Laboratory for Radiologic Informatics

Research in the LRI is in the general area of medical imaging informatics which encompasses digital image acquisition, processing, display and archival. Specific focuses of the LRI include the development of PACS workflow and management software, digital image processing and analysis, image display devices and graphical user interface design, archival strategies, and clinical radiology information systems (RIS) and databases.

Lab focus is on advancing informatics techniques of medical imaging. Steve Wong has focused on developing intrinsic multimodal image fusion techniques for non-invasive surgical planning and diagnosis, image security models and systems using advanced cryptologic technology, and a web-based epilepsy and brain image registry system for clinical neuroscience and neuroimaging research. This registry contains multimodality brain images and associated longitudinal and vertical clinical data from multiple sclerosis, epilepsy surgical planning, and epilepsy radiation treatment. Other effort includes the development of a prototype system of Corba-Java based Multimedia Electronic Medical Record.

Research Collaborations

• Fuji CR Med Physics Plate Analysis
• Fuji CR interface to RIS
• Agfa CR Image Processing
• Canon DR GE DR vs. film Agfa
• ICU workstation Lizardtech Compression for archival
• Lizardtech Compression for image processing

Summary, Future Direction, Areas for Improvement

The LRI is involved in the design, implementation, maintenance, and analysis of clinical PACS and other imaging informatics technologies for clinical use, radiological research and teaching applications. The Lab will continue in its focus advancing digital techniques in medical imaging. Areas of emphasis in the future will include the Integrated Healthcare Enterprise (IHE), image processing including computer aided diagnosis, folder management and workflow, and the utilization of PACS for teaching and research applications. New faculty will be recruited to develop Computer Aided Diagnosis (CAD) and Image Analysis, Computation and Display. These emerging areas represent particularly strong opportunities for collaboration and funding through NIBIB. Recruitment of strong candidates would be greatly enhanced by the ability to expand the LRI into the adjacent, underutilized stack space.

Research Support

• U.S. Army DAMD; PI: R.G. Gould, 10/1/00-9/30/03 Reliability, Security, and Authenticity of Meta Medical Image Archive for the Integrated Healthcare Enterprise; Project Award: $916,343.
• National Library of Medicine Co-PIs: R. G. Gould and K. P. Andriole; 10/2001-9/2002 Connectivity, Security, and Performance of an NGI testbed for Medical Imaging Applications; Project Award: $336,287.
• Agfa Division Technical Imaging Systems, Bayer Corporation; PI: K. P. Andriole; 1/99-12/01 Digital Image Processing Algorithms for Computed Radiography Softcopy Display; Project Award: $150,000.
• Digital Medial Innovation Program Univ. of California; PI: K. P. Andriole; 2/1/99-1/31/00 Digital Image Processing for Computed Radiography; Project Award: $170,425.
• Agfa Division Technical Imaging Systems, Bayer Corp.; Co-PIs: D. E. Avrin and K. P. Andriole; 1/98-12/99 Design of an Intensive Care Unit Display Station for Image review; Project Award: $85,000.
• Canon USA, Inc.; Co-PIs: R. G. Gould and K. P. Andriole; 5/98-10-98 Direct Digital Detector Technology for Filmless Conventional X-Ray Imaging; Project Award: $30,000.
• Agfa Division Technical Imaging Systems, Bayer Corporation; CoPIs: D. E. Avrin, K. P. Andriole, R. L. Arenson; 4/97-12/99 Digital Electronic Teaching File for Radiological Education; Project Award: $100,000.   
• Univ. of Calif. Chancellor's Instructional Improvement Project; PI: K. P. Andriole. 7/95-6/96 Development of Interactive Instructional Courseware for Radiological Imaging in Clinical Medicine; Project Award: $ 4,906.
• National Library of Medicine # NLM93-105/PSP; PI: R. L. Arenson , 4/94-3/97 A High Performance Testbed Network for Telemanagement of Neuro-Imaging; Project Award: $1,542,874.
• NIH/NINDS R01, PI: S. Wong 9/1/98 - 8/31/02 An Electronic Data Warehouse for Epilepsy Research;Project Award: $990,000.                                   
• NIH/NLM R29, PI: S. Wong, 2/1/98-1/31/03 A Multimodality Neuroimaging Database System;Project Award: $495,000.
• Whitaker Foundation, PI: S. Wong, 4/1/96 - 9/31/99 Fusion of Multimodal Brain Images for Non-Invasive Evaluation of Candidates for Epilepsy Surgery; Project Award: $208,989.
•  NIH/NLM N01-LM 6-3547 PI: HK Huang, 9/1/96 - 12/31/99 High Performance Tele-Imaging Infrastructure for Collaborative Health Care; Project Award: $1.9M.
• Hewlett Packard Foundation, PI: S. Wong, 10/1/97 - 9/30/98 Instructional equipment grant for medical imaging education; Project Award: $128,000.
• NIN/NLM Predoctoral Fellowship, PI: K Soo Hoo, Research Sponsor: Wong, 1996-1998 Sponsored Mentor for graduate student Kent Soo Hoo; Project Award: $75,000.
• NSF, PI: S. Wong, 9/1/95 - 2/28/97 Content-based Retrieval of Multimodal Medical Images; Project Award: $55,000.

The LRI has been and continues to be involved in a variety of teaching initiatives at the graduate and post-doctoral levels as well as within the medical school. This instructional activity has included the development of an electronic teaching file with web access. A partial list of students who have rotated through the LRI is given below.

CCTI Graduate Program

More information about CCTI Graduate Program.

1. James Z Wang, Ph.D. Graduate Researcher, Medical Informatics Graduate Program, Stanford University (1996-2001), Now Penn State University Faculty of Information Technology.
2. Richie Lee, M.Sc., Graduate Researcher, SF State University, Computer Science, 2000-2001, PhD student, Bioinformatics, University of Southern California.
3. Mark Zhang, M.Sc., Graduate Researcher, Medical Informatics Graduate Program, UCSF, 1998-2000. Software Developer, Charles Schwab Co.
4. Lin Shao, M.Sc. Graduate Reseacher, Medical Informatics Graduate Program, UCSF, 2000. PhD Program, UCSF BMI.
5. HY Chan, M.Sc., M. Phil, Mathematics, Graduate Researcher, University of Hong Kong, HK, 1999. PhD Program, HKU.
6. CY Chang, M.Sc., Industrial Engineering, Graduate Researcher, Da Yeh University, Taiwan, 1998. Production Engineer, Taiwan Steel.
7. Donny Tjandra, M.Sc. Graduate Researcher, Hayward State University, Computer Science, 1998-2000, Independent Software Consultant.
8. Wan Ching, M. Sc., Graduate Researcher, Golden Gate University, Computer Science, 1998-2000, Software Developer, Charles Schwab Co.
9. Ismail Khalil, Ph.D. EECS Graduate Researcher, UC Berkeley 1996-1998. Developer, a Start-up in the Silicon Valley.
10. Campus English, M. Sc., Graduate Researcher, SF State University, Computer Science, 1996-97, Software Developer in a Bay Area start-up.
11. Jun Wang, PhD, Graduate Researcher, Medical Physics, UCLA. 1996, Software Developer in a Bay Area start-up.
12. Pablo Whaley, B.Sc., Undergraduate Researcher, UC Berkeley, Mathematics, 1996 Summer. Project Manager of Oakland City.
13. Olivia Velez, B.Sc. Undergraduate Researcher, Biological Sciences, Mt. Holyoke College, 96 Summer. Director of IT of a Boston area private hospital
14. Zachary Chun, B.Sc. Undergraduate Researcher, Neuroscience, Brown University, 96 Summer. Medical School student.
15. Liping Zhang (MIS Ph.D. Student Lab Rotation)
16. Anil Padwardin (UCSF Biomedical Informatics (BMI) Student Lab Rotation)
17. Christian Teusch, Foreign Medical Student, Rotation
18. Enrique Terrazas (MIS Ph.D. Student Lab Rotation)
19. Kim Chen (UCSF Postdoc)
20. Rey Banato (MIS Ph.D. Student Lab Rotation)
21. Srinka Ghosh (UCSF-Berkeley Bioengineering Ph.D. Student)
22. Savanah Partridge (UCSF-Berkeley Bioengineering Ph.D. Student)
23. Tuan Trinh (Medical Student)