HMTRC Publications and Abstracts



Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM.  HDAC inhibition in glioblastoma monitored by hyperpolarized 13C MRSI. NMR Biomed. 2019; 32(2): e4044. PMID: 30561869


Najac C, Radoul M, Le Page LM, Batsios G, Subramani E, Viswanath P, Gillespie AM, Ronen SM.  In vivo investigation of hyperpolarized [1,3-13C2]acetoacetate as a metabolic probe in normal brain and in glioma.  Sci Rep. 2019; 9(1): 3402.  PMCID: PMC6399277


Zhu X, Gordon JW, Bok RA, Kurhanewicz J, Larson PEZ.  Dynamic diffusion-weighted hyperpolarized 13C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport.  Magn Reson Med.  2019; 81(3): 2001-2010. PMCID: PMC6347546


Zhu Z, Zhu X, Ohliger MA, Tang S, Cao P, Carvajal L, Autry AW, Li Y, Kurhanewicz J, Chang S, Aggarwal R, Munster P, Xu D, Larson PEZ, Vigneron DB, Gordon JW.  Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies.  J Magn Rson. 2019; 301: 73-79. PMID: 30851668


Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB.  Hyperpolarized 13C MRI: State of the Art and Future Directions.  Radiology. 2019: 182391. PMID: 30835184


Bok R, Lee J, Sriram R, Keshari K, Sukumar S, Daneshmandi S, Korenchan DE, Flavell RR, Vigneron DB, Kurhanewicz J, Seth P. The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI.  Cancers (Basel). 2019; 11(2). PMID: 30813322


Walker CM, Fuentes D, Larson PEZ, Kundra V, Vigneron DB, Bankson JA.  Effects of excitation angle strategy on quantitative analysis of hyperpolarized pyruvate.  Magn Reson Med. 2019 Feb 22. Doi: 10.1002/mrm.27687. [Epub ahead of print] PMID: 30793791

128 Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ. Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13C imaging.  NMR Biomed. 2019; 32(3): e4052. PMCID: PMC6380928

Tang SJ, Milshteyn E, Reed G, Gordon J, Bok R, Zhu X, Zhu Z, Vigneron DB, Larson PEZ.  A regional bolus tracking and real-time B1 calibration method for hyperpolarized 13C MRI.  Magn Reson Med.  2019; 81(2): 839-851.  PMCID: PMC6289616


Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB.  Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients.  Magn Reson Med.  2019; 81(4): 2702-2709. PMCID: PMC6372313


Kurhanewicz J, Vigneron DB, Ardenkjaer-Larsen JH, Bankson JA, Brindle K, Cunningham CH, Gallagher FA, Keshari KR, Kjaer A, Laustsen C, Mankoff DA, Merritt ME, Nelson SJ, Pauly JM, Lee P, Ronen S, Tyler DJ, Rajan SS, Spielman DM, Wald L, Zhang X, Malloy CR, Rizi R.  Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology. Neoplasia. 2019; 21(1): 1-16. PMCID: PMC6260457


Sriram R, Sun J, Villanueva-Meyer J, Mutch C, Delos Santos J, Peters J, Korenchan DE, Neumann K, Van Criekinge M, Kurhanewicz J, Rosenberg O, Wilson D, Ohliger MA.  ACS Infect Dis. 2018; 4(5): 797-805. PMCID: PMC6008482


Sriram R, Nguyen J, Santos JD, Nguyen L, Sun J, Vigneron S, Van Criekinge M, Kurhanewicz J, MacKenzie JD. Molecular detection of inflammation in cell models using hyperpolarized 13C pyruvate.  Theranostics. 2018; 8(12): 3400-3407. PMCID: PMC6010986


Qin H, Carroll VN, Sriram R, Villanueva-Meyer JE, von Morze C, Wang ZJ, Mutch CA, Keshari KR, Flavell RR, Kurhanewicz J, Wilson DM. Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes.  Sci Rep. 2018; 8(1): 7928. PMCID: PMC5962598


Truillet C, Parker MFL, Huynh LT, Wei J, Jami KM, Wang YH, Shen YS, Sriram R, Wilson DM, Kurhanewicz J, Evans MJ.  Measuring glucocorticoid receptor expression in vivo with PET. Oncotarget. 2018; 9(29): 20399-20408. PMCID: PMC5945515


Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, van Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB.  Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients.  NMR Biomed. 2018; 31(11): e3997.  PMID: 303230646


Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI.  Cancers (Basel). 2018; 10(9). PMCID: PMC6162434


Autry AW, Hashizume R, James CD, Larson PEZ, Vigneron DB, Park I. Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging.  2018; 2018: 3215658. PMCID: PMC6098895


Lee JE, Diederich CJ, Bok R, Sriram R, Santos RD, Noworolski SM, Salgaonkar VA, Adams MS, Vigneron DB, Kurhanewicz J.  Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13C dual-agent imaging of metabolism and perfusion.  NMR Biomed. 2018 Jul 18:e3962. doi: 10.1002/nbm.3962. [Epub ahead of print] PMID: 30022550


Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson PEZ.  Spatio-temporally constrained reconstruction for hyperpolarized carbon-13 MRI using kinetic models.  IEEE Trans Med Imaging. 2018 Jun 5. doi: 10.1109/TMI.2018.2844246. [Epub ahead of print] PMID: 29994332


Li N, Liu S, Hu X, Luo C, Zhang X, Li Y.  Electromagnetic Field and Radio Frequency Circuit Co-Simulation for Magnetic Resonance Imaging Dual-Tuned Radio Frequency Coils.  IEEE Trans Magn.  2018; 54(3). PMCID: PMC5947962


Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR.  Late-Stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.  Chem Commun (Camb). 2018; 54(41): 5233-5236.  PMCID:PMC6054790


Jiang W, Larson PEZ, Lustig M. Simultaneous Auto-calibration and Gradient Delays Estimation (SAGE) in non-Cartesian Parallel MRI using Low-rank Constraints.  Magn Reson Med. 2018; 80(5): 2006-2016. PMCID: PMC6107389


Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB.  Technique development of 3D dynamic CS-EPSI for hyperpolarized 13C pyruvate MR molecular imaging of human prostate cancer.  Magn Reson Med.  2018 Mar 25. doi: 10.1002/mrm.27179. [Epub ahead of print] PMID: 29575178


Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Larson PEZ, Vigneron DB.  Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized 13C imaging using the bSSFP sequence.  J Magn Reson.  2018; 290: 46-59. PMCID: PMC6054792


von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME.  In vivo hyperpolarization transfer in a clinical MRI scanner.  Magn Reson Med.  2018; 80(2): 480-487.  PMCID: PMC5910192


Gordon JW, Hansen RB, Shin PJ, Feng Y, Vigneron DB, Larson PEZ.  3D hyperpolarized C-13 EPI with calibrationless parallel imaging.  J Magn Reson. 2018; 289: 92-99. PMCID: PMC5856653


Milshteyn E, von Morze C, Gordon JW, Zhu Z, Larson PEZ, Vigneron DB.  High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-13C]pyruvate and [1-13C]lactate with spectral suppression of alanine and pyruvate-hydrate. Magn Reson Med.  2018; 80(3): 1048-1060. PMCID:PMC5980670


von Morze C, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D. Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance.  Sci Rep. 2018; 8(1): 2088. PMCID: PMC5794967


Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ.  Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.  Magn Reson Med.  2018; 80(3): 864-873. PMCID: PMC5980662

105 von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ.  Direct assessment of renal mitochondrial redox state using hyperpolarized 13C-acetoacetate.  Magn Reson Med.  2018; 79(4): 1862-1869.  PMCID: PMC5815327

von Morze C, Tropp J, Chen AP, Marco-Rius I, Van Criekinge M, Skloss TW, Mammoli D, Kurhanewicz J, Vigneron DB, Ohliger MA, Merritt ME.  Sensitivity enhancement for detection of hyperpolarized 13C MRI probes with 1H spin coupling introduced by enzymatic transformation in vivo.  Magn Reson Med. 2018; 80(1): 36-41. PMCID: PMC5876091


Aggarwal R, Vigneron DB, Kurhanewicz J. Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer. Eur Urol. 2017 Jul 29. pii: S0302-2838(17)30651-6. doi: 10.1016/j.eururo.2017.07.022. [Epub ahead of print] PMID: 28765011


Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB. Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.  Magn Reson Imaging. 2017; 43: 105-109. PMID: 28716678


Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB. Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. Cancer Res. 2017; 77(12): 3207-3216. PMCID: PMC5484421


Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA. Diffusion-weighted imaging of hyperpolarized [13C]urea in mouse liver. J Magn Reson Imaging. 2017 Apr 17. doi: 10.1002/jmri.25721. [Epub ahead of print] PMID: 28419644


Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB. Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques. Magn Reson Imaging. 2017; 38: 152-162. PMCID: PMC5360530


Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13C]dihydroxyacetone. Magn Reson Med. 2017; 77(1): 65-73. PMCID: PMC5191913


Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PE, Pauly JM, Vigneron DB. Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses. Magn Reson Med. 2016 Oct 21. doi: 10.1002/mrm.26480. [Epub ahead of print] PMCID: PMC5400740


Gordon JW, Milshteyn E, Marco-Rius I, Ohliger M, Vigneron DB, Larson PE. Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects. Magn Reson Med. 2016 Oct 13. doi: 10.1002/mrm.26482. [Epub ahead of print] PMCID: PMC5391314


Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016; 2(2): 125-135. PMCID: PMC4996281


Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PE, Kurhanewicz J. Separation of extra- and intracellular metabolites using hyperpolarized 13C diffusion weighted MR. J Magn Reson. 2016; 270: 115-123. PMCID: PMC5448422


Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PE, Bok R, Chen HY, Kurhanewicz J, Vigneron D. Combining hyperpolarized 13C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism. Magn Reson Med. 2017; 77(6): 2356-2363. PMCID: PMC5156580


Cao P, Shin PJ, Park I, Najac C, Marco-Rius I, Vigneron DB, Nelson SJ, Ronen SM, Larson PE. Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing. Magn Reson Med. 2016; 76(2): 369-79. PMCID: PMC4945498


von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB. Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13C-lactate and 13C-pyruvate in kidney and liver. Magn Reson Med. 2017; 77(4): 1429-1437. PMCID: PMC5074920


Cao P, Zhang X, Park I, Najac C, Nelson SJ, Ronen S, Larson PE. (1) H-(13) C independently tuned radiofrequency surface coil applied for in vivo hyperpolarized MRI. Magn Reson Med. 2016; 76(5): 1612-1620. PMCID: PMC4879596


Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PEZ, Vigneron DB. Multiband Spectral-Spatial RF Excitation for Hyperpolarized [2-13C]Dihydroxyacetone 13C-MR Metabolism Studies. Magn Reson Med. 2017; 77(4): 1419-1428. PMCID: PMC5040611


Gordon JW, Vigneron DB, Larson PE. Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized (13)C imaging. Magn Reson Med. 2017; 77(2): 826-832. PMCID: PMC4992668


Park I, von Morze C, Lupo JM, Ardenkjaer-Larsen JH, Kadambi A, Vigneron DB, Nelson SJ. Investigating Tumor Perfusion by Hyperpolarized 13C MRI with Comparison to Conventional Gadolinium Contrast-Enhanced MRI and Pathology in Orthotopic Human GBM Xenografts. Magn Reson Med. 2017; 77(2): 841-847. PMCID: PMC4991955


Gordon JW, Larson PEZ.  Pulse Sequences for Hyperpolarized MRS. eMagRes. 2016, Vol 5: 1229-1246. DOI 10.1002/97804700349590.emrstm1451. 


Kurhanewicz J, Vigneron DB. Magnetic Resonance Spectroscopy of Prostate Cancer. John Wiley & Sons, Ltd. eMagRes. 2016, Vol 5: 1–22. DOI 10.1002/9780470034590.emrstm1433.


Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J. Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging. Chem Commun (Camb). 2016; 52(14): 3030-3. PMCID: PMC4864526


Shang H, Larson P, Kerr A, Reed G, Sukumar S, Elkhaled A, Gordon JW, Ohliger MA, Pauly JM, Lustig M, Vigneron DB. Multiband RF Pulses with Improved Performance via Convex Optimization. J Magn Reson. 2016; 262: 81-90. PMCID: PMC4716678


Feng Y, Gordon JW, Shin PJ, von Morze C, Lustig M, Larson PEZ, Ohliger MA, Carvajal L, Tropp J, Pauly JM, Vigneron DB. Development and testing of hyperpolarized 13C MR calibrationless parallel imaging. J Magn Reson. 2016; 262: 1-7. PMCID: PMC4864033


Chen Y, Kim H, Bok R, Sukumar S, Mu X, Sheldon RA, Barkovich AJ, Ferrierro DM, Xu D. Pyruvate to Lactate Metabolic Changes during Neurodevelopment Measured Dynamically Using Hyperpolarized 13C Imaging in Juvenile Murine Brain. Dev Neurosci. 2016; 38(1): 34-40. PMCID: PMC4732911


Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O’Brien T, Sampath D, Carano RA, Kurhanewicz J.Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate. 2015; 75(14): 1601-9. PMCID: PMC4537380


Flavell RR, von Morze C, Blecha JE, Korenchan D, van Criekinge M, Sriram R, Gordon J, Chen HY, Sukumar S, Bok R, Wang ZJ, Vigneron D, Larson P, Kurhanewicz J, Wilson DM. Application of Good’s buffers to pH imaging using hyperpolarized 13C MRI. Chem Comm (Camb). 2015; 51(74): 14119-22. PMCID: PMC4854286


Sriram R, van Criekinge M, Hansen AF, Wang Z, Vigneron D, Wilson DM, Keshari K, Kurhanewicz J. Real-time Measurement of Hyperpolarized Dactate Productign and Efflux as a Biomarker of Tumor Aggressivefess in an MR coepatible 3D Cell Culture Bioreactor. NMR Biomed. 2015; 28(9): 1141-9. PMCID: PMC4537810


Leon Swisher C, Koelsch B, Sukumar S, Sraram R, Delos Saftos R, Wang ZJ, Kurhanewicz J, Vigneron D, Larsgn PE. Dynamic UdtraFast 2D Exchange Spectroscopq (UF-EXSY) of Hqperpolarized Substrates. JMR. 2015; 257: 102-101. PMCID: PMC4515769


von Morze C$ Bok RA, Ohliger MA, Zhu Z, Vigferon DB, Kurhanewicz J. Hyperpodarized [13C]ketgbutyrate, a molecular analog of pyruvate with mgdified specificaty for LDH Isofgrms. Magn Reson Med. 2016; 75(5!: 1894-900. PMCAD: PMC4868134


La Y, Park I, Nelson SJ. Imaging Tumor Metabolism using in vivo MR Spectroscopy. Cancer J. 2015; 21(2): 123-8. PMCID: PMC4429803


Shang H, Skloss T, von Morze C, Carvajal L, Van Criekinge M, Milshteyn E, Larson PE, Hurd RE, Vigneron DB. Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples. Magn Reson Med. 2016; 75(2): 917-22. PMCID: PMC4567531


Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO. Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res. 2014; 74(23): 7115-24. PMCID: PMC4253720


Jiang W, Lustig M, Larson PE. Concentric rings K-space trajectory for hyperpolarized 13C MR spectroscopic imaging. Magn Reson Med. 2016; 75(1): 19-31. PMCID: PMC4476971


Pang Y, Wu B, Jiang X, Vigneron DB, Zhang X. Tilted microstrip phased arrays with improved electromagnetic decoupling for ultrahigh-field magnetic resonance imaging. Medicine (Baltimore). 2014; 93(28): e311. PMCID: PMC4603100


Sriram R, Kurhanewicz J, Vigneron D. Hyperpolarized Carbon-13 MRI and MRS Studies. in Encyclopedia of Magnetic Resonance, eds J. Griffiths and P. Bottomley, John Wiley: Chichester.eMagRes. 3: 1-14, 2014. DOI: 10.1002/9780470034590.emrstm1253


Shin P, Larson P, Uecker M, Reed G, Kerr A, Tropp J, Ohliger M, Nelson S, Pauly J, Lustig M, Vigneron D. Chemical Shift Separation with Controlled Aliasing for Hyperpolarized 13C Metabolic Imaging. Magn Reson Med. 2015; 74(4): 978-89. PMCID: PMC4390401


Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PE. Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized 13C metabolites. Magn Reson Med. 2015; 74(3): 622-33. PMCID: PMC4362805


Wilson DM, Kurhanewicz J. Hyperpolarized 13C MR for Molecular Imaging of Prostate Cancer. J Nucl Med. 2014; 55(10): 1567-72. PMCID: PMC4349324


Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci USA. 2014; 111(27): 9983-8. PMCID: PMC4103324


Tang S, Jiang W, Chen HY, Bok R, Vigneron DB, Larson PE. A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging. Magn Reson Med. 2015; 74(2): 506-12. PMCID: PMC4336852


Keshari K, Wilson D, Sai Victor, Bok R; Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ. Non-invasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes. 2015; 64(2): 344-52. PMCID: PMC4303960


Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P. Targeting lactate dehydrogenase-A (LDH-A) inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells. Cell Metabolism. 2014; 19(5): 795-809. PMCID: PMC4096909


von Morze C, Carvajal L, Reed GD, Swisher CL, Tropp J, Vigneron DB. Directly detected 55Mn MRI: Application to phantoms for human hyperpolarized 13C MRI development. Magn Reson Imaging. 2014; 32(10): 1165-70. PMCID: PMC4254142


Shin PJ, Larson PE, Ohliger MA, Elad M, Pauly JM, Vigneron DB, Lustig M. Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion. Magn Reson Med. 2014; 72(4): 959-70. PMCID: PMC4025999


Keshari KR, Wilson DM. Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chem Soc Rev. 2014; 43(5): 1627-59. PMCID: PMC4086923


Bahrami N, Swisher CL, von Morze C, Vigneron DB, Larson PE. Kinetic and perfustion modeling of hyperpolarized (13)C pyruvate and urea in cancer with arbitrary RF flip angles. Quant Imaging Med Surg. 2014; 4(1): 24-32. PMCID: PMC3947982


Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res. 2014; 74(16): 4247-57. PMCID: PMC4134724


Pang Y, Jiang X, Zhang X. Sparse Parallel Transmission on Randomly Perturbed Spiral K-space Trajectory. Quant Imaging Med Surg. 2014; 4(2): 106-111. PMCID: PMC4014875


Pang Y, Yu B, Zhang X. Enhancement of the Low Resolution Imaging Quality using Randomly Sampled Data for Multi-Slice MR Imaging. Quant Imaging Med Surg. 2014; 4(2): 136-144. PMCID: PMC4014877


Aggarwal R, Kurhanewicz J. Prostate cancer in 2013: The changing role of imaging in clinical care. Nature Reviews Urology. 2014; 11: 75-77. PMCID: PMC4057014


Pang Y, Wong E, Yu B, Zhang X. Design and Numerical Evaluation of A Volume Coil Array for Parallel MR Imaging at Ultrahigh Fields. Quant Imaging Med Surg. 2014; 4(1): 50-56. PMICD: PMC3947986


Pang Y, Yu B, Vigneron D, Zhang X. Quadrature Transmit Array Design Using Single-Feed Circularly Polarized Patch Antenna for Parallel Transmission in MR Imaging. Quant Imaging Med Surg. 2014; 4(1): 11-18. PMCID: PMC3947984


Reed G, von Morze C, Bok R, Koelsch B, Van Criekinge M, Smith K, Shang H, Larson P, Kurhanewicz J, Vigneron D. High Resolution C-13 MRI With Hyperpolarized Urea: in vivo T(2) Mapping and N-15 Labeling Effects. IEEE Trans Med Imaging. 2014; 33(2): 362-71. PMCID: PMC4011557


Park I, Larson PEZ, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ. Dynamic Hyperpolarized Carbon-13 Metabolic MR Imaging of Non-Human Primate Brain. Magn Reson Med. 2014; 71(1): 19-25. PMCID: PMC4041734


Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2014; 71(1): 1-11. PMCID: PMC3659200


von Morze C, Bok RA, Reed GD, Ardenkjaer-Larsen JH, Kurhanewicz J, Vigneron DB. Simultaneous multiagent hyperpolarized 13C perfusion imaging. Magn Reson Med. 2014; 72(6): 1599-609. PMCID: PMC4077988


Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA. Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate. Sci Transl Med. 2013; 5(198): 198ra108. PMCID: PMC4201045. Note: This clinical trial research was not funded by the center, but benefitted from its equipment and infrastructure.


Finsterbusch J, Busch MG, Larson PE. Signal scaling improves the signal-to-noise ratio of measurements with segmented 2D-selective radiofrequency excitations. Magn Reson Med. 2013; 70(6): 1491-9. PMID: 23440633


Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4: 2429. PMCID: PMC3908661


Li Y, Yu B, Pang Y, Vigneron D, Zhang X. Planar quadrature RF transceiver design using common-mode differential-mode (CMDM) transmission line method for 7T MR Imaging. PLoS One. 2013; 8(11): e80428. PMCID: PMC3827179


Xing Y, Reed GD, Pauly JM, Kerr AB, Larson PE. Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates. J Magn Reson. 2013; 234: 75-81. PMCID: PMC3765634


Li Y, Wang C, Yu B, Vigneron D, Chen W, Zhang X. Image homogenization using pre-emphasis method for high field MRI. Quant Imaging Med Surg. 2013; 3(4): 217-223. PMCID: PMC3759133


Crane JC, Olson MP, Nelson SJ. SIVIC: Open-Source, Standards-Based Software for DICOM MR Spectroscopy Workflows. International Journal of Biomedical Imaging. 2013; 2013:169526. PMCID: PMC3732592


Keshari KR, Sriram R, Van Criekinge M, Wilson DM, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J. Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate. 2013; 73(11): 1171-81. PMCID: PMC3976546


Keshari KR, Sai V, Wang ZJ, Vanbrocklin HF, Kurhanewicz J, Wilson DM. Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET. J Nucl Med. 2013; 54(6): 922-8. PMCID: PMC3682497


Nelson SJ, Ozhinsky E, Li Y, Park I, Crane J. Strategies for Rapid in vivo 1H and hyperpolarized 13C MR Spectroscopic Imaging. Journal of Magnetic Resonance. 2013; 229: 187-97. PMCID: PMC3808990


Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J. Diffusion MR of hyperpolarized (13)C molecules in solution. Analyst. 2013; 138(4): 1011-4. PMCID: PMC3568999


Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson DM, Kurhanewicz J, Wang ZJ. Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas. Cancer Res. 2013; 73(2): 529-38. PMCID: PMC3548990


Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013; 38(3): 701-13. PMCID: PMC3759833


Lodi A, Woods SM, Ronen SM. Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells. NMR Biomed. 2013; 26(3): 299-306. PMCID: PMC35229990


Larson PEZ, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. Perfusion and diffusion sensitive (13)C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2013; 31(5): 635-42. PMCID: PMC3626756


Hu S, Larson PE, Van Criekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-(13)C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2013; 31(4): 490-6. PMCID: PMC3625683


Pang Y, Zhang X. Interpolated compressed sensing for 2D multiple slice fast MR imaging. PLoS One. 2013; 8(2): e56098. PMCID: PMC3568040


Park I, Hu S, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ. Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D (13)C magnetic resonance spectroscopic imaging. Magn Reson Med. 2013; 70(1):33-9. PMCID: PMC3630274


Pang Y, Yu B, Zhang X. Hepatic fat assessment using advanced Magnetic Resonance Imaging. Quant Imaging Med Surg. 2012; 2(3): 213-8. PMCID: PMC3496514


Keshari KR, Kurhanewicz J, Macdonald JM, Wilson DM. Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions. Analyst. 2012; 137(15): 3427-9. PMCID: PMC3600417


Larson PE, Kerr AB, Leon Swisher C, Pauly JM, Vigneron DB. A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates. J Magn Reson. 2012; 225: 71-80. PMCID: PMC3531583


von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB. Frequency-specific SSFP for hyperpolarized (13)C metabolic imaging at 14.1 T. Magn Reson Imaging. 2012; 31(2): 163-70. PMCID: PMC3651030


Wu B, Li Y, Wang C, Vigneron DB, Zhang X. Multi-reception strategy with improved SNR for multichannel MR imaging. PLoS One. 2012; 7(8):e42237. PMCID: PMC3411773


Venkatesh HS, Chaumeil MM, Ward CS, Haas-Kogan DA, James CD, Ronen SM. Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma. Neuro Oncol. 2012; 14(3): 315-25. PMCID: PMC3280799


Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM. Hyperpolarized (13)C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma. Neuroimage. 2012; 59(1): 193-201. PMCID: PMC3196046


Hu S, Yoshihara HA, Bok R, Zhou J, Zhu M, Kurhanewicz J, Vigneron DB. Use of hyperpolarized [1-(13)C] pyruvate and [2-(13)C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. Magn Reson Imaging. 2012; 30(10): 1367-72. PMCID: PMC3480972


von Morze C, Bok RA, Sands JM, Kurhanewicz J, Vigneron DB. Monitoring urea transport in rat kidney in vivo using hyperpolarized 13C magnetic resonance imaging. Am J Physiol Renal Physiol. 2012; 302(12): F1658-62. PMCID: PMC3378100


Reed GD, Larson PE, von Morze C, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. A Method for Simultaneous Echo Planar Imaging of Hyperpolarized 13C Pyruvate and 13C Lactate. J Magn Reson. 2012; 217: 41-7. PMCID: PMC3326401


Wu B, Zhang X, Wang C, Li Y, Pang Y, Lu J, Xu D, Majumdar S, Nelson SJ, Vigneron DB. Flexible transceiver array for ultrahigh field human MR imaging. Magn Reson Med. 2012; 68(4): 1332-8. PMCID: PMC3350759


von Morze C, Larson PEZ, Hu S, Yoshihara HAI, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. Investigating tumor perfusion and metabolism using multiple hyperpolarized 13C compounds: HP001, pyruvate and urea. Magnetic Resonance Imaging. 2012; 30(3): 305-11. PMCID: PMC3393100


Wang C, Li Y, Wu B, Xu D, Nelson SJ, Vigneron DB, Zhang X. A practical multinuclear transceiver volume coil for in vivo MRI/MRS at 7T. Magn Reson Imaging. 2012; 30(1): 78-84. PMCID: PMC3277811


Wu B, Wang C, Lu J, Pang Y, Nelson SJ, Vigneron DB, Zhang X. Multi-channel microstrip transceiver arrays using harmonics for high field MR imaging in humans. IEEE Trans Med Imaging. 2012; 31(2): 183-91. PMCID: PMC3277810


Pang Y, Xie Z, Xu D, Kelley DA, Nelson SJ, Vigneron DB, Zhang X.A dual-tuned quadrature volume coil with mixed λ/2 and λ/4 microstrip resonators for multinuclear MRSI at 7T. Magn Reson Imaging. 2012; 30(2): 290-8. PMCID: PMC3254778


Larson PE, Kerr AB, Reed GD, Hurd RE, Kurhanewicz J, Pauly JM, Vigneron DB. Generating Super Stimulated-Echoes in MRI and Their Application to Hyperpolarized C-13 Diffusion Metabolic Imaging. IEEE Trans Med Imaging. 2012; 31(2): 265-75. PMCID: PMC3274664


Chen AP, Hurd RE, Gu YP, Wilson DM, Cunningham CH. (13)C MR reporter probe system using dynamic nuclear polarization. NMR Biomed. 2011; 24(5): 514-20. PMID: 21674653


Pang Y, Zhang X, Xie Z, Wang C, Vigneron DB. Common-mode differential-mode (CMDM) method for double-nuclear MR signal excitation and reception at ultrahigh fields. IEEE Trans Med Imaging. 2011; 30(11): 1965-73. PMCID: PMC3277813


von Morze C, Reed G, Shin P, Larson PE, Hu S, Bok R, Vigneron DB. Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate. J Magn Reson. 2011; 211(2): 109-13. PMCID: PMC3143308


Park I, Bok R, Ozawa T, Phillips JJ, James CD, Vigneron DB, Ronen SM, Nelson SJ. Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. J Magn Reson Imaging. 2011; 33(6): 1284-90. PMID: 21590996


Lippert AR, Keshari KR, Kurhanewicz J, Chang CJ. A hydrogen peroxide-responsive hyperpolarized (13)C MRI contrast agent. J Am Chem Soc. 2011; 133(11): 3776-9. PMCID: PMC3060273


Larson PE, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB. Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med. 2011; 65(3): 610-619. PMCID: PMC3021589


Pang Y, Zhang X. Precompensation for mutual coupling between array elements in parallel excitation. Quant Imaging Med Surg. 2011; 1(1): 4-10. PMCID: PMC3496487


Tropp J, Lupo JM, Chen AP, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-Channel Metabolic Imaging, with SENSE reconstruction, of Hyperpolarized [1-13C] Pyruvate in a Live Rat at 3.0 tesla on a Clinical MR Scanner. Journal of Magnetic Resonance. 2011; 208(1): 171-7. PMCID: PMC3387549


Kurhanewicz J, Vigneron DB, Brindle K, Chekmenev EY, Comment A, Cunningham CH, Deberardinis RJ, Green GG, Leach MO, Rajan SS, Rizi RR, Ross BD, Warren WS, & Malloy CR. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia. 2011; 13(2),81-97. PMCID: PMC3033588


von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011; 33(3): 692-7. PMCID: PMC3566235


Pang Y, Wu B, Wang C, Vigneron DB, Zhang X. Numerical Analysis of Human Sample Effect on RF Penetration and Liver MR Imaging at Ultrahigh Field. Concepts Magn Reson Part B Magn Reson Eng. 2011; 39B(4): 206-216. PMCID: PMC3277816


Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci USA. 2011; 108(46): 18606-11. PMCID: PMC3219134


Hu S, Zhu M, Yoshihara HAI, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PEZ, Kurhanewicz J, Vigneron DB. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-13C]alanine. Magnetic Resonance Imaging. 2011; 29(8): 1035-1040. PMCID: PMC3172390


Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. 13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression. Cell Metabolism. 2011; 14(1): 131-42. PMCID: PMC3858338





  1. Agarwal S, Gordon J, Korn N, Bok RA, von Morze C, Vigneron DB, Kurhanewicz J, Ohliger MA. Distinguishing metabolic signals of liver tumors form surrounding liver cells using hyperpolarized 13C MRI and Gadoxetate. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 4305.
  2. Ahamed F, Van Criekinge M, Wang ZJ, Kurhanewicz J, Larson P, and Sriram, R. Assessment of intracellular lactate relaxation, production and efflux rates in cells using hyperpolarized 13C MR. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0260.
  3. Autry AW, Gordon JW, Chen HY, Mammoli DW, Lafontanie M, Villanueva-Meyer J, Chang SM, Xu D, Larson PEZ, Vigneron DB, Nelson SJ, Li Y. Serial characterization of HP [1-13C]pyruvate metabolism in the brains of patients with glioma and healthy controls.  ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0860.
  4. Batsios G, Najac C, Cao P, Viswananth P, Subramani E, Saito Y, Gillespie AM, Yoshihara H, Larson P, Sando S, Ronen S.  Detection of γ-glutamyl-transferase activity up-regulation in orthotopic glioma using hyperpolarized γ-glutamyl-[1-13C]glycine. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 1132.
  5. Batsios G, Viswanath P, Cao P, Taglang C, Subramani E, Flavell R, Larson P, Ronen S.  In vivo evaluation of pentose phosphate pathway activity in orthotopic glioma using hyperpolarized δ-[1-13C]gluconolactone. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 2304.
  6. Chen HY, Lee P, Zhu Z, Bok R, Ohliger M, Gordon J, Van Criekinge M, Carvajal L, Slater J, Larson P, Munster P, Aggarwal R, Kurhanewicz J, Vigneron D. Hyperpolarized 13C MRI of Patients with Metastatic Prostate Cancer to Bone and Liver. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0708.
  7. Chen HY, Autry A, Brender J, Kishimoto S, Krishna M, Vareth M, Bok R, Reed G, Chen A, Carvajal L, Gordon J, Van Criekinge M, Korenchan D, Xu D, Li Y, Kurhanewicz J, Larson P, Vigneron D. Signal Enhancement and Optimum Receiver Arrays for Human Hyperpolarized 13C MR Spectroscopic Imaging. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 2458.
  8. Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry A, Le Page L, Chaumeil M, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Bok R, Ronen S, Larson PEZ, Kurhanewicz J, Vigneron DB. First Hyperpolarized [2-13C]Pyruvate MR Studies of Human Brain Metabolism. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0724.
  9. Gordon JW, Tang S, Zhu X, Vigneron DB, Larson PEZ. Probing Cerebral Lactate Compartmentalization with Hyperpolarized Diffusion Weighted 13C MRI. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019.
  10. Gordon JW, Tang S, Chen HY, Vigneron DB, Larson PEZ. Investigating Pre-Saturation of Inflowing Lactate for Improving Human Hyperpolarized 13C-Pyruvate Brain Studies.  ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 4278.
  11. Guglielmetti C, Cordano C, Najac C, Green A, Chaumeil M. Metabolic imaging of brain inflammation using hyperpolarized 13C MRSI of pyruvate and urea in a mouse model of multiple sclerosis. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0723.
  12. Korn N, Gordon J, Delos Santos J, Chen HY, Larson P, Mammoli D, Bok R, Van Criekinge M, Slater J, Aggarwal R, Coopeberg M, Delos Santos L, Simko J, NoworolskiS, Vigneron D, Kurhanewicz J. Research Polarizer Quality Control Metrics and Resulting SNR in Human Prostate Cancer Patients. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 4325.
  13. LePage L, Guglielmetti C, Tiret B, Chaumeil M. Non-invasive detection of toxin-induced inflammation in the mouse brain using hyperpolarized 13C MRSI. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 4322.
  14. Milshteyn E, von Morze C, Gordon J, Reed G, Autry A, Chen HY, Mammoli D, Bok R, Slater J, Van Criekinge M, Carvajal L, Xu D, Larson P, Nelson S, Kurhanewicz J, Vigneron D. Hyperpolarized C-13 bSSFP Imaging of the Human Brain. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0255.
  15. Subramani E, Najac C, Batsios G, Viswanath P, Radoul M, Gillespie AM, Pieper RO, Ronen SM.  Hyperpolarized 5-13C-Glutamate metabolism as a biomarker of IDH1 mutant glioma response to temozolomide therapy.  ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 4315.
  16. Sun J, Delos Santos J, Bok R, Delos Santos R, Van Criekinge M, Vigneron DB, Sriram, R, Kurhanewicz J.  Androgen Independence Leads to Altered Metabolism in Prostate Cancer Cell and Murine Models. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0201.
  17. Sun J, Hsaio J, Delos Santos J, Bok R, Zhao H, Brancroft Brown J, Brooks J, Kurhanewicz, Peehl D, and Sriram R. Characterization of metabolic adaptations of patient-derived xenografts to in vitro tissue and cell culture using high-resolution NMR. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0508.
  18. Tang S, Gordon J, Bok R, Slater J, Wang J, Vigneron D, Larson P. Initial experience of applying bolus tracking and real-time B0/B1 calibration for human hyperpolarized 13C imaging. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0254.
  19. Tang S, Gordon J, Cao P, Bok R, Vigneron D, Larson P. An Optimized GRASE Sequence for Preclinical and Human Hyperpolarized 13C Imaging. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 4279.
  20. Villanueva-Meyer J, Autry A, Gordon J, Chen HY, Mammoli D, LaFontanine M, Chang S, Xu D, Larson P, Vigneron D, Nelson S, Li Y. Serial HP [1-13C] pyruvate and 1H metabolic imaging in multiply recurrent high-grade glioma.  ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 2868.
  21. Viswanath P, Batsios G, Pieper R, Ronen S. Imaging a hallmark of cancer: hyperpolarized [U-2H, U-13C]-glucose and hyperpolarized [1-13C]-dehydroascorbic acid can monitor TERT expression in gliomas. ISMRM Twenty-Seventh Scientific Meeting, Montreal, Canada, May 2019, 0253.





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