Hyperpolarized MRI Technology Resource Center

Our center is dedicated to the development of state-of-the-art imaging techniques, particularly on instruments that will use Carbon-13 based compounds. Our aim is at disseminating optimal new hyperpolarized (HP) 13C MR technologies with optimal training/documentation to advance these emerging molecular imaging methods. Hyperpolarized 13C MR has outstanding research and clinical value, however most aspects of this technology (instrumentation, agent chemistry, DNP/dissolution methodology, MR acquisition, and data analysis) are currently suboptimal and require focused technological development to realize their full potential. The center includes three Technology Research & Development (TR&D) projects led by experienced hyperpolarized MR researchers.


Featured Manuscript*

Development of High Resolution 3D Hyperpolarized Carbon-13 MR Molecular Imaging Techniques

PII: S0730-725X(17)30003-6
DOI: doi: 10.1016/j.mri.2017.01.003
Reference: MRI 8710

Authors:  Eugene Milshteyn, Cornelius von Morze, Galen D. Reed, Hong Shang, Peter J. Shin, Zihan Zhu, Hsin-Yu Chen, Robert Bok, Andrei Goga, John Kurhanewicz, Peder E.Z.Larson, Daniel B. Vigneron


The goal of this project was to develop and apply techniques for T2 mapping and 3D high resolution (1.5 mm isotropic; 0.003 cm3) 13C imaging of hyperpolarized (HP) probes [1-13C]lactate, [1-13C]pyruvate, [2-13C]pyruvate, and [13C,15N2]urea in vivo.

Click on the image below to learn more about this research on high resolution imaging.

*Development of High Resolution 3D Hyperpolarized Carbon-13 MR Molecular Imaging Techniques.  2017



***Please acknowledge NIBIB P41EB013598 in any publications that have benefitted from this center***   


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***If you would like to donate to the Department of Radiology and Biomedical Imaging or to Dr. Daniel Vigneron, please complete the online giving form. To support this new imaging development, under choose a designation, select "other" and enter Dr. Daniel Vigneron. Your kind contribution and support is greatly appreciated by the Department of Radiology and Biomedical Imaging and the HMTRC Executive Members.***