Dissemination and Training

Overview

Specialized training in this new field of hyperpolarized carbon-13 MRI is required since it is very new and very different from conventional MRI and from other molecular imaging techniques. Training in HP 13C MRI sponsored by the center are focused in several areas:

  • Hands-on training of local MS/PhD students and residents
  • Collaborative Project Personnel
  • Junior Faculty
  • Extramural Visitors & Service Projects
  • Hyperpolarized MRI Technology Workshops at BTRC
  • Training at Major Conferences
  • Regular Teleconferences
  • Online Training Coupled with Dissemination

 

TR&D 1: Improved DNP Methodology and HP MR Acquisition Techniques

Spectral-Spatial RF Pulse Design MATLAB package (designed by Adam Kerr and Peder Larson): This package includes Matlab functions to design spectral-spatial RF pulses (also known as spatial-spectral RF pulses) for application to magnetic resonance spectroscopy and imaging, including sample designs for hyperpolarized MRI. 

  • Download: Matlab Central FileExchange
  • Soure code repository: GitHub (You can become a contributor to project and add any code of your own or fix/improve the current software.)

Hyperpolarized MRI Toolbox: The goal of this toolbox is to provide research-level and prototyping software tools for hyperpolarized MRI experiments. It is currently based on MATLAB code, and includes code for designing radiofrequency (RF) pulses, readout gradients, and data reconstruction. 

  • Download: Matlab Central FileExchange
  • Source code repository: GitHub (You can also become a contributor to project and add any code of your own or fix/improve the current software.)

Training: DNP Polarizer Training & MR Sequence and Acquisition Training

MNS Research Pack (GE Healthcare): The MNS Research Pack is a software acquisition package for GE MRI scanners focused on multi-nuclear imaging and spectroscopy for hyperpolarized [1-13C]pyruvate research.  It includes different sequences and semi-automatic pre-scanning. In addition to pre-installed methods, additional RF pulses and trajectories can be designed off-line in Matlab, saved in a file, and read into the sequence. The package is available on request, contact: Rolf.Schulte_at_Research.ge.com

TR&D 2: Novel Hyperpolarized MR Molecular Imaging Probes, Realistic Pre-Clinical Models and Correlative Science Methods

 New Cell and Tissue Culture Bioreactors

Formulation of carbon-13 labeled compounds for dissolution-DNP (.pdf)

Demo: Preparation + QC of Componds for Hyperpolarization (.pdf)

Training: HP Probe Preparation Training & Cell Tissue and Bioreactor Training

TR&D 3: Open-Source Tools for Processing Hyperpolarized MR Data

HP C-13 SIVIC Software

Training: SIVIC Open-Source Software Training

Hyperpolarized MRI Toolbox: The goal of this toolbox is to provide research-level and prototyping software tools for hyperpolarized MRI experiments. It is currently based on MATLAB code, and includes code for designing radiofrequency (RF) pulses, readout gradients, and data reconstruction. 

  • Download: Matlab Central FileExchange
  • Source code repository: GitHub (You can also become a contributor to project and add any code of your own or fix/improve the current software.)

Data and File Sharing Platform

UCSF Box :  A data and file sharing platform that allows invited participants of the International SPINlab User Teleconference to share files and documentations pertaining to this project with individual login and password.   To request Box access, send your request to Jenny Che at [email protected].

National Cancer Institute - IND Regulatory & Manufacturing Resources on Hyperpolarized [13C]  Pyruvate

BioE 297- Hyperpolarized MRI Seminars

Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more.  It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells.  This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments.  This course covers the mechanisms behind Dissolution DNP and experimental considerations. Attendance in this course and completion of a practical hyperpolarizer exam for HyperSense and/or SPINlab operation is required to use the Oxford Instruments HyperSense and/or GE SPINlab DNP polarizers at UCSF.


DATE

TOPIC

28 June 2019

Introduction to Hyperpolarized MR (Renuka Sriram)

Lab: Tour

Link to Lecture Slides

Link to Audio Recording

12 July 2019

DNP Physics & Hardware (Jeremy Gordon)

Lab: Hypersense/SpinLab Operation

Link to Lecture Slides 

Link to Audio Recording

19 July 2019

DNP Agents (Dave Korenchan)

Lab:  Sample Prep

Link to Lecture Slides (Pending)

Link to Audio Recording (Pending)

26 July 2019

MR Acquisition and RF Coils (Jeremy Gordon)

Lab:  Hypersense/SPINlab Operation

Link to Lecture Slides (Pending)

Link to Audio Recording (Pending)

2 August 2019

Hyperpolarized MR Experimental Design (Renuka Sriram)

Lab: Mock Hyperpolarized Studies

Link to Lecture Slides (Pending)

Link to Audio Recording (Pending)

9 August 2019

Integration of Hyperpolarized MR Into Biomedical Research: Liver Disease (Michael Ohliger), Cardiac Disease (Peder Larson).

Lab: Mock Hyperpolarized Studies

Link to Lecture Slides (Pending)

Link to Audio Recording (Pending)

16 August 2019

Hyperpolarized Data Visualization and Analysis (Peder Larson & Jason Crane)

Lab: Hands-on Data Demo

Link to Lecture Slides (Pending)

Link to Audio Recording (Pending)

23 August 2019

Integration of Hyperpolarized MR Into Biomedical Research: Cancer (Pavithra Visnawatch); Neurological (Lydia LePage)

Link to Lecture Slides (Pending)

Link to Audio Recording (Pending)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Tutorials

Title:  Production of Filled Pharmacy Kits (cassettes) and Terminal Sterilization For Human Studies

James B. Slater, RPh, PhD,  Mark Van Criekinge, MS, Jeremy Gordon, PhD, Jennifer Chow, Romelyn Delos Santos.  Click on the image below to view the document