emission Tomography Radiotracers. ACS Sens. 2023 12 22; 8(12):4554-4565.
Schoenmakers JWA, López-Álvarez M, IJpma FFA, Wouthuyzen-Bakker M, McNamara JO, van Oosten M, Jutte PC, van Dijl JM. A fluorogenic micrococcal nuclease-based probe for fast detection and optical imaging of Staphylococcus aureus in prosthetic joint and fracture-related infections. Eur J Nucl Med Mol Imaging. 2024 Aug; 51(10):2988-2997.
Parker MFL, López-Álvarez M, Alanizi AA, Luu JM, Polvoy I, Sorlin AM, Qin H, Lee S, Rabbitt SJ, Pichardo-González PA, Ordonez AA, Blecha J, Rosenberg OS, Flavell RR, Engel J, Jain SK, Ohliger MA, Wilson DM. Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis. J Infect Dis. 2023 10 03; 228(Suppl 4):S281-S290.
Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, Fraser JS, Wilson DM. Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [18F] FDG Yield Potent Sensors of Living Bacteria In Vivo. J Am Chem Soc. 2023 08 16; 145(32):17632-17642.
Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, Fraser JS, Wilson DM. Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from [ 18 F]FDG yield potent sensors of living bacteria in vivo. bioRxiv. 2023 May 20.
López-Álvarez M, Ulmer H, Klay N, van Dijl JM. New In Situ-Generated Polymer-Iodine Complexes with Broad-Spectrum Antimicrobial Activity. Microbiol Spectr. 2022 10 26; 10(5):e0055022.
du Teil Espina M, Fu Y, van der Horst D, Hirschfeld C, López-Álvarez M, Mulder LM, Gscheider C, Haider Rubio A, Huitema M, Becher D, Heeringa P, van Dijl JM. Coating and Corruption of Human Neutrophils by Bacterial Outer Membrane Vesicles. Microbiol Spectr. 2022 10 26; 10(5):e0075322.
du Teil Espina M, Haider Rubio A, Fu Y, López-Álvarez M, Gabarrini G, van Dijl JM. Outer membrane vesicles of the oral pathogen Porphyromonas gingivalis promote aggregation and phagocytosis of Staphylococcus aureus. Front Oral Health. 2022; 3:948524.
López-Álvarez M, Heuker M, Sjollema KA, van Dam GM, van Dijl JM, IJpma FFA, van Oosten M. Bacteria-targeted fluorescence imaging of extracted osteosynthesis devices for rapid visualization of fracture-related infections. Eur J Nucl Med Mol Imaging. 2022 06; 49(7):2276-2289.
Park HY, Zoller SD, Hegde V, Sheppard W, Burke Z, Blumstein G, Hamad C, Sprague M, Hoang J, Smith R, Romero Pastrana F, Czupryna J, Miller LS, López-Álvarez M, Bispo M, van Oosten M, van Dijl JM, Francis KP, Bernthal NM. Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections. Sci Rep. 2021 01 15; 11(1):1622.
Prajapati B, Bernal-Cabas M, López-Álvarez M, Schaffer M, Bartel J, Rath H, Steil L, Becher D, Völker U, Mäder U, van Dijl JM. Double trouble: Bacillus depends on a functional Tat machinery to avoid severe oxidative stress and starvation upon entry into a NaCl-depleted environment. Biochim Biophys Acta Mol Cell Res. 2021 02; 1868(2):118914.
Bispo M, Anaya-Sanchez A, Suhani S, Raineri EJM, López-Álvarez M, Heuker M, Szymanski W, Romero Pastrana F, Buist G, Horswill AR, Francis KP, van Dam GM, van Oosten M, van Dijl JM. Fighting Staphylococcus aureus infections with light and photoimmunoconjugates. JCI Insight. 2020 11 19; 5(22).
López-Álvarez M, Heuker M, Schoenmakers JWA, van Dam GM, McNamara JO, van Dijl JM, van Oosten M. The smart activatable P2&3TT probe allows accurate, fast, and highly sensitive detection of Staphylococcus aureus in clinical blood culture samples. Sci Rep. 2020 11 05; 10(1):19216.
Schoenmakers JWA, Heuker M, López-Álvarez M, Nagengast WB, van Dam GM, van Dijl JM, Jutte PC, van Oosten M. Image-guided in situ detection of bacterial biofilms in a human prosthetic knee infection model: a feasibility study for clinical diagnosis of prosthetic joint infections. Eur J Nucl Med Mol Imaging. 2021 03; 48(3):757-767.
Reeßing F, Bispo M, López-Álvarez M, van Oosten M, Feringa BL, van Dijl JM, Szymanski W. A Facile and Reproducible Synthesis of Near-Infrared Fluorescent Conjugates with Small Targeting Molecules for Microbial Infection Imaging. ACS Omega. 2020 Sep 08; 5(35):22071-22080.
Monterroso B, Zorrilla S, Sobrinos-Sanguino M, Robles-Ramos MA, López-Álvarez M, Margolin W, Keating CD, Rivas G. Bacterial FtsZ protein forms phase-separated condensates with its nucleoid-associated inhibitor SlmA. EMBO Rep. 2019 01; 20(1).