Hyperpolarized MRI Technology Resource Center

Our center is dedicated to the development of state-of-the-art imaging techniques, particularly on instruments that will use Carbon-13 based compounds. Our aim is at disseminating optimal new hyperpolarized (HP) 13C MR technologies with optimal training/documentation to advance these emerging molecular imaging methods. Hyperpolarized 13C MR has outstanding research and clinical value, however most aspects of this technology (instrumentation, agent chemistry, DNP/dissolution methodology, MR acquisition, and data analysis) are currently suboptimal and require focused technological development to realize their full potential. The center includes three Technology Research & Development (TR&D) projects led by experienced hyperpolarized MR researchers.

 


Featured Publication*

Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13C]dihydroxyacetone

PMID:  27859575
PMCID:  PMC519193 (Available on 2018-01-01)
DOI:  10.1002/mrm.26525

Authors:  Irene Marco-Ruis, Cornelius von Morze, Renuka Sriram, Peng Cao, Gene-Yuan Chang, Eugene Milshteyn, Robert Bok, Michael Ohliger, David Pearce, John Kurhanewicz, Peder Larson, Daniel Vigneron, Matthew Merritt

Purpose:

To investigate acute changes in glucose metabolism in liver and kidneys in vivo after a bolus injection of either fructose or glucose, using hyperpolarized [2-13C]dihydroxyacetone.Click on the image below to learn more about this research on high resolution imaging.

*Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13C] dihydroxyacetone. 2017

 


***Please acknowledge NIBIB P41EB013598 in any publications that have benefitted from this center***   

 

Links to other NIH Resource Centers

     

 

 


***If you would like to donate to the Department of Radiology and Biomedical Imaging or to Dr. Daniel Vigneron, please complete the online giving form. To support this new imaging development, under choose a designation, select "other" and enter Dr. Daniel Vigneron. Your kind contribution and support is greatly appreciated by the Department of Radiology and Biomedical Imaging and the HMTRC Executive Members.***