Molecular Imaging Lab (Flavell Lab)

The overall goal of the Molecular Imaging Lab (Flavell Lab) is the development of new molecular imaging probes for better risk stratification and monitoring of response to therapy in patients with cancer. The Molecular Imaging Lab focuses on two modalities, positron emission tomography (PET) and hyperpolarized 13C magnetic resonance imaging. One particular area of interest is studying the microenvironment in cancer and its role in prognosis. Specifically, alterations in tissue pH, metal homeostasis, and immune infiltration are current active targets. 

molecular imaging probes

Research Projects

Project 1

Methodology development for hyperpolarized 13C imaging of tissue pH and other alterations in the tissue microenvironment in cancer. In this strategy, a 13C labeled probe which has a predictable change in change in chemical shift in response to pH is hyperpolarized and administered. By comparison to an ex-vivo standard curve the pH can be determined. One of the probes being actively pursued is 13C, 15N ACES, one of Good’s buffers, with others in development.

Hyperpolarized 13C imaging
 

Project 2

This strategy relies on the use of 18F-FDG derivatives, termed FDG amines, which are protected with a caging group which decomposes upon exposure to mildly acidic conditions, such as seen in a solid tumor. The liberated 18F-FDG can then be absorbed into the adjacent cancer cell.

18F-FDG derivatives

People

Robert Flavell, MD, PhDRobert Flavell, MD, PhD
Principal Investigator
Assistant Professor in Residence

 

 

 


Dave KorenchanDave Korenchan
Postdoctoral Fellow (joining 7/2017)
dave.korenchan@ucsf.edu

 

 


Celine Taglang
Postdoctoral Fellow
celine.taglang@ucsf.edu


 

 


Sinan Wang
Postdoctoral Fellow
sinan.wang@ucsf.edu

 

 

 


Henry Li
MSBI Graduate Student
henry.li@ucsf.edu

 

 

 


Justin Yu
MSBI Graduate Student
justin.yu@ucsf.edu

 

 

Opportunities

We are actively recruiting postdoctoral fellows and graduate students (pdf) with interests in molecular imaging, positron emission tomography, chemistry and radiochemistry, and hyperpolarized 13C MRI. 

Please contact Dr. Flavell with inquiries: robert.flavell@ucsf.edu

News

March 2017
Dr. Flavell was awarded the Howard S. Stern research award by the Society of Abdominal Radiology for his proposal entitled “Imaging of Zn metabolism using hyperpolarized 13C magnetic resonance imaging in prostate cancer".

February 2017
Dr. Robert Flavell was awarded an American Cancer Society individual research grant.

January 2017
Congratulations to Celine Taglang for being awarded a Department of Defense Postdoctoral Early Investigator Research Award.

September 2016
Dr. Robert Flavell was awarded a Department of Defense Physician Research Training Grant, entitled “Detection of aggressive prostate tumors using novel PET and hyperpolarized 13C probes targeting interstitial acidity.

Publications

Featured Publications

Flavell R.R.; Westphalen, A.C.; Liang, C.; Sotto, C.C.; Noworolski, S.M.; Vigneron, D.B.; Wang, Z.J.; Kurhanewicz, J. Abnormal findings on multiparametric prostate magnetic resonance imaging predict disease progression in patients with low risk prostate cancer managed with active surveillance, Abdom Imaging. 2014 Oct; 39(5):1027-35.

Flavell, R.R., Korenchan, D; von Morze, C; Van Criekinge, M; Sriram, R.; Gordon, J.; Subramaniam S.; Bok, R.; Blecha, J.; Vigneron, D.; Keshari K.; Larson, P.; Kurhanewicz J.; Wilson, D.M.  Application of Good’s buffers to pH imaging using hyperpolarized 13C-MRI Chem. Comm. 2015. 51, 14119-22.

Flavell R.R., Truillet C., Regan M.K., Ganguly T., Blecha J.E., Kurhanewicz J., VanBrocklin H.F., Keshari K.R., Chang C.J., Evans M.J., Wilson D.M. Caged [18F]FDG glycosylamines for imaging acidic tumor microenvironment using positron emission tomography, Bioconjugate chem. 2016, 27, 170-8. 

Flavell, R.R., Naeger, D.M., Mari Aparici, C., Hawkins, R.A., Pampaloni, M.H., Behr, S.C. Low FDG avidity malignancy on PET/CT: Pitfalls and Prognostic Significance Radiographics 2016, 36, 293-4.

Korenchan D.E., Flavell R.R., Baligand C., Sriram R., Neumann K., Sukumar S., VanBrocklin H., Vigneron D.B., Wilson D.M., Kurhanewicz J., Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging. Chem Comm., 2016, 52, 3030-3.

Flavell R.R., Wilson D.M., Behr S.C., Recent developments in combined PET/MRI. Curr. Radiol. Rep., 2016, 4(5) 1-10. 

Carroll V., Truillet C., Shen B., Flavell R.R., Shao X, Evans M.J., VanBrocklin H.F., Scott P., Chin F., Wilson D.M. [11C]Ascorbic and [11C]Dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography. Chem. Comm. 2016, 52, 4888-90.

Flavell R.R., Behr S.C., Mabray M.C., Henandez-Pampaloni M., Naeger D.M., Detecting pulmonary nodules in lung cancer patients using whole body FDG PET/CT, high resolution lung reformat of FDG PET/CT, or diagnostic breath hold chest CT. Acad Radiol 2016, in press.

Liu W., Truillet C., Flavell R.R., Brewer T.F., Evans M.J., Wilson D.M., Chang C.J. A reactivity based [18F]FDG probe for in vivo formaldehyde imaging using positron emission tomography. Chem. Sci. 2016, 7, 5503-7.

Complete list of publications:

https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/46224495/?sort=date&direction=ascending

Research gate site:

https://www.researchgate.net/profile/Robert_Flavell?

PET scan detect acidic tumors

PET imaging using 18F-FDG