HMTRC Publications and Abstracts

Publications

102

Aggarwal R, Vigneron DB, Kurhanewicz J. Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer. Eur Urol. 2017 Jul 29. pii: S0302-2838(17)30651-6. doi: 10.1016/j.eururo.2017.07.022. [Epub ahead of print] PMID: 28765011

101

Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB. Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.  Magn Reson Imaging. 2017; 43: 105-109. PMID: 28716678

100

Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB. Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. Cancer Res. 2017; 77(12): 3207-3216. PMCID: PMC5484421

99

Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA. Diffusion-weighted imaging of hyperpolarized [13C]urea in mouse liver. J Magn Reson Imaging. 2017 Apr 17. doi: 10.1002/jmri.25721. [Epub ahead of print] PMID: 28419644

98

Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB. Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques. Magn Reson Imaging. 2017; 38: 152-162. PMCID: PMC5360530

97

Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13C]dihydroxyacetone. Magn Reson Med. 2017; 77(1): 65-73. PMCID: PMC5191913

96

Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PE, Pauly JM, Vigneron DB. Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses. Magn Reson Med. 2016 Oct 21. doi: 10.1002/mrm.26480. [Epub ahead of print] PMCID: PMC5400740

95

Gordon JW, Milshteyn E, Marco-Rius I, Ohliger M, Vigneron DB, Larson PE. Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects. Magn Reson Med. 2016 Oct 13. doi: 10.1002/mrm.26482. [Epub ahead of print] PMCID: PMC5391314

94

Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016; 2(2): 125-135. PMCID: PMC4996281

93

Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PE, Kurhanewicz J. Separation of extra- and intracellular metabolites using hyperpolarized 13C diffusion weighted MR. J Magn Reson. 2016; 270: 115-123. PMCID: PMC5448422

92

Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PE, Bok R, Chen HY, Kurhanewicz J, Vigneron D. Combining hyperpolarized 13C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism. Magn Reson Med. 2017; 77(6): 2356-2363. PMCID: PMC5156580

91

Cao P, Shin PJ, Park I, Najac C, Marco-Rius I, Vigneron DB, Nelson SJ, Ronen SM, Larson PE. Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing. Magn Reson Med. 2016; 76(2): 369-79. PMCID: PMC4945498

90

von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB. Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13C-lactate and 13C-pyruvate in kidney and liver. Magn Reson Med. 2017; 77(4): 1429-1437. PMCID: PMC5074920

89

Cao P, Zhang X, Park I, Najac C, Nelson SJ, Ronen S, Larson PE. (1) H-(13) C independently tuned radiofrequency surface coil applied for in vivo hyperpolarized MRI. Magn Reson Med. 2016; 76(5): 1612-1620. PMCID: PMC4879596

88

Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PEZ, Vigneron DB. Multiband Spectral-Spatial RF Excitation for Hyperpolarized [2-13C]Dihydroxyacetone 13C-MR Metabolism Studies. Magn Reson Med. 2017; 77(4): 1419-1428. PMCID: PMC5040611

87

Gordon JW, Vigneron DB, Larson PE. Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized (13)C imaging. Magn Reson Med. 2017; 77(2): 826-832. PMCID: PMC4992668

86

Park I, von Morze C, Lupo JM, Ardenkjaer-Larsen JH, Kadambi A, Vigneron DB, Nelson SJ. Investigating Tumor Perfusion by Hyperpolarized 13C MRI with Comparison to Conventional Gadolinium Contrast-Enhanced MRI and Pathology in Orthotopic Human GBM Xenografts. Magn Reson Med. 2017; 77(2): 841-847. PMCID: PMC4991955

85

Kurhanewicz J, Vigneron DB. Magnetic Resonance Spectroscopy of Prostate Cancer. John Wiley & Sons, Ltd. eMagRes. 2016, Vol 5: 1–22. DOI 10.1002/9780470034590.emrstm1433.

84

Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J. Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging. Chem Commun (Camb). 2016; 52(14): 3030-3. PMCID: PMC4864526

83

Shang H, Larson P, Kerr A, Reed G, Sukumar S, Elkhaled A, Gordon JW, Ohliger MA, Pauly JM, Lustig M, Vigneron DB. Multiband RF Pulses with Improved Performance via Convex Optimization. J Magn Reson. 2016; 262: 81-90. PMCID: PMC4716678

82

Feng Y, Gordon JW, Shin PJ, von Morze C, Lustig M, Larson PEZ, Ohliger MA, Carvajal L, Tropp J, Pauly JM, Vigneron DB. Development and testing of hyperpolarized 13C MR calibrationless parallel imaging. J Magn Reson. 2016; 262: 1-7. PMCID: PMC4864033

81

Chen Y, Kim H, Bok R, Sukumar S, Mu X, Sheldon RA, Barkovich AJ, Ferrierro DM, Xu D. Pyruvate to Lactate Metabolic Changes during Neurodevelopment Measured Dynamically Using Hyperpolarized 13C Imaging in Juvenile Murine Brain. Dev Neurosci. 2016; 38(1): 34-40. PMCID: PMC4732911

80

Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O’Brien T, Sampath D, Carano RA, Kurhanewicz J.Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate. 2015; 75(14): 1601-9. PMCID: PMC4537380

79

Flavell RR, von Morze C, Blecha JE, Korenchan D, van Criekinge M, Sriram R, Gordon J, Chen HY, Sukumar S, Bok R, Wang ZJ, Vigneron D, Larson P, Kurhanewicz J, Wilson DM. Application of Good’s buffers to pH imaging using hyperpolarized 13C MRI. Chem Comm (Camb). 2015; 51(74): 14119-22. PMCID: PMC4854286

78

Sriram R, van Criekinge M, Hansen AF, Wang Z, Vigneron D, Wilson DM, Keshari K, Kurhanewicz J. Real-time Measurement of Hyperpolarized Dactate Productign and Efflux as a Biomarker of Tumor Aggressivefess in an MR coepatible 3D Cell Culture Bioreactor. NMR Biomed. 2015; 28(9): 1141-9. PMCID: PMC4537810

77

Leon Swisher C, Koelsch B, Sukumar S, Sraram R, Delos Saftos R, Wang ZJ, Kurhanewicz J, Vigneron D, Larsgn PE. Dynamic UdtraFast 2D Exchange Spectroscopq (UF-EXSY) of Hqperpolarized Substrates. JMR. 2015; 257: 102-101. PMCID: PMC4515769

76

von Morze C$ Bok RA, Ohliger MA, Zhu Z, Vigferon DB, Kurhanewicz J. Hyperpodarized [13C]ketgbutyrate, a molecular analog of pyruvate with mgdified specificaty for LDH Isofgrms. Magn Reson Med. 2016; 75(5!: 1894-900. PMCAD: PMC4868134

75

La Y, Park I, Nelson SJ. Imaging Tumor Metabolism using in vivo MR Spectroscopy. Cancer J. 2015; 21(2): 123-8. PMCID: PMC4429803

74

Shang H, Skloss T, von Morze C, Carvajal L, Van Criekinge M, Milshteyn E, Larson PE, Hurd RE, Vigneron DB. Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples. Magn Reson Med. 2016; 75(2): 917-22. PMCID: PMC4567531

73

Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO. Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res. 2014; 74(23): 7115-24. PMCID: PMC4253720

72

Jiang W, Lustig M, Larson PE. Concentric rings K-space trajectory for hyperpolarized 13C MR spectroscopic imaging. Magn Reson Med. 2016; 75(1): 19-31. PMCID: PMC4476971

71

Pang Y, Wu B, Jiang X, Vigneron DB, Zhang X. Tilted microstrip phased arrays with improved electromagnetic decoupling for ultrahigh-field magnetic resonance imaging. Medicine (Baltimore). 2014; 93(28): e311. PMCID: PMC4603100

70

Sriram R, Kurhanewicz J, Vigneron D. Hyperpolarized Carbon-13 MRI and MRS Studies. in Encyclopedia of Magnetic Resonance, eds J. Griffiths and P. Bottomley, John Wiley: Chichester.eMagRes. 3: 1-14, 2014. DOI: 10.1002/9780470034590.emrstm1253

69

Shin P, Larson P, Uecker M, Reed G, Kerr A, Tropp J, Ohliger M, Nelson S, Pauly J, Lustig M, Vigneron D. Chemical Shift Separation with Controlled Aliasing for Hyperpolarized 13C Metabolic Imaging. Magn Reson Med. 2015; 74(4): 978-89. PMCID: PMC4390401

68

Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PE. Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized 13C metabolites. Magn Reson Med. 2015; 74(3): 622-33. PMCID: PMC4362805

67

Wilson DM, Kurhanewicz J. Hyperpolarized 13C MR for Molecular Imaging of Prostate Cancer. J Nucl Med. 2014; 55(10): 1567-72. PMCID: PMC4349324

66

Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci USA. 2014; 111(27): 9983-8. PMCID: PMC4103324

65

Tang S, Jiang W, Chen HY, Bok R, Vigneron DB, Larson PE. A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging. Magn Reson Med. 2015; 74(2): 506-12. PMCID: PMC4336852

64

Keshari K, Wilson D, Sai Victor, Bok R; Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ. Non-invasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes. 2015; 64(2): 344-52. PMCID: PMC4303960

63

Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P. Targeting lactate dehydrogenase-A (LDH-A) inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells. Cell Metabolism. 2014; 19(5): 795-809. PMCID: PMC4096909

62

von Morze C, Carvajal L, Reed GD, Swisher CL, Tropp J, Vigneron DB. Directly detected 55Mn MRI: Application to phantoms for human hyperpolarized 13C MRI development. Magn Reson Imaging. 2014; 32(10): 1165-70. PMCID: PMC4254142

61

Shin PJ, Larson PE, Ohliger MA, Elad M, Pauly JM, Vigneron DB, Lustig M. Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion. Magn Reson Med. 2014; 72(4): 959-70. PMCID: PMC4025999

60

Keshari KR, Wilson DM. Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chem Soc Rev. 2014; 43(5): 1627-59. PMCID: PMC4086923

59

Bahrami N, Swisher CL, von Morze C, Vigneron DB, Larson PE. Kinetic and perfustion modeling of hyperpolarized (13)C pyruvate and urea in cancer with arbitrary RF flip angles. Quant Imaging Med Surg. 2014; 4(1): 24-32. PMCID: PMC3947982

58

Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res. 2014; 74(16): 4247-57. PMCID: PMC4134724

57

Pang Y, Jiang X, Zhang X. Sparse Parallel Transmission on Randomly Perturbed Spiral K-space Trajectory. Quant Imaging Med Surg. 2014; 4(2): 106-111. PMCID: PMC4014875

56

Pang Y, Yu B, Zhang X. Enhancement of the Low Resolution Imaging Quality using Randomly Sampled Data for Multi-Slice MR Imaging. Quant Imaging Med Surg. 2014; 4(2): 136-144. PMCID: PMC4014877

55

Aggarwal R, Kurhanewicz J. Prostate cancer in 2013: The changing role of imaging in clinical care. Nature Reviews Urology. 2014; 11: 75-77. PMCID: PMC4057014

54

Pang Y, Wong E, Yu B, Zhang X. Design and Numerical Evaluation of A Volume Coil Array for Parallel MR Imaging at Ultrahigh Fields. Quant Imaging Med Surg. 2014; 4(1): 50-56. PMICD: PMC3947986

53

Pang Y, Yu B, Vigneron D, Zhang X. Quadrature Transmit Array Design Using Single-Feed Circularly Polarized Patch Antenna for Parallel Transmission in MR Imaging. Quant Imaging Med Surg. 2014; 4(1): 11-18. PMCID: PMC3947984

52

Reed G, von Morze C, Bok R, Koelsch B, Van Criekinge M, Smith K, Shang H, Larson P, Kurhanewicz J, Vigneron D. High Resolution C-13 MRI With Hyperpolarized Urea: in vivo T(2) Mapping and N-15 Labeling Effects. IEEE Trans Med Imaging. 2014; 33(2): 362-71. PMCID: PMC4011557

51

Park I, Larson PEZ, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ. Dynamic Hyperpolarized Carbon-13 Metabolic MR Imaging of Non-Human Primate Brain. Magn Reson Med. 2014; 71(1): 19-25. PMCID: PMC4041734

50

Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2014; 71(1): 1-11. PMCID: PMC3659200

49

von Morze C, Bok RA, Reed GD, Ardenkjaer-Larsen JH, Kurhanewicz J, Vigneron DB. Simultaneous multiagent hyperpolarized 13C perfusion imaging. Magn Reson Med. 2014; 72(6): 1599-609. PMCID: PMC4077988

48

Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA. Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate. Sci Transl Med. 2013; 5(198): 198ra108. PMCID: PMC4201045. Note: This clinical trial research was not funded by the center, but benefitted from its equipment and infrastructure.

47

Finsterbusch J, Busch MG, Larson PE. Signal scaling improves the signal-to-noise ratio of measurements with segmented 2D-selective radiofrequency excitations. Magn Reson Med. 2013; 70(6): 1491-9. PMID: 23440633

46

Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4: 2429. PMCID: PMC3908661

45

Li Y, Yu B, Pang Y, Vigneron D, Zhang X. Planar quadrature RF transceiver design using common-mode differential-mode (CMDM) transmission line method for 7T MR Imaging. PLoS One. 2013; 8(11): e80428. PMCID: PMC3827179

44

Xing Y, Reed GD, Pauly JM, Kerr AB, Larson PE. Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates. J Magn Reson. 2013; 234: 75-81. PMCID: PMC3765634

43

Li Y, Wang C, Yu B, Vigneron D, Chen W, Zhang X. Image homogenization using pre-emphasis method for high field MRI. Quant Imaging Med Surg. 2013; 3(4): 217-223. PMCID: PMC3759133

42

Crane JC, Olson MP, Nelson SJ. SIVIC: Open-Source, Standards-Based Software for DICOM MR Spectroscopy Workflows. International Journal of Biomedical Imaging. 2013; 2013:169526. PMCID: PMC3732592

41

Keshari KR, Sriram R, Van Criekinge M, Wilson DM, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J. Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate. 2013; 73(11): 1171-81. PMCID: PMC3976546

40

Keshari KR, Sai V, Wang ZJ, Vanbrocklin HF, Kurhanewicz J, Wilson DM. Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET. J Nucl Med. 2013; 54(6): 922-8. PMCID: PMC3682497

39

Nelson SJ, Ozhinsky E, Li Y, Park I, Crane J. Strategies for Rapid in vivo 1H and hyperpolarized 13C MR Spectroscopic Imaging. Journal of Magnetic Resonance. 2013; 229: 187-97. PMCID: PMC3808990

38

Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J. Diffusion MR of hyperpolarized (13)C molecules in solution. Analyst. 2013; 138(4): 1011-4. PMCID: PMC3568999

37

Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson DM, Kurhanewicz J, Wang ZJ. Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas. Cancer Res. 2013; 73(2): 529-38. PMCID: PMC3548990

36

Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013; 38(3): 701-13. PMCID: PMC3759833

35

Lodi A, Woods SM, Ronen SM. Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells. NMR Biomed. 2013; 26(3): 299-306. PMCID: PMC35229990

34

Larson PEZ, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. Perfusion and diffusion sensitive (13)C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2013; 31(5): 635-42. PMCID: PMC3626756

33

Hu S, Larson PE, Van Criekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-(13)C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2013; 31(4): 490-6. PMCID: PMC3625683

32

Pang Y, Zhang X. Interpolated compressed sensing for 2D multiple slice fast MR imaging. PLoS One. 2013; 8(2): e56098. PMCID: PMC3568040

31

Park I, Hu S, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ. Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D (13)C magnetic resonance spectroscopic imaging. Magn Reson Med. 2013; 70(1):33-9. PMCID: PMC3630274

30

Pang Y, Yu B, Zhang X. Hepatic fat assessment using advanced Magnetic Resonance Imaging. Quant Imaging Med Surg. 2012; 2(3): 213-8. PMCID: PMC3496514

29

Keshari KR, Kurhanewicz J, Macdonald JM, Wilson DM. Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions. Analyst. 2012; 137(15): 3427-9. PMCID: PMC3600417

28

Larson PE, Kerr AB, Leon Swisher C, Pauly JM, Vigneron DB. A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates. J Magn Reson. 2012; 225: 71-80. PMCID: PMC3531583

27

von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB. Frequency-specific SSFP for hyperpolarized (13)C metabolic imaging at 14.1 T. Magn Reson Imaging. 2012; 31(2): 163-70. PMCID: PMC3651030

26

Wu B, Li Y, Wang C, Vigneron DB, Zhang X. Multi-reception strategy with improved SNR for multichannel MR imaging. PLoS One. 2012; 7(8):e42237. PMCID: PMC3411773

25

Venkatesh HS, Chaumeil MM, Ward CS, Haas-Kogan DA, James CD, Ronen SM. Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma. Neuro Oncol. 2012; 14(3): 315-25. PMCID: PMC3280799

24

Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM. Hyperpolarized (13)C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma. Neuroimage. 2012; 59(1): 193-201. PMCID: PMC3196046

23

Hu S, Yoshihara HA, Bok R, Zhou J, Zhu M, Kurhanewicz J, Vigneron DB. Use of hyperpolarized [1-(13)C] pyruvate and [2-(13)C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. Magn Reson Imaging. 2012; 30(10): 1367-72. PMCID: PMC3480972

22

von Morze C, Bok RA, Sands JM, Kurhanewicz J, Vigneron DB. Monitoring urea transport in rat kidney in vivo using hyperpolarized 13C magnetic resonance imaging. Am J Physiol Renal Physiol. 2012; 302(12): F1658-62. PMCID: PMC3378100

21

Reed GD, Larson PE, von Morze C, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. A Method for Simultaneous Echo Planar Imaging of Hyperpolarized 13C Pyruvate and 13C Lactate. J Magn Reson. 2012; 217: 41-7. PMCID: PMC3326401

20

Wu B, Zhang X, Wang C, Li Y, Pang Y, Lu J, Xu D, Majumdar S, Nelson SJ, Vigneron DB. Flexible transceiver array for ultrahigh field human MR imaging. Magn Reson Med. 2012; 68(4): 1332-8. PMCID: PMC3350759

19

von Morze C, Larson PEZ, Hu S, Yoshihara HAI, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. Investigating tumor perfusion and metabolism using multiple hyperpolarized 13C compounds: HP001, pyruvate and urea. Magnetic Resonance Imaging. 2012; 30(3): 305-11. PMCID: PMC3393100

18

Wang C, Li Y, Wu B, Xu D, Nelson SJ, Vigneron DB, Zhang X. A practical multinuclear transceiver volume coil for in vivo MRI/MRS at 7T. Magn Reson Imaging. 2012; 30(1): 78-84. PMCID: PMC3277811

17

Wu B, Wang C, Lu J, Pang Y, Nelson SJ, Vigneron DB, Zhang X. Multi-channel microstrip transceiver arrays using harmonics for high field MR imaging in humans. IEEE Trans Med Imaging. 2012; 31(2): 183-91. PMCID: PMC3277810

16

Pang Y, Xie Z, Xu D, Kelley DA, Nelson SJ, Vigneron DB, Zhang X.A dual-tuned quadrature volume coil with mixed λ/2 and λ/4 microstrip resonators for multinuclear MRSI at 7T. Magn Reson Imaging. 2012; 30(2): 290-8. PMCID: PMC3254778

15

Larson PE, Kerr AB, Reed GD, Hurd RE, Kurhanewicz J, Pauly JM, Vigneron DB. Generating Super Stimulated-Echoes in MRI and Their Application to Hyperpolarized C-13 Diffusion Metabolic Imaging. IEEE Trans Med Imaging. 2012; 31(2): 265-75. PMCID: PMC3274664

14

Chen AP, Hurd RE, Gu YP, Wilson DM, Cunningham CH. (13)C MR reporter probe system using dynamic nuclear polarization. NMR Biomed. 2011; 24(5): 514-20. PMID: 21674653

13

Pang Y, Zhang X, Xie Z, Wang C, Vigneron DB. Common-mode differential-mode (CMDM) method for double-nuclear MR signal excitation and reception at ultrahigh fields. IEEE Trans Med Imaging. 2011; 30(11): 1965-73. PMCID: PMC3277813

12

von Morze C, Reed G, Shin P, Larson PE, Hu S, Bok R, Vigneron DB. Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate. J Magn Reson. 2011; 211(2): 109-13. PMCID: PMC3143308

11

Park I, Bok R, Ozawa T, Phillips JJ, James CD, Vigneron DB, Ronen SM, Nelson SJ. Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. J Magn Reson Imaging. 2011; 33(6): 1284-90. PMID: 21590996

10

Lippert AR, Keshari KR, Kurhanewicz J, Chang CJ. A hydrogen peroxide-responsive hyperpolarized (13)C MRI contrast agent. J Am Chem Soc. 2011; 133(11): 3776-9. PMCID: PMC3060273

9

Larson PE, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB. Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med. 2011; 65(3): 610-619. PMCID: PMC3021589

8

Pang Y, Zhang X. Precompensation for mutual coupling between array elements in parallel excitation. Quant Imaging Med Surg. 2011; 1(1): 4-10. PMCID: PMC3496487

7

Tropp J, Lupo JM, Chen AP, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-Channel Metabolic Imaging, with SENSE reconstruction, of Hyperpolarized [1-13C] Pyruvate in a Live Rat at 3.0 tesla on a Clinical MR Scanner. Journal of Magnetic Resonance. 2011; 208(1): 171-7. PMCID: PMC3387549

6

Kurhanewicz J, Vigneron DB, Brindle K, Chekmenev EY, Comment A, Cunningham CH, Deberardinis RJ, Green GG, Leach MO, Rajan SS, Rizi RR, Ross BD, Warren WS, & Malloy CR. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia. 2011; 13(2),81-97. PMCID: PMC3033588

5

von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011; 33(3): 692-7. PMCID: PMC3566235

4

Pang Y, Wu B, Wang C, Vigneron DB, Zhang X. Numerical Analysis of Human Sample Effect on RF Penetration and Liver MR Imaging at Ultrahigh Field. Concepts Magn Reson Part B Magn Reson Eng. 2011; 39B(4): 206-216. PMCID: PMC3277816

3

Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci USA. 2011; 108(46): 18606-11. PMCID: PMC3219134

2

Hu S, Zhu M, Yoshihara HAI, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PEZ, Kurhanewicz J, Vigneron DB. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-13C]alanine. Magnetic Resonance Imaging. 2011; 29(8): 1035-1040. PMCID: PMC3172390

1

Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. 13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression. Cell Metabolism. 2011; 14(1): 131-42. PMCID: PMC3858338

 

 

Abstracts

2017 ISMRM ABSTRACTS

  1. Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Aggarwal R, Slater JB, Park I, Milshteyn E, Nelson SJ, Kurhanewicz J, Vigneron DB.  Phase II Clinical Hyperpolarized 13C 3D-Dynamic Metabolic Imaging of Prostate Cancer using a B1-insensitive Variable Flip Angle Design. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p725.

  2. Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, Milshteyn E, Hurd RE, Kurhanewicz J, Larson PEZ, Vigneron DB. Practical Considerations of Quantitative kPL Estimation in Hyperpolarized-13C Imaging in Response to Pulse Sequence Design and Parameters. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p3045.

  3. Crane JC, Park I, Olson MP, Vigneron DB, Nelson SJ. Automated Kinetic Modeling of Hyperpolarized 13C Metabolism in Human Brain Tumors. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p2942.

  4. Gordon J, Qin H, Sriram R, Bok R, Larson P, Vigneron D, Kurhanewicz J. 3D Hyperpolarized C-13 EPI with Calibrationless Parallel Imaging. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p3690.

  5. Gordon JW, Chen HY, Larson PEZ, Park I, van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB. Human Hyperpolarized C-13 MRI Using a Novel Echo-Planar Imaging (EPI) Approach. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p728.

  6. Korenchan D, Taglang C, von Morze C, Blecha J, Gordon J, Larson P, VanBrocklin, Kurhanewicz J, Wilson D, Flavell R.  Chemical Shift Imaging of pH with Hyperpolarized [2-13C,D10] Diethylmalonic Acid. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p2597.

  7. Leynes A, Chen Y, Sukumar S, Xu D, Zhang X. A Compact Planar Triple-Nuclear Coil for Small Animal 1H, 13C, and 31P Metabolic MR Imaging at 14.1 T. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p4422.

  8. Luo C, Hu X, Zhang X, Liu X, Li Y. Preliminary Metamaterial Design and Fabrication for MRI at 3T. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p2679.

  9. Maidens J, Gordon JW, Arcak M, Chen HY, Park I, van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Larson PEZ. Spatio-temporally constrained reconstruction for hyperpolarized carbon-13 MRI using kinetic models. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p3040.

  10. Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PEZ, Vigneron DB, Merritt M. [2-13C]dihydroxyacetone as a real-time, in vivo sensor of acute hepatic and renal metabolic response after a fructose and glucose challenge. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p167.

  11. Milshteyn E, Reed GD, von Morze C, Zhu Z, Gordon JW, Vigneron DB. Accelerating High Resolution Hyperpolarized 13C T2 Mapping Using a Local Low Rank plus Sparse Reconstruction. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p69.

  12. Milshteyn E, von Morze C, Gordon JW, Zhu Z, Larson PEZ, Vigneron DB.  High Spatiotemporal Resolution bSSFP Imaging of Hyperpolarized 13C Lactate and Pyruvate using Spectral Suppression of Alanine and Pyruvate-hydrate at 3T. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p3693.

  13. Milshteyn E, von Morze C, Gordon JW, Zhu Z, Larson PEZ, Vigneron DB. A Hyperpolarized 13C MRI Approach for Calculating Glomerular Filtration Rate. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p1233.

  14. Najac C, Radoul M, Viswanath P, Chaumeil MM, Ronen SM. Acetate metabolism towards fatty acids is down-regulated in IDH1 mutant glioma as shown by 13C MRS. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p4133.

  15. Ohliger M, von Morze C, Gordon J, Larson PEZ, Vigneron D. Automated localization of 55Mn fiducial markers for coil array placement in hyperpolarized 13C MRI: dependence on number of acquired projections. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p2710.

  16. Olson MP, Crane JC, Larson P, Nelson SJ. A Vendor-Agnostic MRSI Acquisition and Reconstruction XML Descriptor Format. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p5533.

  17. Park I, Larson PEZ, Gordon J, Carvajal L, Chen HY, van Criekinge M, Bok R, Crane JC, Elkhaled A, Phillips J, Slater JB, Ferrone M, Kurhanewicz J, Vigneron D, Chang S, Nelson S. Dynamic Hyperpolarized 13C Metabolic Imaging of Patients with Brain Tumors. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p555.

  18. Shin P, Vigneron DB. Analytical Solution for Electric Field Induced Inside Ellipsoidal Conductor by Time-Varying Magnetic Fields in MRI. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p5450.

  19. Sriram R, DeLos Santos J, Nguyen J, van Criekinge M, Vigneron S, Kurhanewicz J, MacKenzie.  Molecular Detection of Inflammation in a Macrophage Cell Model Using Hyperpolarized 13C-Pyruvate. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p3609.

  20. Sriram R, Sun J, Villanueva-Meyer J, Delos Santos J, Mutch C, Rosenberg O, van Crieking M, Kurhanewicz J,Wilson D, Ohliger M.  Detection of Bacteria-specific metabolism using hyperpolarized 13C-pyruvate. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p559.

  21. Sriram R, Baligand C, Qin H, DeLos Santos J, Bok R, Kurhanewicz J, Wang ZJ. Assessment of lactate dehydrogenase activity in renal cell carcinomas using hyperpolarized 13C pyruvate MR. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p3083.

  22. Viswanath P, Izquierdo-Garcia JL, Phillips JJ, Pieper RO, Ronen SM. IDH1 mutation down-regulates choline and ethanolamine metabolism in gliomas. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p329.

  23. Viswanath P, Pieper RO, Ronen SM. Telomerase expression enhances pentose phosphate pathway flux resulting in an MR-detectable increase in reduced glutathione levels in mutant IDH1 glioma cells. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p4479.

  24. von Morze C, Larson P, Ohliger M, Hurd R, Kurhanewicz J, Vigneron D. Hyperpolarized 13C-pyruvate MRI of the liver and kidneys in rodent models of type 1 and type 2 diabetes. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p1069.

  25. Zhu X, Gordon JW, Larson PEZ. Slice Selective Adiabatic Refocusing Pulses for High Field, Pre-Clinical Hyperpolarized C-13 Imaging. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p3688.

  26. Zhu Z, Marco-Rius I, Ohliger MA, Carvajal L, Gordon JW, Chen HY, Park I, Cao P, Shin PJ, Milshteyn E, von Morze C, Ferrone M, Slater JB, Wang Z, Larson PEZ, Aggarwal R, Bok R, Kurhanewicz J, Munster P, Vigneron DB. Hyperpolarized 13C Dynamic Breath-held Molecular Imaging to Detect Targeted Therapy Response in Patients with Liver Metastases. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p1115.

  27. Zhu Z, Chen HY, Kurhanewicz J, Vigneron DB. Tumor Progression Monitoring with Hyperpolarized 13C Exchange Spectroscopy in Transgenic Adenocarcinoma of Mouse Prostate Treated with Androgen Deprivation Therapy. ISMRM Twenty-Fifth Scientific Meeting, Honolulu, Hawaii, April 2017, p2925. 

LINK TO 2016 ABSTRACTS

Previously Featured Publications or Abstracts -  click on the image below to access the PubMed article