Roland Krug, PhD

Associate Professor
Asst. Professor in Residence

Biography

Roland Krug, PhD, is an Associate Professor in the Radiology Department with a joint appointment in Orthopedic Surgery at UCSF. Dr. Krug’s research interests include technical development of Magnetic Resonance Imaging and Spectroscopy methods and advanced digital imaging processing algorithms. His clinical focus includes the early assessement of musculoskeletal degenerations in particular related to osteoporosis and osteoarthritis. More recently, he expanded his interest to the diagnosis and treatment of lower back pain using MRI methods such as MR guided Focused Ultrasound (MRgFUS).

As a principal investigator, Dr. Krug has received substantial support from NIH including two R01 grants. Dr. Krug has more than 50 peer-reviewed articles published in the highest ranking journals in the field and serves as a reviewer for more than 15 scientific journals. He also teaches a class on MR pulse programming in the departmental master program.

Expertise:
Musculoskeletal Imaging

Specialty:
Advanced pulse sequence development for high field MR imaging, MR spectroscopy and MRgFUS temperature assessment.

Professional Interests:
MRI of spine. High-resolution MRI of trabecular and cortical bone, MR fat quantification based on Dixon techniques, image analysis techniques of trabecular bone microstructure. ultra-short-TE (UTE) MRI of cartilage, bone, tendons and ligaments. High-intensity focused ultra-sound (HIFU) applications for bone ablation (temperature mapping of bone using UTE).

Education

Postdoctoral Studies, - Graduate Division, University of California, San Francisco

Honors and Awards

Cover Image "Variable flip angle three-dimensional fast spin-echo sequence", Journal of Magnetic Resonance Imaging, 2015
Editor's Pick: "Bone marrow fat quantification in the presence of trabecular bone", Magnetic Resonance in Medicine, 2014
Magna Cum Laude Merit Award, International Society of Magnetic Resonance in Medicine, 2012
RSNA Trainee Research Prize for research project, Radiological Society of North America, 2012

Publications

Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated with Adjacent Disc Degeneration. Spine (Phila Pa 1976). 2017 Oct 03.
Lansdown DA, Lee S, Sam C, Krug R, Feeley BT, Ma CB. A Prospective, Quantitative Evaluation of Fatty Infiltration Before and After Rotator Cuff Repair. Orthop J Sports Med. 2017 Jul; 5(7):2325967117718537.
Karampinos DC, Ruschke S, Dieckmeyer M, Diefenbach M, Franz D, Gersing AS, Krug R, Baum T. Quantitative MRI and spectroscopy of bone marrow. J Magn Reson Imaging. 2017 Jun 01.
Bucknor MD, Ozhinsky E, Shah R, Krug R, Rieke V. Effect of Sonication Duration and Power on Ablation Depth During MR-Guided Focused Ultrasound of Bone. J Magn Reson Imaging. 2017 Feb 22.
Ozhinsky E, Han M, Bucknor M, Krug R, Rieke V. T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound. J Ther Ultrasound. 2016; 4:26.
Krug R, Do L, Rieke V, Wilson MW, Saeed M. Evaluation of MRI protocols for the assessment of lumbar facet joints after MR-guided focused ultrasound treatment. J Ther Ultrasound. 2016; 4:14.
Saeed M, Krug R, Do L, Hetts SW, Wilson MW. Renal ablation using magnetic resonance-guided high intensity focused ultrasound: Magnetic resonance imaging and histopathology assessment. World J Radiol. 2016 Mar 28; 8(3):298-307.
Nardo L, Carballido-Gamio J, Tang S, Lai A, Krug R. Quantitative assessment of morphology, T1?, and T2 of shoulder cartilage using MRI. Eur Radiol. 2016 Dec; 26(12):4656-4663.
Larson PE, Han M, Krug R, Jakary A, Nelson SJ, Vigneron DB, Henry RG, McKinnon G, Kelley DA. Ultrashort echo time and zero echo time MRI at 7T. MAGMA. 2016 Jun; 29(3):359-70.
Nardo L, Han M, Kretzschmar M, Guindani M, Koch K, Vail T, Krug R, Link TM. Erratum to: Metal artifact suppression at the hip: diagnostic performance at 3.0 T versus 1.5 Tesla. Skeletal Radiol. 2015 Nov; 44(11):1617.
Han M, Rieke V, Scott SJ, Ozhinsky E, Salgaonkar VA, Jones PD, Larson PE, Diederich CJ, Krug R. Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI. Magn Reson Med. 2015 Dec; 74(6):1548-55.
Saeed M, Van TA, Krug R, Hetts SW, Wilson MW. Cardiac MR imaging: current status and future direction. Cardiovasc Diagn Ther. 2015 Aug; 5(4):290-310.
Nardo L, Han M, Kretzschmar M, Kretschmar M, Guindani M, Koch K, Vail T, Krug R, Link TM. Metal artifact suppression at the hip: diagnostic performance at 3.0 T versus 1.5 Tesla. Skeletal Radiol. 2015 Nov; 44(11):1609-16.
Do L, Wilson MW, Krug R, Hetts SW, Saeed M. MRI monitoring of function, perfusion and viability in microembolized moderately ischemic myocardium. Int J Cardiovasc Imaging. 2015 Aug; 31(6):1179-90.
Lee S, Lucas RM, Lansdown DA, Nardo L, Lai A, Link TM, Krug R, Ma CB. Magnetic resonance rotator cuff fat fraction and its relationship with tendon tear severity and subject characteristics. J Shoulder Elbow Surg. 2015 Sep; 24(9):1442-51.
Kretzschmar M, Nardo L, Han MM, Heilmeier U, Sam C, Joseph GB, Koch KM, Krug R, Link TM. Metal artefact suppression at 3 T MRI: comparison of MAVRIC-SL with conventional fast spin echo sequences in patients with Hip joint arthroplasty. Eur Radiol. 2015 Aug; 25(8):2403-11.
Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R. Validation of bone marrow fat quantification in the presence of trabecular bone using MRI. J Magn Reson Imaging. 2015 Aug; 42(2):539-44.
Fields AJ, Han M, Krug R, Lotz JC. Cartilaginous end plates: Quantitative MR imaging with very short echo times-orientation dependence and correlation with biochemical composition. Radiology. 2015 Feb; 274(2):482-9.
Han M, Chiba K, Banerjee S, Carballido-Gamio J, Krug R. Variable flip angle three-dimensional fast spin-echo sequence combined with outer volume suppression for imaging trabecular bone structure of the proximal femur. J Magn Reson Imaging. 2015 May; 41(5):1300-10.
Liebl H, Heilmeier U, Lee S, Nardo L, Patsch J, Schuppert C, Han M, Rondak IC, Banerjee S, Koch K, Link TM, Krug R. In vitro assessment of knee MRI in the presence of metal implants comparing MAVRIC-SL and conventional fast spin echo sequences at 1.5 and 3 T field strength. J Magn Reson Imaging. 2015 May; 41(5):1291-9.
Han M, Larson PE, Liu J, Krug R. Depiction of achilles tendon microstructure in vivo using high-resolution 3-dimensional ultrashort echo-time magnetic resonance imaging at 7 T. Invest Radiol. 2014 May; 49(5):339-45.
Karampinos DC, Melkus G, Baum T, Bauer JS, Rummeny EJ, Krug R. Bone marrow fat quantification in the presence of trabecular bone: initial comparison between water-fat imaging and single-voxel MRS. Magn Reson Med. 2014 Mar; 71(3):1158-65.
Nardo L, Karampinos DC, Lansdown DA, Carballido-Gamio J, Lee S, Maroldi R, Ma CB, Link TM, Krug R. Quantitative assessment of fat infiltration in the rotator cuff muscles using water-fat MRI. J Magn Reson Imaging. 2014 May; 39(5):1178-85.
Alizai H, Nardo L, Karampinos DC, Joseph GB, Yap SP, Baum T, Krug R, Majumdar S, Link TM. Comparison of clinical semi-quantitative assessment of muscle fat infiltration with quantitative assessment using chemical shift-based water/fat separation in MR studies of the calf of post-menopausal women. Eur Radiol. 2012 Jul; 22(7):1592-600.
Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5.
Carballido-Gamio J, Folkesson J, Karampinos DC, Baum T, Link TM, Majumdar S, Krug R. Generation of an atlas of the proximal femur and its application to trabecular bone analysis. Magn Reson Med. 2011 Oct; 66(4):1181-91.
Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S. Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women. Bone. 2011 Mar 01; 48(3):611-21.
Krug R, Burghardt AJ, Majumdar S, Link TM. High-resolution imaging techniques for the assessment of osteoporosis. Radiol Clin North Am. 2010 May; 48(3):601-21.
Ristow O, Stehling C, Krug R, Steinbach L, Sabo G, Ambekar A, Huber M, Link TM. Isotropic 3-dimensional fast spin echo imaging versus standard 2-dimensional imaging at 3.0 T of the knee: artificial cartilage and meniscal lesions in a porcine model. J Comput Assist Tomogr. 2010 Mar-Apr; 34(2):260-9.
Stehling C, Liebl H, Krug R, Lane NE, Nevitt MC, Lynch J, McCulloch CE, Link TM. Patellar cartilage: T2 values and morphologic abnormalities at 3.0-T MR imaging in relation to physical activity in asymptomatic subjects from the osteoarthritis initiative. Radiology. 2010 Feb; 254(2):509-20.
Krug R, Stehling C, Kelley DA, Majumdar S, Link TM. Imaging of the musculoskeletal system in vivo using ultra-high field magnetic resonance at 7 T. Invest Radiol. 2009 Sep; 44(9):613-8.
Wu B, Wang C, Krug R, Kelley DA, Xu D, Pang Y, Banerjee S, Vigneron DB, Nelson SJ, Majumdar S, Zhang X. 7T human spine imaging arrays with adjustable inductive decoupling. IEEE Trans Biomed Eng. 2010 Feb; 57(2):397-403.
Zhao J, Krug R, Xu D, Lu Y, Link TM. MRI of the spine: image quality and normal-neoplastic bone marrow contrast at 3 T versus 1.5 T. AJR Am J Roentgenol. 2009 Apr; 192(4):873-80.
Folkesson J, Krug R, Goldenstein J, Issever AS, Fang C, Link TM, Majumdar S. Evaluation of correction methods for coil-induced intensity inhomogeneities and their influence on trabecular bone structure parameters from MR images. Med Phys. 2009 Apr; 36(4):1267-74.
Stahl R, Krug R, Kelley DA, Zuo J, Ma CB, Majumdar S, Link TM. Assessment of cartilage-dedicated sequences at ultra-high-field MRI: comparison of imaging performance and diagnostic confidence between 3.0 and 7.0 T with respect to osteoarthritis-induced changes at the knee joint. Skeletal Radiol. 2009 Aug; 38(8):771-83.
Carballido-Gamio J, Krug R, Huber MB, Hyun B, Eckstein F, Majumdar S, Link TM. Geodesic topological analysis of trabecular bone microarchitecture from high-spatial resolution magnetic resonance images. Magn Reson Med. 2009 Feb; 61(2):448-56.
Ristow O, Steinbach L, Sabo G, Krug R, Huber M, Rauscher I, Ma B, Link TM. Isotropic 3D fast spin-echo imaging versus standard 2D imaging at 3.0 T of the knee--image quality and diagnostic performance. Eur Radiol. 2009 May; 19(5):1263-72.
Bauer JS, Monetti R, Krug R, Matsuura M, Mueller D, Eckstein F, Rummeny EJ, Lochmueller EM, Raeth CW, Link TM. Advances of 3T MR imaging in visualizing trabecular bone structure of the calcaneus are partially SNR-independent: analysis using simulated noise in relation to micro-CT, 1.5T MRI, and biomechanical strength. J Magn Reson Imaging. 2009 Jan; 29(1):132-40.
Carballido-Gamio J, Link TM, Li X, Han ET, Krug R, Ries MD, Majumdar S. Feasibility and reproducibility of relaxometry, morphometric, and geometrical measurements of the hip joint with magnetic resonance imaging at 3T. J Magn Reson Imaging. 2008 Jul; 28(1):227-35.
Stahl R, Luke A, Ma CB, Krug R, Steinbach L, Majumdar S, Link TM. Prevalence of pathologic findings in asymptomatic knees of marathon runners before and after a competition in comparison with physically active subjects-a 3.0 T magnetic resonance imaging study. Skeletal Radiol. 2008 Jul; 37(7):627-38.
Krug R, Carballido-Gamio J, Banerjee S, Burghardt AJ, Link TM, Majumdar S. In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T. J Magn Reson Imaging. 2008 Apr; 27(4):854-9.
Banerjee S, Krug R, Carballido-Gamio J, Kelley DA, Xu D, Vigneron DB, Majumdar S. Rapid in vivo musculoskeletal MR with parallel imaging at 7T. Magn Reson Med. 2008 Mar; 59(3):655-60.
Krug R, Carballido-Gamio J, Banerjee S, Stahl R, Carvajal L, Xu D, Vigneron D, Kelley DA, Link TM, Majumdar S. In vivo bone and cartilage MRI using fully-balanced steady-state free-precession at 7 tesla. Magn Reson Med. 2007 Dec; 58(6):1294-8.
Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S. Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int. 2008 May; 19(5):653-61.
Blumenfeld J, Carballido-Gamio J, Krug R, Blezek DJ, Hancu I, Majumdar S. Automatic prospective registration of high-resolution trabecular bone images of the tibia. Ann Biomed Eng. 2007 Nov; 35(11):1924-31.
Bauer JS, Banerjee S, Henning TD, Krug R, Majumdar S, Link TM. Fast high-spatial-resolution MRI of the ankle with parallel imaging using GRAPPA at 3 T. AJR Am J Roentgenol. 2007 Jul; 189(1):240-5.
Krug R, Carballido-Gamio J, Burghardt AJ, Haase S, Sedat JW, Moss WC, Majumdar S. Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements. Magn Reson Imaging. 2007 Apr; 25(3):392-8.
Krug R, Han ET, Banerjee S, Majumdar S. Fully balanced steady-state 3D-spin-echo (bSSSE) imaging at 3 Tesla. Magn Reson Med. 2006 Nov; 56(5):1033-40.
Bauer JS, Krause SJ, Ross CJ, Krug R, Carballido-Gamio J, Ozhinsky E, Majumdar S, Link TM. Volumetric cartilage measurements of porcine knee at 1.5-T and 3.0-T MR imaging: evaluation of precision and accuracy. Radiology. 2006 Nov; 241(2):399-406.
Krug R, Banerjee S, Han ET, Newitt DC, Link TM, Majumdar S. Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur. Osteoporos Int. 2005 Nov; 16(11):1307-14.
Banerjee S, Han ET, Krug R, Newitt DC, Majumdar S. Application of refocused steady-state free-precession methods at 1.5 and 3 T to in vivo high-resolution MRI of trabecular bone: simulations and experiments. J Magn Reson Imaging. 2005 Jun; 21(6):818-25.
Krug R, Carballido-Gamio J, Burghardt A, Haase S, Sedat J, Moss W, Majumdar S. Wavelet Based Characterization of Vertebral Trabecular Bone Structure from MR Images of Specimen at 3 Tesla Compared to MicroCT Measurements. Conf Proc IEEE Eng Med Biol Soc. 2005; 7:7040-3.
Krug R, Boese JM, Schad LR. Determination of aortic compliance from magnetic resonance images using an automatic active contour model. Phys Med Biol. 2003 Aug 07; 48(15):2391-404.