RORL Grants

Featured Grants

NIH CT DOSE Collaboration: Partnership for Dose, 5 years, $7.9M total
(PI: Smith-Bindman) 07/02/2014 – 06/30/2019
This multi-site Dissemination and Implementation study will assess diagnostic CT radiation doses across 27 institutions and 150 hospitals, and disseminate findings to the broader radiology and medical community. This mixed methods study includes surveys at each hospital to explore variation in dose and to identify barriers and facilitators to implementing successful dose optimization strategies.  
 
NIH Risk of Cancer in Childhood and Adolescence Associated with Medical Imaging, 5 years, $10.6M total
(PI: Smith-Bindman) 03/01/2015 – 02/28/2020
This study seeks to evaluate patterns of medical imaging and associated radiation exposure in pregnant women and pediatric patients, and to determine the risk of pediatric cancers from in utero exposure and pediatric exposures. 

PCORI Pragmatic Trial of Surveillance Strategies for Patients with Small Pulmonary Nodules, 5 years, $14.5M total 
(PI: Gould) 04/01/2015 – 03/30/2020
This multi-site study seeks to identify optimum surveillance strategies to maximize early diagnosis for individuals with cancerous lung nodules, while minimizing unnecessary surveillance, which contributes to emotional stress, exposure to harmful ionizing radiation, and the discovery of incidental findings that may lead to unnecessary treatment. 

Complete List of Grants

NIH - CT DOSE Collaboration: Partnership for Dose

(PI: Smith-Bindman) 07/02/2014 – 06/30/2019
This multi-site Dissemination and Implementation study will assess diagnostic CT radiation doses across 27 institutions and 150 hospitals, and disseminate findings to the broader radiology and medical community. This mixed methods study includes surveys at each hospital to explore variation in dose and to identify barriers and facilitators to implementing successful dose optimization strategies.

NIH - Risk of Cancer in Childhood and Adolescence Associated with Medical Imaging

(PI: Smith-Bindman) 03/01/2015 – 02/28/2020
This study seeks to evaluate patterns of medical imaging and associated radiation exposure in pregnant women and pediatric patients, and to determine the risk of pediatric cancers from in utero exposure and pediatric exposures.

PCORI - Pragmatic Trial of Surveillance Strategies for Patients with Small Pulmonary Nodules

(PI: Gould) 04/01/2015 – 03/30/2020
This multi-site study seeks to identify optimum surveillance strategies to maximize early diagnosis for individuals with cancerous lung nodules, while minimizing unnecessary surveillance, which contributes to emotional stress, exposure to harmful ionizing radiation, and the discovery of incidental findings that may lead to unnecessary treatment.

PCORI - UCSF CT Radiation Dose Registry to Ensure a Patient Centered Approach for Imaging

P0056817 (PI: Smith-Bindman) 1/01/14 - 12/31/16 

This research collaboration aims to collect detailed data to assess current CT practice, to use these data to develop meaningful metrics to summarize dose at the facility level, to create radiation dose benchmarks, to test organizational strategies for optimizing dose, and to disseminate & implement successful strategies to the larger healthcare community. This is an international collaboration across a large number of institutions in the US, Canada, and the UK. Ultimately, the CT DOSE Registry Project aims to improve patient safety and lower the risk of future cancers related to CT imaging.

CDC - Pediatric Computed Tomography Dose Optimization and Standardization Endeavor

(PI: Smith-Bindman) 9/30/12 - 9/29/14 Other

The broad goals of the research are to collect detailed clinical and imaging based data that permits assessment of current practice, to develop meaningful metrics to summarize dose at the facility level and use these data to develop benchmarks, to create strategies for providing feedback to health care systems in how they are performing, to develop interventions targeted to standardizing dose, and to conduct a randomized clinical trial to test the effectiveness of various strategies for lowering dose.

UCOP - UC DOSE: University of California Dose Optimization and Standardization Endeavor

The UC DOSE grant, funded by the University of California Office of the President, is a collaborative effort to standardize and optimize computed tomography protocols across all five UC Medical Centers. By optimizing the use of lower dose protocols across sites, the grant aims to reduce radiation exposure to patients while maintaining the diagnostic efficiency of the exams. By filling in key gaps in our understanding of radiation associated with CT, we will be prepared to inform the creation of quality standards and guidelines within the UC Health System.

AHRQ - STONE: Study of Tomography of Nephrolithiasis Evaluation

The STONE grant focuses on urolithiasis (urinary stone disease), a very common condition with a lifetime risk of 10-15%. Urolithiasis accounts for 1% of all Emergency Department visits, approximately 1.1 million visits annually to US EDs. Computed Tomography was introduced as an alternative to ultrasonography in 1995, and has been rapidly embraced as the gold standard for diagnostic imaging in patients with suspected urolithiasis in the United States. While there are benefits of utilizing CT, there are also several reasons to question its use with regards to safety and cost. The multicenter grant is a randomized controlled trial of ultrasonography compared with CT for the evaluation of patients with suspected urolithiasis.

CRN Pilot: Medical Radiation Induced Cancers

This grant quantified imaging patterns and radiation exposure among 8 sites of the Cancer Research Network.

NIH - Risk of Cancer Associated of Incidental Findings, K24 Mid-Career Award

This grant was sought primarily to allow Dr. Smith-Bindman to mentor junior trainees (residents. fellows, and junior faculty) on research focused on cancer control and prevention and outcomes in imaging.

NIH - Radiation Exposure from Medical Imaging: Are Doses in Carcinogenic Range?

This grant will quantify patterns of exposure to ionizing radiation from medical imaging in a single large Health Maintenance Organization.

Assessing and Improving Radiologist's Mammography Interpretive Skills

The overall goal of this proposal is to improve radiologists' interpretive skills.

EB004079-01A2 (PI: Smith-Bindman, Lu) 4/01/06 - 12/01/09 NIH

NIH - Statistical Methods for Evaluation and Validation of Diagnostic Tests

This grant is to develop statistical methods for evaluation of non-inferiority test and for accurate estimation of relative risk.

NIH - Biological Basis of Breast Density and Breast Cancer Risk

This purpose of this multidisciplinary study is to better understand the biological basis of the elevated risk of breast cancer.