Hyperpolarized MRI Technology Resource Center

Our center is dedicated to the development of state-of-the-art imaging techniques, particularly on instruments that will use Carbon-13 based compounds. Our aim is at disseminating optimal new hyperpolarized (HP) 13C MR technologies with optimal training/documentation to advance these emerging molecular imaging methods. Hyperpolarized 13C MR has outstanding research and clinical value, however most aspects of this technology (instrumentation, agent chemistry, DNP/dissolution methodology, MR acquisition, and data analysis) are currently suboptimal and require focused technological development to realize their full potential. The center includes three Technology Research & Development (TR&D) projects led by experienced hyperpolarized MR researchers.

 


Featured Publication*

Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion

Authors:  Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J3, Vigneron DB

Purpose:  New magnetic resonance (MR) molecular imaging techniques offer the potential for non-invasive, simultaneous quantification of metabolic and perfusion parameters in tumors. This study applied a 3D dynamic dual-agent hyperpolarized 13C magnetic resonance spectroscopic imaging (MRSI) approach with 13C-pyruvate and 13C-urea to investigate differences in perfusion and metabolism between low and high grade tumors in the TRAMP transgenic mouse model of prostate cancer. Dynamic MR data were corrected for T1 relaxation and RF excitation and modeled to provide quantitative measures of pyruvate to lactate flux (kPL) and urea perfusion (urea AUC) that correlated with TRAMP tumor histologic grade. kPL values were relatively higher for high-grade TRAMP tumors. The increase in kPL flux correlated significantly with higher lactate dehydrogenase activity and mRNA expression of Ldha, Mct1 and Mct4 as well as with more proliferative disease. There was a significant reduction in perfusion in high-grade tumors that associated with increased hypoxia and mRNA expression of Hif1α and Vegf and increased ktrans, attributed to increased blood vessel permeability. In 90% of the high-grade TRAMP tumors, a mismatch in perfusion and metabolism measurements was observed, with low perfusion being associated with increased kPL This perfusion-metabolism mismatch was also associated with metastasis. The molecular imaging approach we developed could be translated to investigate these imaging biomarkers for their diagnostic and prognostic power in future prostate cancer clinical trials.   PMID 28428273  [Click on the image for PubMed page]

*Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion.  2017

 


***Please acknowledge NIBIB P41EB013598 in any publications that have benefitted from this center***   

 

Links to other NIH Resource Centers

     

 

 


***If you would like to donate to the Department of Radiology and Biomedical Imaging or to Dr. Daniel Vigneron, please complete the online giving form. To support this new imaging development, under choose a designation, select "other" and enter Dr. Daniel Vigneron. Your kind contribution and support is greatly appreciated by the Department of Radiology and Biomedical Imaging and the HMTRC Executive Members.***