Research Directions

Research in the LRI is in the general area of medical imaging informatics which encompasses digital image acquisition, processing, display and archival. Specific focuses of the LRI include the development of PACS workflow and management software, digital image processing and analysis, image display devices and graphical user interface design, archival strategies, and clinical radiology information systems (RIS) and databases.

Lab focus is on advancing informatics techniques of medical imaging. Steve Wong has focused on developing intrinsic multimodal image fusion techniques for non-invasive surgical planning and diagnosis, image security models and systems using advanced cryptologic technology, and a web-based epilepsy and brain image registry system for clinical neuroscience and neuroimaging research. This registry contains multimodality brain images and associated longitudinal and vertical clinical data from multiple sclerosis, epilepsy surgical planning, and epilepsy radiation treatment. Other effort includes the development of a prototype system of Corba-Java based Multimedia Electronic Medical Record.

Research Collaborations

  • Fuji CR Med Physics Plate Analysis
  • Fuji CR interface to RIS
  • Agfa CR Image Processing
  • Canon DR GE DR vs. film Agfa
  • ICU workstation Lizardtech Compression for archival
  • Lizardtech Compression for image processing

Summary, Future Direction, Areas for Improvement

The LRI is involved in the design, implementation, maintenance, and analysis of clinical PACS and other imaging informatics technologies for clinical use, radiological research and teaching applications. The Lab will continue in its focus advancing digital techniques in medical imaging. Areas of emphasis in the future will include the Integrated Healthcare Enterprise (IHE), image processing including computer aided diagnosis, folder management and workflow, and the utilization of PACS for teaching and research applications. New faculty will be recruited to develop Computer Aided Diagnosis (CAD) and Image Analysis, Computation and Display. These emerging areas represent particularly strong opportunities for collaboration and funding through NIBIB. Recruitment of strong candidates would be greatly enhanced by the ability to expand the LRI into the adjacent, underutilized stack space.

Research Support

  • U.S. Army DAMD; PI: R.G. Gould, 10/1/00-9/30/03 Reliability, Security, and Authenticity of Meta Medical Image Archive for the Integrated Healthcare Enterprise; Project Award: $916,343.
  • National Library of Medicine Co-PIs: R. G. Gould and K. P. Andriole; 10/2001-9/2002 Connectivity, Security, and Performance of an NGI testbed for Medical Imaging Applications; Project Award: $336,287.
  • Agfa Division Technical Imaging Systems, Bayer Corporation; PI: K. P. Andriole; 1/99-12/01 Digital Image Processing Algorithms for Computed Radiography Softcopy Display; Project Award: $150,000.
  • Digital Medial Innovation Program Univ. of California; PI: K. P. Andriole; 2/1/99-1/31/00 Digital Image Processing for Computed Radiography; Project Award: $170,425.
  • Agfa Division Technical Imaging Systems, Bayer Corp.; Co-PIs: D. E. Avrin and K. P. Andriole; 1/98-12/99 Design of an Intensive Care Unit Display Station for Image review; Project Award: $85,000.
  • Canon USA, Inc.; Co-PIs: R. G. Gould and K. P. Andriole; 5/98-10-98 Direct Digital Detector Technology for Filmless Conventional X-Ray Imaging; Project Award: $30,000.
  • Agfa Division Technical Imaging Systems, Bayer Corporation; CoPIs: D. E. Avrin, K. P. Andriole, R. L. Arenson; 4/97-12/99 Digital Electronic Teaching File for Radiological Education; Project Award: $100,000.   
  • Univ. of Calif. Chancellor's Instructional Improvement Project; PI: K. P. Andriole. 7/95-6/96 Development of Interactive Instructional Courseware for Radiological Imaging in Clinical Medicine; Project Award: $ 4,906.
  • National Library of Medicine # NLM93-105/PSP; PI: R. L. Arenson , 4/94-3/97 A High Performance Testbed Network for Telemanagement of Neuro-Imaging; Project Award: $1,542,874.
  • NIH/NINDS R01, PI: S. Wong 9/1/98 - 8/31/02 An Electronic Data Warehouse for Epilepsy Research;Project Award: $990,000.                                   
  • NIH/NLM R29, PI: S. Wong, 2/1/98-1/31/03 A Multimodality Neuroimaging Database System;Project Award: $495,000.
  • Whitaker Foundation, PI: S. Wong, 4/1/96 - 9/31/99 Fusion of Multimodal Brain Images for Non-Invasive Evaluation of Candidates for Epilepsy Surgery; Project Award: $208,989.
  •  NIH/NLM N01-LM 6-3547 PI: HK Huang, 9/1/96 - 12/31/99 High Performance Tele-Imaging Infrastructure for Collaborative Health Care; Project Award: $1.9M.
  • Hewlett Packard Foundation, PI: S. Wong, 10/1/97 - 9/30/98 Instructional equipment grant for medical imaging education; Project Award: $128,000.
  • NIN/NLM Predoctoral Fellowship, PI: K Soo Hoo, Research Sponsor: Wong, 1996-1998 Sponsored Mentor for graduate student Kent Soo Hoo; Project Award: $75,000.
  • NSF, PI: S. Wong, 9/1/95 - 2/28/97 Content-based Retrieval of Multimodal Medical Images; Project Award: $55,000.