Michael Dae, MD

Professor Emeritus
Prof In Residence


Michael Dae, MD, is Professor Emeritus Residence in Nuclear Medicine Section at the University of California, San Francisco. Dr. Dae obtained his medical degree in Medicine from Duke University in Durham, North Carolina in 1976, and completed his residency in Pediatrics at the Children’s Hospital in Boston, Massachusetts in 1978, followed by a fellowship in Pediatric Cardiology and Nuclear Cardiology from UCSF. Currently, he leads an initiative to increase clinical utilization of cardiac positron emission tomographic imaging (PET) for patients to provide better diagnostic imaging with less radiation exposure, and greater patient experience.

As a research focus, Dr. Dae and his colleagues have developed extensive experience with radionuclide assessment of myocardial sympathetic innervation. They evaluate the ability of MIBG to map sympathetic innervation in various experimental models of cardiac disease, and have characterized the physiologic and electro physiologic consequences of abdominal uptake and distribution of the tracer. Also, Dr. Dae and his colleagues have extensive experience in the pre-clinical and clinical assessment of new medical devices in cardiovascular medicine, ranging from assessment of prototypes to the completion of GLP studies for FDA submissions.

Dr. Dae has published and written 93 articles, 27 book chapters, and 6 significant publications. He is responsible for conceiving studies, assisting with trail designs, supervising performances, and designing imaging aspects of the experiments.

Nuclear Medicine

Nuclear cardiology

Professional Interests:
Development of a noninvasive approach to treat acute and chronic kidney disease

Education and Training:
• Medical School: Duke University, Durham, North Carolina - Medicine
• Internship: Children’s Hospital, Boston, Massachusetts - Pediatrics
• Residency: Children’s Hospital, Boston, Massachusetts - Pediatrics
• Residency: University of California, San Francisco - Nuclear Medicine, Chief Resident
• Fellowship: University of California, San Francisco - Pediatric Cardiology
• Fellowship: University of California, San Francisco - Nuclear Cardiology
• Master of Business Administration: University of San Francisco - Business
• Diplomate, National Board of Medical Examiners
• California License
• American Board of Pediatrics
• American Board of Nuclear Medicine
• Certified - Advanced Cardiac Life Support
• Certified - Basic Life Support
• Level 2 Certification for Competency in Cardiac CT
• Certificate of Proficiency - PET/CT - American College of Radiology
• Certified - Advanced Cardiac Life Support


M.D., 1976 - School of Medicine, Duke University
Clinical Fellowship, - Radiology, University of California, San Francisco
Residency, - School of Medicine, University of California, San Francisco

Honors and Awards

Fellow Award, American College of Cardiology, 2003
Cardiovascular Diseases, Nuclear Medicine, Best Doctors in America, 2003
First Award, NIH, 1988-1993
Pre-Tenure Award, niversity of California, San Francisco, 1988
Academic Senate Faculty Development Award, University of California, San Francisco, 1987
Research Training Grant, PHS, 1978


Dae MW, Liu KD, Solomon RJ, Gao DW, Stillson CA. Effect of Low-Frequency Therapeutic Ultrasound on Induction of Nitric Oxide in CKD: Potential to Prevent Acute Kidney Injury. Kidney Dis (Basel). 2020 Nov; 6(6):453-460.
Dallan LAP, Giannetti NS, Rochitte CE, Polastri TF, San Martin CYB, Hajjar LA, Lima FG, Nicolau JC, Oliveira MT, Dae M, Ribeiro da Silva EE, Kalil Filho R, Lemos Neto PA, Timerman S. Cooling as an Adjunctive Therapy to Percutaneous Intervention in Acute Myocardial Infarction: COOL-MI InCor Trial. Ther Hypothermia Temp Manag. 2021 Sep; 11(3):135-144.
Kurz MC, Lyden P, Dae M, Noc M. Studies Targeting Stroke and Acute Myocardial Infarction. Ther Hypothermia Temp Manag. 2019 03; 9(1):8-12.
Dae M, O'Neill W, Grines C, Dixon S, Erlinge D, Noc M, Holzer M, Dee A. Effects of endovascular cooling on infarct size in ST-segment elevation myocardial infarction: A patient-level pooled analysis from randomized trials. J Interv Cardiol. 2018 Jun; 31(3):269-276.
Mateos-Pérez JM, Desco M, Dae MW, García-Villalba C, Cussó L, Vaquero JJ. Automatic TAC extraction from dynamic cardiac PET imaging using iterative correlation from a population template. Comput Methods Programs Biomed. 2013 Aug; 111(2):308-14.
Vaquero JJ, Gao DW, García-Villaba C, Bacharach S, Vanbrocklin H, Fang Q, Desco M, Lee R, Dae M. Approach to assessing myocardial perfusion in rats using static [13N]-ammonia images and a small-animal PET. Mol Imaging Biol. 2012 Oct; 14(5):541-5.
Sayre GA, Bacharach SL, Dae MW, Seo Y. Combining dynamic and ECG-gated ⁸²Rb-PET for practical implementation in the clinic. Nucl Med Commun. 2012 Jan; 33(1):4-13.
Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ. Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PLoS One. 2010 Apr 28; 5(4):e10384.
Nikolic SD, Khairkhahan A, Ryu M, Champsaur G, Breznock E, Dae M. Percutaneous implantation of an intraventricular device for the treatment of heart failure: experimental results and proof of concept. J Card Fail. 2009 Nov; 15(9):790-7.
Botvinick E, Davis J, Dae M, O'Connell J, Schechtmann N, Abbott J, Morady F, Lanzer P, Iskikian J, Scheinman M. Localization of ventricular tachycardia exit site and subsequent contraction sequence and functional effects with bedside radionuclide angiography. JACC Cardiovasc Imaging. 2008 Sep; 1(5):605-13.
Dae MW. Pediatric nuclear cardiology. Semin Nucl Med. 2007 Sep; 37(5):382-90.
Seo Y, Gao DW, Hasegawa BH, Dae MW, Franc BL. Rodent brain imaging with SPECT/CT. Med Phys. 2007 Apr; 34(4):1217-20.
Banki N, Kopelnik A, Tung P, Lawton MT, Gress D, Drew B, Dae M, Foster E, Parmley W, Zaroff J. Prospective analysis of prevalence, distribution, and rate of recovery of left ventricular systolic dysfunction in patients with subarachnoid hemorrhage. J Neurosurg. 2006 Jul; 105(1):15-20.
Sharkey H, Nikolic S, Khairkhahan A, Dae M. Left ventricular apex occluder. Description of a Ventricular Partitioning Device. EuroIntervention. 2006 May; 2(1):125-7.
Banki NM, Kopelnik A, Dae MW, Miss J, Tung P, Lawton MT, Drew BJ, Foster E, Smith W, Parmley WW, Zaroff JG. Acute neurocardiogenic injury after subarachnoid hemorrhage. Circulation. 2005 Nov 22; 112(21):3314-9.
Khush K, Kopelnik A, Tung P, Banki N, Dae M, Lawton M, Smith W, Drew B, Foster E, Zaroff J. Age and aneurysm position predict patterns of left ventricular dysfunction after subarachnoid hemorrhage. J Am Soc Echocardiogr. 2005 Feb; 18(2):168-74.
Frelinger AL, Furman MI, Barnard MR, Krueger LA, Dae MW, Michelson AD. Combined effects of mild hypothermia and glycoprotein IIb/IIIa antagonists on platelet-platelet and leukocyte-platelet aggregation. Am J Cardiol. 2003 Nov 01; 92(9):1099-101.
Hale SL, Dae MW, Kloner RA. Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarction. Cardiovasc Res. 2003 Sep 01; 59(3):715-22.
Wu MC, Gao DW, Sievers RE, Lee RJ, Hasegawa BH, Dae MW. Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice. J Am Coll Cardiol. 2003 Aug 06; 42(3):576-82.
Dae MW, Gao DW, Ursell PC, Stillson CA, Sessler DI. Safety and efficacy of endovascular cooling and rewarming for induction and reversal of hypothermia in human-sized pigs. Stroke. 2003 Mar; 34(3):734-8.
Dixon SR, Whitbourn RJ, Dae MW, Grube E, Sherman W, Schaer GL, Jenkins JS, Baim DS, Gibbons RJ, Kuntz RE, Popma JJ, Nguyen TT, O'Neill WW. Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction. J Am Coll Cardiol. 2002 Dec 04; 40(11):1928-34.
Wu MC, Hasegawa BH, Dae MW. Performance evaluation of a pinhole SPECT system for myocardial perfusion imaging of mice. Med Phys. 2002 Dec; 29(12):2830-9.
Dae MW, Gao DW, Sessler DI, Chair K, Stillson CA. Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs. . 2002 May; 282(5):H1584-91.
Johnson LL, Thambar S, Donahay T, Dae M, Williams DO. Effect of endomyocardial laser channels on regional innervation shown with (125)I-MIBG and autoradiography. J Nucl Med. 2002 Apr; 43(4):551-5.
Gao DW, Talke PO, Dae MW. Effects of reduced sympathetic activity on myocardial metaiodobenzylguanidine (MIBG) washout. J Auton Pharmacol. 2001 Jun; 21(3):159-64.
Da Silva AJ, Tang HR, Wong KH, Wu MC, Dae MW, Hasegawa BH. Absolute quantification of regional myocardial uptake of 99mTc-sestamibi with SPECT: experimental validation in a porcine model. J Nucl Med. 2001 May; 42(5):772-9.
Arheden H, Saeed M, Higgins CB, Gao DW, Ursell PC, Bremerich J, Wyttenbach R, Dae MW, Wendland MF. Reperfused rat myocardium subjected to various durations of ischemia: estimation of the distribution volume of contrast material with echo-planar MR imaging. Radiology. 2000 May; 215(2):520-8.
Redberg RF, Nishino M, McElhinney DB, Dae MW, Botvinick EH. Long-term estrogen replacement therapy is associated with improved exercise capacity in postmenopausal women without known coronary artery disease. Am Heart J. 2000 Apr; 139(4):739-44.
Oka RK, De Marco T, Haskell WL, Botvinick E, Dae MW, Bolen K, Chatterjee K. Impact of a home-based walking and resistance training program on quality of life in patients with heart failure. Am J Cardiol. 2000 Feb 01; 85(3):365-9.
Arheden H, Saeed M, Higgins CB, Gao DW, Bremerich J, Wyttenbach R, Dae MW, Wendland MF. Measurement of the distribution volume of gadopentetate dimeglumine at echo-planar MR imaging to quantify myocardial infarction: comparison with 99mTc-DTPA autoradiography in rats. Radiology. 1999 Jun; 211(3):698-708.
Bremerich J, Wendland MF, Arheden H, Wyttenbach R, Gao DW, Huberty JP, Dae MW, Higgins CB, Saeed M. Microvascular injury in reperfused infarcted myocardium: noninvasive assessment with contrast-enhanced echoplanar magnetic resonance imaging. J Am Coll Cardiol. 1998 Sep; 32(3):787-93.
Bobba K, Botvinick EH, Sciammarella MG, Starsken NF, Zhu YY, Lapidus A, Dae MW. Is there any advantage to the acquisition of 24-hour thallium images, in the presence of persistent perfusion defects at 4 h after reinjection? Eur J Nucl Med. 1998 May; 25(5):509-14.
Botvinick EH, O'Connell JW, Kadkade PP, Glickman SL, Dae MW, Cohen TJ, Abbott J, Krishnan R. Potential added value of three-dimensional reconstruction and display of single photon emission computed tomographic gated blood pool images. J Nucl Cardiol. 1998 May-Jun; 5(3):245-55.
Wendland MF, Saeed M, Arheden H, Gao DW, Canet E, Bremerich J, Dae MW, Higgins CB. Toward necrotic cell fraction measurement by contrast-enhanced MRI of reperfused ischemically injured myocardium. Acad Radiol. 1998 Apr; 5 Suppl 1:S42-4; discussion S45-6.
DePuey EG, Port S, Wackers FJ, Rozanski A, Botvinick EH, Dae MW, Tamaki N. Nonperfusion applications in nuclear cardiology: report of a task force of the American Society of Nuclear Cardiology. J Nucl Cardiol. 1998 Mar-Apr; 5(2):218-31.
Kalki K, Blankespoor SC, Brown JK, Hasegawa BH, Dae MW, Chin M, Stillson C. Myocardial perfusion imaging with a combined x-ray CT and SPECT system. J Nucl Med. 1997 Oct; 38(10):1535-40.
Segall GM, Stepp C, Kadkade PP, Dae MW, Botvinick EH. Fast acquisition of myocardial SPECT images with Tc-99m sestamibi for the diagnosis of coronary artery disease. J Nucl Cardiol. 1997 Sep-Oct; 4(5):358-63.
Dae MW, Lee RJ, Ursell PC, Chin MC, Stillson CA, Moise NS. Heterogeneous sympathetic innervation in German shepherd dogs with inherited ventricular arrhythmia and sudden cardiac death. Circulation. 1997 Aug 19; 96(4):1337-42.
Ellis WS, Eisenberg SJ, Auslander DM, Dae MW, Zakhor A, Lesh MD. Deconvolution: a novel signal processing approach for determining activation time from fractionated electrograms and detecting infarcted tissue. Circulation. 1996 Nov 15; 94(10):2633-40.
Dae MW, O'Connell JW, Botvinick EH, Chin MC. Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content. Cardiovasc Res. 1995 Aug; 30(2):270-80.
Lurie KG, Dae MW, Dutton J, Velazquez-Rocha SJ, O'Connell JW. Metaiodobenzylguanidine as an index of atrioventricular nodal adrenergic activity. J Nucl Med. 1995 Jun; 36(6):1096-101.
Segall GM, Atwood JE, Botvinick EH, Dae MW, Lucas JR. Variability of normal coronary anatomy: implications for the interpretation of thallium-SPECT myocardial perfusion images in single-vessel disease. J Nucl Med. 1995 Jun; 36(6):944-51.
Dae MW. Scintigraphy of myocardial innervation with metaiodobenzylguanidine (MIBG): is there a clinical application? J Nucl Cardiol. 1995 Mar-Apr; 2(2 Pt 1):151-4.
Lee MA, Dae MW, Langberg JJ, Griffin JC, Chin MC, Finkbeiner WE, O'Connell JW, Botvinick E, Scheinman MM, Rosenqvist M. Effects of long-term right ventricular apical pacing on left ventricular perfusion, innervation, function and histology. J Am Coll Cardiol. 1994 Jul; 24(1):225-32.
Krishnan R, Lu J, Dae MW, Botvinick EH. Does myocardial perfusion scintigraphy demonstrate clinical usefulness in patients with markedly positive exercise tests? An assessment of the method in a high-risk subset. Am Heart J. 1994 Apr; 127(4 Pt 1):804-16.
Dae MW. Imaging of myocardial sympathetic innervation with metaiodobenzylguanidine. J Nucl Cardiol. 1994 Mar-Apr; 1(2 Pt 2):S23-30.
Wolfe CL, O'Connell JW, Sievers RE, Cobb C, Dae MW, Botvinick E. Assessment of perfused left ventricular mass in normal, ischemic, and reperfused myocardium by means of single-photon emission computed tomography of technetium-99m isonitrile. Am Heart J. 1993 Dec; 126(6):1275-86.
Yu KK, Saeed M, Wendland MF, Dae MW, Velasquez-Rocha S, Derugin N, Higgins CB. Comparison of T1-enhancing and magnetic susceptibility magnetic resonance contrast agents for demarcation of the jeopardy area in experimental myocardial infarction. Invest Radiol. 1993 Nov; 28(11):1015-23.
Botvinick EH, Dae MW, Krishnan R, Ewing S. Hypertrophic cardiomyopathy in the young: another form of ischemic cardiomyopathy? J Am Coll Cardiol. 1993 Sep; 22(3):805-7.
Krishnan R, Lu J, Zhu YY, Dae MW, Botvinick EH. Myocardial perfusion scintigraphy in left bundle branch block: a perspective on the issue from image analysis in a clinical context. Am Heart J. 1993 Sep; 126(3 Pt 1):578-86.
Lucas JR, Botvinick EH, Dae MW. Myocardial viability: evidence provided by the analysis of left ventricular systolic function. Coron Artery Dis. 1993 Jun; 4(6):485-94.
Starksen NF, O'Connell W, Dae MW, Botvinick EH. Basal interventricular septal thallium-201 defects: real or artifact? Clin Nucl Med. 1993 Apr; 18(4):291-7.
Botvinick EH, Zhu YY, O'Connell WJ, Dae MW. A quantitative assessment of patient motion and its effect on myocardial perfusion SPECT images. J Nucl Med. 1993 Feb; 34(2):303-10.
Munoz del Romeral L, Dae MW, Ports TA, Botvinick EH. Diagnostic and prognostic value of ambulatory electrocardiographic monitoring. Am Heart J. 1992 Nov; 124(5):1213-9.
Fischbein NJ, Dae MW, Sandler ED. A unique finding on I-123 MIBG imaging: pericardial effusion. Clin Nucl Med. 1992 Sep; 17(9):745.
Dae MW, De Marco T, Botvinick EH, O'Connell JW, Hattner RS, Huberty JP, Yuen-Green MS. Scintigraphic assessment of MIBG uptake in globally denervated human and canine hearts--implications for clinical studies. J Nucl Med. 1992 Aug; 33(8):1444-50.
Watters TA, Botvinick EH, Dae MW, Cahalan M, Urbanowicz J, Benefiel DJ, Schiller NB, Goldstone G, Reilly L, Stoney RJ. Comparison of the findings on preoperative dipyridamole perfusion scintigraphy and intraoperative transesophageal echocardiography: implications regarding the identification of myocardium at ischemic risk. J Am Coll Cardiol. 1991 Jul; 18(1):93-100.
Botvinick EH, Dae MW. Dipyridamole perfusion scintigraphy. Semin Nucl Med. 1991 Jul; 21(3):242-65.
Oeff M, Scheinman MM, Abbott JA, Botvinick EH, Griffin JC, Herre JM, Dae MW. Phase image triangulation of accessory pathways in patients undergoing catheter ablation of posteroseptal pathways. Pacing Clin Electrophysiol. 1991 Jun; 14(6):1072-85.
Dae MW, Herre JM, O'Connell JW, Botvinick EH, Newman D, Munoz L. Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction. J Am Coll Cardiol. 1991 May; 17(6):1416-23.
Rosenqvist M, Isaaz K, Botvinick EH, Dae MW, Cockrell J, Abbott JA, Schiller NB, Griffin JC. Relative importance of activation sequence compared to atrioventricular synchrony in left ventricular function. Am J Cardiol. 1991 Jan 15; 67(2):148-56.
Zhu YY, Chung WS, Botvinick EH, Dae MW, Lim AD, Ports TA, Danforth JW, Wolfe CL, Goldschlager N, Chatterjee K. Dipyridamole perfusion scintigraphy: the experience with its application in one hundred seventy patients with known or suspected unstable angina. Am Heart J. 1991 Jan; 121(1 Pt 1):33-43.
Dae MW, Botvinick EH. Imaging of the heart using metaiodobenzylguanidine. J Thorac Imaging. 1990 Jul; 5(3):31-6.
Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA. Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting. Anesthesiology. 1990 Apr; 72(4):607-12.
Botvinick EH, Dae MW, O'Connell JW. Blood pool scintigraphy. Cardiol Clin. 1989 Aug; 7(3):537-63.
Dae MW, O'Connell JW, Botvinick EH, Ahearn T, Yee E, Huberty JP, Mori H, Chin MC, Hattner RS, Herre JM. Scintigraphic assessment of regional cardiac adrenergic innervation. Circulation. 1989 Mar; 79(3):634-44.
Botvinick EH, O'Connell WJ, Dae MW, Hattner RS, Schechtmann NM. Analysis of thallium-201 "washout" from parametric color coded images. J Nucl Med. 1988 Mar; 29(3):302-10.
Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA. Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study. Am Heart J. 1985 Aug; 110(2):335-41.
Dae MW, Botvinick EH. Characterization of conduction and concentration abnormalities by scintigraphic phase analysis. Int J Cardiol. 1984 Feb; 5(2):244-53.