Dissemination and Training

Overview

Specialized training in this new field of hyperpolarized carbon-13 MRI is required since it is very new and very different from conventional MRI and from other molecular imaging techniques. Training in HP 13C MRI sponsored by the center are focused in several areas:

  • Hands-on training of local MS/PhD students and residents
  • Collaborative Project Personnel
  • Junior Faculty
  • Extramural Visitors & Service Projects
  • Hyperpolarized MRI Technology Workshops at BTRC
  • Training at Major Conferences
  • Regular Teleconferences
  • Online Training Coupled with Dissemination

 

TR&D 1: Improved DNP Methodology and HP MR Acquisition Techniques

Spectral-Spatial RF Pulse Design MATLAB package (designed by Adam Kerr and Peder Larson): This package includes Matlab functions to design spectral-spatial RF pulses (also known as spatial-spectral RF pulses) for application to magnetic resonance spectroscopy and imaging, including sample designs for hyperpolarized MRI. 

  • Download: Matlab Central FileExchange
  • Soure code repository: GitHub (You can become a contributor to project and add any code of your own or fix/improve the current software.)

Hyperpolarized MRI Toolbox: The goal of this toolbox is to provide research-level and prototyping software tools for hyperpolarized MRI experiments. It is currently based on MATLAB code, and includes code for designing radiofrequency (RF) pulses, readout gradients, and data reconstruction. 

  • Download: Matlab Central FileExchange
  • Source code repository: GitHub (You can also become a contributor to project and add any code of your own or fix/improve the current software.)

Training: DNP Polarizer Training & MR Sequence and Acquisition Training

MNS Research Pack (GE Healthcare): The MNS Research Pack is a software acquisition package for GE MRI scanners focused on multi-nuclear imaging and spectroscopy for hyperpolarized [1-13C]pyruvate research.  It includes different sequences and semi-automatic pre-scanning. In addition to pre-installed methods, additional RF pulses and trajectories can be designed off-line in Matlab, saved in a file, and read into the sequence. The package is available on request, contact: Rolf.Schulte_at_Research.ge.com

TR&D 2: Novel Hyperpolarized MR Molecular Imaging Probes, Realistic Pre-Clinical Models and Correlative Science Methods

 New Cell and Tissue Culture Bioreactors

Formulation of carbon-13 labeled compounds for dissolution-DNP (.pdf)

Demo: Preparation + QC of Componds for Hyperpolarization (.pdf)

Training: HP Probe Preparation Training & Cell Tissue and Bioreactor Training

TR&D 3: Open-Source Tools for Processing Hyperpolarized MR Data

HP C-13 SIVIC Software

Training: SIVIC Open-Source Software Training

Hyperpolarized MRI Toolbox: The goal of this toolbox is to provide research-level and prototyping software tools for hyperpolarized MRI experiments. It is currently based on MATLAB code, and includes code for designing radiofrequency (RF) pulses, readout gradients, and data reconstruction. 

  • Download: Matlab Central FileExchange
  • Source code repository: GitHub (You can also become a contributor to project and add any code of your own or fix/improve the current software.)

Data and File Sharing Platform

UCSF Box :  A data and file sharing platform that allows invited participants of the International SPINlab User Teleconference to share files and documentations pertaining to this project with individual login and password.   To request Box access, send your request to Jenny Che at hmtrc@ucsf.edu.

National Cancer Institute - IND Regulatory & Manufacturing Resources on Hyperpolarized [13C]  Pyruvate