Featured Grants

Imaging and Tissue Biomarkers for Improved Management of Patients with Newly Diagnosed GBM

NIH RO1 CA127612 (PI: Nelson ) 6/01/12 - 5/31/14 NIH

The objective of this proposal is to utilize advanced MR imaging techniques to assist in the clinical management of patients with newly diagnosed glioblastoma multiforme (GBM).

Response to Therapy for Patients with Glioma Using Hyperpolarized C-13 Pyruvate

NIH 1R21CA170148-01 (PI: Nelson) 07/23/2012 - 06/30/2014

The goal is to perform an early phase clinical trial that will demonstrate the application of hyperpolarized C-13 MR metabolic imaging as a new and unique tool for detecting early response to therapy in patients with Glioblastoma (GBM).

Preparing for Human Studies using the SpinLab Polarizer

Investigator-Sponsored Research (PIs: Nelson, Vigneron, Ferrone) 07/01/2012 - 06/30/2014 GE Healthcare

The goal of this collaborative research project is to establish the procedures necessary to prepare hyperpolarized agents for such studies and to obtain data that will provide the basis for obtaining approvals to perform new clinical trials.

Ultra high field MR for Patients with Neurological and Musculoskeletal Disease: Phase II Improved imaging and contrast mechanisms using the MR950 platform

Investigator Initiated Research (PI: Nelson) 02/01/2013 - 01/30/2015 GE Healthcare

The goal of this project is to obtain MR imaging data from patients using the 7T whole body scanner in the Surbeck Laboratory. The subjects will include individuals for whom the assessment of disease severity and treatment response have been challenging using conventional imaging methods. Population that have been identified as being of interest are patients with psychiatric diseases, Multiple Sclerosis, radiation injury or osteoarthritis.

Hyperpolarized MRI Technology Resource Center

NIH/NBIB P41EB013598 (PI: Vigneron) 08/01/2011 - 07/31/2016

With the increasing interest and number of DNP polarizers, we feel it is timely and beneficial to this emerging field to establish a Hyperpolarized MRI Technology Resource Center to develop, investigate and disseminate new hyperpolarized MR techniques, new 13C agents and specialized analysis open-source software for data reconstruction and interpretation. The Technology Research & Development projects will leverage the extensive DNP facilities and experience of the project leaders to develop improved, robust hyperpolarized MRI methods. These technology developments will be driven by Collaborative Projects led by outstanding clinical and basic scientists who aim to use hyperpolarized carbon-13 MRI to accomplish the scientific goals of their funded research. These technical developments will also be disseminated to the Service Project investigators for extramural feedback and then widely to the scientific community via a dedicated website and onsite training. This center will provide state-of-the art training in this new metabolic imaging field and sponsor a yearly symposium focused on hyperpolarized MR technology development.

Open-Source Tools for Processing Hyperpolarized MR Data

Project 3 (PI: Nelson)

The goal of this TR&D project is to develop novel, open-source, DICOM compliant, cross-platform software tools for reconstruction, quantification and visualization of hyperpolarized MR data as driven by the needs of the Collaborative Projects. There are currently no other packages available for analysis of the results obtained using the fast imaging and spectroscopy pulse sequences associated with this new in vivo technology. This address a pressing need because the multi-dimensional data produced following injection of pre-polarized imaging probes provide dramatic improvements in sensitivity over conventional methods and unique information about metabolic processes within living systems.

MR Metabolic Imaging of Response to Targeted Therapies in GBM

NIH/NCI 1R01CA154915 (PIs: Nelson, Ronen) 09/08/2011 - 06/30/2016

The main goal of this study is to develop and mechanistically validate MR-detectable metabolic biomarkers in order to evaluate the molecular response of glioblastoma multiforme (GBM) to novel therapies that target oncogenic signaling pathways, which are activated within such lesions.

Translation and Evaluation of a Multiparametric Prostate Cancer 3T MRI Exam

NIH R01CA137207 (PIs: Kurhanewicz, Vigneron, Hurd) 08/09/2010 - 06/30/2015

The goal of this collaborative research with GE Healthcare is to translate and validate a new 3 Tesla multiparametric imaging exam for improved prostate cancer patient-specific treatment planning and early assessment of therapeutic response.
Role: Co-Investigator

Imaging and Tissue Biomarkers in Patients with Newly Diagnosed GBM

NIH 5R01CA127612-05 (PI: Nelson) 04/28/2008 - 01/31/2014

The objective is to integrate metabolic and physiologic MR imaging data into the clinical management of patients with newly diagnosed GBM who are being treated with a combination of radiation, temozolamide and anti-angiogenic therapies. The project has developed improved metabolic imaging methods for serial evaluation of response to therapy and is providing data from patients being treated with bevacizumab that are of interest for comparing with the results from Project 1 of the P01.

Imaging and Tissue Biomarkers in the Treatment of Brain Tumors

NIH P01CA118816-05 (PI: Berger)  07/01/2007 - 06/30/2013

The overall goal is to integrate advances in technological development of physiologic neuro-imaging and tissue biomarkeers in the management of patients with brain tumors and to translate this knowledge to optimize delivery of novel agents into the brain parenchyma.

Imaging and Tissue Biomarkers for Patients with Newly Diagnosed GBM

Project 1 (PI: Nelson)

Project 1 evaluates areas where metabolic and physiologic imaging methods may be used to optimize treatment with focal therapies.

Imaging and Tissue Correlate Core

Core B (PI: Nelson)

The Imaging and Tissue Correlate Core will provide services to all projects to centralize efficient and integrated management of this PPG.

Brain Tumor SPORE Grant

NIH P50 CA097257 (PI: Berger) 05/01/2007 - 04/30/2013

This continuation SPORE proposal includes 5 translational research projects and 4 Cores - Administrative Core, Biostatistics and Clinical Core, Tissue Core and a Pre-Clinical Animal Core - and represents the efforts of interdisciplinary teams of investigators from the Neuro-Oncology Program of the UCSF Cancer Center to apply their knowledge and expertise to translational research focused on brain tumors.

Prognostic value of magnetic resonance spectroscopic imaging parameters for patients with glioma

Project 2 (PI: Nelson)

Project 2 goals are to determine whether the quantitative parameters derived from metabolic and physiologic imaging characteristics are predictive of the biologic behavior of recurrent low grade gliomas and can be used to aid in determining treatment therapy.