Xiaoliang Zhang, PhD

Associate Professor
Adjunct Professor

Biography

Xiaoliang Zhang, PhD, is a Professor and Director of the Parallel Imaging and High Field MR Technology Lab in the Department of Radiology and Program in Bioengineering at the University of California, San Francisco, a faculty member of California Institute of Biosciences (QB3), and a core faculty member of UCSF/UC Berkeley Joint Graduate Group in Bioengineering. Dr. Zhang obtained his PhD in Biomedical Engineering from the University of Minnesota, Minneapolis, and joined UCSF faculty in September 2006. He is professionally trained in the prestigious Center for Magnetic Resonance Research (CMRR) at the University of Minnesota.

Dr Zhang is an internationally recognized MR imaging scientist and a pioneer in the development of ultrahigh field MR technology for human MR imaging applications. Dr. Zhang’s research interests include fast MR imaging techniques for biomedical applications, electromagnetic problems and computational electromagnetism in in-vivo magnetic resonance imaging at high static fields, parallel imaging and compressed sensing based fast imaging methods, RF transceive arrays and system at ultra high magnetic fields, MRI compatibility and safety of implanted medical devices, steerable MR catheter imaging device, MagnetoFilter, and brain metabolism and function mapping using MRI.

Dr. Zhang has served as Principal Investigator, co-Principal Investigator and co-investigator for numerous NIH grants, and is a primary mentor in his trainee's NIH K99/R00 award (NIH Pathway to Independence Award). Dr. Zhang has published more than 200 journal articles, peer-reviewed conference papers and book chapters.

Dr Zhang is active in research community service, dedicating his time and effort to NIH study sections, grant reviews for many different countries and organizations, editorial boards of primary MR imaging journals, and teaching for ISMRM educational program and workshops. He has received many awards, including Distinguished Investigator Award bestowed by Academy of Radiology Research, Washington DC. He is President (elect) of Overseas Chinese Society for Magnetic Resonance in Medicine (OCSMRM).

Expertise:
Biomedical Engineering

Specialty:
Parallel imaging and compressed sensing based fast imaging, parallel excitation, MR RF hardware and system, ultra-high field MR technology, interventional medical devices.

Professional Interests:
High-field magnetic resonance imaging, new hardware technology (RF transceiver, probes, parallel imaging arrays), and their in vivo applications, anatomic and metabolic imaging in health and disease, interventional MR.

Education and Training:
• Doctor of Philosophy: University of Minnesota, Minneapolis - Biomedical Engineering

Honors and Awards

Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2017
Peng-Cheng Scholar, Chinese Academy of Sciences, 2016
President (elect), OCSMRM, 2015
Distinguished Investigator Award, Academy of Radiology Research, Washington DC, 2014
Distinguished Editorial Board Member Award, Quantitative Imaging in Medicine and Surgery, 2014
Outstanding Overseas Young Scholar Award, National Natural Science Foundation of China, 2012

Publications

Zhang X. Sensitivity enhancement of traveling wave MRI using free local resonators: an experimental demonstration. Quant Imaging Med Surg. 2017 Apr; 7(2):170-176.
Zhang X, Martin A, Jordan C, Lillaney P, Losey A, Pang Y, Hu J, Wilson M, Cooke D, Hetts SW. Design of catheter radio frequency coils using coaxial transmission line resonators for interventional neurovascular MR imaging. Quant Imaging Med Surg. 2017 Apr; 7(2):187-194.
Qi S, Mu YF, Cui LB, Zhang J, Guo F, Tan QR, Shi M, Liu K, Xi YB, Zhang NY, Zhang XL, He Y, Yang J, Yin H. Anomalous gray matter structural networks in recent onset post-traumatic stress disorder. Brain Imaging Behav. 2017 Mar 14.
Yan X, Zhang X, Gore JC, Grissom WA. Improved traveling-wave efficiency in 7T human MRI using passive local loop and dipole arrays. Magn Reson Imaging. 2017 Jun; 39:103-109.
Li N, Liu S, Hu X, Luo C, Zhang X, Li Y. The Electromagnetic Field and Radio Frequency Circuit Co-simulation for Magnetic Resonance Imaging Dual-tuned Radio Frequency Coils. IEEE T Magnetics. 2017; accepted.
Hu X, Li Y, Zhang L, Zhang X, Liu X, Chung YC. A 32-channel coil system for MR vessel wall imaging of intracranial and extracranial arteries at 3T. Magn Reson Imaging. 2017 Feb; 36:86-92.
Yan X, Zhang X, Xue R, Gore JC, Grissom WA. Optimizing the ICE decoupling element distance to improve monopole antenna arrays for 7 Tesla MRI. Magn Reson Imaging. 2016 Nov; 34(9):1264-1268.
Yan X, Xue R, Wei L, Zhang X. . Eight-channel monopole array using magnetic wall decoupling for human head MR imaging at 7 T. Appl Magn Reson. 2016.
Luo C, Hu X, Li C, Chen X, Zhang X, Liu S, Liu X, Zheng H, Li Y, Ji C, Luan L. Electromagnetic Simulation of Influence of Metamaterial for Magnetic Resonance Imaging at 3T. Materials Science Forum. 2016; 848:347-350.
Rutledge O, Kwak T, Cao P, Zhang X. Design and test of a double-nuclear RF coil for (1)H MRI and (13)C MRSI at 7T. J Magn Reson. 2016 06; 267:15-21.
Hu X, Zhang L, Zhang X, Zhu H, Chen X, Zhang Y, Chung YC, Liu X, Zheng H, Li Y. An 8-channel RF coil array for carotid artery MR imaging in humans at 3 T. Med Phys. 2016 Apr; 43(4):1897.
Yan X, Cao Z, Zhang X. Simulation verification of SNR and parallel imaging improvements by ICE-decoupled loop array in MRI. Appl Magn Reson. 2016 Apr; 47(4):395-403.
Liu LP, Cui LB, Zhang XX, Cao J, Chang N, Tang X, Qi S, Zhang XL, Yin H, Zhang J. Diagnostic Performance of Diffusion-weighted Magnetic Resonance Imaging in Bone Malignancy: Evidence From a Meta-Analysis. Medicine (Baltimore). 2015 Nov; 94(45):e1998.
Milshteyn E, Zhang X. The Need and Initial Practice of Parallel Imaging and Compressed Sensing in Hyperpolarized 13C MRI in vivo. OMICS J Radiol. 2015; 4(4).
Yan X, Zhang X. Decoupling and matching network for monopole antenna arrays in ultrahigh field MRI. Quant Imaging Med Surg. 2015 Aug; 5(4):546-51.
Yan X, Xue R, Zhang X. Closely-spaced double-row microstrip RF arrays for parallel MR imaging at ultrahigh fields. Appl Magn Reson. 2015 Nov; 46(11):1239-1248.
Zhang Y, Liu Y, Sun B, Zhang X, Jiang X.. Practical Design of Multi-Channel MOSFET RF Transmission System for 7T Animal MR Imaging. Concept in Magn Reson Part B. 2015; 45B(4):191-200.
Yan X, Wei L, Xue R, Zhang X. Hybrid monopole/loop coil array for human head MR imaging at 7T. Appl Magn Reson. 2015 May 01; 46(5):541-550.
Yan X, Xue R, Wei L, Zhang X. Eight-channel monopole array using ICE decoupling for human head MR imaging at 7 T. Applied Magn Reson. 2015; in press.
Yan X, Pedersen JO, Wei L, Zhang X, Xue R. Multichannel Double-Row Transmission Line Array for Human MR Imaging at Ultrahigh Fields. IEEE Trans Biomed Eng. 2015 Jun; 62(6):1652-9.
Yan X, Zhang X, Wei L, Xue R.. Design and test of magnetic wall decoupling for dipole coil array for MR imaging at the ultrahigh field of 7T. Applied Magnetic Resonance. 2015; 46(1):59-66.
Yan X, Xie Z, Pedersen JO, Zhang X. Theoretical analysis of magnetic wall decoupling method for radiative antenna arrays in ultrahigh magnetic field MRI. Concept in Magn Reson Part B. 2015; Epub ahead of print, DOI: 10.1.
Pang Y, Wu B, Jiang X, Vigneron DB, Zhang X. Tilted microstrip phased arrays with improved electromagnetic decoupling for ultrahigh-field magnetic resonance imaging. Medicine (Baltimore). 2014 Dec; 93(28):e311.
Wang YX, Lo GG, Yuan J, Larson PE, Zhang X. Magnetic resonance imaging for lung cancer screen. J Thorac Dis. 2014 Sep; 6(9):1340-8.
Yan X, Xue R, Zhang X. A monopole/loop dual-tuned RF coil for ultrahigh field MRI. Quant Imaging Med Surg. 2014 Aug; 4(4):225-31.
Pang Y, Yu B, Zhang X. Enhancement of the low resolution image quality using randomly sampled data for multi-slice MR imaging. Quant Imaging Med Surg. 2014 Apr; 4(2):136-44.
Pang Y, Jiang X, Zhang X. Sparse parallel transmission on randomly perturbed spiral k-space trajectory. Quant Imaging Med Surg. 2014 Apr; 4(2):106-11.
Ji JX, Zhang X. Parallel and sparse MR imaging: methods and instruments-Part 2. Quant Imaging Med Surg. 2014 Apr; 4(2):68-70.
Yan X, Zhang X, Wei L, Xue R. Magnetic wall decoupling method for monopole coil array in ultrahigh field MRI: a feasibility test. Quant Imaging Med Surg. 2014 Apr; 4(2):79-86.
Yan X, Zhang X, Feng B, Ma C, Wei L, Xue R. 7T transmit/receive arrays using ICE decoupling for human head MR imaging. IEEE Trans Med Imaging. 2014 Sep; 33(9):1781-7.
Pang Y, Wong EW, Yu B, Zhang X. Design and numerical evaluation of a volume coil array for parallel MR imaging at ultrahigh fields. Quant Imaging Med Surg. 2014 Feb; 4(1):50-6.
Pang Y, Yu B, Vigneron DB, Zhang X. Quadrature transmit array design using single-feed circularly polarized patch antenna for parallel transmission in MR imaging. Quant Imaging Med Surg. 2014 Feb; 4(1):11-8.
Zhang X, Ji JX. Parallel and sparse MR imaging: methods and instruments-Part 1. Quant Imaging Med Surg. 2014 Feb; 4(1):1-3.
Hu X, Chen X, Liu X, Zheng H, Li Y, Zhang X. Parallel imaging performance investigation of an 8-channel common-mode differential-mode (CMDM) planar array for 7T MRI. Quant Imaging Med Surg. 2014 Feb; 4(1):33-42.
Du F, Cooper AJ, Thida T, Sehovic S, Lukas SE, Cohen BM, Zhang X, Ongür D. In vivo evidence for cerebral bioenergetic abnormalities in schizophrenia measured using 31P magnetization transfer spectroscopy. JAMA Psychiatry. 2014 Jan; 71(1):19-27.
Li Y, Yu B, Pang Y, Vigneron DB, Zhang X. Planar quadrature RF transceiver design using common-mode differential-mode (CMDM) transmission line method for 7T MR imaging. PLoS One. 2013; 8(11):e80428.
Qi S, Mu Y, Liu K, Zhang J, Huan Y, Tan Q, Shi M, Wang Q, Chen Y, Wang H, Wang H, Zhang N, Zhang X, Xiong L, Yin H. Cortical inhibition deficits in recent onset PTSD after a single prolonged trauma exposure. Neuroimage Clin. 2013; 3:226-33.
Li Y, Wang C, Yu B, Vigneron D, Chen W, Zhang X. Image homogenization using pre-emphasis method for high field MRI. Quant Imaging Med Surg. 2013 Aug; 3(4):217-23.
Pang Y, Zhang X. Interpolated compressed sensing for 2D multiple slice fast MR imaging. PLoS One. 2013; 8(2):e56098.
Zhang X. Erratum to Investigation of multichannel phased array performance for fetal MR imaging on 1.5T clinical MR system. Quant Imaging Med Surg 2011; 1: 24-30. Quant Imaging Med Surg. 2013; 3(2):129.
Pang Y, Yu B, Zhang X. Hepatic fat assessment using advanced Magnetic Resonance Imaging. Quant Imaging Med Surg. 2012 Sep; 2(3):213-8.
Li Y, Zhang X. Advanced MR Imaging Technologies in Fetuses. OMICS J Radiol. 2012 Sep; 1(4):e113.
Wu B, Li Y, Wang C, Vigneron DB, Zhang X. Multi-reception strategy with improved SNR for multichannel MR imaging. PLoS One. 2012; 7(8):e42237.
Zhang X, Pang Y. Parallel Excitation in Ultrahigh Field Human MR Imaging and Multi-Channel Transmit System. OMICS J Radiol. 2012 May; 1(3):e110.
Zhu XH, Qiao H, Du F, Xiong Q, Liu X, Zhang X, Ugurbil K, Chen W. Quantitative imaging of energy expenditure in human brain. Neuroimage. 2012 May 01; 60(4):2107-17.
Wu B, Zhang X, Wang C, Li Y, Pang Y, Lu J, Xu D, Majumdar S, Nelson SJ, Vigneron DB. Flexible transceiver array for ultrahigh field human MR imaging. Magn Reson Med. 2012 Oct; 68(4):1332-8.
Pang Y, Zhang X. Precompensation for mutual coupling between array elements in parallel excitation. Quant Imaging Med Surg. 2011 Dec; 1(1):4-10.
Wang C, Li Y, Wu B, Xu D, Nelson SJ, Vigneron DB, Zhang X. A practical multinuclear transceiver volume coil for in vivo MRI/MRS at 7 T. Magn Reson Imaging. 2012 Jan; 30(1):78-84.
Pang Y, Xie Z, Xu D, Kelley DA, Nelson SJ, Vigneron DB, Zhang X. A dual-tuned quadrature volume coil with mixed ?/2 and ?/4 microstrip resonators for multinuclear MRSI at 7 T. Magn Reson Imaging. 2012 Feb; 30(2):290-8.
Pang Y, Wu B, Wang C, Vigneron DB, Zhang X. Numerical Analysis of Human Sample Effect on RF Penetration and Liver MR Imaging at Ultrahigh Field. Concepts Magn Reson Part B Magn Reson Eng. 2011 Oct; 39B(4):206-216.
Wu B, Wang C, Lu J, Pang Y, Nelson SJ, Vigneron DB, Zhang X. Multi-channel microstrip transceiver arrays using harmonics for high field MR imaging in humans. IEEE Trans Med Imaging. 2012 Feb; 31(2):183-91.
Pang Y, Vigneron DB, Zhang X. Parallel traveling-wave MRI: a feasibility study. Magn Reson Med. 2012 Apr; 67(4):965-78.
Pang Y, Xie Z, Li Y, Xu D, Vigneron D, Zhang X. Resonant Mode Reduction in Radiofrequency Volume Coils for Ultrahigh Field Magnetic Resonance Imaging. Materials (Basel). 2011 Jul 28; 4(8):1333-1344.
Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5.
Li Y, Xie Z, Pang Y, Vigneron D, Zhang X. ICE decoupling technique for RF coil array designs. Med Phys. 2011 Jul; 38(7):4086-93.
Pang Y, Zhang X, Xie Z, Wang C, Vigneron DB. Common-mode differential-mode (CMDM) method for double-nuclear MR signal excitation and reception at ultrahigh fields. IEEE Trans Med Imaging. 2011 Nov; 30(11):1965-73.
Zhang J, Tan Q, Yin H, Zhang X, Huan Y, Tang L, Wang H, Xu J, Li L. Decreased gray matter volume in the left hippocampus and bilateral calcarine cortex in coal mine flood disaster survivors with recent onset PTSD. Psychiatry Res. 2011 May 31; 192(2):84-90.
Lu J, Pang Y, Wang C, Wu B, Vigneron DB, Zhang X. Evaluation of Common RF Coil Setups for MR Imaging at Ultrahigh Magnetic Field: A Numerical Study. Int Symp Appl Sci Biomed Commun Technol. 2011; 2011.
Li Y, Pang Y, Vigneron D, Glenn O, Xu D, Zhang X. Investigation of multichannel phased array performance for fetal MR imaging on 1.5T clinical MR system. Quant Imaging Med Surg. 2011 Jan 01; 1(1):24-30.
Lu J, Pang Y, Wang C, Wu B, Vigneron D, Zhang X. Evaluation of Common RF Coil Setups for MR Imaging at Ultrahigh Magnetic Field: A Numerical Study. Proceedings of ISABEL. 2011; 4:DOI:10.1145/2093698.2093768.
Dafni H, Larson PE, Hu S, Yoshihara HA, Ward CS, Venkatesh HS, Wang C, Zhang X, Vigneron DB, Ronen SM. Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor. Cancer Res. 2010 Oct 01; 70(19):7400-10.
Zhu X, Du F, Zhang N, Zhang Y, Liu X, Zhang X, Ugurbil K, Chen W. Study of Brain Metabolism, Energy and Function using In Vivo MRS. Biological Magnetic Resonance. 2010; 30.
Wu B, Wang C, Kelley DA, Xu D, Vigneron DB, Nelson SJ, Zhang X. Shielded microstrip array for 7T human MR imaging. IEEE Trans Med Imaging. 2010 Jan; 29(1):179-84.
Wu B, Wang C, Krug R, Kelley DA, Xu D, Pang Y, Banerjee S, Vigneron DB, Nelson SJ, Majumdar S, Zhang X. 7T human spine imaging arrays with adjustable inductive decoupling. IEEE Trans Biomed Eng. 2010 Feb; 57(2):397-403.
Zhu XH, Du F, Zhang N, Zhang Y, Lei H, Zhang X, Qiao H, Ugurbil K, Chen W. Advanced In Vivo Heteronuclear MRS Approaches for Studying Brain Bioenergetics Driven by Mitochondria. Methods Mol Biol. 2009; 489:317-57.
Du F, Zhu XH, Qiao H, Zhang X, Chen W. Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain. Magn Reson Med. 2007 Jan; 57(1):103-14.
Lee J, Hu Q, Nakamura Y, Wang X, Zhang X, Zhu X, Chen W, Yang Q, Zhang J. Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 Tesla. J Magn Reson Imaging. 2006 Dec; 24(6):1269-76.
Wu B, Zhang X, Qu P, Shen GX. Capacitively decoupled tunable loop microstrip (TLM) array at 7 T. Magn Reson Imaging. 2007 Apr; 25(3):418-24.
Qiao H, Zhang X, Zhu XH, Du F, Chen W. In vivo 31P MRS of human brain at high/ultrahigh fields: a quantitative comparison of NMR detection sensitivity and spectral resolution between 4 T and 7 T. Magn Reson Imaging. 2006 Dec; 24(10):1281-6.
Wu B, Zhang X, Qu P, Shen GX. Design of an inductively decoupled microstrip array at 9.4 T. J Magn Reson. 2006 Sep; 182(1):126-32.
Yang QX, Mao W, Wang J, Smith MB, Lei H, Zhang X, Ugurbil K, Chen W. Manipulation of image intensity distribution at 7.0 T: passive RF shimming and focusing with dielectric materials. J Magn Reson Imaging. 2006 Jul; 24(1):197-202.
Zhang X, Zhu XH, Chen W. Higher-order harmonic transmission-line RF coil design for MR applications. Magn Reson Med. 2005 May; 53(5):1234-9.
Zhu XH, Zhang N, Zhang Y, Zhang X, Ugurbil K, Chen W. In vivo 17O NMR approaches for brain study at high field. NMR Biomed. 2005 Apr; 18(2):83-103.
Zhang X, Ugurbil K, Sainati R, Chen W. An inverted-microstrip resonator for human head proton MR imaging at 7 tesla. IEEE Trans Biomed Eng. 2005 Mar; 52(3):495-504.
Adriany G, Van de Moortele PF, Wiesinger F, Moeller S, Strupp JP, Andersen P, Snyder C, Zhang X, Chen W, Pruessmann KP, Boesiger P, Vaughan T, Ugurbil K. Transmit and receive transmission line arrays for 7 Tesla parallel imaging. Magn Reson Med. 2005 Feb; 53(2):434-45.
Yang QX, Wang J, Collins CM, Smith MB, Zhang X, Ugurbil K, Chen W. Phantom design method for high-field MRI human systems. Magn Reson Med. 2004 Nov; 52(5):1016-20.
Zhang X, Zhu XH, Tian R, Zhang Y, Merkle H, Chen W. Measurement of arterial input function of 17O water tracer in rat carotid artery by using a region-defined (REDE) implanted vascular RF coil. MAGMA. 2003 Jul; 16(2):77-85.
Zhang X, Ugurbil K, Chen W. A microstrip transmission line volume coil for human head MR imaging at 4T. J Magn Reson. 2003 Apr; 161(2):242-51.
Lei H, Zhu XH, Zhang XL, Ugurbil K, Chen W. In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: an initial experience. Magn Reson Med. 2003 Feb; 49(2):199-205.
Lei H, Zhu X, Zhang X, Qiao H, Ugurbil K, Chen . 31P-31P coupling and ATP T2 measurement in human brain at 7T. Magn Reson Med. 2003; 50:656-658.
Zhu XH, Zhang Y, Tian RX, Lei H, Zhang N, Zhang X, Merkle H, Ugurbil K, Chen W. Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13194-9.
Wang J, Yang QX, Zhang X, Collins CM, Smith MB, Zhu XH, Adriany G, Ugurbil K, Chen W. Polarization of the RF field in a human head at high field: a study with a quadrature surface coil at 7.0 T. Magn Reson Med. 2002 Aug; 48(2):362-9.
Yang QX, Wang J, Zhang X, Collins CM, Smith MB, Liu H, Zhu XH, Vaughan JT, Ugurbil K, Chen W. Analysis of wave behavior in lossy dielectric samples at high field. Magn Reson Med. 2002 May; 47(5):982-9.
Collins CM, Yang QX, Wang JH, Zhang X, Liu H, Michaeli S, Zhu XH, Adriany G, Vaughan JT, Anderson P, Merkle H, Ugurbil K, Smith MB, Chen W. Different excitation and reception distributions with a single-loop transmit-receive surface coil near a head-sized spherical phantom at 300 MHz. Magn Reson Med. 2002 May; 47(5):1026-8.
Baertlein B, Ozbay O, Ibrahim T, Lee R, Zhang X, Yu Y, Kangarlu A, and Robitaille P. Authors’ reply on Comments on “Theoretical Model for an MRI Radio Frequency Resonator”. IEEE Trans Biomed Eng. 2002; 49(5):495-496.
Zhang X, Ugurbil K, Chen W. Microstrip RF surface coil design for extremely high-field MRI and spectroscopy. Magn Reson Med. 2001 Sep; 46(3):443-50.
Abduljalil AM, Kangarlu A, Zhang X, Burgess RE, Robitaille PM. Acquisition of human multislice MR images at 8 Tesla. J Comput Assist Tomogr. 1999 May-Jun; 23(3):335-40.
Robitaille PM, Abduljalil AM, Kangarlu A, Zhang X, Yu Y, Burgess R, Bair S, Noa P, Yang L, Zhu H, Palmer B, Jiang Z, Chakeres DM, Spigos D. Human magnetic resonance imaging at 8 T. NMR Biomed. 1998 Oct; 11(6):263-5.
Tan Z, Zhang X, Li S. CuCl vapor laser. Journal of Optoelectronics and Laser. 1991; 2:87-89.
Chef R. [Change in calcium metabolism in women during prolonged treatment with 2,5 mg of Lyndiol]. Bull Soc R Belge Gynecol Obstet. 1967; 37(4):255-63.