Timothy Durazzo, PhD

Associate Professor
RESID PHYS/SUBSPEC 4-8/NON REP

Biography

Timothy C. Durazzo, PhD, is an Associate Professor in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco and a Research Scientist at the San Francisco Veterans Affairs Medical Center. Dr. Durazzo obtained his BA in Psychology from San Diego State University in 1988, and he received his PhD in Clinical Psychology and Clinical Neuropsychology from Oklahoma State University in Stillwater, Oklahoma in 1996. Dr. Durazzo completed a one-year internship in Clinical Psychology and Clinical Neuropsychology from the Palo Alto VA Medical Center, California in 1996, followed by a postdoctoral fellowship in Clinical Neuropsychology and Neuroscience from the University of Washington School of Medicine in Seattle, Washington in 1998.

Dr. Durazzo’s research revolves around three primary areas of interest. First, alcohol and substance use disorders. He and his colleagues are the first group to publish research specifically addressing the neurobiologic and neurocognitive effects of concurrent chronic cigarette smoking in alcohol disorders and recovery. Second, investigating chronic cigarette smoking by exploring the effects of chronic cigarette smoking of magnetic resonance-derived measures of brain morphology, metabolites, perfusion and diffusion as well as neurocognitive functioning in healthy non-substance abusing participants. Lastly, traumatic brain injury, which is focused on identifying and quantitating factors contributing to post-concussive syndrome in mild traumatic brain injuries.

Dr. Durazzo presently serves as a reviewer for 25 scientific journals. He has 39 published articles and he has written 49 peer-reviewed articles, 56 abstracts, and 5 significant publications.

Expertise:
Neuroscience and Neuropsychology

Specialty:
Neurobiological and neurocognitive, alcohol and substance disorders, chronic cigarette smoking, traumatic brain injury

Professional Interests:
Magnetic resonance spectroscopy, magnetic resonance imaging, perfusion, neuropsychology, angiography, alcohol use disorders, cigarette smoking, cerebral blood flow, brain physiology

Education and Training:
• Associate Degree: Skyline College, San Bruno, California
• Bachelor of Art: San Diego State University, California - Psychology
• Doctor of Philosophy: Oklahoma State University, Stillwater - Clinical Psychology and Clinical Neuropsychology
• Internship: Palo Alto VA Medical Center, California - Clinical Psychology and Clinical Neuropsychology
• Postdoctoral Fellowship: University of Washington School of Medicine, Seattle - Clinical Neuropsychology and Neuroscience

Honors and Awards

Early Career Investigators Travel Award, National Institute on Drug Abuse, 2009
APEX Award for Publication Excellence in Education and Training, SAMSA, 2004

Publications

Mon A, Abé C, Durazzo TC, Meyerhoff DJ. Fat may affect magnetic resonance signal intensity and brain tissue volumes. Obes Res Clin Pract. 2016 Mar-Apr; 10(2):211-5.
Durazzo TC, Meyerhoff DJ, Murray DE. Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults. Int J Environ Res Public Health. 2015; 12(7):8198-213.
Durazzo TC, Meyerhoff DJ, Mon A, Abé C, Gazdzinski S, Murray DE. Chronic Cigarette Smoking in Healthy Middle-Aged Individuals Is Associated With Decreased Regional Brain N-acetylaspartate and Glutamate Levels. Biol Psychiatry. 2016 Mar 15; 79(6):481-8.
Durazzo TC, Mattsson N, Weiner MW. Interaction of Cigarette Smoking History With APOE Genotype and Age on Amyloid Level, Glucose Metabolism, and Neurocognition in Cognitively Normal Elders. Nicotine Tob Res. 2016 Feb; 18(2):204-11.
Pennington DL, Durazzo TC, Schmidt TP, Abé C, Mon A, Meyerhoff DJ. Alcohol Use Disorder with and without Stimulant Use: Brain Morphometry and Its Associations with Cigarette Smoking, Cognition, and Inhibitory Control. PLoS One. 2015; 10(3):e0122505.
Murray DE, Durazzo TC, Mon A, Schmidt TP, Meyerhoff DJ. Brain perfusion in polysubstance users: Relationship to substance and tobacco use, cognition, and self-regulation. Drug Alcohol Depend. 2015 May 1; 150:120-8.
Durazzo TC, Pennington DL, Schmidt TP, Meyerhoff DJ. Effects of cigarette smoking history on neurocognitive recovery over 8 months of abstinence in alcohol-dependent individuals. Alcohol Clin Exp Res. 2014 Nov; 38(11):2816-25.
Mon A, Durazzo TC, Abe C, Gazdzinski S, Pennington D, Schmidt T, Meyerhoff DJ. Structural brain differences in alcohol-dependent individuals with and without comorbid substance dependence. Drug Alcohol Depend. 2014 Nov 1; 144:170-7.
Durazzo TC, Mon A, Gazdzinski S, Yeh PH, Meyerhoff DJ. Serial longitudinal magnetic resonance imaging data indicate non-linear regional gray matter volume recovery in abstinent alcohol-dependent individuals. Addict Biol. 2015 Sep; 20(5):956-67.
Hoefer ME, Pennington DL, Durazzo TC, Mon A, Abé C, Truran D, Hutchison KE, Meyerhoff DJ. Genetic and behavioral determinants of hippocampal volume recovery during abstinence from alcohol. Alcohol. 2014 Nov; 48(7):631-8.
Durazzo TC, Mattsson N, Weiner MW, Korecka M, Trojanowski JQ, Shaw LM. History of cigarette smoking in cognitively-normal elders is associated with elevated cerebrospinal fluid biomarkers of oxidative stress. Drug Alcohol Depend. 2014 Sep 1; 142:262-8.
Durazzo TC, Mattsson N, Weiner MW. Smoking and increased Alzheimer's disease risk: a review of potential mechanisms. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S122-45.
Schmidt TP, Pennington DL, Durazzo TC, Meyerhoff DJ. Postural stability in cigarette smokers and during abstinence from alcohol. Alcohol Clin Exp Res. 2014 Jun; 38(6):1753-60.
Mon A, Abé C, Durazzo TC, Meyerhoff DJ. Effects of fat on MR-measured metabolite signal strengths: implications for in vivo MRS studies of the human brain. NMR Biomed. 2013 Dec; 26(12):1768-74.
Durazzo TC, Meyerhoff DJ, Nixon SJ. Interactive effects of chronic cigarette smoking and age on hippocampal volumes. Drug Alcohol Depend. 2013 Dec 1; 133(2):704-11.
Abé C, Mon A, Hoefer ME, Durazzo TC, Pennington DL, Schmidt TP, Meyerhoff DJ. Metabolic abnormalities in lobar and subcortical brain regions of abstinent polysubstance users: magnetic resonance spectroscopic imaging. Alcohol Alcohol. 2013 Sep-Oct; 48(5):543-51.
Durazzo TC, Abadjian L, Kincaid A, Bilovsky-Muniz T, Boreta L, Gauger GE. The influence of chronic cigarette smoking on neurocognitive recovery after mild traumatic brain injury. J Neurotrauma. 2013 Jun 1; 30(11):1013-22.
Durazzo TC, Pennington DL, Schmidt TP, Mon A, Abé C, Meyerhoff DJ. Neurocognition in 1-month-abstinent treatment-seeking alcohol-dependent individuals: interactive effects of age and chronic cigarette smoking. Alcohol Clin Exp Res. 2013 Oct; 37(10):1794-803.
Pennington DL, Durazzo TC, Schmidt TP, Mon A, Abé C, Meyerhoff DJ. The effects of chronic cigarette smoking on cognitive recovery during early abstinence from alcohol. Alcohol Clin Exp Res. 2013 Jul; 37(7):1220-7.
Meyerhoff DJ, Durazzo TC, Ende G. Chronic alcohol consumption, abstinence and relapse: brain proton magnetic resonance spectroscopy studies in animals and humans. Curr Top Behav Neurosci. 2013; 13:511-40.
Yeo RA, Thoma RJ, Gasparovic C, Monnig M, Harlaar N, Calhoun VD, Kalyanam R, Mayer AR, Durazzo TC, Hutchison KE. Neurometabolite concentration and clinical features of chronic alcohol use: a proton magnetic resonance spectroscopy study. Psychiatry Res. 2013 Feb 28; 211(2):141-7.
Durazzo TC, Insel PS, Weiner MW. Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking. Alzheimers Dement. 2012 Nov; 8(6):513-9.
Abé C, Mon A, Durazzo TC, Pennington DL, Schmidt TP, Meyerhoff DJ. Polysubstance and alcohol dependence: unique abnormalities of magnetic resonance-derived brain metabolite levels. Drug Alcohol Depend. 2013 Jun 1; 130(1-3):30-7.
Durazzo TC, Hutchison KE, Fryer SL, Mon A, Meyerhoff DJ. Associations of Cigarette Smoking and Polymorphisms in Brain-Derived Neurotrophic Factor and Catechol-O-Methyltransferase with Neurocognition in Alcohol Dependent Individuals during Early Abstinence. Front Pharmacol. 2012; 3:178.
Mon A, Durazzo TC, Gazdzinski S, Hutchison KE, Pennington D, Meyerhoff DJ. Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals. Genes Brain Behav. 2013 Feb; 12(1):98-107.
Durazzo TC, Mon A, Pennington D, Abé C, Gazdzinski S, Meyerhoff DJ. Interactive effects of chronic cigarette smoking and age on brain volumes in controls and alcohol-dependent individuals in early abstinence. Addict Biol. 2014 Jan; 19(1):132-43.
Kuceyeski A, Meyerhoff DJ, Durazzo TC, Raj A. Loss in connectivity among regions of the brain reward system in alcohol dependence. Hum Brain Mapp. 2013 Dec; 34(12):3129-42.
Mon A, Durazzo TC, Meyerhoff DJ. Glutamate, GABA, and other cortical metabolite concentrations during early abstinence from alcohol and their associations with neurocognitive changes. Drug Alcohol Depend. 2012 Sep 1; 125(1-2):27-36.
Durazzo TC, Mon A, Gazdzinski S, Meyerhoff DJ. Chronic cigarette smoking in alcohol dependence: associations with cortical thickness and N-acetylaspartate levels in the extended brain reward system. Addict Biol. 2013 Mar; 18(2):379-91.
Durazzo TC, Meyerhoff DJ, Nixon SJ. A comprehensive assessment of neurocognition in middle-aged chronic cigarette smokers. Drug Alcohol Depend. 2012 Apr 1; 122(1-2):105-11.
Mon A, Delucchi K, Durazzo TC, Gazdzinski S, Meyerhoff DJ. A mathematical formula for prediction of gray and white matter volume recovery in abstinent alcohol dependent individuals. Psychiatry Res. 2011 Nov 30; 194(2):198-204.
Cardenas VA, Durazzo TC, Gazdzinski S, Mon A, Studholme C, Meyerhoff DJ. Brain morphology at entry into treatment for alcohol dependence is related to relapse propensity. Biol Psychiatry. 2011 Sep 15; 70(6):561-7.
Durazzo TC, Tosun D, Buckley S, Gazdzinski S, Mon A, Fryer SL, Meyerhoff DJ. Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence. Alcohol Clin Exp Res. 2011 Jun; 35(6):1187-200.
Durazzo TC, Meyerhoff DJ, Nixon SJ. Chronic cigarette smoking: implications for neurocognition and brain neurobiology. Int J Environ Res Public Health. 2010 Oct; 7(10):3760-91.
Durazzo TC, Fryer SL, Rothlind JC, Vertinski M, Gazdzinski S, Mon A, Meyerhoff DJ. Measures of learning, memory and processing speed accurately predict smoking status in short-term abstinent treatment-seeking alcohol-dependent individuals. Alcohol Alcohol. 2010 Nov-Dec; 45(6):507-13.
Gazdzinski S, Durazzo TC, Mon A, Meyerhoff DJ. Body mass index is associated with brain metabolite levels in alcohol dependence--a multimodal magnetic resonance study. Alcohol Clin Exp Res. 2010 Dec; 34(12):2089-96.
Durazzo TC, Gazdzinski S, Mon A, Meyerhoff DJ. Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment. Alcohol. 2010 May; 44(3):201-10.
Durazzo TC, Pathak V, Gazdzinski S, Mon A, Meyerhoff DJ. Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependence. J Stud Alcohol Drugs. 2010 Mar; 71(2):278-89.
Gazdzinski S, Durazzo TC, Mon A, Yeh PH, Meyerhoff DJ. Cerebral white matter recovery in abstinent alcoholics--a multimodality magnetic resonance study. Brain. 2010 Apr; 133(Pt 4):1043-53.
Gazdzinski S, Millin R, Kaiser LG, Durazzo TC, Mueller SG, Weiner MW, Meyerhoff DJ. BMI and neuronal integrity in healthy, cognitively normal elderly: a proton magnetic resonance spectroscopy study. Obesity (Silver Spring). 2010 Apr; 18(4):743-8.
Wang JJ, Durazzo TC, Gazdzinski S, Yeh PH, Mon A, Meyerhoff DJ. MRSI and DTI: a multimodal approach for improved detection of white matter abnormalities in alcohol and nicotine dependence. NMR Biomed. 2009 Jun; 22(5):516-22.
Yeh PH, Simpson K, Durazzo TC, Gazdzinski S, Meyerhoff DJ. Tract-Based Spatial Statistics (TBSS) of diffusion tensor imaging data in alcohol dependence: abnormalities of the motivational neurocircuitry. Psychiatry Res. 2009 Jul 15; 173(1):22-30.
Mon A, Durazzo TC, Gazdzinski S, Meyerhoff DJ. The impact of chronic cigarette smoking on recovery from cortical gray matter perfusion deficits in alcohol dependence: longitudinal arterial spin labeling MRI. Alcohol Clin Exp Res. 2009 Aug; 33(8):1314-21.
Durazzo TC, Gazdzinski S, Yeh PH, Meyerhoff DJ. Combined neuroimaging, neurocognitive and psychiatric factors to predict alcohol consumption following treatment for alcohol dependence. Alcohol Alcohol. 2008 Nov-Dec; 43(6):683-91.
Durazzo TC, Rothlind JC, Gazdzinski S, Meyerhoff DJ. The relationships of sociodemographic factors, medical, psychiatric, and substance-misuse co-morbidities to neurocognition in short-term abstinent alcohol-dependent individuals. Alcohol. 2008 Sep; 42(6):439-49.
Meyerhoff DJ, Durazzo TC. Proton magnetic resonance spectroscopy in alcohol use disorders: a potential new endophenotype? Alcohol Clin Exp Res. 2008 Jul; 32(7):1146-58.
Gazdzinski S, Durazzo TC, Weiner MW, Meyerhoff DJ. Are treated alcoholics representative of the entire population with alcohol use disorders? A magnetic resonance study of brain injury. Alcohol. 2008 Mar; 42(2):67-76.
Gazdzinski S, Durazzo TC, Yeh PH, Hardin D, Banys P, Meyerhoff DJ. Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics. Psychiatry Res. 2008 Feb 28; 162(2):133-45.
Durazzo TC, Rothlind JC, Cardenas VA, Studholme C, Weiner MW, Meyerhoff DJ. Chronic cigarette smoking and heavy drinking in human immunodeficiency virus: consequences for neurocognition and brain morphology. Alcohol. 2007 Nov; 41(7):489-501.
Yeh PH, Gazdzinski S, Durazzo TC, Sjöstrand K, Meyerhoff DJ. Hierarchical linear modeling (HLM) of longitudinal brain structural and cognitive changes in alcohol-dependent individuals during sobriety. Drug Alcohol Depend. 2007 Dec 1; 91(2-3):195-204.
Durazzo TC, Meyerhoff DJ. Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism. Front Biosci. 2007; 12:4079-100.
Durazzo TC, Gazdzinski S, Meyerhoff DJ. The neurobiological and neurocognitive consequences of chronic cigarette smoking in alcohol use disorders. Alcohol Alcohol. 2007 May-Jun; 42(3):174-85.
Durazzo TC, Rothlind JC, Gazdzinski S, Banys P, Meyerhoff DJ. Chronic smoking is associated with differential neurocognitive recovery in abstinent alcoholic patients: a preliminary investigation. Alcohol Clin Exp Res. 2007 Jul; 31(7):1114-27.
Cardenas VA, Studholme C, Gazdzinski S, Durazzo TC, Meyerhoff DJ. Deformation-based morphometry of brain changes in alcohol dependence and abstinence. Neuroimage. 2007 Feb 1; 34(3):879-87.
Durazzo TC, Cardenas VA, Studholme C, Weiner MW, Meyerhoff DJ. Non-treatment-seeking heavy drinkers: effects of chronic cigarette smoking on brain structure. Drug Alcohol Depend. 2007 Feb 23; 87(1):76-82.
Durazzo TC, Rothlind JC, Gazdzinski S, Banys P, Meyerhoff DJ. A comparison of neurocognitive function in nonsmoking and chronically smoking short-term abstinent alcoholics. Alcohol. 2006 May; 39(1):1-11.
Gazdzinski S, Durazzo T, Jahng GH, Ezekiel F, Banys P, Meyerhoff D. Effects of chronic alcohol dependence and chronic cigarette smoking on cerebral perfusion: a preliminary magnetic resonance study. Alcohol Clin Exp Res. 2006 Jun; 30(6):947-58.
Durazzo TC, Gazdzinski S, Rothlind JC, Banys P, Meyerhoff DJ. Brain metabolite concentrations and neurocognition during short-term recovery from alcohol dependence: Preliminary evidence of the effects of concurrent chronic cigarette smoking. Alcohol Clin Exp Res. 2006 Mar; 30(3):539-51.
Meyerhoff DJ, Tizabi Y, Staley JK, Durazzo TC, Glass JM, Nixon SJ. Smoking comorbidity in alcoholism: neurobiological and neurocognitive consequences. Alcohol Clin Exp Res. 2006 Feb; 30(2):253-64.
Gazdzinski S, Durazzo TC, Studholme C, Song E, Banys P, Meyerhoff DJ. Quantitative brain MRI in alcohol dependence: preliminary evidence for effects of concurrent chronic cigarette smoking on regional brain volumes. Alcohol Clin Exp Res. 2005 Aug; 29(8):1484-95.
Gazdzinski S, Durazzo TC, Meyerhoff DJ. Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependence. Drug Alcohol Depend. 2005 Jun 1; 78(3):263-73.
Durazzo TC, Gazdzinski S, Banys P, Meyerhoff DJ. Cigarette smoking exacerbates chronic alcohol-induced brain damage: a preliminary metabolite imaging study. Alcohol Clin Exp Res. 2004 Dec; 28(12):1849-60.