David Norman, MD

Professor Emeritus

Biography

David Norman, MD, is a Professor Emeritus and former Chief of Neuroradiology in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. He received his medical degree from Ursinus College, University of Pennsylvania Medical School in Collegeville, Pennsylvania, and completed his residency from Columbia University Medical Center in New York. Following military service in Vietnam and Denver, Dr. Norman completed a Neuroradiology fellowship at UCSF. In 2006, after a long and prolific career, Dr. Norman retired from the Department of Radiology.

Dr. Norman was among the first to highlight the use of MR imaging in the spinal cord, and his many subsequent contributions have contributed to current understanding of many disease states. Dr. Norman was integral to the development of new interventional angiographic techniques, and when MR imaging emerged, he made a name for UCSF in the new technology. In 1981 he wrote an article on dynamic computed tomography, which is published in the American Journal of Roentgenology. He was one of the first to detail the basis of the perfusion techniques that are used today. In that article, he wrote, “The concept of corrected mean transit time (MTT) applied to rapid sequence scans after intravenous bolus injection of contrast material provides quantitative data on hemispheric flow.” After 25 years, MTT maps are used everyday in the reading room.

Expertise:
Neuroradiology

Specialty:
MR imaging

Professional Interests:
Development of new interventional angiopgraphic techniques, MR and CT

Education and Training:
• Medical School: Ursinus College of Pennsylvania Medical School, Collegeville
• Internship: Hospital of the University of Pennsylvania, Philadelphia
• Residency: Columbia University Medical Center, New York - Radiology
• Fellowship: University of California, San Francisco - Neuroradiology
• California State Medical License (1970-present)
• Ohio State Medical License (1998, inactive)
• New York State Medical License (1999, inactive)
• National Medical Boards (1968-Present)
• Radiology Certificate (1972)
• Neuroradiology Certificate of Added Qualification (1996)

Education

Clinical Fellowship, - Radiology, University of California, San Francisco

Honors and Awards

Fellow, American College of Radiology, 1982
Sommer Memorial Lecturer, 1978
Alpha Omega Alpha, 1967

Publications

Wort JL, Ackermann K, Giannoulis A, Stewart AJ, Norman DG, Bode BE. Sub-Micromolar Pulse Dipolar EPR Spectroscopy Reveals Increasing CuII -labelling of Double-Histidine Motifs with Lower Temperature. Angew Chem Int Ed Engl. 2019 08 19; 58(34):11681-11685.
Iordanova B, Rosenbaum D, Norman D, Weiner M, Studholme C. MR imaging anatomy in neurodegeneration: a robust volumetric parcellation method of the frontal lobe gyri with quantitative validation in patients with dementia. AJNR Am J Neuroradiol. 2006 Sep; 27(8):1747-54.
Du AT, Schuff N, Chao LL, Kornak J, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. Age effects on atrophy rates of entorhinal cortex and hippocampus. Neurobiol Aging. 2006 May; 27(5):733-40.
Du AT, Schuff N, Chao LL, Kornak J, Ezekiel F, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiol Aging. 2005 Apr; 26(4):553-9.
Du AT, Schuff N, Laakso MP, Zhu XP, Jagust WJ, Yaffe K, Kramer JH, Miller BL, Reed BR, Norman D, Chui HC, Weiner MW. Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus. Neurology. 2002 Jun 11; 58(11):1635-41.
Hsu YY, Schuff N, Amend DL, Du AT, Norman D, Chui HC, Jagust WJ, Weiner MW. Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes. Alzheimer Dis Assoc Disord. 2002 Apr-Jun; 16(2):58-64.
Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, Kramer J, Jagust W, Miller B, Wolkowitz OM, Yaffe K, Weiner MW. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD. Neurology. 2002 Mar 26; 58(6):928-35.
Mungas D, Jagust WJ, Reed BR, Kramer JH, Weiner MW, Schuff N, Norman D, Mack WJ, Willis L, Chui HC. MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology. 2001 Dec 26; 57(12):2229-35.
Du AT, Schuff N, Amend D, Laakso MP, Hsu YY, Jagust WJ, Yaffe K, Kramer JH, Reed B, Norman D, Chui HC, Weiner MW. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001 Oct; 71(4):441-7.
Capizzano AA, Vermathen P, Laxer KD, Ende GR, Norman D, Rowley H, Matson GB, Maudsley AA, Segal MR, Weiner MW. Temporal lobe epilepsy: qualitative reading of 1H MR spectroscopic images for presurgical evaluation. Radiology. 2001 Jan; 218(1):144-51.
Meyerhoff DJ, Bloomer C, Schuff N, Ezekiel F, Norman D, Clark W, Weiner MW, Fein G. Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imaging. Addict Biol. 1999 Oct; 4(4):405-19.
Schuff N, Amend DL, Meyerhoff DJ, Tanabe JL, Norman D, Fein G, Weiner MW. Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain. Radiology. 1998 Apr; 207(1):91-102.
Schuff N, Amend D, Ezekiel F, Steinman SK, Tanabe J, Norman D, Jagust W, Kramer JH, Mastrianni JA, Fein G, Weiner MW. Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study. Neurology. 1997 Dec; 49(6):1513-21.
Rooney WD, Goodkin DE, Schuff N, Meyerhoff DJ, Norman D, Weiner MW. 1H MRSI of normal appearing white matter in multiple sclerosis. Mult Scler. 1997 Aug; 3(4):231-7.
MacKay S, Ezekiel F, Di Sclafani V, Meyerhoff DJ, Gerson J, Norman D, Fein G, Weiner MW. Alzheimer disease and subcortical ischemic vascular dementia: evaluation by combining MR imaging segmentation and H-1 MR spectroscopic imaging. Radiology. 1996 Feb; 198(2):537-45.
MacKay S, Meyerhoff DJ, Constans JM, Norman D, Fein G, Weiner MW. Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging. Arch Neurol. 1996 Feb; 53(2):167-74.
Constans JM, Meyerhoff DJ, Norman D, Fein G, Weiner MW. 1H and 31P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects. Neuroradiology. 1995 Nov; 37(8):615-23.
Meyerhoff DJ, MacKay S, Constans JM, Norman D, Van Dyke C, Fein G, Weiner MW. Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging. Ann Neurol. 1994 Jul; 36(1):40-7.