Michael Ohliger, MD, PhD

Assistant Professor

Biography

Michael Ohliger, MD, PhD, is an Assistant Professor in Residence in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Ohliger obtained his PhD in Medical Physics from the Massachusetts Institute of Technology Harvard/MIT Division of Health Sciences and Technology in 2005, and he received his MD in Medicine from Harvard Medical School in Cambridge, Massachusetts in 2007. He completed his residency in Diagnostic Radiology from UCSF in 2012, followed by a fellowship in Abdominal Imaging from UCSF in 2013. He accepted the position of Assistant Professor in Residence at UCSF and SFGH, in July 2013.

Dr. Ohliger’s main research interest is the development and clinical translation of new MRI techniques for the abdomen and pelvis, with a focus on molecular imaging with hyperpolarized carbon-13 compounds. He is also interested in providing his expertise in developing new technology for patients with applications to liver, kidney, and prostate cancer. Dr. Ohliger has projects using diffusion tractography to help visualize the prostate capsule and plan to explore the application of new techniques such as (arterial spin labeling) using MRI’s to measure perfusion without intravenous contrast.

Dr. Ohliger has 13 published articles and he has written 18 peer-reviewed articles and 12 abstracts.

Expertise:
Abdominal Imaging

Specialty:
Abdomen and pelvis

Professional Interests:
Cancer, abdominal imaging, genitourinary imaging, magnetic resonance imaging, physics, radiation, molecular imaging, hyperpolarized carbon, nuclear magnetic resonance, liver, kidney, prostate, bowel

Education and Training:
• Medical School: Harvard Medical School, Boston, Massachusetts - Medicine
• Internship: Brigham and Women’s Hospital, Boston, Massachusetts - Medicine
• Residency: University of California, San Francisco - Diagnostic Radiology
• Fellowship: University of California, San Francisco - Abdominal Imaging
• Doctor of Philosophy: Massachusetts Institute of Technology Harvard/MIT, Boston, Division of Health Sciences and Technology - Medical Physics
• California Physician and Surgeon License
• California X-ray Supervisor and Operator Certificate
• American Board of Radiology Certificate in Diagnostic Radiology

Education

Fellowship, 2013
Abdominal Imaging, University of Calufornia, San Francisco
Residency, 2012 Radiology, University of California, San Francisco
MD, 2007 Medicine, Harvard Medical School
PhD, 2005 Medical Physics, Massachusetts Institute of Trchnology

Honors and Awards

Research Scholar Award, Radiological Society of North America, 2014-2016
Molecular Imaging Travel Award, Radiological Society of North America, 2011
Cum Laude Award, Radiological Society of North America, 2011
Fleischner Research Award, Beth Israel Deaconess Medical Center Department of Radiology, Boston, MA, 2005

Publications

Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM. Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. Sci Rep. 2017 Aug 11; 7(1):7903.
Hicks RM, Loening AM, Ohliger MA, Vasanawala SS, Hope TA. Variable refocusing flip angle single-shot fast spin echo imaging of liver lesions: increased speed and lesion contrast. Abdom Radiol (NY). 2017 Jul 08.
Horowitz JM, Venkatesh SK, Ehman RL, Jhaveri K, Kamath P, Ohliger MA, Samir AE, Silva AC, Taouli B, Torbenson MS, Wells ML, Yeh B, Miller FH. Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel. Abdom Radiol (NY). 2017 Jun 17.
Ohliger MA, Hope TA, Chapman JS, Chen LM, Behr SC, Poder L. PET/MR Imaging in Gynecologic Oncology. Magn Reson Imaging Clin N Am. 2017 Aug; 25(3):667-684.
Wilson DM, Di Gialleonardo V, Wang ZJ, Carroll V, Von Morze C, Taylor A, Sai V, VanCriekinge M, Bok R, Ohliger MA, Keshari KR. Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis. Sci Rep. 2017 Apr 20; 7:46014.
Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA. Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver. J Magn Reson Imaging. 2017 Apr 17.
Lambert JW, Sun Y, Gould RG, Ohliger MA, Li Z, Yeh BM. An Image-Domain Contrast Material Extraction Method for Dual-Energy Computed Tomography. Invest Radiol. 2016 Nov 22.
Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-(13) C]dihydroxyacetone. Magn Reson Med. 2016 Nov 17.
Dotson B, Lambert JW, Wang ZJ, Sun Y, Ohliger MA, Winklhofer S, Yeh BM. Benefit of iodine density images to reduce out-of-field image artifacts at rapid kVp switching dual-energy CT. Abdom Radiol (NY). 2016 Nov 16.
Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PE, Pauly JM, Vigneron DB. Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses. Magn Reson Med. 2016 Oct 21.
Gordon JW, Milshteyn E, Marco-Rius I, Ohliger M, Vigneron DB, Larson PE. Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects. Magn Reson Med. 2016 Oct 13.
Ehman EC, Umetsu SE, Ohliger MA, Fidelman N, Ferrell LD, Yeh BM, Yee J, Hope TA. Imaging prediction of residual hepatocellular carcinoma after locoregional therapy in patients undergoing liver transplantation or partial hepatectomy. Abdom Radiol (NY). 2016 Aug 3.
Ehman EC, Phelps AS, Ohliger MA, Rhee SJ, MacKenzie JD, Courtier JL. Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation. Clin Imaging. 2016 Nov - Dec; 40(6):1135-1139.
Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PE, Bok R, Chen HY, Kurhanewicz J, Vigneron D. Combining hyperpolarized (13) C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism. Magn Reson Med. 2016 Jun 14.
Hicks RM, Yee J, Ohliger MA, Weinstein S, Kao J, Ikram NS, Hope TA. Comparison of diffusion-weighted imaging and T2-weighted single shot fast spin-echo: Implications for LI-RADS characterization of hepatocellular carcinoma. Magn Reson Imaging. 2016 Sep; 34(7):915-21.
Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB. Multiband spectral-spatial RF excitation for hyperpolarized [2-(13) C]dihydroxyacetone (13) C-MR metabolism studies. Magn Reson Med. 2016 Mar 28.
Shang H, Larson PE, Kerr A, Reed G, Sukumar S, Elkhaled A, Gordon JW, Ohliger MA, Pauly JM, Lustig M, Vigneron DB. Multiband RF pulses with improved performance via convex optimization. J Magn Reson. 2016 Jan; 262:81-90.
Feng Y, Gordon JW, Shin PJ, von Morze C, Lustig M, Larson PE, Ohliger MA, Carvajal L, Tropp J, Pauly JM, Vigneron DB. Development and testing of hyperpolarized (13)C MR calibrationless parallel imaging. J Magn Reson. 2016 Jan; 262:1-7.
Hope TA, Verdin EF, Bergsland EK, Ohliger MA, Corvera CU, Nakakura EK. Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging. EJNMMI Phys. 2015 Dec; 2(1):21.
Lee SA, Plett SK, Luetkemeyer AF, Borgo GM, Ohliger MA, Conrad MB, Cookson BT, Sengupta DJ, Koehler JE. Bartonella quintana Aortitis in a Man with AIDS, Diagnosed by Needle Biopsy and 16S rRNA Gene Amplification. J Clin Microbiol. 2015 Aug; 53(8):2773-6.
von Morze C, Bok RA, Ohliger MA, Zhu Z, Vigneron DB, Kurhanewicz J. Hyperpolarized [(13) C]ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH isoforms. Magn Reson Med. 2016 May; 75(5):1894-900.
Shin PJ, Larson PE, Uecker M, Reed GD, Kerr AB, Tropp J, Ohliger MA, Nelson SJ, Pauly JM, Lustig M, Vigneron DB. Chemical shift separation with controlled aliasing for hyperpolarized (13) C metabolic imaging. Magn Reson Med. 2015 Oct; 74(4):978-89.
Hope TA, Ohliger MA, Qayyum A. MR imaging of diffuse liver disease: from technique to diagnosis. Radiol Clin North Am. 2014 Jul; 52(4):709-24.
Shin PJ, Larson PE, Ohliger MA, Elad M, Pauly JM, Vigneron DB, Lustig M. Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion. Magn Reson Med. 2014 Oct; 72(4):959-70.
Courtier J, Ohliger M, Rhee SJ, Terreblanche O, Heyman MB, MacKenzie JD. Shooting a moving target: use of real-time cine magnetic resonance imaging in assessment of the small bowel. J Pediatr Gastroenterol Nutr. 2013 Oct; 57(4):426-31.
Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013 Sep; 38(3):701-13.
Lattanzi R, Grant AK, Polimeni JR, Ohliger MA, Wiggins GC, Wald LL, Sodickson DK. Performance evaluation of a 32-element head array with respect to the ultimate intrinsic SNR. NMR Biomed. 2010 Feb; 23(2):142-51.
Ohliger MA, Sodickson DK. An introduction to coil array design for parallel MRI. NMR Biomed. 2006 May; 19(3):300-15.
Ohliger MA, Greenman RL, Giaquinto R, McKenzie CA, Wiggins G, Sodickson DK. Concentric coil arrays for parallel MRI. Magn Reson Med. 2005 Nov; 54(5):1248-60.
Willig-Onwuachi JD, Yeh EN, Grant AK, Ohliger MA, McKenzie CA, Sodickson DK. Phase-constrained parallel MR image reconstruction. J Magn Reson. 2005 Oct; 176(2):187-98.
Yeh EN, Stuber M, McKenzie CA, Botnar RM, Leiner T, Ohliger MA, Grant AK, Willig-Onwuachi JD, Sodickson DK. Inherently self-calibrating non-Cartesian parallel imaging. Magn Reson Med. 2005 Jul; 54(1):1-8.
Yeh EN, McKenzie CA, Ohliger MA, Sodickson DK. Parallel magnetic resonance imaging with adaptive radius in k-space (PARS): constrained image reconstruction using k-space locality in radiofrequency coil encoded data. Magn Reson Med. 2005 Jun; 53(6):1383-92.
Sodickson DK, Hardy CJ, Zhu Y, Giaquinto RO, Gross P, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Grant AK, Rofsky NM. Rapid volumetric MRI using parallel imaging with order-of-magnitude accelerations and a 32-element RF coil array: feasibility and implications. Acad Radiol. 2005 May; 12(5):626-35.
Zhu Y, Hardy CJ, Sodickson DK, Giaquinto RO, Dumoulin CL, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Rofsky NM. Highly parallel volumetric imaging with a 32-element RF coil array. Magn Reson Med. 2004 Oct; 52(4):869-77.
Ohliger MA, Ledden P, McKenzie CA, Sodickson DK. Effects of inductive coupling on parallel MR image reconstructions. Magn Reson Med. 2004 Sep; 52(3):628-39.
Ohliger MA, Grant AK, Sodickson DK. Ultimate intrinsic signal-to-noise ratio for parallel MRI: electromagnetic field considerations. Magn Reson Med. 2003 Nov; 50(5):1018-30.
McKenzie CA, Yeh EN, Ohliger MA, Price MD, Sodickson DK. Self-calibrating parallel imaging with automatic coil sensitivity extraction. Magn Reson Med. 2002 Mar; 47(3):529-38.
Sodickson DK, McKenzie CA, Ohliger MA, Yeh EN, Price MD. Recent advances in image reconstruction, coil sensitivity calibration, and coil array design for SMASH and generalized parallel MRI. MAGMA. 2002 Jan; 13(3):158-63.
McKenzie CA, Ohliger MA, Yeh EN, Price MD, Sodickson DK. Coil-by-coil image reconstruction with SMASH. Magn Reson Med. 2001 Sep; 46(3):619-23.
Foster MH, Kieber-Emmons T, Ohliger M, Madaio MP. Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies. Immunol Res. 1994; 13(2-3):186-206.