John Mackenzie, MD

Associate Professor
Chief of Pediatric Radiology
Assoc Professor in Residence

Biography

John MacKenzie, MD, is Associate Professor, Chief of Radiology at Mission Bay Medical Center, and Section Chief of Pediatric Radiology at the University of California, San Francisco. He provides expert interpretation and consultation on pediatric imaging studies for a broad spectrum of congenital and acquired fetal and neonatal conditions and disorders affecting children and adolescents. Prior to accepting his UCSF position, Dr. MacKenzie was a member of the faculty at Stanford University as the Chief of Pediatric Musculoskeletal Imaging at Lucile Packard Children’s Hospital from 2007-2010.

Dr. MacKenzie is a nationally recognized expert in the imaging of the pediatric musculoskeletal system and is asked to lecture on this topic across the country. Dr. MacKenzie’s research focuses on developing imaging techniques for the detection and treatment monitoring of childhood diseases.

Dr. MacKenzie has been awarded grants from the National Institutes of Health, National Academies Keck Futures Initiative Imaging Science, Radiological Society of North America and the Society of Pediatric Radiology. He has served as the Principal Investigator and Co-Principal Investigator on these projects. His work is published in 5 book chapters, 14 review articles, and 42 peer-reviewed research articles.

Expertise:
Pediatric Radiology
Pediatric Musculoskeletal Imaging

Specialty:
Specialized imaging for infants, children with a focus on pediatric bones and joints

Professional Interests:
Pediatric imaging, musculoskeletal imaging, arthritis and immunology, molecular imaging, hyperpolarized carbon-13 imaging, magnetic resonance imaging

Education and Training:
• Medical School: Albert Einstein College of Medicine, New York - Medicine
• Internship: Hospital of the University of Pennsylvania - Medicine
• Residency: Brigham and Women’s Hospital, Boston - Radiology
• Fellowship: Hospital of the University of Pennsylvania - Musculoskeletal Imaging
• Fellowship: Children’s Hospital of Philadelphia - Pediatric Imaging
• Master of Science: Stanford University, California - Biological Science
• Bachelor’s of Science: Stanford University, California - Computer Science and Biology
• Medical License, California
• Diagnostic Radiology, American Board of Radiology
• Pediatric Imaging, Certificate of Added Qualification, American Board of Radiology

Education

Fellowship, 2007 - Radiology - Pediatric Imaging, Children's Hospital of Philadelphia
Fellowship, 2006 - Radiology - Musculoskeletal Radiology, Hospital of the University of Pennsylvania
Residency, 2005 - Radiology - Diagnostic Imaging, Harvard: Brigham & Women's Hospital
Internship, 2001 - Medicine, Hospital of the University of Pennsylvania
M.D., 2000 - School of Medicine, Albert Einstein College of Medicine
B.S., 1995 - Double major: Computer Science & Biology with Honors, Stanford University
M.S., 1995 - Biology, Stanford University

Honors and Awards

Maxine Papadakis Award for Faculty Professionalism and Respect (outstanding instruction for 3rd-4th, UCSF School of Medicine, 2017
Great Experience Award, UCSF Medical Center, 2016
Invited Lecturer; "Hyperpolarized Carbon-13 MRI for Pediatrics Disease", UCSF Department of Pediatrics Grand Rounds, 2013
Award for Best Scientific Poster (mentor to Julia Nguyen), UCSF Department of Radiology, 2013
Award for Best Scientific Poster (mentor to Linda Nguyen), UCSF Department of Radiology, 2012
Poster Presentation Award - Isolated Fallopian Tubal torsion: Causes, Imaging Findings, and How to, Radiology Society of North America, 2012
Coro Faculty Leadership Collaborative, University of California, San Francisco, 2012
Award for Best Paper Presentation - Carbon-13 Imaging of Pediatric Disease, Pacific Coast Pediatric Radiology Association, 2011
Futures Initiative – Imaging Science Conference, National Academies Keck Futures Initiative, 2010
Fellow Research Trainee Prize, Radiology Society of North America, 2007
Resident Award for Research, Brigham and Women’s Hospital Radiology Department, 2005
RSNA Roentgen Resident/Fellow Research Award, Radiology Society of North America, 2005
Research Resident Scholarship, Siemens Medical Systems, 2004
Resident Research Trainee Prize, Radiology Society of North America, 2004
Resident Award for Research, Brigham and Women’s Hospital Radiology Department, 2004
MRI Fellowship Program, ISMRM/Amersham Health, 2004
Leonard Holman Pathway Research Resident, American Board of Radiology, 2003-2005
Resident Award for Teaching, Brigham and Women’s Hospital Radiology Department, 2002
Resident Award for Teaching, Brigham and Women’s Hospital Radiology Department, 2002
Introduction to Research Program, Radiology Society of North America, 2002
Research Scholarship, Albert Einstein College of Medicine, 2000
Alpha Omega Alpha, Albert Einstein College of Medicine, 2000
Summer Research Grant Scholar, Harvard Medical School, 1997
Firestone Medal for Excellence in Biological Research, Stanford University, 1995
Award for Excellence in Teaching Biological Sciences, Stanford University, 1993
Boettcher Scholarship, 1988

Publications

Edwards EA, Pigg N, Courtier J, Zapala MA, MacKenzie JD, Phelps AS. Intussusception: past, present and future. Pediatr Radiol. 2017 Aug; 47(9):1101-1108.
Poynton CB, Lee MM, Li Y, Laszik Z, Worters PW, Mackenzie JD, Courtier J. Intravoxel incoherent motion analysis of renal allograft diffusion with clinical and histopathological correlation in pediatric kidney transplant patients: A preliminary cross-sectional observational study. Pediatr Transplant. 2017 Sep; 21(6).
Oates A, Ahuja S, Lee MM, Phelps AS, Mackenzie JD, Courtier JL. Pediatric renal transplant biopsy with ultrasound guidance: the 'core' essentials. Pediatr Radiol. 2017 Jun 01.
Li Y, Lee MM, Worters PW, MacKenzie JD, Laszik Z, Courtier JL. Pilot Study of Renal Diffusion Tensor Imaging as a Correlate to Histopathology in Pediatric Renal Allografts. AJR Am J Roentgenol. 2017 Jun; 208(6):1358-1364.
Leelakanok N, Zapala MA, Edwards EA, Phelps AS, Mackenzie JD, Courtier J. Incidental Findings on Pediatric Abdominal Magnetic Resonance Angiography. Acad Radiol. 2017 Sep; 24(9):1107-1113.
Franc BL, Goth S, MacKenzie J, Li X, Blecha J, Lam T, Jivan S, Hawkins RA, VanBrocklin H. In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis. Mol Imaging. 2017 Jan 01; 16:1536012117712638.
Phelps A, Ramachandran R, Courtier J, Perito E, Rosenthal P, MacKenzie JD. Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation? Clin Imaging. 2017 Jan - Feb; 41:95-100.
Zhang Y, Yang L, MacKenzie JD, Ramachandran R, Chen DZ. A seeding-searching-ensemble method for gland segmentation in H&E-stained images. BMC Med Inform Decis Mak. 2016 Jul 21; 16 Suppl 2:80.
Ehman EC, Phelps AS, Ohliger MA, Rhee SJ, MacKenzie JD, Courtier JL. Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation. Clin Imaging. 2016 Nov - Dec; 40(6):1135-1139.
Steineck A, MacKenzie JD, Twist CJ. Premature physeal closure following 13-cis-retinoic acid and prolonged fenretinide administration in neuroblastoma. Pediatr Blood Cancer. 2016 Nov; 63(11):2050-3.
Winger BA, Foy E, Sud SR, MacKenzie JD, Pua HH, Lau AH, Heyman MB, Laszik Z, Tureen J. Mycobacterium bovis Enterocolitis in an Immunocompromised Host. J Pediatr Gastroenterol Nutr. 2016 Jul; 63(1):e17-9.
Li Y, Phelps A, Zapala MA, MacKenzie JD, MacKenzie TC, Courtier J. Magnetic resonance imaging of Müllerian duct anomalies in children. Pediatr Radiol. 2016 May; 46(6):796-805.
Patel MV, Leibowich S, Courtier JL, Rhee S, MacKenzie JD. Disodium gadoxetate uptake in progressive familial intrahepatic cholestasis type I: Enhancing our understanding of the cholestatic disease. Radiol Case Rep. 2013; 8(1):661.
Kim MJ, Rinsky LA, MacKenzie JD. Scapular stress fracture initially masquerading as tumor or infection. Radiol Case Rep. 2011; 6(4):510.
Lambert JW, Phelps AS, Courtier JL, Gould RG, MacKenzie JD. Image quality and dose optimisation for infant CT using a paediatric phantom. Eur Radiol. 2016 May; 26(5):1387-95.
Courtier J, Cardenas A, Tan C, Towne M, Rhee SJ, Heyman MB, MacKenzie JD. Nonanesthesia magnetic resonance enterography in young children: feasibility, technique, and performance. J Pediatr Gastroenterol Nutr. 2015 Jun; 60(6):754-61.
Basta AM, Courtier J, Phelps A, Copp HL, MacKenzie JD. Scrotal swelling in the neonate. J Ultrasound Med. 2015 Mar; 34(3):495-505.
Courtier J, Cardenas A, Tan C, Towne M, Rhee SJ, Heyman M, MacKenzie JD. Non-Anesthesia MR Enterography in Very Young Children-Feasibility, Technique and Performance. J Pediatr Gastroenterol Nutr. 2015 Jan 05.
Phelps AS, Naeger DM, Courtier JL, Lambert JW, Marcovici PA, Villanueva-Meyer JE, MacKenzie JD. Pairwise comparison versus Likert scale for biomedical image assessment. AJR Am J Roentgenol. 2015 Jan; 204(1):8-14.
Lin C, MacKenzie JD, Courtier JL, Gu JT, Milojevic D. Magnetic resonance imaging findings in juvenile spondyloarthropathy and effects of treatment observed on subsequent imaging. Pediatr Rheumatol Online J. 2014; 12:25.
Lambert J, MacKenzie JD, Cody DD, Gould R. Techniques and tactics for optimizing CT dose in adults and children: state of the art and future advances. J Am Coll Radiol. 2014 Mar; 11(3):262-6.
Koc G, Courtier JL, Phelps A, Marcovici PA, MacKenzie JD. Computed tomography depiction of small pediatric vessels with model-based iterative reconstruction. Pediatr Radiol. 2014 Jul; 44(7):787-94.
Wang J, MacKenzie JD, Ramachandran R, Chen DZ. Identifying neutrophils in H&E staining histology tissue images. Med Image Comput Comput Assist Interv. 2014; 17(Pt 1):73-80.
Courtier J, Ohliger M, Rhee SJ, Terreblanche O, Heyman MB, MacKenzie JD. Shooting a moving target: use of real-time cine magnetic resonance imaging in assessment of the small bowel. J Pediatr Gastroenterol Nutr. 2013 Oct; 57(4):426-31.
Koc G, Courtier JL, Kim JS, Miniati DN, MacKenzie JD. Intra-abdominal inverted umblical cord in gastroschisis: a unique ultrasound finding. Pediatr Radiol. 2014 Jan; 44(1):109-11.
Patel AS, Soares B, Courtier J, Mackenzie JD. Radiation dose reduction in pediatric CT-guided musculoskeletal procedures. Pediatr Radiol. 2013 Oct; 43(10):1303-8.
Courtier J, Robbins E, Soares B, Horvai A, Mackenzie JD. Primary mixed malignant tumor of bone in an 18-year-old male: Report of a case with radiologic-pathologic correlation. J Bone Oncol. 2012 Dec; 1(3):101-5.
Shive ML, Baskin LS, Harris CR, Bonham M, MacKenzie JD. Ureteral fibroepithelial polyp causing urinary obstruction. J Radiol Case Rep. 2012 Jul; 6(7):23-8.
Courtier JL, Perito ER, Rhee S, Tsai P, Heyman MB, MacKenzie JD. Targeted MRI contrast agents for pediatric hepatobiliary disease. J Pediatr Gastroenterol Nutr. 2012 Apr; 54(4):454-62.
Mackenzie JD, Hernandez A, Pena A, Ruppert K, Khrichenko D, Gonzalez L, Jawad AF, Wells L, Smith-Whitley K, Jaramillo D. Magnetic resonance imaging in children with sickle cell disease--detecting alterations in the apparent diffusion coefficient in hips with avascular necrosis. Pediatr Radiol. 2012 Jun; 42(6):706-13.
Phelps A, Naeger DM, MacKenzie J, Qayyum A. Educating radiology residents in the new era: implementation and evaluation of online end-of-rotation examinations. Acad Radiol. 2011 Nov; 18(11):1442-6.
Gu JT, Nguyen L, Chaudhari AJ, MacKenzie JD. Molecular characterization of rheumatoid arthritis with magnetic resonance imaging. Top Magn Reson Imaging. 2011 Apr; 22(2):61-9.
MacKenzie JD, Yen YF, Mayer D, Tropp JS, Hurd RE, Spielman DM. Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy. Radiology. 2011 May; 259(2):414-20.
MacKenzie JD, Vasanawala SS. State-of-the-art in pediatric body and musculoskeletal magnetic resonance imaging. Semin Ultrasound CT MR. 2010 Apr; 31(2):86-99.
Melvin JS, Mackenzie JD, Nacke E, Sennett BJ, Wells L. MRI of HAGL lesions: four arthroscopically confirmed cases of false-positive diagnosis. AJR Am J Roentgenol. 2008 Sep; 191(3):730-4.
MacKenzie JD, Vasanawala SS. Advances in pediatric MR imaging. Magn Reson Imaging Clin N Am. 2008 Aug; 16(3):385-402, v.
MacKenzie JD. MR arthrography made simple: indications and techniques. Pediatr Radiol. 2008 May; 38 Suppl 2:S240-2.
MacKenzie JD, Nazario-Larrieu J, Cai T, Ledbetter MS, Duran-Mendicuti MA, Judy PF, Rybicki FJ. Reduced-dose CT: effect on reader evaluation in detection of pulmonary embolism. AJR Am J Roentgenol. 2007 Dec; 189(6):1371-9.
MacKenzie JD, Gonzalez L, Hernandez A, Ruppert K, Jaramillo D. Diffusion-weighted and diffusion tensor imaging for pediatric musculoskeletal disorders. Pediatr Radiol. 2007 Aug; 37(8):781-8.
Choi MH, MacKenzie JD, Dalinka MK. Imaging features of crystal-induced arthropathy. Rheum Dis Clin North Am. 2006 May; 32(2):427-46, viii.
Shu KM, MacKenzie JD, Smith JB, Blinder EM, Bourgeois LM, Ledbetter S, Castronovo FP, Judy PF, Rybicki F. Lowering the thyroid dose in screening examinations of the cervical spine. Emerg Radiol. 2006 Mar; 12(3):133-6.
Villalba ML, Huynh B, So M, Mackenzie JD, Ledbetter S, Rybicki F. An ovary with a twist: a case of interesting sonographic findings of ovarian torsion. J Emerg Med. 2005 Nov; 29(4):443-6.
Vargas TM, Rybicki FJ, Ledbetter SM, MacKenzie JD. Atlantoaxial instability associated with an orthotopic os odontoideum: a multimodality imaging assessment. Emerg Radiol. 2005 Jun; 11(4):223-5.
Viscomi S, Shu KM, Blinder EM, MacKenzie JD, Ledbetter S, Rybicki FJ. Quantification of clinical consultations in academic emergency radiology. Acad Radiol. 2004 Nov; 11(11):1294-7.
Blinder E, MacKenzie JD, Cranmer HH, Ledbetter S, Rybicki F. Uterine rupture with peritonitis in a nongravid uterus eight weeks after cesarean section. Emerg Radiol. 2003 Apr; 10(1):57-9.
MacKenzie JD, Siddiqi F, Babb JS, Bagley LJ, Mannon LJ, Sinson GP, Grossman RI. Brain atrophy in mild or moderate traumatic brain injury: a longitudinal quantitative analysis. AJNR Am J Neuroradiol. 2002 Oct; 23(9):1509-15.
Seidl KJ, Wilshire JA, MacKenzie JD, Kantor AB, Herzenberg LA, Herzenberg LA. Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2262-7.
Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, Herzenberg LA, Herzenberg LA. Frequent occurrence of identical heavy and light chain Ig rearrangements. Int Immunol. 1997 May; 9(5):689-702.
Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, Herzenberg LA, Herzenberg LA. Recurrent identical rearrangement and repeated expression of identical heavy and light chains in single anti-phosphatidylcholine B cells. Ann N Y Acad Sci. 1997 Apr 05; 815:484-8.
Kantor AB, Merrill CE, MacKenzie JD, Herzenberg LA, Hillson JL. Development of the antibody repertoire as revealed by single-cell PCR of FACS-sorted B-cell subsets. Ann N Y Acad Sci. 1995 Sep 29; 764:224-7.