Hyperpolarized MRI Technology Resource Center

The Hyperpolarized MRI Technology Resource Center (HMTRC)  is a Biomedical Resource Technology Center funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) focuses on the development and dissemination of new advances in dissolution DNP techniques and instrumentation, specialized data acquisition methodology, and analysis software for biomedical research. 

Hyperpolarized MR is an emerging molecular imaging method to monitor enzymatic conversions through key, previously-inaccessible biochemical pathways.  Through numerous studies to date, hyperpolarized carbon-13 MR has shown outstanding research and potential clinical value, but requires major technological development to realize its full potential.  This motivation, coupled with the rapidly expanding interest at other sites, compelled us to create the “Hyperpolarized MRI Technology Resource Center”.  

This center is based on three Technology Research & Development (TR&D) projects led by experienced hyperpolarized MR researchers.  TR&D1 is focused on DNP polarizer and MR acquisition development and pre-clinical animal studies.  TR&D2 focuses on the development of new robust and realistic pre-clinical models for HP MR studies, optimization of current HP probes & investigation of new HP probes, and the development of methods that provide appropriate correlative pathologic, biologic and other imaging data for understanding and validating HP MR findings.  TR&D3 focuses on the development of a free open-source specialized data analysis platform for HP MR data reconstruction and interpretation.  All TR&D developments are driven in a push-pull interaction by the independently funded Collaborative Projects and the technology resources of the center are utilized by Service Projects and disseminated to all interested investigators through hands-on workshops, symposia, visits/training, formal courses, and our center website.  

The goal of the HMTRC is to collaboratively develop new technology to advance this field in order to better identify and understand human disease and ultimately to translate and disseminate these techniques for improved healthcare.  

Featured Publications*

Publication #1 Title:  Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13C MRSI

Authors: Hsin-Yu Chen Adam W. Autry Jeffrey R. Brender Shun Kishimoto Murali C. Krishna Maryam Vareth Robert A. Bok Galen D. Reed Lucas Carvajal Jeremy W. Gordon Mark van Criekinge David E. Korenchan Albert P. Chen Duan Xu Yan Li Susan M. Chang John Kurhanewicz Peder Larson Daniel B. Vigneron.

Abstract: With the initiation of human hyperpolarized 13C (HP‐13C) trials at multiple sites and the development of improved acquisition methods, there is an imminent need to maximally extract diagnostic information to facilitate clinical interpretation. This study aims to improve human HP‐13C MR spectroscopic imaging through means of Tensor Rank truncation‐Image enhancement (TRI) and optimal receiver combination (ORC).

Publication #2 Title: Characterization of serial hyperpolarized 13 C metabolic imaging in patients with glioma

Authors:  Adam W Autry, Jeremy W Gordon,  Hsin-Yu Chen, Marisa LaFontaine, Robert Bok, Mark Van Criekinge,  James B Slater, Lucas Carvajal, Javier E Villanueva-Meyer, Susan M Chang, Jennifer L Clarke, Janine M Lupo, Duan Xu, Peder E Z Larson, Daniel B Vigneron, Yan Li.

Abstract: Hyperpolarized carbon-13 (HP-13C) MRI is a non-invasive imaging technique for probing brain metabolism, which may improve clinical cancer surveillance. This work aimed to characterize the consistency of serial HP-13C imaging in patients undergoing treatment for brain tumors and determine whether there is evidence of aberrant metabolism in the tumor lesion compared to normal-appearing tissue.

Featured Publication #1: Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13C MRSI

Featured Publication #2: Characterization of serial hyperpolarized 13 C metabolic imaging in patients with glioma.  PMCID: PMC7334458 

 Link to Previously Featured Publications

***Please acknowledge NIBIB P41EB013598 in any publications that have benefitted from this center***   


Links to other NIH Resource Centers




***If you would like to donate to the Department of Radiology and Biomedical Imaging or to Dr. Daniel Vigneron, please complete the online giving form. To support this new imaging development, under choose a designation, select "other" and enter Dr. Daniel Vigneron. Your kind contribution and support is greatly appreciated by the Department of Radiology and Biomedical Imaging and the HMTRC Executive Members.***