Olga Tymofiyeva, PhD

Associate Professor
Associate Adjunct Professor
View full UCSF Profile

Biography

Dr. Olga Tymofiyeva is an Associate Professor in the UCSF Department of Radiology and Biomedical Imaging. Dr. Tymofiyeva holds her degrees in Physics (PhD, University of Wuerzburg, Germany), Electrical Engineering (MSc, University of Applied Sciences, Karlsruhe, Germany and BSc, NTUU “KPI”, Kyiv, Ukraine), and Psychology (BSc, University of Hagen, Germany). Her main research interest is non-invasive mapping of structural and functional connectivity in the developing brain, from premature neonates to adolescents and young adults. She develops and applies advanced MRI techniques to study the neurobiological substrates of mental disorders (in particular, adolescent depression) and effects of mind-body interventions on children and adolescents. Dr. Tymofiyeva is currently the Principal Investigator for an NIH-funded study of brain plasticity in adolescents undergoing a mindfulness meditation training, the "BrainChange" study: https://radiology.ucsf.edu/research/labs/BrainChange.

Education

B.Sc., 2018 - Psychology, University of Hagen (distant learning)
Postdoctoral training, 2014 - Biomedical Imaging, University of California, San Francisco
Ph.D., 2010 - Physics, University of Würzburg
M.Sc., 2005 - Electrical Engineering, Karlsruhe University of Applied Sciences
B.Sc., 2002 - Electrical Engineering, National Technical University of Ukraine “KPI”

Honors and Awards

Surbeck Young Investigators Award, 3rd place, UCSF, 2013
Outstanding Poster Presentation Award, UCSF, 2012
Outstanding Oral Presentation Award, UCSF, 2011
Surbeck Young Investigators Award, 2nd place, UCSF, 2011
Young Investigator Award, 1st Place, ESMRMB, 2009
DAAD-Siemens scholarship for Master Studies, DAAD, 2003-2005

Publications

Rebecca Hu, Olga Tymofiyeva, Benjamin S. Sipes, Angela Jakary, Eva Henje, Tony T. Yang. 3.47 Resilience and Amygdala Function in Healthy Adolescents. Journal of the American Academy of Child & Adolescent Psychiatry. 2023 Oct 1; 62(10):s221-s222.
Rebecca Hu, Olga Tymofiyeva, Eva Henje, Benjamin S. Sipes, Angela Jakary, Tony T. Yang. 5.61 Effect of a Mindfulness Meditation-Based Intervention on Resilience in Healthy Adolescents. Journal of the American Academy of Child & Adolescent Psychiatry. 2023 Oct 1; 62(10):s278-s279.
Olga Tymofiyeva, Benjamin S. Sipes, Angela Jakary, Rebecca Hu, Eva Henje, Tony T. Yang. 6.95 Structural Brain Connectivity Correlates of Suicidal Ideation in Adolescents. Journal of the American Academy of Child & Adolescent Psychiatry. 2023 Oct 1; 62(10):s316.
Tymofiyeva O, Reeves KW, Shaw C, Lopez E, Aziz S, Max JE, Yang TT. A Systematic Review of MRI Studies and the "Emotional paiN and social Disconnect (END)" Brain Model of Suicidal Behavior in Youth. Behav Neurol. 2023; 2023:7254574.
Lowet DS, Vaida F, Hesselink JR, Ewing-Cobbs L, Schachar RJ, Chapman SB, Bigler ED, Wilde EA, Saunders AE, Yang TT, Tymofiyeva O, Huang M, Max JE. Novel Oppositional Defiant Disorder or Conduct Disorder 24 Months After Traumatic Brain Injury in Children and Adolescents. J Neuropsychiatry Clin Neurosci. 2024; 36(1):53-62.
Tymofiyeva O, Hu R, Kidambi R, Nguyen C, Max JE, Yang TT. A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma. Front Hum Neurosci. 2022; 16:1022791.
Freimer D, Yang TT, Ho TC, Tymofiyeva O, Leung C. The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment. Brain Behav Immun Health. 2022 Dec; 26:100541.
Sipes BS, Jakary A, Li Y, Max JE, Yang TT, Tymofiyeva O. Resting state brain subnetwork relates to prosociality and compassion in adolescents. Front Psychol. 2022; 13:1012745.
Brandon Nguyen, Olga Tymofiyeva, Benjamin S. Sipes, Angela Jakary, Daniel Freimer, Yi Li, Tony T. Yang. 2.45 Neural Correlates of Smartphone Dependence and Links to Depression in Adolescents. Journal of the American Academy of Child & Adolescent Psychiatry. 2022 Oct 1; 61(10):s197.
Max JE, Drake I, Vaida F, Hesselink JR, Ewing-Cobbs L, Schachar RJ, Chapman SB, Bigler ED, Wilde EA, Saunders AE, Yang TT, Tymofiyeva O, Levin HS. Novel Psychiatric Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents. J Neuropsychiatry Clin Neurosci. 2023; 35(2):141-150.
Tymofiyeva O, Hu MY, Sipes BS, Jakary A, Glidden DV, Jariwala N, Bhandari S, Parks KC, Nguyen C, Henje E, Yang TT. A Feasibility Study of a Remotely-Delivered Mindfulness-Based Training for Adolescents During the COVID-19 Pandemic. Front Psychiatry. 2022; 13:838694.
Sipes BS, Yang TT, Parks KC, Jariwala N, Tymofiyeva O. A Domain-General Developmental "Do-GooD" Network Model of Prosocial Cognition in Adolescence: A Systematic Review. Front Behav Neurosci. 2022; 16:815811.
Lowet DS, Vaida F, Hesselink JR, Levin HS, Ewing-Cobbs L, Schachar RJ, Chapman SB, Bigler ED, Wilde EA, Saunders AE, Yang TT, Tymofiyeva O, Max JE. Novel Oppositional Defiant Disorder 12 Months After Traumatic Brain Injury in Children and Adolescents. J Neuropsychiatry Clin Neurosci. 2022; 34(2):149-157.
Ramirez A, Peyvandi S, Cox S, Gano D, Xu D, Tymofiyeva O, McQuillen PS. Neonatal brain injury influences structural connectivity and childhood functional outcomes. PLoS One. 2022; 17(1):e0262310.
Lowet DS, Kolan A, Vaida F, Hesselink JR, Levin HS, Ewing-Cobbs L, Schachar RJ, Chapman SB, Bigler ED, Wilde EA, Saunders AE, Yang TT, Tymofiyeva O, Arif H, Max JE. Novel Oppositional Defiant Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents. J Neuropsychiatry Clin Neurosci. 2022; 34(1):68-76.
Olga Tymofiyeva, Melody Hu, Benjamin Sipes, Namasvi Jariwala, Angela Jakary, Ca Nguyen, Kendall Parks, Eva Henje, Tony Yang. 1.3 A Feasibility Study of a Remotely Delivered Mindfulness Training for Adolescents During the COVID-19 Pandemic. Journal of the American Academy of Child & Adolescent Psychiatry. 2021 Oct 11; 60(10):s140.
Max JE, Troyer EA, Arif H, Vaida F, Wilde EA, Bigler ED, Hesselink JR, Yang TT, Tymofiyeva O, Wade O, Paulsen JS. Traumatic Brain Injury in Children and Adolescents: Psychiatric Disorders 24 Years Later. J Neuropsychiatry Clin Neurosci. 2022; 34(1):60-67.
Arif H, Troyer EA, Paulsen JS, Vaida F, Wilde EA, Bigler ED, Hesselink JR, Yang TT, Tymofiyeva O, Wade O, Max JE. Long-Term Psychiatric Outcomes in Adults with History of Pediatric Traumatic Brain Injury. J Neurotrauma. 2021 06 01; 38(11):1515-1525.
Tymofiyeva O, Gaschler R. Training-Induced Neural Plasticity in Youth: A Systematic Review of Structural and Functional MRI Studies. Front Hum Neurosci. 2020; 14:497245.
Tymofiyeva O, Henje E, Yuan JP, Huang CY, Connolly CG, Ho TC, Bhandari S, Parks KC, Sipes BS, Yang TT, Xu D. Reduced anxiety and changes in amygdala network properties in adolescents with training for awareness, resilience, and action (TARA). Neuroimage Clin. 2021; 29:102521.
Tymofiyeva O, Yuan JP, Kidambi R, Huang CY, Henje E, Rubinstein ML, Jariwala N, Max JE, Yang TT, Xu D. Neural Correlates of Smartphone Dependence in Adolescents. Front Hum Neurosci. 2020; 14:564629.
Olga Tymofiyeva, Chiung-Yu Huang, Sarina Bhandari, Eric Lopez, Kendall Parks, Namasvi Jariwala, Benjamin Sipes, Tony T. Yang. 1.4 CHILDHOOD TRAUMA AND AMYGDALA-ORBITOFRONTAL ANATOMICAL CONNECTIVITY IN ADOLESCENTS. Journal of the American Academy of Child & Adolescent Psychiatry. 2020 Oct 1; 59(10):s140.
Yuan JP, Connolly CG, Henje E, Sugrue LP, Yang TT, Xu D, Tymofiyeva O. Gray Matter Changes in Adolescents Participating in a Meditation Training. Front Hum Neurosci. 2020; 14:319.
Tymofiyeva O, Zhou VX, Lee CM, Xu D, Hess CP, Yang TT. MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future. Front Hum Neurosci. 2020; 14:237.
Olga Tymofiyeva, Justin Yuan, Roma Kidambi, Chiung-Yu Huang, Eva Henje Blom, Mark Rubinstein, Duan Xu, Tony T. Yang. 4.32 SMARTPHONE DEPENDENCE, BRAIN CONNECTIVITY, AND LINKS TO DEPRESSION IN ADOLESCENTS. Journal of the American Academy of Child & Adolescent Psychiatry. 2019 Oct 1; 58(10):s229-s230.
Tymofiyeva O, Yuan JP, Huang CY, Connolly CG, Henje Blom E, Xu D, Yang TT. Application of machine learning to structural connectome to predict symptom reduction in depressed adolescents with cognitive behavioral therapy (CBT). Neuroimage Clin. 2019; 23:101914.
Justin Yuan, Melanie Morrison, Angela Jakary, Sabine Mueller, Olga Tymofiyeva, Duan Xu, Janine Lupo. MEDU-15. STRUCTURAL BRAIN NETWORK PROPERTIES AND COGNITIVE IMPAIRMENT IN ADOLESCENTS AFTER RADIATION THERAPY. Neuro-Oncology. 2019 Apr 23; 21(Supplement_2):ii106-ii106.
Yuan JP, Henje Blom E, Flynn T, Chen Y, Ho TC, Connolly CG, Dumont Walter RA, Yang TT, Xu D, Tymofiyeva O. Test-Retest Reliability of Graph Theoretic Metrics in Adolescent Brains. Brain Connect. 2019 03; 9(2):144-154.
Tymofiyeva O, Gano D, Trevino RJ, Glass HC, Flynn T, Lundy SM, McQuillen PS, Ferriero DM, Barkovich AJ, Xu D. Aberrant Structural Brain Connectivity in Adolescents with Attentional Problems Who Were Born Prematurely. AJNR Am J Neuroradiol. 2018 11; 39(11):2140-2147.
Olga Tymofiyeva, Justin Yuan, Colm Connolly, Eva Henje Blom, Duan Xu, Tony T. Yang. 5.48 Using MRI to Predict Depression Symptom Improvement in Depressed Adolescents Undergoing Cbt. Journal of the American Academy of Child & Adolescent Psychiatry. 2018 Oct 1; 57(10):s242.
LeWinn KZ, Strigo IA, Connolly CG, Ho TC, Tymofiyeva O, Sacchet MD, Weng HY, Blom EH, Simmons AN, Yang TT. An exploratory examination of reappraisal success in depressed adolescents: Preliminary evidence of functional differences in cognitive control brain regions. J Affect Disord. 2018 11; 240:155-164.
J.C. Nelson, Scott Mackin, Duygu Tosun, Olga Tymofiyeva. Session 112 Emerging Multimodal Neuroimaging Findings in LATE Life Depression. American Journal of Geriatric Psychiatry. 2018 Mar 1; 26(3):s11-s12.
Tymofiyeva O, Henje Blom E, Ho TC, Connolly CG, Lindqvist D, Wolkowitz OM, Lin J, LeWinn KZ, Sacchet MD, Han LKM, Yuan JP, Bhandari SP, Xu D, Yang TT. High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression. J Affect Disord. 2018 05; 232:283-290.
Boldt J, Rottner K, Schmitter M, Hopfgartner A, Jakob P, Richter EJ, Tymofiyeva O. High-resolution MR imaging for dental impressions: a feasibility study. Clin Oral Investig. 2018 Apr; 22(3):1209-1213.
Ho TC, Sacchet MD, Connolly CG, Margulies DS, Tymofiyeva O, Paulus MP, Simmons AN, Gotlib IH, Yang TT. Inflexible Functional Connectivity of the Dorsal Anterior Cingulate Cortex in Adolescent Major Depressive Disorder. Neuropsychopharmacology. 2017 Nov; 42(12):2434-2445.
Henje Blom E, Tymofiyeva O, Chesney MA, Ho TC, Moran P, Connolly CG, Duncan LG, Baldini L, Weng HY, Acree M, Goldman V, Hecht FM, Yang TT. Feasibility and Preliminary Efficacy of a Novel RDoC-Based Treatment Program for Adolescent Depression: "Training for Awareness Resilience and Action" (TARA)-A Pilot Study. Front Psychiatry. 2016; 7:208.
Cui J, Tymofiyeva O, Desikan R, Flynn T, Kim H, Gano D, Hess CP, Ferriero DM, Barkovich AJ, Xu D. Microstructure of the Default Mode Network in Preterm Infants. AJNR Am J Neuroradiol. 2017 Feb; 38(2):343-348.
Connolly CG, Ho TC, Blom EH, LeWinn KZ, Sacchet MD, Tymofiyeva O, Simmons AN, Yang TT. Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression. J Affect Disord. 2017 Jan 01; 207:86-94.
Tymofiyeva O, Connolly CG, Ho TC, Sacchet MD, Henje Blom E, LeWinn KZ, Xu D, Yang TT. DTI-based connectome analysis of adolescents with major depressive disorder reveals hypoconnectivity of the right caudate. J Affect Disord. 2017 Jan 01; 207:18-25.
Sacchet MD, Ho TC, Connolly CG, Tymofiyeva O, Lewinn KZ, Han LK, Blom EH, Tapert SF, Max JE, Frank GK, Paulus MP, Simmons AN, Gotlib IH, Yang TT. Large-Scale Hypoconnectivity Between Resting-State Functional Networks in Unmedicated Adolescent Major Depressive Disorder. Neuropsychopharmacology. 2016 11; 41(12):2951-2960.
Henje Blom E, Ho TC, Connolly CG, LeWinn KZ, Sacchet MD, Tymofiyeva O, Weng HY, Yang TT. The neuroscience and context of adolescent depression. Acta Paediatr. 2016 Apr; 105(4):358-65.
Chen Y, Tymofiyeva O, Hess CP, Xu D. Effects of rejecting diffusion directions on tensor-derived parameters. Neuroimage. 2015 Apr 01; 109:160-70.
Tymofiyeva O, Hess CP, Xu D, Barkovich AJ. Structural MRI connectome in development: challenges of the changing brain. Br J Radiol. 2014 Jul; 87(1039):20140086.
Tymofiyeva O, Ziv E, Barkovich AJ, Hess CP, Xu D. Brain without anatomy: construction and comparison of fully network-driven structural MRI connectomes. PLoS One. 2014; 9(5):e96196.
Ziv E, Tymofiyeva O, Ferriero DM, Barkovich AJ, Hess CP, Xu D. A machine learning approach to automated structural network analysis: application to neonatal encephalopathy. PLoS One. 2013; 8(11):e78824.
Hopfgartner AJ, Tymofiyeva O, Ehses P, Rottner K, Boldt J, Richter EJ, Jakob PM. Dynamic MRI of the TMJ under physical load. Dentomaxillofac Radiol. 2013; 42(9):20120436.
Tymofiyeva O, Hess CP, Ziv E, Lee PN, Glass HC, Ferriero DM, Barkovich AJ, Xu D. A DTI-based template-free cortical connectome study of brain maturation. PLoS One. 2013; 8(5):e63310.
Tymofiyeva O, Vaegler S, Rottner K, Boldt J, Hopfgartner AJ, Proff PC, Richter EJ, Jakob PM. Influence of dental materials on dental MRI. Dentomaxillofac Radiol. 2013; 42(6):20120271.
Tymofiyeva O, Proff PC, Rottner K, Düring M, Jakob PM, Richter EJ. Diagnosis of dental abnormalities in children using 3-dimensional magnetic resonance imaging. J Oral Maxillofac Surg. 2013 Jul; 71(7):1159-69.
Tymofiyeva O, Hess CP, Ziv E, Tian N, Bonifacio SL, McQuillen PS, Ferriero DM, Barkovich AJ, Xu D. Towards the "baby connectome": mapping the structural connectivity of the newborn brain. PLoS One. 2012; 7(2):e31029.
Tymofiyeva O, Schmid F, von Kienlin M, Breuer FA, Rottner K, Boldt J, Richter EJ, Jakob PM. On precise localization of boundaries between extended uniform objects in MRI: tooth imaging as an example. MAGMA. 2011 Feb; 24(1):19-28.
Tymofiyeva O, Boldt J, Rottner K, Schmid F, Richter EJ, Jakob PM. High-resolution 3D magnetic resonance imaging and quantification of carious lesions and dental pulp in vivo. MAGMA. 2009 Dec; 22(6):365-74.
Tymofiyeva O, Rottner K, Jakob PM, Richter EJ, Proff P. Three-dimensional localization of impacted teeth using magnetic resonance imaging. Clin Oral Investig. 2010 Apr; 14(2):169-76.
O. Tymofiyeva, K. Rottner, J. Boldt, F. Schmid, E. -J. Richter, P. M. Jakob. In Vivo 3D Imaging of Carious Lesions and Dental Pulp Using Magnetic Resonance. World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. 2009 Jan 1; 25/11:216-218.
O. Tymofiyeva, K. Rottner, D. Gareis, J. Boldt, F. Schmid, M.A. Lopez, E.-J. Richter, P.M. Jakob. In vivo MRI-based dental impression using an intraoral RF receiver coil. Concepts in Magnetic Resonance Part B. 2008 Oct 1; 33B(4):244-251.
Tymofiyeva O, Rottner K, Gareis D, Boldt J, Schmid F, Lopez MA, Richter E-J, Jakob PM. In vivo MRI-based dental impression using an intraoral RF receiver coil. Concept Magn Reson B: Magn Reson Eng. 2008; (33B):244-251.
Tymofiyeva O, Proff P, Richter EJ, Jakob P, Fanghänel J, Gedrange T, Rottner K. Correlation of MRT imaging with real-time axiography of TMJ clicks. Ann Anat. 2007; 189(4):356-61.