Michael Dae, MD

Professor Emeritus
Prof In Residence

Biography

Michael Dae, MD, is Professor Emeritus Residence in Nuclear Medicine Section at the University of California, San Francisco. Dr. Dae obtained his medical degree in Medicine from Duke University in Durham, North Carolina in 1976, and completed his residency in Pediatrics at the Children’s Hospital in Boston, Massachusetts in 1978, followed by a fellowship in Pediatric Cardiology and Nuclear Cardiology from UCSF. Currently, he leads an initiative to increase clinical utilization of cardiac positron emission tomographic imaging (PET) for patients to provide better diagnostic imaging with less radiation exposure, and greater patient experience.

As a research focus, Dr. Dae and his colleagues have developed extensive experience with radionuclide assessment of myocardial sympathetic innervation. They evaluate the ability of MIBG to map sympathetic innervation in various experimental models of cardiac disease, and have characterized the physiologic and electro physiologic consequences of abdominal uptake and distribution of the tracer. Also, Dr. Dae and his colleagues have extensive experience in the pre-clinical and clinical assessment of new medical devices in cardiovascular medicine, ranging from assessment of prototypes to the completion of GLP studies for FDA submissions.

Dr. Dae has published and written 93 articles, 27 book chapters, and 6 significant publications. He is responsible for conceiving studies, assisting with trail designs, supervising performances, and designing imaging aspects of the experiments.

Expertise:
Nuclear Medicine

Specialty:
Nuclear cardiology

Professional Interests:
Development of a noninvasive approach to treat acute and chronic kidney disease

Education and Training:
• Medical School: Duke University, Durham, North Carolina - Medicine
• Internship: Children’s Hospital, Boston, Massachusetts - Pediatrics
• Residency: Children’s Hospital, Boston, Massachusetts - Pediatrics
• Residency: University of California, San Francisco - Nuclear Medicine, Chief Resident
• Fellowship: University of California, San Francisco - Pediatric Cardiology
• Fellowship: University of California, San Francisco - Nuclear Cardiology
• Master of Business Administration: University of San Francisco - Business
• Diplomate, National Board of Medical Examiners
• California License
• American Board of Pediatrics
• American Board of Nuclear Medicine
• Certified - Advanced Cardiac Life Support
• Certified - Basic Life Support
• Level 2 Certification for Competency in Cardiac CT
• Certificate of Proficiency - PET/CT - American College of Radiology
• Certified - Advanced Cardiac Life Support

Education

M.D., 1976 - School of Medicine, Duke University
Clinical Fellowship, - Radiology, University of California, San Francisco
Residency, - School of Medicine, University of California, San Francisco

Honors and Awards

Fellow Award, American College of Cardiology, 2003
Cardiovascular Diseases, Nuclear Medicine, Best Doctors in America, 2003
First Award, NIH, 1988-1993
Pre-Tenure Award, niversity of California, San Francisco, 1988
Academic Senate Faculty Development Award, University of California, San Francisco, 1987
Research Training Grant, PHS, 1978

Publications

Dallan LAP, Giannetti NS, Rochitte CE, Polastri TF, San Martin CYB, Hajjar LA, Nicolau JC, Oliveira MT, Dae M, Ribeiro da Silva EE, Kalil Filho R, Lemos Neto PA, Timerman S. Cooling as an Adjunctive Therapy to Percutaneous Intervention in Acute Myocardial Infarction: COOL-MI InCor Trial. Ther Hypothermia Temp Manag. 2020 Jun 17.
Kurz MC, Lyden P, Dae M, Noc M. Studies Targeting Stroke and Acute Myocardial Infarction. Ther Hypothermia Temp Manag. 2019 03; 9(1):8-12.
Dae M, O'Neill W, Grines C, Dixon S, Erlinge D, Noc M, Holzer M, Dee A. Effects of endovascular cooling on infarct size in ST-segment elevation myocardial infarction: A patient-level pooled analysis from randomized trials. J Interv Cardiol. 2018 Jun; 31(3):269-276.
Mateos-Pérez JM, Desco M, Dae MW, García-Villalba C, Cussó L, Vaquero JJ. Automatic TAC extraction from dynamic cardiac PET imaging using iterative correlation from a population template. Comput Methods Programs Biomed. 2013 Aug; 111(2):308-14.
Vaquero JJ, Gao DW, García-Villaba C, Bacharach S, Vanbrocklin H, Fang Q, Desco M, Lee R, Dae M. Approach to assessing myocardial perfusion in rats using static [13N]-ammonia images and a small-animal PET. Mol Imaging Biol. 2012 Oct; 14(5):541-5.
Sayre GA, Bacharach SL, Dae MW, Seo Y. Combining dynamic and ECG-gated 8²Rb-PET for practical implementation in the clinic. Nucl Med Commun. 2012 Jan; 33(1):4-13.
Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ. Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PLoS One. 2010 Apr 28; 5(4):e10384.
Nikolic SD, Khairkhahan A, Ryu M, Champsaur G, Breznock E, Dae M. Percutaneous implantation of an intraventricular device for the treatment of heart failure: experimental results and proof of concept. J Card Fail. 2009 Nov; 15(9):790-7.
del Romeral LM, Stillson C, Lesh M, Dae M, Botvinick E. The relationship of myocardial contraction and electrical excitation--the correlation between scintigraphic phase image analysis and electrophysiologic mapping. J Nucl Cardiol. 2009 Sep-Oct; 16(5):792-800.
Botvinick E, Davis J, Dae M, O'Connell J, Schechtmann N, Abbott J, Morady F, Lanzer P, Iskikian J, Scheinman M. Localization of ventricular tachycardia exit site and subsequent contraction sequence and functional effects with bedside radionuclide angiography. JACC Cardiovasc Imaging. 2008 Sep; 1(5):605-13.
Dae MW. Pediatric nuclear cardiology. Semin Nucl Med. 2007 Sep; 37(5):382-90.
Seo Y, Gao DW, Hasegawa BH, Dae MW, Franc BL. Rodent brain imaging with SPECT/CT. Med Phys. 2007 Apr; 34(4):1217-20.
Banki N, Kopelnik A, Tung P, Lawton MT, Gress D, Drew B, Dae M, Foster E, Parmley W, Zaroff J. Prospective analysis of prevalence, distribution, and rate of recovery of left ventricular systolic dysfunction in patients with subarachnoid hemorrhage. J Neurosurg. 2006 Jul; 105(1):15-20.
Sharkey H, Nikolic S, Khairkhahan A, Dae M. Left ventricular apex occluder. Description of a Ventricular Partitioning Device. EuroIntervention. 2006 May; 2(1):125-7.
Banki NM, Kopelnik A, Dae MW, Miss J, Tung P, Lawton MT, Drew BJ, Foster E, Smith W, Parmley WW, Zaroff JG. Acute neurocardiogenic injury after subarachnoid hemorrhage. Circulation. 2005 Nov 22; 112(21):3314-9.
Khush K, Kopelnik A, Tung P, Banki N, Dae M, Lawton M, Smith W, Drew B, Foster E, Zaroff J. Age and aneurysm position predict patterns of left ventricular dysfunction after subarachnoid hemorrhage. J Am Soc Echocardiogr. 2005 Feb; 18(2):168-74.
Frelinger AL, Furman MI, Barnard MR, Krueger LA, Dae MW, Michelson AD. Combined effects of mild hypothermia and glycoprotein IIb/IIIa antagonists on platelet-platelet and leukocyte-platelet aggregation. Am J Cardiol. 2003 Nov 01; 92(9):1099-101.
Hale SL, Dae MW, Kloner RA. Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarction. Cardiovasc Res. 2003 Sep 01; 59(3):715-22.
Wu MC, Gao DW, Sievers RE, Lee RJ, Hasegawa BH, Dae MW. Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice. J Am Coll Cardiol. 2003 Aug 06; 42(3):576-82.
Dae MW, Gao DW, Ursell PC, Stillson CA, Sessler DI. Safety and efficacy of endovascular cooling and rewarming for induction and reversal of hypothermia in human-sized pigs. Stroke. 2003 Mar; 34(3):734-8.
Dixon SR, Whitbourn RJ, Dae MW, Grube E, Sherman W, Schaer GL, Jenkins JS, Baim DS, Gibbons RJ, Kuntz RE, Popma JJ, Nguyen TT, O'Neill WW. Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction. J Am Coll Cardiol. 2002 Dec 04; 40(11):1928-34.
Wu MC, Hasegawa BH, Dae MW. Performance evaluation of a pinhole SPECT system for myocardial perfusion imaging of mice. Med Phys. 2002 Dec; 29(12):2830-9.
Dae MW, Gao DW, Sessler DI, Chair K, Stillson CA. Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1584-91.
Johnson LL, Thambar S, Donahay T, Dae M, Williams DO. Effect of endomyocardial laser channels on regional innervation shown with (125)I-MIBG and autoradiography. J Nucl Med. 2002 Apr; 43(4):551-5.
Mokhtarani M, Mahgoub AN, Morioka N, Doufas AG, Dae M, Shaughnessy TE, Bjorksten AR, Sessler DI. Buspirone and meperidine synergistically reduce the shivering threshold. Anesth Analg. 2001 Nov; 93(5):1233-9.
Yoshioka K, Gao DW, Chin M, Stillson C, Penades E, Lesh M, O'Connell W, Dae M. Heterogeneous sympathetic innervation influences local myocardial repolarization in normally perfused rabbit hearts. Circulation. 2000 Mar 07; 101(9):1060-6.
De Marco T, Dae M, Yuen-Green MS, Kumar S, Sudhir K, Keith F, Amidon TM, Rifkin C, Klinski C, Lau D. Iodine-123 metaiodobenzylguanidine scintigraphic assessment of the transplanted human heart: evidence for late reinnervation. J Am Coll Cardiol. 1995 Mar 15; 25(4):927-31.
Foster E, O'Kelly B, LaPidus A, Sandler D, Tucker K, Dae M, Schiller NB, Botvinick EH. Segmental analysis of resting echocardiographic function and stress scintigraphic perfusion: implications for myocardial viability. Am Heart J. 1995 Jan; 129(1):7-14.
Newman D, Munoz L, Chin M, Franz M, Herre J, Scheinman MM, Botvinick E, Dae M. Effects of canine myocardial infarction on sympathetic efferent neuronal function: scintigraphic and electrophysiologic correlates. Am Heart J. 1993 Nov; 126(5):1106-12.
Verrier ED, Crombleholme TM, Sauer L, Longaker M, Langer JC, Flake AW, Dae M, Brem H, Harrison MR. Neonatal model of heterotopic heart transplantation in pigs. J Thorac Cardiovasc Surg. 1989 Jul; 98(1):127-35; discussion 135-6.
Dae M, Wen YM, Botvinick EH, Scheinman M. ECG left anterior fascicular block reveals diverse patterns on scintigraphic phase analysis. Am Heart J. 1989 Apr; 117(4):861-9.
Schechtmann N, Botvinick EH, Dae M, Scheinman MM, O'Connell JW, Davis J, Winston S, Schwartz A, Abbott J. The scintigraphic characteristics of ventricular pre-excitation through Mahaim fibers with the use of phase analysis. J Am Coll Cardiol. 1989 Mar 15; 13(4):882-91.
Zhu YY, Lee W, Botvinick E, Dae M, Chatterjee K, Danforth J, Ports T. The clinical and pathophysiologic implications of pain, ST abnormalities, and scintigraphic changes induced during dipyridamole infusion: their relationships to the peripheral hemodynamic response. Am Heart J. 1988 Oct; 116(4):1071-80.
Zhu YY, Botvinick E, Dae M, Golden J, Hattner R, Scheinman M. Gallium lung scintigraphy in amiodarone pulmonary toxicity. Chest. 1988 Jun; 93(6):1126-31.
Botvinick EH, Dae M. Dipyridamole myocardial perfusion scintigraphy. West J Med. 1988 Apr; 148(4):454-5.
Herre JM, Wetstein L, Lin YL, Mills AS, Dae M, Thames MD. Effect of transmural versus nontransmural myocardial infarction on inducibility of ventricular arrhythmias during sympathetic stimulation in dogs. J Am Coll Cardiol. 1988 Feb; 11(2):414-21.
Botvinick E, Schechtmann N, Dae M, Scheinman M, Davis J, Herre J, Iskikian T, Abbott J. Augmented preexcitation assessed by scintigraphic phase analysis during atrial pacing. Am Heart J. 1987 Oct; 114(4 Pt 1):738-45.
Axelrod RJ, De Marco T, Dae M, Botvinick EH, Chatterjee K. Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure. J Am Coll Cardiol. 1987 May; 9(5):1124-30.
Blumlein S, Bouchard A, Schiller NB, Dae M, Byrd BF, Ports T, Botvinick EH. Quantitation of mitral regurgitation by Doppler echocardiography. Circulation. 1986 Aug; 74(2):306-14.
Canhasi B, Dae M, Botvinick E, Lanzer P, Schechtmann N, Faulkner D, O'Connell W, Schiller N. Interaction of "supplementary" scintigraphic indicators of ischemia and stress electrocardiography in the diagnosis of multivessel coronary disease. J Am Coll Cardiol. 1985 Sep; 6(3):581-8.
Wahr DW, Ports TA, Botvinick EH, Dae M, Schechtmann N, Huberty J, Hattner RS, O'Connell JW, Turley K. The effects of coronary angioplasty and reperfusion on distribution of myocardial flow. Circulation. 1985 Aug; 72(2):334-43.
Dae M, Canhasi B, Botvinick E, Olvera S, Schechtmann N, Engelstad B, Hattner R, Schiller N, O'Connell W, Faulkner D. The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy. Invest Radiol. 1985 Jul; 20(4):388-92.
Frais M, Botvinick E, Shosa D, O'Connell W, Pacheco Alvarez J, Dae M, Hattner R, Faulkner D. Phase image characterization of localized and generalized left ventricular contraction abnormalities. J Am Coll Cardiol. 1984 Nov; 4(5):987-98.
Botvinick E, Frais M, O'Connell W, Faulkner D, Scheinman M, Morady F, Sung R, Shosa D, Dae M. Phase image evaluation of patients with ventricular pre-excitation syndromes. J Am Coll Cardiol. 1984 Mar; 3(3):799-814.