HMTRC Events Calendar

The Hyperpolarized MRI Technology Resource Center holds numerous lectures, seminars, hands-on workshops, retreats, and course.  Below is a list of present and future events, as well as those we had organized in the past.  To schedule new events with our center, please email hmtrc@ucsf.edu

 

DATE

EVENT

LOCATION

Thursday, March 23 - Friday, March 24, 2017

2017 HMTRC WORKSHOP
The March 2017 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes hands-on training, lectures, and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Bioreactors, Animal Preps, Chemistry & sterile Pharmacy Preps, Clinical Translation, and Software.

Details of the workshop, can be found in the:
Workshop Program.

On-line Workshop Presentations (Morning Sessions)
On-line Workshop Presentations (Evening Sessions)

 

For Guest Speaker Registration, contact Jenny Che, Program Mgr.

All UCSF Staff Registration, email hmtrc@ucsf.edu

For All Other Registration for the HMTRC Workshop at https://www.123signup.com/register?id=pshvj.

UCSF Mission Bay Campus

 

Monday, December 12, 2016
12:00pm - 1:00pm

Exit Seminar
WenWen Jiang
Graduate Student

Title: "Rapid & Robust Non-Cartesian Magnetic Resonance Imaging Methods" (Presentation)

Abstract: Magnetic resonance imaging (MRI) is a very powerful non-invasive medical imaging modality. Non-Cartesian imaging schemes not only allow efficient imaging acquisitions, but also generate new image contrast, thus enabling many promising MR imaging applications.


This work develops computational techniques for two rapid non-Cartesian imaging methods (concentric rings imaging and 3D radial imaging) and demonstrates their advanced applications in hyperpolarized carbon-13 MR spectroscopic imaging and pulmonary imaging. In addition, this work proposes a general retrospective correction method for gradient system delays for non-Cartesian imaging.. 

Mission Bay,
Genentech Hall N-114/Winsley Room

Hosted by: Dr. Peder Larson (UCSF) & MIchael "Miki" Lustig (UC Berkeley)

 

Thursday, November 17, 2016
11:00am-12:00pm

Guest Speaker Presentation
Justin Lau
PhD Candidate
University of Toronto

Title: "Interleaved Echo-Planar Imaging of Hyperpolarized Molecules: From Rats to Humans" (Lecture)

 

Mission Bay,
Byers Hall 212

Hosted by Dr. Vigneron

Monday, June 27, 2016
11:00am-12:00pm

Guest Speaker Presentation
Matthew Merritt, PhD
Associate Professor
University of Florida
Department of Biochemistry and Molecular Biology
Title: "Substrate selection in the hypertrophic and failing mouse heart" (Lecture)
Abstract: Hypertrophy and failure of the heart is characterized by profound changes in selection of nutrients for the production of acetyl-CoA. Recent results with hyperpolarized pyruvate have shown that metabolism of carbohydrates can be assayed in a straightforward manner in functioning tissues. Despite these technical advances, more work is needed to properly interpret the findings. A series of experiments have been carried out to compare steady state carbon-13 methods with results obtained with hyperpolarized MR. Results in the normal heart, in a model of hypertrophy, and a model of congestive heart failure will be presented.

Mission Bay,
Byers Hall 212

Tuesday, March 29 - Wednesday, March 30, 2016
 

2016 HMTRC WORKSHOP
The March 2016 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes hands-on training, lectures, and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Bioreactors, Animal Preps, Chemistry & sterile Pharmacy Preps, Clinical Translation, and Software.

Details of the workshop, can be found in the: Workshop Program.
On-line Workshop Presentations (Morning Sessions)
On-line Workshop Presentations (Evening Sessions)

Register for the HMTRC Workshop at https://www.123signup.com/register?id=pshty.

UCSF Mission Bay Campus

 

Past Events

Wednesday, August 26, 2015
11:00am-4:00pm

Hyperpolarized Probes Workshop 
The Hyperpolarized Carbon-13 MRI Technology Development Workshop on Hyperpolarized Probes includes presentations that focus on new probe developments and also two 30 minute panel discussions associated with the pre-clinical and clinical needs of the collaborative projects for new probes.

UCSF Mission Bay Campus, 
Byers Hall 212

Tuesday, July 28, 2015
11:00am-12:00pm

Guest Speaker Presentation
Matthew Merritt, PhD

Assistant Professor
University of Texas Southwestern Medical Center
Advanced Imaging Research Center, Radiology

Title: "Increased TCA Cycle Turnover in the Failing Heart: A Role for Anaplerotic Therapy" (Lecture) 

Mission Bay,
Byers Hall 212

Summer Quarter 2015; July 9 -
August 27

THURS-2:00pm-3:00pm (lecture) & 3:00pm-5:00pm (lab)

UCSF Bioengineering 297: Hyperpolarized MR Seminar
Faculty: Dr. Peder Larson

Course Description: Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more.  It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells.  This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments.  This course covers the mechanisms behind Dissolution DNP and experimental considerations.

Mission Bay,
Byers Hall 215 (Lectures); Biomedial NMR & Surbeck Laboratory (Lab)

Thursday, April 30, 2015
2:30pm-3:30pm

Guest Speaker Presentation
James A. Bankson, PhD
Associate Professor
University of Texas MD Anderson Cancer Center
Department of Imaging Physics, Division of Diagnostic Imaging

Title: "Modeling and Model-Based Imaging of HP Substrates"(Lecture)
 

Mission Bay,
Byers Hall 212

Winter Quarter 2015; January 19 - March 20
MW-2:00pm-3:30pm

UCSF Bioengineering 241: Magnetic Resonance Spectroscopy 
Faculty: Dr. John Kurhanewicz

Guest Lecturer: Dr. Peder Larson 

Course Description: This course assumes a basic understanding of magnetic resonance physics and will cover in detail the topic of nuclear magnetic resonance spectroscopy including both in vitro and in vivo applications. The course will cover basic theory, underlying biochemistry and physiology, basic and advanced techniques for acquiring and processing MR spectroscopic data, and biomedical applications for this emerging medical imaging modality. The course will also have four hands-on labs that will allow students to actually acquire and analyze spectroscopy data from human tissue extracts, a 3D cell culture bioreactor and a murine model of cancer. In addition to 2 didactic lectures per week, the course will have weekly discussion sessions focused on understanding the material covered in both lectures and labs. While not a pre-requisite, taking either Bioengineering 240, Biomedical Imaging 201, or a similar course that covers the basics of magnetic resonance imaging or NMR is advised. (Lecture & Lab) 

Mission Bay, 
Byer Hall 215 (Lectures); Biomedical NMR Lab (Lab)

Thursday, January 15, 2015
12:15pm-1:15pm

Guest Speaker Presentation 
Michael J. Harsh 
Vice President and Executive Advisor GE Ventures 
Title: "Technology Innovation at GE Healthcare"(Lecture) 

Mission Bay, 
Mission Hall 1401

Tuesday, November 18, 2014
11:00am-12:00pm

Guest Speaker Presentation 
Hideo Utsumi, PhD 
Professor, Research Managing Director, Innovation Center for Medical Redox Navigation, Kyushu University 
Title: "Redox molecular imaging using in vivo DNP-MRI" (Lecture) 

Mission Bay, 
Byers Hall 215

Friday, October 3, 2014
10:30am-11:30am

Guest Speaker Presentation 
Mathew Merritt, PhD 
Assistant Professor University of Texas Southwestern Medical Center Advanced Imaging Research Center, Radiology 
Title: "Substrate Selection in Heart Failure"(Lecture) 

Mission Bay, 
Byers Hall 212

Tuesday, March 11, 2014
8:00am-8:00pm

2014 HMTRC WORKSHOP 
The March 2014 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes lectures, hands-on training and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Bioreactors, Animal Preps, Chemistry Preps and Software. 

Details of the workshop, can be found in the: Workshop Program 
On-line Workshop Presentations

UCSF Mission Bay, 
Genentech Hall Auditorium (600 16th Street, San Francisco, CA 94158)

Thursday, March 6, 2014
1:00pm-2:00pm

Guest Speaker Presentation 
Leo Tam, PhD 
Post-doctoral Fellow Yale University, Biomedical Imaging 
Title: "Nonlinear Gradient Encoding: Design and Implementation on a 3T Human Scanner" (Lecture)

Mission Bay, 
Byers Hall 212

Thursday, January 23, 2014
4:00pm-5:00pm

Guest Speaker Presentation 
Sonal Josan, PhD 
Senior Research Scientist Stanford University Department of Radiology 
Title: "Dynamic metabolic imaging with 3D spiral CSI for hyperpolarized [2-13C]pyruvate" (Lecture) 

Mission Bay, 
Byers Hall 212

Thursday, January 16, 2014
12:00pm-1:00pm

Guest Speaker Presentation 
Matthew Merritt, PhD 
Assistant Professor
 University of Texas Southwestern Medical Center Advanced Imaging Research Center, Radiology 
Title: 
"Hyperpolarized Carbon-13 Studies of Intermediary Metabolism: Gluconeogenesis in the Liver, Compartmentation and Substrate Competition in the Heart" (Lecture) 

Mission Bay, 
Byers Hall 215

Friday, January 10, 2014
9:30am

Coil Day at UC Berkeley (workshop)

Cory 140, 
the newest instructional lab (donated by TI and Agilent)

Tuesday, November 19, 2013
8:30am-3:30pm

2013 HMTRC Retreat (Lecture & Poster Sessions) 
The UCSF Hyperpolarized MRI Technology Resource Center (HMTRC) will be holding a center retreat focused on the recent and future technological developments of the center. The retreat will include presentations from each of the Technology Research and Development (TR&D) projects on technical development updates and future directions followed by a poster session during lunch and each of the poster presenters are invited to present a summary of their poster. 

Presidio, Golden Gate Club, 
Hawthorn Room (135 Fisher Loop, San Francisco, CA 94129 

Driving Directions

Summer Quarter 2013;
July 2 – August 13, 2013; 

Tuesdays – 3:00pm-3:45pm (lectures); 
3:45pm-4:30pm (lab)

UCSF Bioengineering 297: 
Hyperpolarized MR Seminar
 (Lectures & Lab) 
Instructors: Peder Larson, PhD; Cornelius vonMoze, PhD; David Wilson, MD, PhD; Subramaniam Sukumar, PhD, and Mark van Criekinge 

Course Description: Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more. It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells. This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments. This course covers the mechanisms behind Dissolution DNP and experimental considerations. Attendance in this course and completion of a practical HyperSense operation Exam is required to used the Oxford Instruments HyperSense DNP polarizers at UCSF.

Mission Bay, 
Byers Hall 215 (Lectures); 
Biomedical NMR Lab or Surbeck Lab for Advanced Imaging (Lab)

Tuesday, July 23, 2013
10:00am-11:00am

Guest Speaker Presentation 
Brandon Armstrong, PhD 
Post-doctoral Fellow Harvard University, Department of Physics 
AA., Martinos Center for Biomedical Imaging at Massachusetts General Hospital 
Title: "Advances in Free Radical Imaging Using Overhauser-Enhanced MRI" (Lecture) 

Mission Bay, 
Byers Hall 215

Tuesday, February 12, 2012
10:30am

Guest Speaker Presentation 
Dr. Jeff M. Sands, MD 
Professor of Medicine and Physiology, 
Renal Division Director 
Emory University 
Title: "Regulation of Renal Urea Transport"(Lecture) 

Mission Bay, 
Byers Hall 212

Tuesday, March 20, 2012 
8:00am-8:00pm

2012 HMTRC WORKSHOP 
Hyperpolarized Carbon-13 MRI Technology Development (Lectures & Hands-on Workshop) 
The March 2012 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes lectures, hands-on training and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Bioreactors, Animal Preps, Chemistry Preps and Software. 

Details of the workshop, can be found in the Workshop Program. 

Register for the HMTRC Workshop at https://www.123signup.com/register?id=crqpt 

Mission Bay, 
Genentech Hall Auditorium (600 16th Street, San Francisco, CA 94158)


Winter Quarter 2012; January 11 – March 12
MW – 2:00pm-3:30pm

UCSF Bioengineering 241: Magnetic Resonance Spectroscopy (Course) 
Faculty: Drs. John Kurhanewicz, Dan Vigneron, Sarah Nelson, Sabrina Ronen, Susan Moyher Noworolski, Duan Xu, Peder Larson

Course Description: This course will cover a broad spectrum from basic MR physics to clinical applications of MR spectroscopy that provides noninvasive physiologic and biochemical information. The course will cover basic theory, underlying biochemistry and physiology, basic and advanced techniques for acquiring and processing MR spectroscopic data, and biomedical applications for this emerging medical imaging modality. Bio-engineering 240, which provides basics of conventional MR imaging, is not a pre-requisite but is advised. 

Mission Bay, 
Byers Hall 215

Thursday, February 23, 2012;
4:30pm

Journal Club 
1) Lau AZ, Chen AP, Hurd RE, Cunningham CH. Spectral-spatial excitation for rapid imaging of DNP compounds. NMR in Biomedicine. 2011. doi:10.1002/nbm.1743 

2) Mansson S, Petersson JS, Scheffler K. Fast metabolite mapping in the pig heart after injection of hyperpolarized (13)C-pyruvate with low-flip angle balanced steady-state free precession imaging. Magnetic Resonance in Medicine. 2012. doi:10.1002/mrm.24183 

3) Wiesinger F, Weidl E, Menzel MI, Janich MA, Khegai O, Glaser SJ, Haase A, et al. IDEAL spiral CSI for dynamic metabolic MRI imaging of hyperpolarized [1-(13)C]pyruvate. Magnetic Resonance in Medicine. 2011. doi.10.1002/mrm.23212 

Mission Bay, 
Byers Hall 209

Monday, February 6, 2012
3:30pm-4:30pm

Guest Speaker Presentation 
Marie Schroeder, PhD 
Sir Henry Wellcome Post-doctoral Fellow, 
Department of Physiology, Anatomy and Genetics 
University of Oxford 
Title: 
"Visualising Cardiomyocyte Function Using Hyperpolarised Carbon-13 Magnetic Resonance"(Lecture) 

Mission Bay, 
Byers Hall, BH-212

Thursday, January 19, 2012;
4:30pm

Journal Club 
Witney TH, Kettunen MI, Brindle KM. Kinetic Modeling of Hyperpolarized 13C Label Exchange between Pyruvate and Lactate in Tumor Cells. The Journal of Biological Chemistry. 2011; 286(28): 24572-24580. 

Mission Bay, 
Byers Hall 209

Friday, December 9, 2011
10:00am-11:00am

Guest Speaker Presentation 
Professor Howard Halpern, MD, PhD 
Center for EPR Imaging In Vivo Physiology, 
Department of Radiation and Cellular Oncology, 
University of Chicago
 
Title: "Oxygen Images of Tumors in Living Animals from Mice to Rabbits and Beyond"(Lecture) 

Mission Bay, 
Byers Hall 212

November 27 – December 2, 2011

RSNA 2011 Presentation 
Michael Ohliger, MD, PhD 

Title: "Basic Principles of Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy" (Educational Exhibit) 

RSNA Conference;
Space Number: LL-MIE2453

November 27 – December 2, 2011

Visit SIVIC at RSNA 2011 
Title "Visualization and Analysis of Dynamic MRSI and Perfusion MRI Using the Open-Source SIVIC Software Framework" (Educational Exhibit) 

RSNA Conference;
Space Number: LL-INE1174

Monday, July 18, 2011
4:00pm-5:00pm

Guest Speaker Presentation 
Professor Robert Griffin, PhD 
Director, Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology (MIT)
 
Title: "High Frequency Dynamic Nuclear Polarization in Rotating Solids -- Amyloid and Membrane Proteins" (Lecture) 

Mission Bay, 
Byers Hall 212