Hyperpolarized MRI Technology Resource Center

 

The Hyperpolarized MRI Technology Resource Center (HMTRC)  is a Biomedical Resource Technology Center funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) focuses on the development and dissemination of new advances in dissolution DNP techniques and instrumentation, specialized data acquisition methodology, and analysis software for biomedical research. 

Hyperpolarized MR is an emerging molecular imaging method to monitor enzymatic conversions through key, previously-inaccessible biochemical pathways.  Through numerous studies to date, hyperpolarized carbon-13 MR has shown outstanding research and potential clinical value, but requires major technological development to realize its full potential.  This motivation, coupled with the rapidly expanding interest at other sites, compelled us to create the “Hyperpolarized MRI Technology Resource Center”.  

This center is based on three Technology Research & Development (TR&D) projects led by experienced hyperpolarized MR researchers.  TR&D1 is focused on DNP polarizer and MR acquisition development and pre-clinical animal studies.  TR&D2 focuses on the development of new robust and realistic pre-clinical models for HP MR studies, optimization of current HP probes & investigation of new HP probes, and the development of methods that provide appropriate correlative pathologic, biologic and other imaging data for understanding and validating HP MR findings.  TR&D3 focuses on the development of a free open-source specialized data analysis platform for HP MR data reconstruction and interpretation.  All TR&D developments are driven in a push-pull interaction by the independently funded Collaborative Projects and the technology resources of the center are utilized by Service Projects and disseminated to all interested investigators through hands-on workshops, symposia, visits/training, formal courses, and our center website.  

The goal of the HMTRC is to collaboratively develop new technology to advance this field in order to better identify and understand human disease and ultimately to translate and disseminate these techniques for improved healthcare.  


Featured Publications*

Publication #1 Title:  A variable resolution approach for improved acquisition of hyperpolarized 13C metabolic MRI

Authors: Jeremy W Gordon, Adam W Autry, Shuyu Tang, Jasmine Y Graham, Robert A Bok, Xucheng Zhu, Javier E Villanueva-Meyer, Yan Li, Michael A Ohilger, Maria Roselle Abraham, Duan Xu, Daniel B Vigneron, Peder E Z Larson.

Abstract: To ameliorate tradeoffs between a fixed spatial resolution and signal-to-noise ratio (SNR) for hyperpolarized 13C MRI.


Publication #2 Title: Slice profile effects on quantitative analysis of hyperpolarized pyruvate

Authors:  Christopher M. Walker, Jeremy W. Gordon, Zhan Xu, Keith A. Michel, Liang Li, Peder E.Z. Larson, Daniel B. Vigneron, James A. Bankson.

Abstract: Magnetic resonance imaging of hyperpolarized pyruvate provides a new imaging biomarker for cancer metabolism, based on the dynamic in vivo conversion of hyperpolarized pyruvate to lactate. Methods for quantification of signal evolution need to be robust and reproducible across a range of experimental conditions. Pharmacokinetic analysis of dynamic spectroscopic imaging data from hyperpolarized pyruvate and its metabolites generally assumes that signal arises from ideal rectangular slice excitation profiles. In this study, we examined whether this assumption could lead to bias in kinetic analysis of hyperpolarized pyruvate and, if so, whether such a bias can be corrected.

Featured Publication #1: A variable resolution approach for improved acquisition of hyperpolarized 13C metabolic MRI. PMID: 32697867

Featured Publication #2: Slice profile effects on quantitative analysis of hyperpolarized pyruvate  PMID: 32743881

 

 Link to Previously Featured Publications


***Please acknowledge NIBIB P41EB013598 in any publications that have benefitted from this center***   

 

Links to other NIH Resource Centers

     

 

 


***If you would like to donate to the Department of Radiology and Biomedical Imaging or to Dr. Daniel Vigneron, please complete the online giving form. To support this new imaging development, under choose a designation, select "other" and enter Dr. Daniel Vigneron. Your kind contribution and support is greatly appreciated by the Department of Radiology and Biomedical Imaging and the HMTRC Executive Members.***